2025
Leveraging Artificial Intelligence in the Diagnosis and Management of Pulmonary Embolism
Mojibian H, Khosla A. Leveraging Artificial Intelligence in the Diagnosis and Management of Pulmonary Embolism. 2025, 1-15. DOI: 10.1007/978-3-030-70904-4_72-1.Peer-Reviewed Original Research
2022
Are there sex differences in risk for exertional heat stroke? A translational approach
Giersch GEW, Garcia CK, Stachenfeld N, Charkoudian N. Are there sex differences in risk for exertional heat stroke? A translational approach. Quarterly Journal Of Experimental Physiology And Cognate Medical Sciences 2022, 107: 1136-1143. PMID: 35598159, DOI: 10.1113/ep090402.Peer-Reviewed Original ResearchConceptsExertional heat strokeHeat strokeRisk factorsTranslational approachCentral nervous system dysfunctionNervous system dysfunctionFemale sex hormonesSex differencesHuman researchOrgan damageFatal conditionSystem dysfunctionSex hormonesPhysical activityStrokeTranslational modelOccupational workersRiskMilitary personnelAnimalsTreatmentHuman modelReviewFuture investigationsPhysiological differencesHyperammonemia syndrome in immunosuppressed individuals
Roberts SC, Malik W, Ison MG. Hyperammonemia syndrome in immunosuppressed individuals. Current Opinion In Infectious Diseases 2022, 35: 262-268. PMID: 35665721, PMCID: PMC9179651, DOI: 10.1097/qco.0000000000000828.Peer-Reviewed Original ResearchConceptsLung transplant recipientsHyperammonemia syndromeUreaplasma sppTransplant recipientsImmunosuppressed individualsSolid organ transplant populationLung transplant donorsOrgan transplant populationPeri-transplant periodAppropriate antimicrobial therapyUrease-producing organismsHigh mortality rateTransplant populationTransplant donorsClinical manifestationsFatal conditionAntimicrobial therapySurveillance studyMortality rateSystemic infectionSyndromeDonor colonizationAntibiotic resistanceRapid diagnosticsRecipients
2021
Pulmonary CTA Reporting: AJR Expert Panel Narrative Review.
Tan S, Nance J, Haramati L, Rajiah P, Sherk W, Le Gal G, Stojanovska J. Pulmonary CTA Reporting: AJR Expert Panel Narrative Review. American Journal Of Roentgenology 2021, 218: 396-404. PMID: 34612678, DOI: 10.2214/ajr.21.26646.Peer-Reviewed Original ResearchConceptsPulmonary embolismPulmonary CTANarrative reviewAJR Expert Panel Narrative ReviewInvasive managementOutpatient basisSignificant thrombusFatal conditionCTA reportsClinical significanceAppropriate managementMedical teamPractice settingsInsignificant findingsRadiology reportsPertinent findingsCTARelevant findingsReportFindingsEmbolismReviewThrombusUbiquitous studiesMalignant hyperthermia in severe COVID-19: 2 case reports
Ehteshami-Afshar S, Nikooie R, Reddy P, Chichra A, Siegel M. Malignant hyperthermia in severe COVID-19: 2 case reports. Emergency And Critical Care Medicine 2021, 1: 45-48. PMID: 38630110, PMCID: PMC8447731, DOI: 10.1097/ec9.0000000000000013.Peer-Reviewed Original Research
2020
A Systematic Review of Cardiogenic Shock in the Setting of Severe Aortic Stenosis: Prevalence, Management, and Outcomes
Essa M, Essa M, Berardi C, Aneni E, Fleming J, Trejo-Paredes M, Bellumkonda L, F. Faridi K, Sugeng L. A Systematic Review of Cardiogenic Shock in the Setting of Severe Aortic Stenosis: Prevalence, Management, and Outcomes. American Journal Of Cardiovascular Research 2020, 1-9. DOI: 10.31487/nl.ajcr.2020.01.02.Peer-Reviewed Original ResearchBalloon aortic valvuloplastySevere aortic stenosisSurgical valve replacementCardiogenic shockAortic stenosisSystematic reviewCommon valvular heart diseaseProcedure-related complicationsValvular heart diseaseTranscatheter aortic valveHospital mortalityAortic valvuloplastyValve replacementPrimary outcomeCirculatory supportFatal conditionAortic valveHeart diseaseStudy protocolBetter outcomesPatientsMedical emergencyStenosisAdditional outcomesMortality
2019
A Systematic Review of Cardiogenic Shock in the Setting of Severe Aortic Stenosis: Prevalence, Management and Outcomes
Essa M, Aneni E, Bernardi C, Fleming J, Paredes M, Frumento K, Abdelmessih M, Sugeng L, Bellumkonda L. A Systematic Review of Cardiogenic Shock in the Setting of Severe Aortic Stenosis: Prevalence, Management and Outcomes. Journal Of Cardiac Failure 2019, 25: s51. DOI: 10.1016/j.cardfail.2019.07.143.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementBalloon aortic valvuloplastyMechanical circulatory supportSurgical valve replacementAortic stenosisValve replacementPrevalence of ASCommon valvular heart diseaseMechanical circulatory support devicesCardiogenic shock managementSevere aortic stenosisAortic valve replacementProcedure-related complicationsValvular heart diseaseCirculatory support devicesHospital mortalityAortic valvuloplastyCardiogenic shockPrimary outcomeValve interventionCirculatory supportFatal conditionShock managementHeart diseaseStudy protocol
2016
Plexin C1 deficiency permits synaptotagmin 7–mediated macrophage migration and enhances mammalian lung fibrosis
Peng X, Moore M, Mathur A, Zhou Y, Sun H, Gan Y, Herazo‐Maya J, Kaminski N, Hu X, Pan H, Ryu C, Osafo‐Addo A, Homer RJ, Feghali‐Bostwick C, Fares W, Gulati M, Hu B, Lee C, Elias JA, Herzog EL. Plexin C1 deficiency permits synaptotagmin 7–mediated macrophage migration and enhances mammalian lung fibrosis. The FASEB Journal 2016, 30: 4056-4070. PMID: 27609773, PMCID: PMC5102121, DOI: 10.1096/fj.201600373r.Peer-Reviewed Original ResearchConceptsLung fibrosisPlexin C1Macrophage migrationPulmonary fibrosisBone marrow-derived cellsSynaptotagmin-7Idiopathic pulmonary fibrosisInterstitial lung diseaseMarrow-derived cellsTGF-β1 overexpressionFatal conditionLung diseaseMonocyte migrationUnrecognized observationCollagen accumulationFibrosisMice showBoyden chamberGenetic deletionLungMouse macrophagesSemaphorin receptorsMacrophagesC1s deficiencyDeficiency
2015
Sustained therapeutic response to riboflavin in a child with a progressive neurological condition, diagnosed by whole-exome sequencing
Shashi V, Petrovski S, Schoch K, Crimian R, Case LE, Khalid R, El-Dairi MA, Jiang YH, Mikati MA, Goldstein DB. Sustained therapeutic response to riboflavin in a child with a progressive neurological condition, diagnosed by whole-exome sequencing. Molecular Case Studies 2015, 1: a000265. PMID: 27148562, PMCID: PMC4850881, DOI: 10.1101/mcs.a000265.Peer-Reviewed Original ResearchWhole-exome sequencingTherapeutic responseImmediate clinical responseSustained therapeutic responseProgressive neurological conditionMotor weaknessClinical responseMedical managementFatal conditionCase reportSensory ataxiaBrown-VialettoProgressive conditionNeurological conditionsDisease processSyndrome 2Patient careAccurate diagnosisRiboflavin therapyVision impairmentTherapyPromising outcomesDiagnosisChildrenReport
2006
Fatal Factitious Cushing’s Syndrome and Invasive Aspergillosis: Case Report and Review of Literature
Kansagara DL, Tetrault J, Hamill C, Moore C, Olson B. Fatal Factitious Cushing’s Syndrome and Invasive Aspergillosis: Case Report and Review of Literature. Endocrine Practice 2006, 12: 651-655. PMID: 17229661, DOI: 10.4158/ep.12.6.651.Peer-Reviewed Case Reports and Technical NotesConceptsFactitious Cushing's syndromeCushing's syndromeInvasive aspergillosisDiffuse pulmonary infiltratesUntreated Cushing's syndromeFatal septic shockInvasive pulmonary aspergillosisMechanism of immunosuppressionInvasive fungal infectionsHealth care providersReview of literaturePulmonary infiltratesFulminant infectionSeptic shockImmunologic aspectsPulmonary aspergillosisClinical findingsCase reportFatal conditionDifficult diagnosisAdrenal cortexTreatment considerationsFactitious illnessPatient's homeSyndromeNecrotizing Infection of the Spine
Spock CR, Miki RA, Shah RV, Grauer JN. Necrotizing Infection of the Spine. Spine 2006, 31: e342-e344. PMID: 16688026, DOI: 10.1097/01.brs.0000217631.73632.37.Peer-Reviewed Original ResearchConceptsNecrotizing infectionAggressive surgical debridementMultifocal necrotizing fasciitisMultisystem organ failureSite of involvementDiabetic foot ulcersLumbar involvementSurgical debridementDiabetic patientsNecrotizing fasciitisOrgan failureFoot ulcersFatal conditionCase reportSuch infectionsBACKGROUND DATALumbar spineInfectionPatientsSpinal componentsSoft tissueSpineFasciitisPotential focusGrave consequences
2001
Molecular mechanisms of TGF‐β antagonism by interferon γ and cyclosporine A in lung fibroblasts
EICKELBERG O, PANSKY A, KOEHLER E, BIHL M, TAMM M, HILDEBRAND P, PERRUCHOUD A, KASHGARIAN M, ROTH M. Molecular mechanisms of TGF‐β antagonism by interferon γ and cyclosporine A in lung fibroblasts. The FASEB Journal 2001, 15: 797-806. PMID: 11259398, DOI: 10.1096/fj.00-0233com.Peer-Reviewed Original ResearchMeSH KeywordsCells, CulturedCollagenCyclosporineDNA-Binding ProteinsExtracellular MatrixFibroblastsGenes, ReporterHumansInterferon-gammaLungModels, BiologicalOligonucleotides, AntisenseProto-Oncogene Proteins c-junPulmonary FibrosisSignal TransductionSTAT1 Transcription FactorTrans-ActivatorsTranscription Factor AP-1Transforming Growth Factor betaConceptsCollagen depositionLung fibroblastsIFN-gammaExcess extracellular matrix depositionGrowth factor-beta activityPrimary human lung fibroblastsFibrotic lung diseaseHuman lung fibroblastsTGF-beta antagonismAP-1IFN-gamma treatmentExtracellular matrix depositionLung fibrosisFatal conditionLung diseaseMolecular mechanismsPathological featuresInterferon γTranscription factor AP-1Future therapiesPharmacological agentsJunD homodimersFactor AP-1Novel targetDirect inhibition
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