2025
EXTRACELLULAR VESICLES IN MAJOR DEPRESSIVE DISORDER AND THEIR RELATIONSHIP TO TREATMENT OUTCOME
Eggerstorfer *, Zadka Ł, Rusak A, Godbersen G, Opalińska A, Unterholzner J, Haczkiewicz-Leśniak K, Silberbauer L, Hahn A, Murgaš M, Gomułkiewicz A, Rujescu D, Podhorska-Okołów M, Lanzenberger R, Gryglewski G. EXTRACELLULAR VESICLES IN MAJOR DEPRESSIVE DISORDER AND THEIR RELATIONSHIP TO TREATMENT OUTCOME. The International Journal Of Neuropsychopharmacology 2025, 28: i32-i33. PMCID: PMC11815236, DOI: 10.1093/ijnp/pyae059.056.Peer-Reviewed Original ResearchMDD patientsPathophysiology of psychiatric disordersPlasma of MDD patientsOutcome of MDDAntidepressant treatment responseSerotonin transporter occupancyDepression Rating ScaleTreated with escitalopramHealthy controlsExpression of SLC6A4Expression of exosome markersAntidepressant treatmentDepressive disorderSerotonin transporterExosomal markersPsychiatric disordersTransporter occupancyNanoparticle tracking analysisMDDMental disordersMRNA expressionDiverse neurotransmittersRating ScaleCD9 expressionExtracellular vesicles
2024
Early-treatment cerebral blood flow change as a predictive biomarker of antidepressant treatment response: evidence from the EMBARC clinical trial.
Dang Y, Lu B, Vanderwal T, Castellanos F, Yan C. Early-treatment cerebral blood flow change as a predictive biomarker of antidepressant treatment response: evidence from the EMBARC clinical trial. Psychological Medicine 2024, 54: 3053-3062. PMID: 38720516, DOI: 10.1017/s0033291724001156.Peer-Reviewed Original ResearchMajor depressive disorderBrain regionsTreatment of Major Depressive DisorderHamilton Depression Rating Scale scoresBiomarkers of antidepressant treatment responseCerebral blood flowBiosignatures of Antidepressant ResponseDepression Rating Scale scoresSerotonin reuptake inhibitor treatmentAntidepressant treatment responseResponse to antidepressantsTreatment responseRating Scale scoresBiomarkers of treatment responseAssociated with increased cerebral perfusionEstablishing ModeratorsAntidepressant responseAntidepressant effectsDepressive disorderTemporal cortexNeural biomarkersPostcentral regionsCerebral blood flow changesWhole-brainDisabling illness
2022
Development of a model to predict antidepressant treatment response for depression among Veterans
Puac-Polanco V, Ziobrowski H, Ross E, Liu H, Turner B, Cui R, Leung L, Bossarte R, Bryant C, Joormann J, Nierenberg A, Oslin D, Pigeon W, Post E, Zainal N, Zaslavsky A, Zubizarreta J, Luedtke A, Kennedy C, Cipriani A, Furukawa T, Kessler R. Development of a model to predict antidepressant treatment response for depression among Veterans. Psychological Medicine 2022, 53: 5001-5011. PMID: 37650342, PMCID: PMC10519376, DOI: 10.1017/s0033291722001982.Peer-Reviewed Original ResearchConceptsMajor depressive disorderVeterans Health AdministrationTreatment responseAntidepressant medicationADM treatmentDepression Symptomatology-Self ReportUS Veterans Health AdministrationBaseline self-reported dataAntidepressant treatment responseSheehan Disability ScaleBaseline symptom severityBeginning of treatmentVHA patientsQuick InventoryDisability ScaleDepressive disorderTreatment characteristicsSelf-report assessmentsTreatment selectionAlternative treatmentHealth AdministrationPatientsSymptom severityROC curveSelf-reported data
2020
ERICH3: vesicular association and antidepressant treatment response
Liu D, Zhuang Y, Zhang L, Gao H, Neavin D, Carrillo-Roa T, Wang Y, Yu J, Qin S, Kim D, Liu E, Nguyen T, Biernacka J, Kaddurah-Daouk R, Dunlop B, Craighead W, Mayberg H, Binder E, Frye M, Wang L, Weinshilboum R. ERICH3: vesicular association and antidepressant treatment response. Molecular Psychiatry 2020, 26: 2415-2428. PMID: 33230203, PMCID: PMC8141066, DOI: 10.1038/s41380-020-00940-y.Peer-Reviewed Original ResearchConceptsSingle-nucleotide polymorphismsAssociated with SSRI responseGenome-wide association studiesSSRI treatment outcomeAntidepressant treatment responseVesicular functionSerotonin reuptake inhibitorsClathrin heavy chainHuman iPSC-derived neuronsPlasma 5-HT concentrationsVesicle-like structuresSSRI responseSSRI trialMDD trialsMDD patientsDepressive disorderSSRI therapyReuptake inhibitorsGenome-wideIPSC-derived neuronsSK-N-SH cellsAssociation studiesInteracting proteinsERICH3Neuronal cell types
2012
Neuritin produces antidepressant actions and blocks the neuronal and behavioral deficits caused by chronic stress
Son H, Banasr M, Choi M, Chae SY, Licznerski P, Lee B, Voleti B, Li N, Lepack A, Fournier NM, Lee KR, Lee IY, Kim J, Kim JH, Kim YH, Jung SJ, Duman RS. Neuritin produces antidepressant actions and blocks the neuronal and behavioral deficits caused by chronic stress. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 11378-11383. PMID: 22733766, PMCID: PMC3396528, DOI: 10.1073/pnas.1201191109.Peer-Reviewed Original ResearchConceptsChronic unpredictable stressAntidepressant actionAtrophy of dendritesDepressive-like behaviorAntidepressant treatment responseSymptoms of depressionExpression of neuritinActivity-dependent genesAntidepressant treatmentLimbic structuresHippocampal expressionUnpredictable stressTreatment responseMood disordersBehavioral deficitsNeuronal plasticityTreatment reversesAnxiety behaviorChronic stressNeuritinDendrite branchingUnique actionHippocampusNeuroplasticityModel of stressDoes Antidepressant Treatment Improve Cognition in Older People with Schizophrenia or Schizoaffective Disorder and Comorbid Subsyndromal Depression?
Dawes SE, Palmer BW, Meeks T, Golshan S, Kasckow J, Mohamed S, Zisook S. Does Antidepressant Treatment Improve Cognition in Older People with Schizophrenia or Schizoaffective Disorder and Comorbid Subsyndromal Depression? Neuropsychobiology 2012, 65: 168-172. PMID: 22456094, PMCID: PMC3701889, DOI: 10.1159/000331141.Peer-Reviewed Original ResearchConceptsSchizoaffective disorderCognitive deficitsDepression Rating Scale scoresHamilton Depression Rating ScaleFlexible-dose treatmentAntidepressant treatment responseDepression Rating ScaleTreatment of depressionMajor depressive disorderRating Scale scoresBaseline cognitive statusPlacebo groupAntidepressant medicationCurrent medicationsPlacebo augmentationFunctional disabilityCognitive composite scoreSubsyndromal depressionDepressive disorderSubsyndromal symptomsTreatment responseTreatment groupsDose treatmentScale scoreCognitive status
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