2025
Associations between childhood trauma and adolescent psychiatric disorders in Brazil: a longitudinal, population-based birth cohort study
Bailey M, Fairchild G, Hammerton G, Bauer A, Carpena M, Murray J, Santos I, Barros A, Tovo-Rodrigues L, Danese A, Halligan S, Matijasevich A. Associations between childhood trauma and adolescent psychiatric disorders in Brazil: a longitudinal, population-based birth cohort study. The Lancet Global Health 2025, 13: e309-e318. PMID: 39890231, DOI: 10.1016/s2214-109x(24)00452-2.Peer-Reviewed Original ResearchConceptsLow-income and-middle-income countriesPopulation attributable fractionPelotas Birth CohortAdolescent psychiatric disordersAnxiety disordersPsychiatric disordersTrauma exposureCumulative traumaBirth cohortLongitudinal associationsChildhood traumaMood disordersComputed population attributable fractionsTrauma loadPopulation-based birth cohort studyMental disordersRisk of mental disordersAnd Middle-Income CountriesExposure to childhood traumaPrevalence of trauma exposureAssociated with increased oddsAssociated with mental disordersBirth cohort studyIncreased exposure to traumaBurden of traumaMaternal Emotional Availability Supports Child Communicative Development Regardless of Child Temperament—Findings From the FinnBrain Birth Cohort Study
Ollas‐Skogster D, Korja R, Yada A, Mainela‐Arnold E, Karlsson H, Bridgett D, Rautakoski P, Karlsson L, Nolvi S. Maternal Emotional Availability Supports Child Communicative Development Regardless of Child Temperament—Findings From the FinnBrain Birth Cohort Study. Infancy 2025, 30: e12649. PMID: 39853895, PMCID: PMC11758768, DOI: 10.1111/infa.12649.Peer-Reviewed Original ResearchConceptsFinnBrain Birth Cohort StudyEmotional availabilityEarly communication developmentCommunication developmentChild temperamentMaternal EAAssociated with early language developmentPath model of associationsEarly language developmentEmotional aspects of parentingInfant communicative developmentMother-child dyadsBirth cohort studyAspects of parentingModel of associationTemperament traitsLanguage developmentMaternal caregivingTemperamentPath modelLongitudinal effectsSurgency/extraversionCohort studyEmotional aspectsCommunication skills
2024
The fetal origins of metabolic health: exploring the association between newborn biological age and metabolism hormones in childhood
Jia Z, Qiu F, He Y, Chen H, Yang C, Liu H, Zheng T, Xu S, Wang S, Li Y. The fetal origins of metabolic health: exploring the association between newborn biological age and metabolism hormones in childhood. BMC Medicine 2024, 22: 429. PMID: 39379967, PMCID: PMC11462715, DOI: 10.1186/s12916-024-03629-z.Peer-Reviewed Original ResearchConceptsRestricted cubic splinesLeptin levelsMetabolic hormonesMetabolic healthDNA methylationRestricted cubic spline analysisProspective birth cohort studyDNA methylation ageMother-child pairsBirth cohort studyDNA copy numberFetal originMitochondrial DNA copy numberResultsThe linear regression analysisReal-time PCRCohort studyHorvath's epigenetic clockInsulin levelsInverse associationLeptinQuantitative real-time PCRInfinium MethylationEPIC BeadChipElectrochemiluminescence assayLinear regression analysisMetabolic statusPrenatal arsenic metabolite exposure is associated with increased newborn mitochondrial DNA copy number: evidence from a birth cohort study
Qiu F, Zhang H, Wang X, Jia Z, He Y, Wu Y, Li Z, Zheng T, Xia W, Xu S, Li Y. Prenatal arsenic metabolite exposure is associated with increased newborn mitochondrial DNA copy number: evidence from a birth cohort study. Environmental Science And Pollution Research 2024, 31: 38142-38152. PMID: 38789711, DOI: 10.1007/s11356-024-32933-7.Peer-Reviewed Original ResearchDNA copy numberThird trimesterUrinary arsenic species concentrationsNewborn mitochondrial DNA copy numberMother-newborn pairsDose-response trendMitochondria DNA copy numberReal-time polymerase chain reactionBirth cohort studyMetabolite exposureCopy numberMitochondrial DNA copy numberOne-unit incrementCovariate-adjusted modelsBlood mtDNAcnQuantitative real-time polymerase chain reactionPolymerase chain reactionCohort studyTrimesterMetabolite levelsPotential associationStatistical significanceArsenic metabolitesChain reactionMtDNAcnFaecal transplantation from exuberant toddlers increases exploratory behaviour in juvenile rats: A FinnBrain Birth Cohort Study
Aatsinki A, Collins J, Kara N, Wilmes L, Deady C, Nolvi S, Eskola E, Huovinen V, Hakanen H, Bridgett D, Korja R, Keskitalo A, Munukka E, Salin I, Isokääntä H, Dickens A, Lamichhane S, Kallonen T, Lahti L, Clarke G, Dinan T, Cryan J, Karlsson H, O'Mahony S, Karlsson L. Faecal transplantation from exuberant toddlers increases exploratory behaviour in juvenile rats: A FinnBrain Birth Cohort Study. Neuroscience Applied 2024, 3: 104675. DOI: 10.1016/j.nsa.2024.104675.Peer-Reviewed Original Research
2023
Associations of Trimester-Specific Exposure to Perchlorate, Thiocyanate, and Nitrate with Childhood Neurodevelopment: A Birth Cohort Study in China
Li J, Tu F, Wan Y, Qian X, Mahai G, Wang A, Ma J, Yang Z, Xia W, Xu S, Zheng T, Li Y. Associations of Trimester-Specific Exposure to Perchlorate, Thiocyanate, and Nitrate with Childhood Neurodevelopment: A Birth Cohort Study in China. Environmental Science And Technology 2023, 57: 20480-20493. PMID: 38015815, DOI: 10.1021/acs.est.3c06013.Peer-Reviewed Original ResearchMental Development IndexOffspring neurodevelopmentMaternal exposureQuantile sum regression analysesTrimester-specific analysesTrimester-specific exposureBirth cohort studyRegression analysisBayesian kernel machine regression (BKMR) analysisCohort studyEarly pregnancyFirst trimesterSecond trimesterPrenatal exposureChildhood neurodevelopmentUrinary thiocyanateBirth cohortTrimesterNeurodevelopmentUrine samplesSensitive windowExposureAssociationMixture exposurePoint decreaseRecent ambient temperature and fine particulate matter (PM2.5) exposure is associated with urinary kidney injury biomarkers in children
Politis M, Gutiérrez-Avila I, Just A, Pizano-Zárate M, Tamayo-Ortiz M, Greenberg J, Téllez-Rojo M, Sanders A, Rosa M. Recent ambient temperature and fine particulate matter (PM2.5) exposure is associated with urinary kidney injury biomarkers in children. The Science Of The Total Environment 2023, 907: 168119. PMID: 37884142, PMCID: PMC10842020, DOI: 10.1016/j.scitotenv.2023.168119.Peer-Reviewed Original ResearchConceptsDistributed lag nonlinear modelParticulate matterAverage PM<sub>2.5</sub>Satellite-based spatio-temporal modelUrinary kidney injury biomarkersFine particulate matterExposure to ambient temperatureAir pollutionAerodynamic diameterBirth cohort studySpatio-temporal modelParticipating residentsCohort studyLimited researchEnvironmental exposuresMean temperatureDaily mean temperatureVisitsDaily temperatureAmbient temperatureMatterExposurePM2.5Linear regressionPollution
2022
Prenatal Metal Exposures and Associations with Kidney Injury Biomarkers in Children
Politis M, Yao M, Gennings C, Tamayo-Ortiz M, Valvi D, Kim-Schulze S, Qi J, Amarasiriwardena C, Pantic I, Tolentino M, Estrada-Gutierrez G, Greenberg J, Téllez-Rojo M, Wright R, Sanders A, Rosa M. Prenatal Metal Exposures and Associations with Kidney Injury Biomarkers in Children. Toxics 2022, 10: 692. PMID: 36422900, PMCID: PMC9699100, DOI: 10.3390/toxics10110692.Peer-Reviewed Original ResearchKidney injury biomarkersInjury biomarkersKidney biomarkersGamma-induced protein 10Glomerular filtration rateBirth cohort studyAlpha-1-microglobulinQuantile sum (WQS) regressionPrenatal metal exposureKidney injuryCohort studyUrinary CdPregnant womenSecond trimesterKidney diseasePrenatal exposureFiltration rateCystatin CUrinary metalsNull associationProtein 10A1MMetal exposureBiomarkersProtein 1Associations Between ADHD Symptoms and Maternal and Birth Outcomes: An Exploratory Analysis in a Multi-Country Cohort of Expectant Mothers
Murray A, Taut D, Baban A, Hemady C, Walker S, Osafo J, Sikander S, Tomlinson M, Du Toit S, Marlow M, Ward C, Fernando A, Madrid B, Van Thang V, Tuyen H, Dunne M, Hughes C, Fearon P, Valdebenito S, Eisner M. Associations Between ADHD Symptoms and Maternal and Birth Outcomes: An Exploratory Analysis in a Multi-Country Cohort of Expectant Mothers. Journal Of Attention Disorders 2022, 26: 1882-1894. PMID: 35815439, PMCID: PMC9597155, DOI: 10.1177/10870547221105064.Peer-Reviewed Original ResearchConceptsADHD symptomsSignificant associationLongitudinal birth cohort studyLow birth weightBirth cohort studyGreater mental health supportLow social supportMental health difficultiesMental health supportCohort studyBirth outcomesPremature birthThird trimesterRegular screeningBirth weightUnplanned pregnancyTobacco useDepressive symptomsExpectant mothersPregnancyFetal developmentUnwanted pregnancyHealth difficultiesSymptomsAlcohol use
2021
Prenatal attachment: using measurement invariance to test the validity of comparisons across eight culturally diverse countries
Foley S, Hughes C, Murray A, Baban A, Fernando A, Madrid B, Osafo J, Sikander S, Abbasi F, Walker S, Luong-Thanh B, Vo T, Tomlinson M, Fearon P, Ward C, Valdebenito S, Eisner M. Prenatal attachment: using measurement invariance to test the validity of comparisons across eight culturally diverse countries. Archives Of Women's Mental Health 2021, 24: 619-625. PMID: 33559754, PMCID: PMC8266779, DOI: 10.1007/s00737-021-01105-8.Peer-Reviewed Original ResearchConceptsMaternal-fetal attachmentMiddle-income countriesHigh-income countriesExpectant mothersProspective birth cohort studyBirth cohort studyFirst-time mothersPrenatal Attachment InventoryCohort studyThird trimesterPregnant womenMaternal healthFirst infantMaternal behaviorGroup comparisonsMean levelsMothersInfantsSingle latent factorFuture studiesPlace childrenChildrenChild outcomesSimilar informationPAI
2020
Evidence for Better Lives Study: a comparative birth-cohort study on child exposure to violence and other adversities in eight low- and middle-income countries - foundational research (study protocol)
Valdebenito S, Murray A, Hughes C, Băban A, Fernando A, Madrid B, Ward C, Osafo J, Dunne M, Sikander S, Walker S, Van Thang V, Tomlinson M, Fearon P, Shenderovich Y, Marlow M, Chathurika D, Taut D, Eisner M. Evidence for Better Lives Study: a comparative birth-cohort study on child exposure to violence and other adversities in eight low- and middle-income countries - foundational research (study protocol). BMJ Open 2020, 10: e034986. PMID: 33039982, PMCID: PMC7552842, DOI: 10.1136/bmjopen-2019-034986.Peer-Reviewed Original ResearchConceptsBiological stress markersPregnant womenStress markersDry blood spot samplesPrenatal intimate partner violenceBirth cohort studyPredictors of exposureBlood spot samplesAdverse childhood experiencesHigh-quality longitudinal dataLast trimesterLater healthEpidemiological estimatesEthical approvalHealth servicesEffective interventionsRecruiting sitesPhysical healthChildren's exposureSubstance useParticipant recruitmentPrenatal stageIntimate partner violenceSpot samplesLongitudinal studyFunctional Outcomes of Children Identified Early in the Developmental Period as at Risk for ASD Utilizing the The Norwegian Mother, Father and Child Cohort Study (MoBa)
Stenberg N, Schjølberg S, Shic F, Volkmar F, Øyen AS, Bresnahan M, Svendsen BK, von Tetzchner S, Thronæs NT, Macari S, Cicchetti DV, Chawarska K, Suren P, Øien RA. Functional Outcomes of Children Identified Early in the Developmental Period as at Risk for ASD Utilizing the The Norwegian Mother, Father and Child Cohort Study (MoBa). Journal Of Autism And Developmental Disorders 2020, 51: 922-932. PMID: 32424708, PMCID: PMC7954713, DOI: 10.1007/s10803-020-04539-8.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderChild Cohort StudyCohort studyAutism symptomsLanguage disordersM-CHATSpectrum disorderLower IQDevelopmental concernsNorwegian MotherDevelopmental periodIntellectual disabilityEarly interventionBirth cohort studyMonths of ageChildrenItem criteriaFunctional outcomeBetter outcomesGreater severitySwift accessEarly identificationIQDisordersFathersSex-specific influence of prenatal air pollutant exposure on neonatal neurobehavioral development and the sensitive window
Chen B, Huang S, He J, He Q, Chen S, Liu X, Peng S, Luo D, Duan Y. Sex-specific influence of prenatal air pollutant exposure on neonatal neurobehavioral development and the sensitive window. Chemosphere 2020, 254: 126824. PMID: 32335443, DOI: 10.1016/j.chemosphere.2020.126824.Peer-Reviewed Original ResearchConceptsAir pollution exposurePollution exposurePrenatal exposure to PM<sub>2.5</sub>Exposure to PM<sub>2.5</sub>Adverse effects of air pollution exposureEffects of air pollution exposurePrenatal air pollution exposureThree-pollutant modelsMonitoring station dataInverse distance weighting methodTrimester-specific associationsNeonatal behavioral neurological assessmentMultivariable restricted cubic spline functionsAssociated with behavioral scoresDistance weighting methodSensitive time windowMother-newborn pairsNeurobehavioral developmentSensitive windowNeonatal neurobehavioral developmentRestricted cubic spline functionsBehavioral neurological assessmentDose-dependent mannerDose-response relationshipBirth cohort studyWhat Research Questions Should the Next Generation of Birth Cohort Studies Address? An International Delphi Study of Experts
Brown R, Eisner M, Valdebenito S, Walker S, Tomlinson M, Hughes C, Ward C, Osafo J, Sikander S, Fearon P, Dunne M, Madrid B, Baban A, Van Thang V, Fernando A, Murray A. What Research Questions Should the Next Generation of Birth Cohort Studies Address? An International Delphi Study of Experts. Academic Pediatrics 2020, 21: 43-52. PMID: 32272232, DOI: 10.1016/j.acap.2020.03.011.Peer-Reviewed Original Research
2019
Multi–Polygenic Score Approach to Identifying Individual Vulnerabilities Associated With the Risk of Exposure to Bullying
Schoeler T, Choi S, Dudbridge F, Baldwin J, Duncan L, Cecil C, Walton E, Viding E, McCrory E, Pingault J. Multi–Polygenic Score Approach to Identifying Individual Vulnerabilities Associated With the Risk of Exposure to Bullying. JAMA Psychiatry 2019, 76: 730-738. PMID: 30942833, PMCID: PMC6583782, DOI: 10.1001/jamapsychiatry.2019.0310.Peer-Reviewed Original ResearchConceptsMental health vulnerabilitiesMAIN OUTCOMEPopulation-based birth cohort studyHealth vulnerabilityIndividual vulnerabilityBody mass indexBirth cohort studyDiagnosis of depressionYears of ageDate of deliveryAttention-deficit/hyperactivity disorderAvon Longitudinal StudyMental health problemsPolygenic score approachLast followCohort studyMass indexMultivariable analysisRisk of exposureAssessment of exposureRisk factorsPrevention strategiesHealth problemsSignificant associationALSPAC data
2018
Residential mobility during pregnancy in Urban Gansu, China
Tang Z, Zhang H, Bai H, Chen Y, Zhao N, Zhou M, Cui H, Lerro C, Lin X, Lv L, Zhang C, Zhang H, Xu R, Zhu D, Dang Y, Han X, Xu X, Lin R, Yao T, Su J, Ma B, Liu X, Wang Y, Wang W, Liu S, Luo J, Huang H, Liang J, Jiang M, Qiu W, Bell ML, Qiu J, Liu Q, Zhang Y. Residential mobility during pregnancy in Urban Gansu, China. Health & Place 2018, 53: 258-263. PMID: 30196043, PMCID: PMC6556377, DOI: 10.1016/j.healthplace.2018.08.021.Peer-Reviewed Original ResearchConceptsBirth outcomesMaternal complicationsPregnant womenLow birth weightAdverse birth outcomesEnvironmental exposuresBirth cohort studyMultivariate logistic regressionTime of deliveryCohort studyPreterm birthThird trimesterBirth weightMaternal characteristicsMaternal residencePregnancyLogistic regressionComplicationsExposure misclassificationAsian populationsLower likelihoodBirth defectsDisease associationsOutcomesExposureAssociations between repeated ultrasound measures of fetal growth and biomarkers of maternal oxidative stress and inflammation in pregnancy
Ferguson K, Kamai E, Cantonwine D, Mukherjee B, Meeker J, McElrath T. Associations between repeated ultrasound measures of fetal growth and biomarkers of maternal oxidative stress and inflammation in pregnancy. American Journal Of Reproductive Immunology 2018, 80: e13017. PMID: 29984454, PMCID: PMC6160349, DOI: 10.1111/aji.13017.Peer-Reviewed Original ResearchConceptsAssociated with reduced fetal growthFetal growthAssociated with poorer childAdult health outcomesOxidative stress markersBirth cohort studyInterquartile rangeAssociated with head circumferenceRepeated-measures modelFetal weight z-scoreAssociated with fetal weightOxidative stressHealth outcomesStandard deviation decreaseWeight z-scoreStress markersSecondary analysisMaternal oxidative stressCohort studyZ-scoreFetal weightMaternal inflammationDeviation decreasePreterm birthHead circumferenceEffects of prenatal exposure to ambient air pollutant PM10 on ultrasound-measured fetal growth
Zhao N, Qiu J, Ma S, Zhang Y, Lin X, Tang Z, Zhang H, Huang H, Ma N, Huang Y, Bell ML, Liu Q, Zhang Y. Effects of prenatal exposure to ambient air pollutant PM10 on ultrasound-measured fetal growth. International Journal Of Epidemiology 2018, 47: 1072-1081. PMID: 29529195, PMCID: PMC6124630, DOI: 10.1093/ije/dyy019.Peer-Reviewed Original ResearchConceptsAbnormal fetal growthFetal growthPrenatal exposurePM10 exposureBiparietal diameterFemur lengthAbdominal circumferenceHead circumferenceImportant public health implicationsPost-natal consequencesFetal growth parametersBirth cohort studyLimited epidemiological studiesPublic health implicationsCohort studyPregnant womenUltrasound examinationFetal overgrowthM3 increaseEpidemiological studiesExposure windowsMixed-effects modellingHigh levelsAmbient particulate matterUltrasound measurements
2017
Longitudinal Profiles of Thyroid Hormone Parameters in Pregnancy and Associations with Preterm Birth
Johns L, Ferguson K, McElrath T, Mukherjee B, Seely E, Meeker J. Longitudinal Profiles of Thyroid Hormone Parameters in Pregnancy and Associations with Preterm Birth. PLOS ONE 2017, 12: e0169542. PMID: 28060899, PMCID: PMC5217954, DOI: 10.1371/journal.pone.0169542.Peer-Reviewed Original ResearchConceptsRisk of preterm birthPreterm birthNested case-control study of preterm birthThyroid hormonesSubclinical alterationsPregnant womenCase-control study of preterm birthThyroid diseaseOdds of preterm birthOngoing birth cohort studyNested case-control studyStudy of preterm birthAssociated with preterm birthBirth cohort studyTime pointsMultivariate logistic regression modelOverall preterm birthSpontaneous preterm birthWeeks of gestationClinical thyroid diseaseOvert thyroid diseaseThyroid hormone parametersMaternal thyroid hormone concentrationsMaternal thyroid hormonesLogistic regression models
2016
Prenatal and Perinatal Risk Factors and the Promise of Birth Cohort Studies: Origins of Obsessive-Compulsive Disorder
Fernandez TV, Leckman JF. Prenatal and Perinatal Risk Factors and the Promise of Birth Cohort Studies: Origins of Obsessive-Compulsive Disorder. JAMA Psychiatry 2016, 73: 1117-1118. PMID: 27706471, PMCID: PMC5180419, DOI: 10.1001/jamapsychiatry.2016.2092.Peer-Reviewed Original Research
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