2025
Associations between blood donors, component modifications, and the alloimmunization of transfusion recipients
Yu H, Karafin M, Tormey C, Goel R, Spencer B, Hendrickson J, Hauser R. Associations between blood donors, component modifications, and the alloimmunization of transfusion recipients. Transfusion 2025, 65: 588-603. PMID: 39821794, DOI: 10.1111/trf.18135.Peer-Reviewed Original ResearchRisk of RBC alloimmunizationRed blood cell unitsRed blood cellsTransfusion recipientsBlood donorsRBC alloimmunizationMultivariate conditional logistic regression analysisConditional logistic regression analysisRisk of alloimmunizationIrradiated red blood cellsCase-control studyLogistic regression analysisSickle cell diseaseAlloantibody formationAlloimmunization eventsRecipient variablesAlloimmunizationRecipient EpidemiologyRecipient diagnosisSub-analysisDecreased riskCell diseaseOlder donorsLow riskTransfusion
2022
Clodronate inhibits alloimmunization against distinct red blood cell alloantigens in mice
Arthur CM, Patel SR, Sharma A, Zerra PE, Chonat S, Jajosky RP, Fasano RM, Patel R, Bennett A, Zhou X, Luckey CJ, Hudson KE, Eisenbarth SC, Josephson CD, Roback JD, Hendrickson JE, Stowell SR. Clodronate inhibits alloimmunization against distinct red blood cell alloantigens in mice. Transfusion 2022, 62: 948-953. PMID: 35470900, PMCID: PMC9491148, DOI: 10.1111/trf.16872.Peer-Reviewed Original ResearchConceptsRBC alloimmunizationRBC transfusionAntibody formationPreclinical modelsRed blood cell transfusionBlood cell alloantigensBlood cell transfusionTransfusion of RBCsTransfusion-dependent patientsDevelopment of alloantibodiesIgG antibody formationAlloantigen exposureHOD RBCsCell transfusionPost transfusionAlloantibody formationPharmacological removalIgG antibodiesTransfusionAlloimmunizationClodronateMarginal sinusPrior treatmentDay 5KEL antigen
2021
Marginal zone B cells mediate a CD4 T-cell–dependent extrafollicular antibody response following RBC transfusion in mice
Zerra PE, Patel SR, Jajosky RP, Arthur CM, McCoy JW, Allen JWL, Chonat S, Fasano RM, Roback JD, Josephson CD, Hendrickson J, Stowell SR. Marginal zone B cells mediate a CD4 T-cell–dependent extrafollicular antibody response following RBC transfusion in mice. Blood 2021, 138: 706-721. PMID: 33876205, PMCID: PMC8394907, DOI: 10.1182/blood.2020009376.Peer-Reviewed Original ResearchConceptsMarginal zone B cellsRBC transfusionMZ B cellsB cellsHOD RBCsAlloantibody formationAntibody responseAntibody formationAntigen-specific germinal center B cellsB cell-deficient recipientsCD4 T-cell depletionRed blood cell transfusionCD4 T cell activationRBC alloantibody formationBlood cell transfusionT-cell depletionCD4 T cellsProbability of complicationsExtrafollicular antibody responsesGerminal center B cellsFollicular B cellsT cell activationRBC alloimmunizationCell transfusionSubsequent transfusions
2020
Red blood cell alloimmunization and sickle cell disease: a narrative review on antibody induction
Hendrickson JE. Red blood cell alloimmunization and sickle cell disease: a narrative review on antibody induction. Annals Of Blood 2020, 5: 33-33. PMID: 33554044, PMCID: PMC7861514, DOI: 10.21037/aob-2020-scd-01.Peer-Reviewed Original ResearchSickle cell diseaseRBC alloantibody formationRace-matched controlsAlloantibody formationCell diseaseImmune systemRed blood cell alloimmunizationRed blood cell alloantibodiesWhite blood cell subsetsAntigen variantsFcγ receptor polymorphismsT cell subsetsBlood cell subsetsType 1 interferonFree hemeRBC alloimmunizationRBC alloantibodiesAntibody inductionPlatelet countCell subsetsReceptor polymorphismsHigh prevalenceMurine studiesMurine modelHuman studiesPassive anti‐C acquired in the setting of Rh immune globulin administration following Rh mismatched apheresis platelet transfusion: A case series
Sostin N, Ross R, Balbuena‐Merle R, Hendrickson JE, Tormey CA. Passive anti‐C acquired in the setting of Rh immune globulin administration following Rh mismatched apheresis platelet transfusion: A case series. Journal Of Clinical Apheresis 2020, 35: 224-226. PMID: 32110829, DOI: 10.1002/jca.21773.Peer-Reviewed Original ResearchConceptsPlatelet transfusionsRh immune globulin administrationRisk/benefit ratioApheresis platelet transfusionImmune globulin administrationRhIG immunoprophylaxisImmune globulinTransfusion supportAlloantibody formationCase seriesNegative recipientsAlloimmunization riskRhIG administrationReproductive agePassive transferPLT transfusionsTransfusionBlood bankBenefit ratioRhIGApheresis PLTsAdministrationImmunoprophylaxisPatientsSetting
2019
Recipient factors influencing red blood cell alloimmunization
Hendrickson J. Recipient factors influencing red blood cell alloimmunization. ISBT Science Series 2019, 15: 194-200. DOI: 10.1111/voxs.12485.Peer-Reviewed Original ResearchSickle cell diseaseRBC alloantibodiesMyelodysplastic syndromeRed blood cell alloimmunizationRed blood cell alloantibodiesRBC alloantibody formationReductionist murine modelHaemolytic transfusion reactionsType of inflammationHigh prevalence ratesForms of autoimmunityDetectable alloantibodiesRBC alloimmunizationTransfusion avoidanceTransfusion burdenAlloantibody formationAntigen matchingRecipient factorsAntibody screenPatient populationHaemolytic diseaseRBC exposureRisk factorsTransfusion reactionsMurine modelTransfusion-related red blood cell alloantibodies: induction and consequences
Tormey CA, Hendrickson JE. Transfusion-related red blood cell alloantibodies: induction and consequences. Blood 2019, 133: 1821-1830. PMID: 30808636, PMCID: PMC6484385, DOI: 10.1182/blood-2018-08-833962.Peer-Reviewed Original ResearchConceptsTransfusion recipientsBlood donorsPreventative strategiesBlood product exposureCompatible RBC unitsRBC alloantibody formationHemolytic transfusion reactionsDevelopment of alloantibodiesAdaptive immune factorsJudicious transfusionRBC alloimmunizationImmunomodulatory therapyAlloantibody formationBlood transfusionRBC alloantibodiesRecipient variablesFuture pregnanciesImmune factorsTransfusion reactionsBlood productsHemolytic diseaseFuture transfusionsHuman studiesTransfusionAlloantibodies
2018
Marginal Zone B Cells Induce Alloantibody Formation Following RBC Transfusion
Patel SR, Gibb DR, Girard-Pierce K, Zhou X, Rodrigues LC, Arthur CM, Bennett AL, Jajosky RP, Fuller M, Maier CL, Zerra PE, Chonat S, Smith NH, Tormey CA, Hendrickson JE, Stowell SR. Marginal Zone B Cells Induce Alloantibody Formation Following RBC Transfusion. Frontiers In Immunology 2018, 9: 2516. PMID: 30505302, PMCID: PMC6250814, DOI: 10.3389/fimmu.2018.02516.Peer-Reviewed Original ResearchConceptsMZ B cellsMarginal zone B cellsRBC transfusionB cellsKEL RBCsImmune factorsAntibody formationRBC antigensRed blood cell alloimmunizationKey immune factorsSpecific immune compartmentCD4 T cellsFollicular B cellsAlloantibody formationImmune compartmentAntibody responseT cellsTherapeutic modalitiesTransfusionImmunological challengeImmune pathwaysMarginal sinusSplenic compartmentsImmune constituentsAlloimmunization
2017
The impact of vaccination on RBC alloimmunization in a murine model
Natarajan P, Santhanakrishnan M, Tormey CA, Hendrickson JE. The impact of vaccination on RBC alloimmunization in a murine model. Vox Sanguinis 2017, 112: 598-600. PMID: 28597520, PMCID: PMC5575953, DOI: 10.1111/vox.12541.Peer-Reviewed Original ResearchConceptsImmune responseMurine modelRBC alloantibody formationDamage-associated molecular patternsImpact of vaccinationRBC alloimmunizationAlloantibody formationHepB vaccineRBC transfusionAdaptive immunityAnimal modelsAlloimmunizationMolecular patternsVaccineVaccinationFuture studiesResponseTransfusionImmunity
2016
Understanding red blood cell alloimmunization triggers
Hendrickson JE, Tormey CA. Understanding red blood cell alloimmunization triggers. Hematology 2016, 2016: 446-451. PMID: 27913514, PMCID: PMC6142457, DOI: 10.1182/asheducation-2016.1.446.Peer-Reviewed Original ResearchConceptsRBC alloimmunizationRed blood cellsRisk factorsBlood cellsWhite blood cellsBlood group antigensPregnancy outcomesAlloantibody formationRBC alloantibodiesRBC transfusionRecipient factorsTransfusion safetyAlloimmunizationAnimal modelsHuman studiesPrevention strategiesDonor plasmaDanger signalsParticular antigenGroup antigensAntigenTransfusionPregnancyNonrespondersCells
2013
KEL RBC Transfusion Induces IgG Anti-KEL Antibodies Independent Of CD4 T Cells
Stowell S, Girard-Pierce K, Arthur C, Smith N, Zimring J, Hendrickson J. KEL RBC Transfusion Induces IgG Anti-KEL Antibodies Independent Of CD4 T Cells. Blood 2013, 122: 41. DOI: 10.1182/blood.v122.21.41.41.Peer-Reviewed Original ResearchCD4 T cellsMHC class IIRBC alloantibody formationRBC transfusionT cellsKEL RBCsIsotype controlAlloantibody formationC57BL/6 recipientsRBC alloantibodiesRBC alloantigensClass IICD-4 T-cellsCD4 T-cell depletionRed blood cell transfusionCD4 T cell helpMHC class II antigensChronic transfusion therapyBlood cell transfusionT-cell depletionHemolytic transfusion reactionsIsotype control antibodyClass II antigensT cell helpMHC antigen presentation
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