2022
Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites
Cao Y, Oh J, Xue M, Huh WJ, Wang J, Gonzalez-Hernandez JA, Rice TA, Martin AL, Song D, Crawford JM, Herzon SB, Palm NW. Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites. Science 2022, 378: eabm3233. PMID: 36302024, PMCID: PMC9993714, DOI: 10.1126/science.abm3233.Peer-Reviewed Original ResearchConceptsColorectal cancerInflammatory bowel disease patientsBowel disease patientsInflammatory bowel diseaseIndigenous gut microbesBowel diseaseDisease patientsCommensal microbiotaDNA damageColon tumorigenesisElicit DNA damageGut microbesGenotoxic metabolitesGut commensalsMorganella morganiiPatientsGenotoxic chemicalsDiseaseMicrobiotaMetabolitesGenotoxicityCancerMiceFull spectrumDamage8 Mechanisms of Damage After Cerebral Hemorrhage
Aronowski J, Sansing L, Xi G, Zhang J. 8 Mechanisms of Damage After Cerebral Hemorrhage. 2022, 92-102.e9. DOI: 10.1016/b978-0-323-69424-7.00008-9.ChaptersIntracerebral hemorrhageBrain damageTreatment of ICHPathogenesis of ICHPre-clinical animal modelsIschemic brain injuryNeurovascular unitCerebral hemorrhageSecondary injuryBrain injuryAnimal modelsTherapeutic interventionsOxidative stressPromising targetHemorrhageInjuryMechanisms of damageNoxious componentsDamageInflammationPathogenesisPathobiologyBlood
2020
Fertility Preservation for Pediatric and Adolescent Patients With Cancer: Medical and Ethical Considerations
Klipstein S, Fallat M, Savelli S, Katz A, Macauley R, Mercurio M, Moon M, Okun A, Weise K, Rogers Z, Allen C, Harper J, Lipton J, Wetmore C, Wilson H, Yates A, Rescorla F, Brandt M, Caty M, Heiss K, Holcomb G, Meyers R, Moss R. Fertility Preservation for Pediatric and Adolescent Patients With Cancer: Medical and Ethical Considerations. Pediatrics 2020, 145: e20193994. PMID: 32071259, DOI: 10.1542/peds.2019-3994.Peer-Reviewed Original ResearchConceptsFertility preservationAdolescent patientsTreatment of infertilityAdjuvant therapyPotential adverse consequencesHematologic malignanciesGonadal axisClinical reportsSolid tumorsCancerReproductive technologiesGonad removalMedical aspectsPatientsInfertilityAdverse consequencesTreatmentGerm cellsEthical considerationsDamageChemotherapySurgeryMalignancyRadiotherapySubfertility
2019
Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage
Uderhardt S, Martins A, Tsang J, Lämmermann T, Germain R. Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell 2019, 177: 541-555.e17. PMID: 30955887, PMCID: PMC6474841, DOI: 10.1016/j.cell.2019.02.028.Peer-Reviewed Original ResearchConceptsTissue-resident macrophagesTissue homeostasisDiverse tissuesCell deathOrgan architectureIndividual cellsNeutrophil swarmsResident macrophagesDense swarmsLocal cell injuryIntravital imagingLocal disruptionParenchymal cell deathDynamic intravital imagingInescapable consequenceCell damageCell injuryHomeostasisMacrophagesCascadeInflammatory damageDamageCellsAccumulationDisruption
2018
FAMI Screws for Mandibulo-Maxillary fixation in mandibular fracture treatment – Clinico-radiological evaluation
Kauke M, Safi AF, Timmer M, Nickenig HJ, Zöller J, Kreppel M. FAMI Screws for Mandibulo-Maxillary fixation in mandibular fracture treatment – Clinico-radiological evaluation. Journal Of Cranio-Maxillofacial Surgery 2018, 46: 566-572. PMID: 29459185, DOI: 10.1016/j.jcms.2018.01.003.Peer-Reviewed Original ResearchConceptsMandibulo-maxillary fixationMandibular fracture treatmentVisible complicationsMMF screwsFracture siteFracture-related complicationsNerve function impairmentDental hard tissue damageFracture treatmentMucosal signsNerve damageRadiological evaluationFunction impairmentCondylar fracturesSuccessful treatmentPostoperative malocclusionArch barsComplicationsHard tissue damageTissue damageSafe methodTreatmentScrewsFixationDamage
2017
Nitrogen mustard-induced corneal injury involves the sphingomyelin-ceramide pathway
Charkoftaki G, Jester JV, Thompson DC, Vasiliou V. Nitrogen mustard-induced corneal injury involves the sphingomyelin-ceramide pathway. The Ocular Surface 2017, 16: 154-162. PMID: 29129753, PMCID: PMC7376578, DOI: 10.1016/j.jtos.2017.11.004.Peer-Reviewed Original ResearchConceptsCorneal damageNM exposureSphingomyelin-ceramide pathwayCorneal stromaIrreversible corneal damageNitrogen mustardAltered lipid profileSulfur mustardCorneal injuryLipid profileCentral corneaCorneal epitheliumRabbit eyesSpecific sphingomyelinsPotent vesicantCorneaOrgan cultureStromaLipidomic analysisExposureMorphological changesDamaging effectsDamageInjuryPathwayAnimal Models of Traumatic Brain Injury
Kaur T, Jamwal S, Bansal P. Animal Models of Traumatic Brain Injury. 2017, 89-103. DOI: 10.1007/978-981-10-5981-0_7.Peer-Reviewed Original ResearchTraumatic brain injuryHead injuryBrain injuryPrimary head injurySecondary head injuryBrain contusionNeuronal damageBrain lacerationSecondary injuryPhysical functioningClinical reportsAnimal modelsCell lossInjurySharp objectsMolecular changesDistant tissuesBrainViolent blowConsciousness of personsContusionHospitalizationLacerationPeriod of hoursDamage
2016
Long-term continuous monitoring of the preterm brain with diffuse optical tomography and electroencephalography: a technical note on cap manufacturing
Galderisi A, Brigadoi S, Cutini S, Moro S, Lolli E, Meconi F, Benavides-Varela S, Baraldi E, Amodio P, Cobelli C, Trevisanuto D, Dell’Acqua R. Long-term continuous monitoring of the preterm brain with diffuse optical tomography and electroencephalography: a technical note on cap manufacturing. Neurophotonics 2016, 3: 045009-045009. PMID: 28042587, PMCID: PMC5180615, DOI: 10.1117/1.nph.3.4.045009.Peer-Reviewed Original ResearchSkin damagePreterm brainPreterm neonatesNeonatal populationNewborn brainNursing proceduresData recording phaseOxygenation changesDiffuse optical tomographyBrainNeonatesTomographyLong-term continuous monitoringReliable channelsOptical tomographyPretermElectroencephalography acquisitionTechnical noteNursesDamage
2015
Quantifying hyperoxia-mediated damage to mammalian respiratory cilia-driven fluid flow using particle tracking velocimetry optical coherence tomography
Gamm UA, Huang BK, Syed M, Zhang X, Bhandari V, Choma MA. Quantifying hyperoxia-mediated damage to mammalian respiratory cilia-driven fluid flow using particle tracking velocimetry optical coherence tomography. Journal Of Biomedical Optics 2015, 20: 080505-080505. PMID: 26308164, PMCID: PMC4874052, DOI: 10.1117/1.jbo.20.8.080505.Peer-Reviewed Original ResearchConceptsOptical coherence tomographyMouse tracheaCoherence tomographyDrug-mediated modulationIntensive care unitRisk-benefit profileRespiratory failureCare unitOxygen supplementationRespiratory mucosaRespiratory epitheliumIndispensable treatmentImpaired capacityClinical useHyperoxiaTracheaFlow quantificationTomographyTreatmentDamagePatientsMucosaSupplementationEpithelium
2013
Diabetic neuropathy
Vadivelu N. Diabetic neuropathy. International Journal Of Nutrition Pharmacology Neurological Diseases 2013, 3: 332-334. DOI: 10.4103/2231-0738.119839.Peer-Reviewed Original ResearchDiabetic neuropathyNerve conduction testsPainful diabetic neuropathyLong-term diabetesFoot examsCentral sensitizationNerve damageSerious complicationsTerm diabetesCommon siteNeuropathyConduction testsDiabetesCell damageOxidative stressPainGene therapyTreatmentPlant extractsComplicationsPatientsTherapyDamageSensitization
2012
Genotoxic and Anti-Genotoxic Effects of Vanillic Acid Against Mitomycin C-Induced Genomic Damage in Human Lymphocytes In Vitro
Erdem M, Cinkilic N, Vatan O, Yilmaz D, Bagdas D, Bilaloglu R. Genotoxic and Anti-Genotoxic Effects of Vanillic Acid Against Mitomycin C-Induced Genomic Damage in Human Lymphocytes In Vitro. Asian Pacific Journal Of Cancer Prevention 2012, 13: 4993-4998. PMID: 23244097, DOI: 10.7314/apjcp.2012.13.10.4993.Peer-Reviewed Original ResearchConceptsAnti-genotoxic effectsMitomycin CHuman blood lymphocyte culturesCytokinesis-block micronucleus testBlood lymphocyte culturesLow doseHigh doseLymphocyte culturesHuman lymphocytesMicronucleus testAlkaline cometDoseGenotoxic damageGenotoxic effectsStrong antioxidantNegative controlOxidative damageGenomic damageVanillic acidChromosome levelPresent studyRates of DNADNA damageDamageSimilar results
2008
CD8+ T-cells and their interaction with other cells in damage to islet β-cells
Wong F, Siew L, Wen L. CD8+ T-cells and their interaction with other cells in damage to islet β-cells. Biochemical Society Transactions 2008, 36: 316-320. PMID: 18481949, DOI: 10.1042/bst0360316.Peer-Reviewed Original ResearchConceptsT cellsHuman type 1 diabetesAntigen-presenting cellsType 1 diabetesAutoimmune attackDiabetes developmentAntigenic targetsEffector stageToxic mediatorsVariety of cellsAnimal modelsTarget antigenImmune systemΒ-cellsMechanisms of damageCellsEarly stagesDamageCD8DiabetesCytokinesLymphocytesAntigen
2004
Excitotoxicity
Lipton S. Excitotoxicity. 2004, 291-313. DOI: 10.1002/3527603867.ch14.Peer-Reviewed Original ResearchSignaling pathways to neuronal damage and apoptosis in human immunodeficiency virus type 1-associated dementia: Chemokine receptors, excitotoxicity, and beyond
Kaul M, Lipton S. Signaling pathways to neuronal damage and apoptosis in human immunodeficiency virus type 1-associated dementia: Chemokine receptors, excitotoxicity, and beyond. Journal Of NeuroVirology 2004, 10: 97-101. PMID: 14982746, DOI: 10.1080/753312759.Peer-Reviewed Original ResearchConceptsNeuronal damageChemokine receptorsN-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicityHuman immunodeficiency virus-1 (HIV-1) infectionHuman immunodeficiency virus type 1Immunodeficiency virus type 1Applicable therapeutic interventionReceptor-mediated excitotoxicityVirus-1 infectionVirus type 1HIV infectionInflammatory factorsHIV-1Therapeutic interventionsType 1Downstream mechanismsExcitotoxicityDementiaInfectionReceptorsNeuropathologyPathwayDamage
2002
Integrins regulate the apoptotic response to DNA damage through modulation of p53
Lewis JM, Truong TN, Schwartz MA. Integrins regulate the apoptotic response to DNA damage through modulation of p53. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 3627-3632. PMID: 11904424, PMCID: PMC122574, DOI: 10.1073/pnas.062698499.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesApoptosisCaspase 3CaspasesCell AdhesionCell SurvivalChromosome AberrationsCyclin-Dependent Kinase Inhibitor p16DNA DamageFibroblastsHumansIntegrinsMelanomaMiceMutationNuclear ProteinsOrgan SpecificityProto-Oncogene ProteinsProto-Oncogene Proteins c-mdm2Radiation, IonizingSarcomaTumor Cells, CulturedTumor Suppressor Protein p14ARFTumor Suppressor Protein p53ConceptsTumor cellsTherapy-resistant tumorsModulation of p53Susceptible tumor cellsDNA damageLevels of p53Low p53 levelsApoptosis of cellsTherapy resistanceAntiintegrin antibodiesCancer cellsP53 levelsSurvival of cellsP53Nonadherent cellsCell typesSurvivalApoptotic responseCellsP19 ARFApoptosisChromosomal instabilityFibroblastic cell typesDamageChemotherapy
2001
Potential complication of bioabsorbable screw fixation for osteochondritis dissecans of the knee
Scioscia T, Giffin J, Allen C, Harner C. Potential complication of bioabsorbable screw fixation for osteochondritis dissecans of the knee. Arthroscopy The Journal Of Arthroscopic And Related Surgery 2001, 17: 1-5. PMID: 11172259, DOI: 10.1053/jars.2001.17995.Peer-Reviewed Original ResearchConceptsBioabsorbable screw fixationOsteochondritis dissecansScrew fixationCartilage damageIntra-articular loose bodiesMedial femoral condyleAcute episodePotential complicationsArthroscopic examinationBioabsorbable screwsLoose bodiesTibial plateauFemoral condyleCase 1DissecansKneeScrew headScrewsFixationPainComplicationsPatientsSurgeryEffusionDamage
2000
Biophysical Characterization of gp41 Aggregates Suggests a Model for the Molecular Mechanism of HIV-associated Neurological Damage and Dementia*
Caffrey M, Braddock D, Louis J, Abu-Asab M, Kingma D, Liotta L, Tsokos M, Tresser N, Pannell L, Watts N, Steven A, Simon M, Stahl S, Wingfield P, Clore G. Biophysical Characterization of gp41 Aggregates Suggests a Model for the Molecular Mechanism of HIV-associated Neurological Damage and Dementia*. Journal Of Biological Chemistry 2000, 275: 19877-19882. PMID: 10747981, DOI: 10.1074/jbc.m001036200.Peer-Reviewed Original ResearchMeSH KeywordsAIDS Dementia ComplexBrainBrain DiseasesChromatography, GelEndopeptidasesExtracellular SpaceHIV Envelope Protein gp41HIV SeropositivityHumansHydrogen-Ion ConcentrationImmunohistochemistryMembrane GlycoproteinsMicroscopy, ElectronProtein BindingProtein Structure, TertiaryRetroviridae ProteinsConceptsNeurological damageBrains of HIVHuman immunodeficiency virusImmunodeficiency virusEnvelope protein gp41HIVBrain tissueDementiaHigh molecular weight formExtracellular aggregatesMolecular weight formsSimian immunodeficiency virus gp41Gp41Molecular mechanismsWeight formsHIV gp41HIV envelope protein gp41Extracellular ectodomainBiochemical methodsDamagePatientsImmunohistochemistryHigh molecular weight aggregatesBrainFrontal lobe dysfunction and aggression Conceptual issues and research findings
Hawkins K, Trobst K. Frontal lobe dysfunction and aggression Conceptual issues and research findings. Aggression And Violent Behavior 2000, 5: 147-157. DOI: 10.1016/s1359-1789(98)00033-0.Peer-Reviewed Original Research
1999
Origin of DNA damage in ejaculated human spermatozoa.
Sakkas D, Mariethoz E, Manicardi G, Bizzaro D, Bianchi PG, Bianchi U. Origin of DNA damage in ejaculated human spermatozoa. Reviews Of Reproduction 1999, 4: 31-7. PMID: 10051100, DOI: 10.1530/ror.0.0040031.Peer-Reviewed Original ResearchConceptsDNA damageMammalian sperm chromatinGenetics ProjectNuclear DNA damageCell surface proteinsSperm chromatinCertain malesMolecular basisMature spermatozoonSurface proteinsStrand breaksHuman spermatozoaDNASperm apoptosisApoptosisSpermatozoaChromatinMale infertilityUnique mannerProteinOriginAbnormal sperm parametersDamageArea of researchFA
1996
Levels of 5‐hydroxymethyl‐2′‐deoxyuridine in DNA from blood as a marker of breast cancer
Djuric Z, Heilbrun L, Simon M, Smith D, Luongo D, LoRusso P, Martino S. Levels of 5‐hydroxymethyl‐2′‐deoxyuridine in DNA from blood as a marker of breast cancer. Cancer 1996, 77: 691-696. PMID: 8616761, DOI: 10.1002/(sici)1097-0142(19960215)77:4<691::aid-cncr15>3.0.co;2-w.Peer-Reviewed Original Research
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