2025
Igniting Language Intelligence: The Hitchhiker's Guide from Chain-of-Thought Reasoning to Language Agents
Zhang Z, Yao Y, Zhang A, Tang X, Ma X, He Z, Wang Y, Gerstein M, Wang R, Liu G, Zhao H. Igniting Language Intelligence: The Hitchhiker's Guide from Chain-of-Thought Reasoning to Language Agents. ACM Computing Surveys 2025, 57: 1-39. DOI: 10.1145/3719341.Peer-Reviewed Original ResearchLanguage agentsComplex reasoning tasksReasoning capabilitiesReasoning methodologyLanguage modelCOTS techniquesReasoning approachReasoning tasksTheoretical proofLanguage instructionLinguistic contextEmpirical performanceLanguage intelligenceReasoning performanceHitchhiker’s GuideLanguageSurvey articleEnhance interpretationAdvanced cognitive abilitiesCOTSResearch dimensionsExecutive actionProspective research avenuesCognitive abilitiesCOTS approachInternational perspective on social cognition in schizophrenia: current stage and the next steps
Corbera S, Kurtz M, Achim A, Agostoni G, Amado I, Assaf M, Barlati S, Bechi M, Cavallaro R, Ikezawa S, Okano H, Okubo R, Penadés R, Uchino T, Vita A, Yamada Y, Bell M. International perspective on social cognition in schizophrenia: current stage and the next steps. European Psychiatry 2025, 68: e9. PMID: 39812093, PMCID: PMC11795453, DOI: 10.1192/j.eurpsy.2024.1776.Peer-Reviewed Original ResearchConceptsSocial cognitionSocial neuroscienceAssess social cognitionSocial cognitive measuresSocial cognitive abilitiesClinical psychologyCognitive measuresSocial dysfunctionCognitive abilitiesSchizophreniaCognitive evaluationFunctional difficultiesCognitionCognitive scienceClinical practiceNeuroscienceMounting evidenceInternational scientific researchPsychologyCliniciansPsychiatryPoor clinical outcomesScientific rigorIllnessResearch
2024
Effects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes
Huguet G, Renne T, Poulain C, Dubuc A, Kumar K, Kazem S, Engchuan W, Shanta O, Douard E, Proulx C, Jean-Louis M, Saci Z, Mollon J, Schultz L, Knowles E, Cox S, Porteous D, Davies G, Redmond P, Harris S, Schumann G, Dumas G, Labbe A, Pausova Z, Paus T, Scherer S, Sebat J, Almasy L, Glahn D, Jacquemont S. Effects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes. Cell Genomics 2024, 4: 100721. PMID: 39667348, PMCID: PMC11701252, DOI: 10.1016/j.xgen.2024.100721.Peer-Reviewed Original ResearchConceptsCopy-number variantsGenome-wide association studiesAssociation studiesCognitive abilitiesBiological processesEffect of gene dosageNeurodevelopmental disordersAssociated with cognitionHigher cognitive performanceGene dosageGene setsAssociated with higher cognitive performanceCognitive performanceGenesCell typesEffect sizeCognitionDeletionDuplicationDisordersNon-brain tissuesMedical comorbiditiesAbilityVariantsBrainThe Human Accelerated Region HAR202 Controls NPAS3 Expression in the Developing Forebrain Displaying Differential Enhancer Activity Between Modern and Archaic Human Sequences
Caporale A, Cinalli A, Rubinstein M, Franchini L. The Human Accelerated Region HAR202 Controls NPAS3 Expression in the Developing Forebrain Displaying Differential Enhancer Activity Between Modern and Archaic Human Sequences. Molecular Biology And Evolution 2024, 41: msae186. PMID: 39241178, PMCID: PMC11461159, DOI: 10.1093/molbev/msae186.Peer-Reviewed Original ResearchArchaic humansHuman lineageLiving relativesNPAS3 expressionComparative functional analysisMouse developing brainNervous systemEnhancer reporter assaysZebrafish nervous systemOrthologous sequencesTransgenic miceDeveloping brainNucleotide substitutionsPhenotypic evolutionTranscriptional enhancersHuman sequenceChimpanzeesNeurodevelopmental genesCognitive abilitiesMiceHumansPhenotypic differencesHOMOReporter expressionExpression patternsObjective and subjective experiences of childhood maltreatment and their relationships with cognitive deficits: a cohort study in the USA
Danese A, Widom C. Objective and subjective experiences of childhood maltreatment and their relationships with cognitive deficits: a cohort study in the USA. The Lancet Psychiatry 2024, 11: 720-730. PMID: 39147460, DOI: 10.1016/s2215-0366(24)00224-4.Peer-Reviewed Original ResearchConceptsMeasures of childhood maltreatmentExperiences of childhood maltreatmentMeasures of maltreatmentChildhood maltreatmentCognitive deficitsRetrospective reports of childhood maltreatmentReports of childhood maltreatmentSelf-reportNational Institute of Mental HealthInstitute of Mental HealthPervasive cognitive deficitsNon-verbal intelligenceMeasures of neglectRetrospective self-reportsVerbal intelligenceAutobiographical memoryExecutive functionMaltreated childrenCognitive abilitiesPsychopathologyCognitive testsCognitive functionGroup differencesProcessing speedRetrospective reportsProbiotic Lactobacilli Ameliorate Antibiotic-Induced Cognitive and Behavioral Impairments in Mice
Yarullina D, Novoselova V, Alexandrova A, Arslanova A, Yakovleva O, Shaidullov I, Nikolaev Y, El-Registan G, Kudrin V, Sitdikova G. Probiotic Lactobacilli Ameliorate Antibiotic-Induced Cognitive and Behavioral Impairments in Mice. Microbiology Research 2024, 15: 1471-1485. DOI: 10.3390/microbiolres15030099.Peer-Reviewed Original ResearchObject recognition testOpen field testMetabolite 5-hydroxyindoleacetic acidNovel object recognition testAnxiety-related behaviorT-maze testGut microbiotaInfluence brain functionMicrobiota-gut-brain axisMicrobiota-gut-brainAntibiotic-inducedRegulating anxietyT-mazeRecognition testExploratory activityCognitive abilitiesBehavioral disordersBehavioral testsAntibiotic-treated miceFerrous oxidation-xylenol orange (FOX) assayBrain functionProbiotic lactobacilli strainsMRS brothLactobacilli strainsAdministration of probioticsThe trajectory of anxiety symptoms during the transition from childhood to young adulthood is predicted by IQ and sex, but not polygenic risk scores
Salto A, Salum G, Hoffmann M, Santoro M, Zugman A, Pan P, Belangero S, Ito L, Doretto V, Croci M, Brañas M, de Giusti C, Da Silva‐Jr F, Ribeiro S, Miguel E, Leckman J. The trajectory of anxiety symptoms during the transition from childhood to young adulthood is predicted by IQ and sex, but not polygenic risk scores. JCPP Advances 2024, 5: e12268. PMID: 40060001, PMCID: PMC11889643, DOI: 10.1002/jcv2.12268.Peer-Reviewed Original ResearchAnxiety symptomsIntelligence quotientTrajectory class membershipPolygenic risk scoresTrajectory classesLate adolescenceCourse of anxiety symptomsScreen for Child Anxiety Related DisordersTrajectories of anxiety symptomsBrazilian High-Risk CohortYoung adulthoodEffect of intelligence quotientAnxiety related disordersHigh-decreasing classClass membershipLongitudinal studyConfirmatory factor analysisGrowth mixture modelingIncidence of anxiety symptomsInternalizing symptomatologyLow-increasing classHigher IQCognitive abilitiesAnxiety riskFactor analysisSpatial Sequence Attention Network for Schizophrenia Classification from Structural Brain MR Images
Shaik N, Cherukuri T, Calhoun V, Ye D. Spatial Sequence Attention Network for Schizophrenia Classification from Structural Brain MR Images. 2024, 00: 1-5. DOI: 10.1109/isbi56570.2024.10635528.Peer-Reviewed Original ResearchCognitive abilitiesStructural MRIAttention mechanismSchizophrenia classificationChronic mental disordersIndividual cognitive abilitiesTransfer learning paradigmDeep learning methodologyMental disordersSchizophreniaFeature mapsFeature representationConvolutional blocksAttention networkBrain MR imagesLearning paradigmSocial interactionClassification of individualsStructural brain MR imagesGray matterLearning methodologyExcitable networksClinical datasetsBrainManual observation
2023
Triple Interactions Between the Environment, Brain, and Behavior in Children: An ABCD Study
Zhi D, Jiang R, Pearlson G, Fu Z, Qi S, Yan W, Feng A, Xu M, Calhoun V, Sui J. Triple Interactions Between the Environment, Brain, and Behavior in Children: An ABCD Study. Biological Psychiatry 2023, 95: 828-838. PMID: 38151182, PMCID: PMC11006588, DOI: 10.1016/j.biopsych.2023.12.019.Peer-Reviewed Original ResearchFunctional network connectivityCognitive abilitiesABCD studyMental healthLongitudinal predictionBehavioral developmentSleep problemsBrain functional network connectivityHigher cognitive abilitiesDefault mode networkChildren's behavioral developmentUnique protective factorsBrain functional connectivityCognitive controlTriple interactionFamily conflictMode networkMediation analysisFunctional connectivityInfluence behaviorFunctional networksProtective factorsSchool environmentChildhood developmentEnvironmental exposuresMaternal social support during and after pregnancy and child cognitive ability: examining timing effects in two cohorts.
Lähdepuro A, Räikkönen K, Pham H, Thompson-Felix T, Eid R, O'Connor T, Glover V, Lahti J, Heinonen K, Wolford E, Lahti-Pulkkinen M, O'Donnell K. Maternal social support during and after pregnancy and child cognitive ability: examining timing effects in two cohorts. Psychological Medicine 2023, 54: 1661-1670. PMID: 38087866, DOI: 10.1017/s0033291723003550.Peer-Reviewed Original ResearchChildren's cognitive abilitiesChildren's cognitive developmentGeneral cognitive abilityMaternal social supportCognitive abilitiesCognitive developmentSocial supportChildren's general cognitive abilitiesWechsler Intelligence ScaleMaternal experienceIntelligence ScaleTiming effectsAvon Longitudinal StudyMaternal anxietySensitive periodLongitudinal studyMaternal symptomsProspective longitudinal cohortAnxietyChildrenLess attentionDepressionLongitudinal cohortSupportWISCEpigenetic age acceleration as a biomarker for impaired cognitive abilities in adulthood following early life adversity and psychiatric disorders
Felt J, Yusupov N, Harrington K, Fietz J, Zhang Z, Sliwinski M, Ram N, O'Donnell K, Group B, Meaney M, Putnam F, Noll J, Binder E, Shenk C. Epigenetic age acceleration as a biomarker for impaired cognitive abilities in adulthood following early life adversity and psychiatric disorders. Neurobiology Of Stress 2023, 27: 100577. PMID: 37885906, PMCID: PMC10597797, DOI: 10.1016/j.ynstr.2023.100577.Peer-Reviewed Original ResearchEarly life adversityPsychiatric disordersEpigenetic age accelerationLife adversityAge accelerationProspective cohort studyBiological agingNon-abused controlsCohort studyNeurocognitive screeningPeripheral bloodCommunity cohortNeurocognitive declineIndependent cohortCognitive declineEarly screeningMental disordersCohortGrimAge clockDisordersBiomarkersLower general cognitive abilityEarly declineNeurocognitive abilitiesCognitive abilitiesDevelopment of peak alpha frequency reflects a distinct trajectory of neural maturation in autistic children
Finn C, Han G, Naples A, Wolf J, McPartland J. Development of peak alpha frequency reflects a distinct trajectory of neural maturation in autistic children. Autism Research 2023, 16: 2077-2089. PMID: 37638733, DOI: 10.1002/aur.3017.Peer-Reviewed Original ResearchConceptsPeak alpha frequencyAutism spectrum disorderCognitive abilitiesAutistic childrenNonverbal IQNeural maturationSpectrum disorderTypical age-related increaseAlpha frequencyDifferent developmental trajectoriesDistinct trajectoriesSample of childrenCurrent study clarifiesDiagnostic groupsNeurotypical childrenNeurotypical controlsBehavioral measuresDevelopmental trajectoriesDiagnostic statusAge-related increaseFunction of ageIQEffect of ageBivariate relationsPrevious findingsThe Meso-Expression Test (MET): A Novel Assessment of Emotion Perception
LaPalme M, Barsade S, Brackett M, Floman J. The Meso-Expression Test (MET): A Novel Assessment of Emotion Perception. Journal Of Intelligence 2023, 11: 145. PMID: 37504788, PMCID: PMC10381771, DOI: 10.3390/jintelligence11070145.Peer-Reviewed Original ResearchEmotion perceptionEmotional intelligenceEmotion perception abilityImportant psychosocial outcomesEmpathic concernCognitive abilitiesPerception abilityPsychosocial outcomesStudy 4Study 1Study 2Study 3Ability researchSocial interactionSocial connectednessInterpersonal communicationMeasurement equivalencePerceiver groupsConstruct validityPerceptionResearch paradigmVideo displayPrimary facetsNovel assessmentVideo-based assessmentA Pilot Trial of SPACE (Supportive Parenting for Anxious Childhood Emotions) in Autism
Rozenblat S, Shimshoni Y, Lebowitz E, Perez M, Koller J. A Pilot Trial of SPACE (Supportive Parenting for Anxious Childhood Emotions) in Autism. Child Psychiatry & Human Development 2023, 56: 249-263. PMID: 37353645, DOI: 10.1007/s10578-023-01555-4.Peer-Reviewed Original ResearchFamily accommodationAnxious Childhood EmotionsAverage cognitive abilityCognitive behavior therapySymptom severityAnxiety symptom severityChildhood EmotionsChildhood anxietyCognitive abilitiesSupportive parentingChild distressAutistic populationManualized treatmentAutistic childrenReliable changeGreater functional impairmentAutismWeekly sessionsAnxietyPoor treatment outcomesPreliminary evidencePreliminary efficacyDistressPilot trialCaregiver burdenEarly adversity changes the economic conditions of mouse structural brain network organization
Carozza S, Holmes J, Vértes P, Bullmore E, Arefin T, Pugliese A, Zhang J, Kaffman A, Akarca D, Astle D. Early adversity changes the economic conditions of mouse structural brain network organization. Developmental Psychobiology 2023, 65: e22405. PMID: 37607894, PMCID: PMC10505050, DOI: 10.1002/dev.22405.Peer-Reviewed Original ResearchConceptsEarly adversityStructural brain network organizationPostnatal stressBrain network organizationMental health outcomesEarly life adversityCognitive abilitiesNeural processesLife adversityConnectome organizationAdversityStructural connectomeConnectomeNetwork organizationGenerative processMouse connectomeHealth outcomesLong-distance connectionsOrganizationEffective responseAdaptive mechanismsAbilityStressWiring costInterpretable LSTM model reveals transiently-realized patterns of dynamic brain connectivity that predict patient deterioration or recovery from very mild cognitive impairment
Gao Y, Lewis N, Calhoun V, Miller R. Interpretable LSTM model reveals transiently-realized patterns of dynamic brain connectivity that predict patient deterioration or recovery from very mild cognitive impairment. Computers In Biology And Medicine 2023, 161: 107005. PMID: 37211004, PMCID: PMC10365638, DOI: 10.1016/j.compbiomed.2023.107005.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentDynamic functional network connectivityCognitive impairmentResting-state functional magnetic resonance imagingDementia interventionsFunctional magnetic resonance imagingAlzheimer's diseaseCognitive healthPatient deteriorationFunctional network connectivityCognitive abilitiesShort-term memoryRs-fMRIBrain connectivityResolved measurementsDynamic brain connectivityMagnetic resonance imagingPeripheral inflammation is associated with impairments of inhibitory behavioral control and visual sensorimotor function in psychotic disorders
Zhang L, Lizano P, Xu Y, Rubin L, Lee A, Lencer R, Reilly J, Keefe R, Keedy S, Pearlson G, Clementz B, Keshavan M, Gershon E, Tamminga C, Sweeney J, Hill S, Bishop J. Peripheral inflammation is associated with impairments of inhibitory behavioral control and visual sensorimotor function in psychotic disorders. Schizophrenia Research 2023, 255: 69-78. PMID: 36965362, PMCID: PMC10175233, DOI: 10.1016/j.schres.2023.03.030.Peer-Reviewed Original ResearchConceptsCognitive domainsInhibitory controlGeneral cognitive abilitySpecific cognitive domainsInhibitory behavioral controlC-reactive proteinPsychotic disordersPsychosis spectrum disordersCognitive abilitiesPeripheral inflammationInflammation factorsSpectrum disorderSensorimotor functionSensorimotor tasksNeurobehavioral domainsGreater deficitsSubgroup of individualsBehavioral controlPsychosis subgroupsCognitive impairmentPreliminary evidenceHigher inflammation scoresNeurobehavioral batteryBrain anatomyBehavioral monitoringSelf-perceived memory is negatively associated with chronic disease awareness: Evidence from blood biomarker data
Lin Z, Fu M, Chen X. Self-perceived memory is negatively associated with chronic disease awareness: Evidence from blood biomarker data. SSM - Population Health 2023, 22: 101361. PMID: 36852376, PMCID: PMC9958050, DOI: 10.1016/j.ssmph.2023.101361.Peer-Reviewed Original ResearchSelf-perceived memoryCognitive abilitiesCognitive misperceptionsChronic disease awarenessImpaired cognitive abilityCognitive measuresDisease awarenessOlder Chinese adultsHealth-related decisionsOlder adultsMemoryOpposite patternLongitudinal studyRetirement Longitudinal StudyBlood biomarker dataNegative associationLow disease awarenessMultivariate logistic regressionSelf-reported diagnosisMisperceptionsTargeted interventionsAdultsIndividualsAwarenessDiabetes status
2022
Exploring communicative competence in autistic children who are minimally verbal: The Low Verbal Investigatory Survey for Autism (LVIS)
Naples A, Tenenbaum E, Jones R, Righi G, Sheinkopf S, Eigsti I. Exploring communicative competence in autistic children who are minimally verbal: The Low Verbal Investigatory Survey for Autism (LVIS). Autism 2022, 27: 1391-1406. PMID: 36373838, PMCID: PMC10183057, DOI: 10.1177/13623613221136657.Peer-Reviewed Original ResearchConceptsVerbal autistic childrenAutistic childrenCommunication skillsMeasures of languageParent-report measuresChildren's communication skillsSymptoms of autismLack of wordsVerbal childrenAutism symptomatologyCognitive abilitiesLanguage abilityCommunicative abilitiesVerbal languageCommunicative competenceHelpful interventionsAlternative formsLanguageAutismChildrenClinical implicationsWordsSkillsCommunicationAbilityPredictability modulates neural response to eye contact in ASD
Naples AJ, Foss-Feig JH, Wolf JM, Srihari VH, McPartland JC. Predictability modulates neural response to eye contact in ASD. Molecular Autism 2022, 13: 42. PMID: 36309762, PMCID: PMC9618208, DOI: 10.1186/s13229-022-00519-0.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderEvent-related potentialsNeural responsesAdult participantsAmplitude of N170Perception of gazeP300 event-related potentialExperiment twoN170 responseAnxiety symptomologyCognitive abilitiesNeural basisExperiment oneNeural processingASD sampleSpectrum disorderInterpersonal interactionsN170P300 responseAutistic womenEye contactEye trackingSocial interactionSocial contextSocial world
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