2024
NCS-1 protein regulates TRPA1 channel through the PI3K pathway in breast cancer and neuronal cells
Sánchez J, Alemán A, Henao J, Olaya J, Ehrlich B. NCS-1 protein regulates TRPA1 channel through the PI3K pathway in breast cancer and neuronal cells. Journal Of Physiology And Biochemistry 2024, 80: 451-463. PMID: 38564162, PMCID: PMC11074019, DOI: 10.1007/s13105-024-01016-z.Peer-Reviewed Original ResearchConceptsTransient receptor potential channel ankyrin 1Breast cancerPI3K pathwayNCS-1Chemotherapy-induced peripheral neuropathyCa2+ channelsK pathwayCa2+ influxNCS-1 expressionBreast cancer cellsCa2+ sensorCa2+ homeostasisCa2+ dynamicsNeuronal calcium sensor-1MDA-MB-231Fura-2Open probabilityPain sensationAnkyrin 1Peripheral neuropathyTRPA1 channelsCo-immunoprecipitationChannel functionRegulatory componentsCellular pathways
2014
A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain
Gui J, Liu B, Cao G, Lipchik AM, Perez M, Dekan Z, Mobli M, Daly NL, Alewood PF, Parker LL, King GF, Zhou Y, Jordt SE, Nitabach MN. A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain. Current Biology 2014, 24: 473-483. PMID: 24530065, PMCID: PMC3949122, DOI: 10.1016/j.cub.2014.01.013.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBinding SitesDrug Evaluation, PreclinicalFemaleGene LibraryHumansMolecular Sequence DataNAV1.2 Voltage-Gated Sodium ChannelOocytesPeptidesProtein Structure, TertiarySpider VenomsTransient Receptor Potential ChannelsVoltage-Gated Sodium Channel BlockersXenopus ProteinsConceptsTransient receptor potential ankyrin 1Ion channel modifiersProTxIon channel transient receptor potential ankyrin 1Channel modifiersPeptide toxinsSpecific peptidesIon channelsVoltage-gated sodium channelsContext of painS1-S4Spider venomPotential clinical applicationsTRPA1 antagonistTRPA1 functionAnkyrin 1PeptidesModifiersPeptide antagonistAntagonistSodium channelsPharmacological reagentsReagentsClinical applicationNav1.2
2013
TRPA1-Dependent Pruritus in IL-13–Induced Chronic Atopic Dermatitis
Oh MH, Oh SY, Lu J, Lou H, Myers AC, Zhu Z, Zheng T. TRPA1-Dependent Pruritus in IL-13–Induced Chronic Atopic Dermatitis. The Journal Of Immunology 2013, 191: 5371-5382. PMID: 24140646, PMCID: PMC4175413, DOI: 10.4049/jimmunol.1300300.Peer-Reviewed Original ResearchMeSH KeywordsAcetanilidesAnimalsCalcium ChannelsCells, CulturedChronic DiseaseCytokinesDermatitis, AtopicDisease Models, AnimalHumansInterleukin-13Mast CellsMiceMice, Inbred C57BLMice, TransgenicNerve FibersNerve Tissue ProteinsNeuropeptidesPruritusPurinesTh1-Th2 BalanceTransient Receptor Potential ChannelsTRPA1 Cation ChannelUp-RegulationConceptsTransient receptor potential ankyrin 1Chronic atopic dermatitisAtopic dermatitisMast cellsChronic itchTRPA1 expressionAfferent nervesIL-13Nerve fibersInhibition of TRPA1Histamine-independent itchSensory nerve fibersAfferent nerve fibersDorsal root gangliaNovel neural mechanismAD skinAD miceItch pathwaysLesional skinRoot gangliaInflammatory environmentHealthy subjectsSpecific antagonistMouse modelAnkyrin 1
2011
Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants
Willis DN, Liu B, Ha MA, Jordt S, Morris JB. Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. The FASEB Journal 2011, 25: 4434-4444. PMID: 21903934, PMCID: PMC3236628, DOI: 10.1096/fj.11-188383.Peer-Reviewed Original ResearchConceptsTransient receptor potential ankyrin 1Irritation responseMenthol effectsCold-sensitive sensory neuronsSensory TRP channelsSmoking-related morbiditySensory irritation responseEffect of mentholTransient receptor potential melastatin 8 (TRPM8) ion channelActivation of TRPM8TRPM8 agonistTRPM8 antagonistsCapsaicin receptorRespiratory tractSensory neuronsAnkyrin 1Pharmacological actionsNicotine addictionSmoking behaviorRespiratory irritationTRP channelsAgonistsSmoke constituentsAvailable cigarettesCigarettes
2009
TRPA1 Antagonists Block the Noxious Effects of Toxic Industrial Isocyanates and Tear Gases
Bessac B, Sivula M, von Hehn C, Caceres A, Escalera J, Jordt S. TRPA1 Antagonists Block the Noxious Effects of Toxic Industrial Isocyanates and Tear Gases. The FASEB Journal 2009, 23: 580.11-580.11. DOI: 10.1096/fasebj.23.1_supplement.580.11.Peer-Reviewed Original ResearchTransient receptor potential ankyrin 1Tear gas agentsSame neuronal receptorNoxious effectsTear gasesActivation of Ca2Adverse health effectsNocifensive behaviorAirway irritationCutaneous exposureTRPA1 antagonistSensory neuronsAnkyrin 1Neuronal receptorsPharmacological inhibitionGenetic ablationHealth effectsMembrane currentsFrequent exposureNoxious chemicalsExposureIon channelsSimilar responsesCa2Lacrimation
1997
Structure and Organization of the Human Ankyrin-1 Gene BASIS FOR COMPLEXITY OF PRE-mRNA PROCESSING*
Gallagher P, Tse W, Scarpa A, Lux S, Forget B. Structure and Organization of the Human Ankyrin-1 Gene BASIS FOR COMPLEXITY OF PRE-mRNA PROCESSING*. Journal Of Biological Chemistry 1997, 272: 19220-19228. PMID: 9235914, DOI: 10.1074/jbc.272.31.19220.Peer-Reviewed Original ResearchConceptsGenomic structureANK-1 geneSpectrin-binding domainMembrane-binding domainIntron/exon boundariesAlternative polyadenylation signalsPre-mRNA processingBrain-specific transcriptFurther genetic studiesErythrocyte membrane proteinsErythroid transcriptsCommon hemolytic anemiaGene basisAlternative splicingRegulatory domainProtein domainsChromosomal genesMembrane proteinsKilobase pairsPolyadenylation signalMembrane skeletonPlasma membraneExon boundariesGenetic studiesAnkyrin 1
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