2025
MAT2A inhibitor AG-270/S095033 in patients with advanced malignancies: a phase I trial
Gounder M, Johnson M, Heist R, Shapiro G, Postel-Vinay S, Wilson F, Garralda E, Wulf G, Almon C, Nabhan S, Aguado-Fraile E, He P, Romagnoli M, Hossain M, Narayanaswamy R, Sadou-Dubourgnoux A, Cooper M, Askoxylakis V, Burris H, Tabernero J. MAT2A inhibitor AG-270/S095033 in patients with advanced malignancies: a phase I trial. Nature Communications 2025, 16: 423. PMID: 39762248, PMCID: PMC11704051, DOI: 10.1038/s41467-024-55316-5.Peer-Reviewed Original ResearchConceptsAdvanced malignanciesEvidence of clinical activityPaired tumor biopsiesTreatment-related toxicityPhase I trialPhase 1 trialFirst-in-humanLiver function testsProof-of-mechanismHomozygous MTAP deletionPlasma SAM concentrationsPartial responseConcentrations of S-adenosylmethionineTumor biopsiesI trialSafety profileMTAP deletionHomozygous deletionMAT2A inhibitionClinical activityPlasma concentrationsFunction testsPatientsSecondary objectivesMaximal reduction
2024
The Clinical Utility of Pulmonary Function Tests in the Diagnosis and Characterization of Central Airway Obstruction: A Narrative Review
Ampazis D, Vlachakos V, Anagnostopoulos N, Tzouvelekis A, Sampsonas F. The Clinical Utility of Pulmonary Function Tests in the Diagnosis and Characterization of Central Airway Obstruction: A Narrative Review. Journal Of Clinical Medicine 2024, 13: 6299. PMID: 39518438, PMCID: PMC11546877, DOI: 10.3390/jcm13216299.Peer-Reviewed Original ResearchDiagnostic Yield and Clinical Utility of Coronary Angiography Versus Coronary Function Testing in Women With Angina and Nonobstructive Coronary Arteries
Cigarroa N, Latif N, Maayah M, Khokhar A, Kunnirickal S, Schwann A, Maciejewski K, Odanovic N, Mazure C, Spatz E, Pfau S, Lansky A, Shah S. Diagnostic Yield and Clinical Utility of Coronary Angiography Versus Coronary Function Testing in Women With Angina and Nonobstructive Coronary Arteries. Journal Of The American Heart Association 2024, 13: e035852. PMID: 39291500, PMCID: PMC11681466, DOI: 10.1161/jaha.124.035852.Peer-Reviewed Original ResearchCoronary function testingNonobstructive coronary arteriesInvasive coronary angiographyCoronary microvascular dysfunctionCoronary angiographyVasomotor disordersFunction testsCoronary arteryAntianginal therapyDiagnostic yieldVasospastic anginaMicrovascular dysfunctionDiagnostic yield of invasive coronary angiographyNonobstructive coronary artery diseaseSuspected ischemic heart diseaseCalcium channel blockersCoronary vasomotor disordersSymptomatic myocardial bridgingCoronary artery diseaseIschemic heart diseaseChannel blockersAnatomic diagnosisEndothelial dysfunctionArtery diseaseMyocardial bridgingBH04 A global survey to assess practice of laboratory testing in alopecia areata by hair specialists
O’Connor C, Asfour L, Bokhari L, Cotsarelis G, Cotter C, Craiglow B, Cutlar L, Dhurat R, Dlova N, Doche I, Donovan J, Eisman S, Melo D, Harries M, Hordinsky M, Kazmi A, King B, Meah N, Ohyama M, Ovcharenko J, Primez R, Piraccini B, Rudnicka L, Corralo D, Shapiro J, Sinclair R, Smith B, Starace M, Galvan S, Wang K, York K, McDonald I, Wall D. BH04 A global survey to assess practice of laboratory testing in alopecia areata by hair specialists. British Journal Of Dermatology 2024, 191: i74-i75. DOI: 10.1093/bjd/ljae090.151.Peer-Reviewed Original ResearchLiver function testsFunction testsHIV testingHepatitis BLipid testingAlopecia areataSeverity of Alopecia ToolScreening bloodHair disordersRenal function testsRisk of cardiovascular diseaseJanus kinase inhibitorsDermatology Life Quality IndexJanus kinaseBritish Association of DermatologistsLife Quality IndexLaboratory testsHair loss disorderSystemic therapyThyroid testsIdentification of comorbiditiesImmune-mediatedRenal functionThyroid diseaseAssociation of DermatologistsOutcomes of a Formal Hematopoietic Cell Transplantation Survivorship Program on Screening for Late Effects
Newcomb R, Gao L, Vanderklish J, Tse A, Saylor M, Danielson C, Wali N, Frigault M, McAfee S, Spitzer T, DeFilipp Z, Chen Y, Amonoo H, El-Jawahri A. Outcomes of a Formal Hematopoietic Cell Transplantation Survivorship Program on Screening for Late Effects. Transplantation And Cellular Therapy 2024, 30: 700-711. PMID: 38685402, PMCID: PMC11223964, DOI: 10.1016/j.jtct.2024.04.018.Peer-Reviewed Original ResearchConceptsHematopoietic cell transplantationAllogeneic hematopoietic cell transplantationPromote screening adherencePost-HCTScreening adherenceCell transplantationPost-transplant complicationsSurvivorship programsCox proportional hazards regressionProportion of patientsPulmonary function testsProportional hazards regressionEndocrine evaluationMedian timeSecondary cancersRetrospective analysisEvaluate efficacyPrimary outcomeHazards regressionFunction testsPatientsLate effectsScreening outcomesScreening domainsTransfer careThe Impact of Preprocedural Platelet Function Testing on Periprocedural Complication Rates Associated With Pipeline Flow Diversion: An International Multicenter Study
Vranic J, Dmytriw A, Berglar I, Alotaibi N, Cancelliere N, Stapleton C, Rabinov J, Harker P, Gupta R, Bernstock J, Koch M, Raymond S, Mascitelli J, Patterson T, Seinfeld J, White A, Case D, Roark C, Gandhi C, Al-Mufti F, Cooper J, Matouk C, Sujijantarat N, Devia D, Ocampo-Navia M, Villamizar-Torres D, Puentes J, Salem M, Baig A, Namaani K, Kühn A, Pukenas B, Jankowitz B, Burkhardt J, Siddiqui A, Jabbour P, Singh J, Puri A, Regenhardt R, Pereira V, Patel A. The Impact of Preprocedural Platelet Function Testing on Periprocedural Complication Rates Associated With Pipeline Flow Diversion: An International Multicenter Study. Neurosurgery 2024, 95: 179-185. PMID: 38634693, DOI: 10.1227/neu.0000000000002956.Peer-Reviewed Original ResearchPlatelet function testsPipeline Embolization DeviceDual antiplatelet therapyGroup patientsIntracranial complicationsDAPT regimenThromboembolic complicationsPED treatment of intracranial aneurysmsResults of platelet function testingPipeline Embolization Device embolizationPipeline Embolization Device treatmentFunction testsIntracranial aneurysmsPipeline flow diversionPermanent neurological disabilityInternational multicenter studyFlow diversionTreatment of intracranial aneurysmsUnruptured intracranial aneurysmsWilcoxon rank-sumClopidogrel nonrespondersComplication rateMulticenter studyAntiplatelet therapyFisher's exactReal-world evaluation of an algorithmic machine-learning-guided testing approach in stable chest pain: a multinational, multicohort study
Oikonomou E, Aminorroaya A, Dhingra L, Partridge C, Velazquez E, Desai N, Krumholz H, Miller E, Khera R. Real-world evaluation of an algorithmic machine-learning-guided testing approach in stable chest pain: a multinational, multicohort study. European Heart Journal - Digital Health 2024, 5: 303-313. PMID: 38774380, PMCID: PMC11104476, DOI: 10.1093/ehjdh/ztae023.Peer-Reviewed Original ResearchRisk of acute myocardial infarctionAssociated with lower oddsHospital health systemCoronary artery diseaseCardiac testingRisk of adverse outcomesUK BiobankHealth systemProvider-drivenLower oddsAssociated with better outcomesAcute myocardial infarctionBlack raceStable chest painFemale sexReal world evaluationDiabetes historyMulticohort studyFunction testsSuspected coronary artery diseaseYounger ageRisk profileAdverse outcomesMultinational cohortPost hoc analysisHousehold food insecurity is associated with greater autonomic dysfunction testing score in Latinos with type 2 diabetes
Bermúdez-Millán A, Feinn R, Lampert R, Pérez-Escamilla R, Segura-Pérez S, Wagner J. Household food insecurity is associated with greater autonomic dysfunction testing score in Latinos with type 2 diabetes. PLOS ONE 2024, 19: e0297681. PMID: 38394186, PMCID: PMC10889858, DOI: 10.1371/journal.pone.0297681.Peer-Reviewed Original ResearchConceptsDiastolic blood pressureAutonomic function testsAutonomic nervous systemType 2 diabetesHousehold food insecurityDysfunction indexFunction testsHigher diastolic blood pressureAverage diastolic blood pressureAssociated with ANS dysfunctionU.S. Household Food Security Survey ModuleHousehold Food Security Survey ModuleFood Security Survey ModuleBaseline supineFood insecuritySustained handgripBenefit health outcomesLow-income LatinosANS dysfunctionScore 0Improve food accessHandgrip testInsulin useBlood pressureHeart rate variabilityDevelopmental changes in lung function of mice are independent of sex as a biological variable
Bärnthaler T, Ramachandra A, Ebanks S, Guerrera N, Sharma L, Dela Cruz C, Humphrey J, Manning E. Developmental changes in lung function of mice are independent of sex as a biological variable. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2024, 326: l627-l637. PMID: 38375577, PMCID: PMC11380952, DOI: 10.1152/ajplung.00120.2023.Peer-Reviewed Original ResearchPulmonary function testsWeeks of ageStatic complianceMale miceInspiratory capacityLung functionBody weight-basedHuman lung pathologiesLung function of miceFemale C57BL/6J miceLung function parametersSex-dependent changesFunction of miceMeasures of lung functionIndependent of sexPreclinical modelsFemale miceC57BL/6J miceLung pathologyFunction testsMiceWeight-basedLungLung disease researchWeeks
2023
Effect of Burosumab on Muscle Function and Strength, and Rates of ATP Synthesis in Skeletal Muscle in Adults With XLH
Insogna K, Sullivan R, Parziale S, Deng Y, Carrano D, Simpson C, Dufour S, Carpenter T, Petersen K. Effect of Burosumab on Muscle Function and Strength, and Rates of ATP Synthesis in Skeletal Muscle in Adults With XLH. The Journal Of Clinical Endocrinology & Metabolism 2023, 109: e1061-e1071. PMID: 37930769, DOI: 10.1210/clinem/dgad642.Peer-Reviewed Original ResearchSymptoms of painMuscle function testsFunction testsMuscle strengthMuscle functionSkeletal muscleLower extremity joint painSTS testMuscle function studiesImproved muscle functionTreatment-naïve adultsSynthesis rateMonths of studyJoint painThird doseSymptomatic adultsClinical trialsRight calfATP synthesis rateBurosumabPainMuscle concentrationsXLHSymptomsMuscleSpectrum of Clinical Presentations, Imaging Findings, and HLA Types in Immune Checkpoint Inhibitor–Induced Hypophysitis
Quandt Z, Kim S, Villanueva-Meyer J, Coupe C, Young A, Kang J, Yazdany J, Schmajuk G, Rush S, Ziv E, Perdigoto A, Herold K, Lechner M, Su M, Tyrrell J, Bluestone J, Anderson M, Masharani U. Spectrum of Clinical Presentations, Imaging Findings, and HLA Types in Immune Checkpoint Inhibitor–Induced Hypophysitis. Journal Of The Endocrine Society 2023, 7: bvad012. PMID: 36860908, PMCID: PMC9969737, DOI: 10.1210/jendso/bvad012.Peer-Reviewed Original ResearchPD-1/PD-L1 inhibitor monotherapyImmune-related adverse eventsPD-L1 inhibitor monotherapyMagnetic resonance imagingCheckpoint inhibitorsInhibitor monotherapyHLA typesPD-1/PD-L1 inhibitorsCTLA-4/PDCTLA-4 inhibitorsImmune checkpoint inhibitorsPD-L1 inhibitorsThyroid function testsInhibitor combination therapyTiming of onsetAdverse eventsMRI changesClinical presentationFunction testsImaging findingsCombination therapyMean ageInhibitor exposureEffect modificationHLA typingAssessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women
Siblini H, Al-Hendy A, Segars J, González F, Taylor H, Singh B, Flaminia A, Flores V, Christman G, Huang H, Johnson J, Zhang H. Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women. Nutrients 2023, 15: 320. PMID: 36678191, PMCID: PMC9861948, DOI: 10.3390/nu15020320.Peer-Reviewed Original ResearchConceptsReproductive-aged womenLiver function testsUterine fibroidsUnexplained infertilityClomiphene citrateSerum liver function testsEpigallocatechin gallateSigns of drugSerum folate levelsGreen tea catechinsHepatic safetyPremenopausal womenProspective cohortDaily doseLiver injuryFunction testsTreatment armsLiver toxicityClinical studiesCommon causeFolate levelsEarly safety assessmentInterim analysisNormal rangeUse of EGCGType 2 cytokine genes as allergic asthma risk factors after viral bronchiolitis in early childhood
Dong Z, Myklebust Å, Johnsen I, Jartti T, Døllner H, Risnes K, DeWan A. Type 2 cytokine genes as allergic asthma risk factors after viral bronchiolitis in early childhood. Frontiers In Immunology 2023, 13: 1054119. PMID: 36685501, PMCID: PMC9852873, DOI: 10.3389/fimmu.2022.1054119.Peer-Reviewed Original ResearchConceptsAllergic asthmaViral bronchiolitisRisk factorsViral infectionDetailed lung function testsAllergic asthma developmentHistory of bronchiolitisHuman Metapneumovirus InfectionVariable airway obstructionAsthma risk factorsType 2 cytokinesDevelopment of asthmaLung function testsGenetic variantsCohort of childrenSpecific viral infectionsEarly childhoodType 2 cytokine genesSchool agePotential candidate targetAirway obstructionMetapneumovirus infectionMedian ageAsthma developmentFunction tests
2022
Two-Year Analysis of a New Oral Testosterone Undecanoate (TU) Formulation in Hypogonadal Men: Efficacy, Impact on Psychosexual Function, and Safety.
Honig S, Gittelman M, Kaminetsky J, Wang C, Amory J, Rohowsky N, Dudley R, Woun Seo B, Newmark J, Swerdloff R. Two-Year Analysis of a New Oral Testosterone Undecanoate (TU) Formulation in Hypogonadal Men: Efficacy, Impact on Psychosexual Function, and Safety. The Journal Of Sexual Medicine 2022, 19: 1750-1758. PMID: 37057401, DOI: 10.1016/j.jsxm.2022.09.002.Peer-Reviewed Original ResearchConceptsTestosterone replacement therapyPsychosexual Daily QuestionnaireLiver function testsOral TUSerum T concentrationsSexual functionT concentrationsTU therapyHypogonadal menFunction testsEffective long-term treatment optionProstate-specific antigen levelHigh-density lipoprotein cholesterolLong-term treatment optionAdult hypogonadal menOral testosterone undecanoateTotal testosterone levelsSystolic blood pressureTotal T concentrationsActive-controlled trialYears of treatmentLong-term safetySignificant changesEugonadal rangeCardiovascular endpointsCOVID-19 and the liver: a narrative review of the present state of knowledge
Thandassery RB, Dranoff JA, Perisetti A, Taddei T. COVID-19 and the liver: a narrative review of the present state of knowledge. Translational Gastroenterology And Hepatology 2022, 0: 0-0. PMID: 36300154, PMCID: PMC9468988, DOI: 10.21037/tgh-20-243.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsChronic liver diseaseLiver diseaseLiver injuryComorbid conditionsAcute respiratory distress syndromeDirect viral cytotoxicityNon-immunosuppressed patientsAdvanced liver diseaseLiver function testsThird of patientsEpithelial cellsRespiratory distress syndromeResolution of diseaseResolution of illnessOngoing pandemicNovel corona virus diseaseType 2 pneumocytesCOVID-19Biliary epithelial cellsGastrointestinal epithelial cellsCorona Virus DiseaseLiver dysfunctionDistress syndromeFunction testsUninterrupted carePresentation of concurrent thrombotic thrombocytopenic purpura and Graves’ disease
Casasanta N, Shah N, Troy K, Edwards C, Patel R. Presentation of concurrent thrombotic thrombocytopenic purpura and Graves’ disease. Blood Coagulation & Fibrinolysis 2022, 33: 422-424. PMID: 35867945, DOI: 10.1097/mbc.0000000000001154.Peer-Reviewed Original ResearchConceptsThrombotic thrombocytopenic purpuraThrombocytopenic purpuraGraves' diseaseAutoimmune diseasesConcurrent thrombotic thrombocytopenic purpuraDeficient activity of ADAMTS13Retrospective review of patientsDiagnosing TTPUncontrolled autoimmune diseaseReview of patientsThyroid function testsAutoimmune thyroid diseaseActivity of ADAMTS13Thrombotic microangiopathyRetrospective reviewThyroid diseaseAutoimmune disordersStandard treatmentFunction testsDeficient activityPatientsThyrotoxicosisPurpuraDiseaseGravesA guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation—part 2: systematic review of evidence regarding resection extent in generally healthy patients
Detterbeck FC, Mase VJ, Li AX, Kumbasar U, Bade BC, Park HS, Decker RH, Madoff DC, Woodard GA, Brandt WS, Blasberg JD. A guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation—part 2: systematic review of evidence regarding resection extent in generally healthy patients. Journal Of Thoracic Disease 2022, 0: 0-0. PMID: 35813747, PMCID: PMC9264068, DOI: 10.21037/jtd-21-1824.Peer-Reviewed Original ResearchNon-randomized comparisonHealthy patientsResection extentIndividual patientsSystematic reviewStage I lung cancerI lung cancerStage I NSCLCCharacteristics of patientsPulmonary function testsLong-term outcomesRisk of recurrenceVideo-assisted approachSublobar resectionWedge resectionRandomized trialsFunction testsLung cancerResidual confoundingEffect modifiersShort-term benefitsLobectomyPatientsPubMed systematic reviewMargin distanceA guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation—part 4: systematic review of evidence involving SBRT and ablation
Park HS, Detterbeck FC, Madoff DC, Bade BC, Kumbasar U, Mase VJ, Li AX, Blasberg JD, Woodard GA, Brandt WS, Decker RH. A guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation—part 4: systematic review of evidence involving SBRT and ablation. Journal Of Thoracic Disease 2022, 0: 0-0. PMID: 35813762, PMCID: PMC9264060, DOI: 10.21037/jtd-21-1826.Peer-Reviewed Original ResearchLong-term outcomesNon-randomized comparisonIndividual patientsSystematic reviewStage I lung cancerI lung cancerCharacteristics of patientsStage I NSCLCPulmonary function testsMinority of patientsShort-term outcomesStereotactic body radiotherapyThermal ablationLate toxicityPulmonary functionRandomized trialsFunction testsAdjusted comparisonsBody radiotherapyLung cancerResidual confoundingEffect modifiersShort-term benefitsPatientsPubMed systematic reviewCognitive dysfunction following COVID-19 infection
Hadad R, Khoury J, Stanger C, Fisher T, Schneer S, Ben-Hayun R, Possin K, Valcour V, Aharon-Peretz J, Adir Y. Cognitive dysfunction following COVID-19 infection. Journal Of NeuroVirology 2022, 28: 430-437. PMID: 35618983, PMCID: PMC9134977, DOI: 10.1007/s13365-022-01079-y.Peer-Reviewed Original ResearchConceptsDisease severityPulmonary function testsDetailed medical historyLong-term sequelaeCOVID-19 infectionTotal MoCA scoreMontreal Cognitive AssessmentNormal laboratory testsCognitive performancePhonemic fluencyExecutive functionAge 49.5Neurologic consultationNeurological examinationBrain CTFunction testsNeurological consultationHealthy patientsNeurologic syndromeCOVID clinicMedical historyPremorbid conditionsCognitive dysfunctionMoCA scoresMoCA testDecreased Exercise-Induced Changes in Prefrontal Cortex Hemodynamics Are Associated With Depressive Symptoms
Crum J, Ronca F, Herbert G, Funk S, Carmona E, Hakim U, Jones I, Hamer M, Hirsch J, Hamilton A, Tachtsidis I, Burgess P. Decreased Exercise-Induced Changes in Prefrontal Cortex Hemodynamics Are Associated With Depressive Symptoms. Frontiers In Neuroergonomics 2022, 3: 806485. PMID: 38235451, PMCID: PMC10790946, DOI: 10.3389/fnrgo.2022.806485.Peer-Reviewed Original ResearchCardiopulmonary exercise testPhysical activityDepressive symptomsPrefrontal cortexActivation changesRostral prefrontal cortexExercise-induced changesExecutive function tasksMental health interventionsPrefrontal cortex hemodynamicsExecutive functionCPET assessmentFunction tasksAcute exerciseFunction testsExercise testAcute effectsInferior frontal gyrusExecutive function testsHealth interventionsNeural effectsAerobic fitnessDepressed moodSymptomsPhysical fitness
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