2023
Regulatory T cells in skin regeneration and wound healing
Knoedler S, Knoedler L, Kauke-Navarro M, Rinkevich Y, Hundeshagen G, Harhaus L, Kneser U, Pomahac B, Orgill D, Panayi A. Regulatory T cells in skin regeneration and wound healing. Military Medical Research 2023, 10: 49. PMID: 37867188, PMCID: PMC10591349, DOI: 10.1186/s40779-023-00484-6.Peer-Reviewed Original ResearchConceptsRegulatory T cellsT cellsRole of TregsIntegumentary systemNew treatment modalitiesTissue-resident cellsSubsequent wound healing processCutaneous wound healingExcessive inflammationImmune homeostasisTreatment modalitiesImmune cellsSkin adnexaWound healing processImmune responseTregsHealing processWound repairWound healingHealingEpidermal integrityCellsCollateral damageAdnexaInflammationFibroblasts – the cellular choreographers of wound healing
Knoedler S, Broichhausen S, Guo R, Dai R, Knoedler L, Kauke-Navarro M, Diatta F, Pomahac B, Machens H, Jiang D, Rinkevich Y. Fibroblasts – the cellular choreographers of wound healing. Frontiers In Immunology 2023, 14: 1233800. PMID: 37646029, PMCID: PMC10461395, DOI: 10.3389/fimmu.2023.1233800.Peer-Reviewed Original ResearchConceptsFibroblast diversityInnate immune cellsNovel treatment modalitiesWound healing functionsFascial connective tissueRole of fibroblastsTreatment modalitiesImmune cellsWound repairScar tissueDiversityFibroblastsConnective tissueHealing processWound healingComprehensive understandingMachineryTissueHealing functionCascade
2018
Bone Marrow-Derived Cells Trafficking to the Oviduct: Effect of Ischemia-Reperfusion Injury
Sahin C, Mamillapalli R, Taylor HS. Bone Marrow-Derived Cells Trafficking to the Oviduct: Effect of Ischemia-Reperfusion Injury. Reproductive Sciences 2018, 25: 1037-1044. PMID: 29658434, PMCID: PMC6346346, DOI: 10.1177/1933719118770552.Peer-Reviewed Original ResearchConceptsBone marrow-derived cellsRecruitment of BMDCsMarrow-derived cellsReperfusion injuryFallopian tubeFemale miceWild-type female miceIschemia-reperfusion injuryEquivalent surgeryIR injuryBMDC recruitmentMale miceBone marrowMammalian reproductive tractInjuryIschemiaReproductive tractMiceHealing processEarly embryo developmentOviductCrucial organCellsCritical roleRecruitment
2013
Comparação da retração aguda do stent entre o suporte vascular bioabsorvível eluidor de everolimus e dois diferentes stents metálicos farmacológicos
Borghi T, Costa J, Abizaid A, Chamié D, Veloso e Silva M, Taiguara D, Costa R, Staico R, Feres F, Chaves Á, Siqueira D, Sousa A, Sousa J. Comparação da retração aguda do stent entre o suporte vascular bioabsorvível eluidor de everolimus e dois diferentes stents metálicos farmacológicos. Journal Of Transcatheter Interventions 2013, 21: 326-331. DOI: 10.1590/s2179-83972013000400005.Peer-Reviewed Original ResearchMetallic drug-eluting stentsPercutaneous coronary interventionDrug-eluting stentsBioresorbable vascular scaffoldAcute recoilSecond-generation metallic drug-eluting stentsAcute luminal gainNon-complex lesionsAngiographic characteristicsNo significant differenceEverolimus-eluting stentPolymeric materialsMaximum inflation pressureCoronary interventionBalloon deflationStentCobalt-chromium everolimus-eluting stentPatientsSignificant differenceVascular scaffoldsBiolimus-eluting stentInflation pressureLuminal gainHealing processBalloonThe promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling
Zhao Y, Tian Q, Frenkel S, Liu C. The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling. Biomaterials 2013, 34: 6412-6421. PMID: 23746860, PMCID: PMC3713419, DOI: 10.1016/j.biomaterials.2013.05.030.Peer-Reviewed Original ResearchConceptsBone healing processBone formationHealing processEctopic bone formationTNF-α transgenic miceBone healingTNFR2-deficient miceRole of PGRNTreatment of fracturesTNF-α signalingEndochondral ossificationPotential molecular targetsEctopic bone formation modelInflammatory osteoclastogenesisTNF/TNFRPGRN deficiencyInflammatory conditionsDeficient miceRecombinant PGRNBone regenerationTransgenic micePGRNMiceCritical mediatorGrowth factor
2007
Growth Factor Expression With Different Wound Treatments After Laser Resurfacing
Lee C, Whang J, Lazova R, Ciesielski TE, Thomson JG, McCarthy T, Persing JA. Growth Factor Expression With Different Wound Treatments After Laser Resurfacing. Aesthetic Surgery Journal 2007, 27: 55-64. PMID: 19341630, DOI: 10.1016/j.asj.2006.12.002.Peer-Reviewed Original ResearchGrowth factorHealing processWound healingReverse transcriptase-polymerase chain reactionChain reactionTranscriptase-polymerase chain reactionTranscription-polymerase chain reactionWound treatmentGrowth factor expressionMessenger RNA levelsDifferent wound treatmentsControl subjectsBiopsy specimensOcclusive dressingHistologic evaluationPetrolatum ointmentHistologic studyHuman epidermal keratinocytesTreatment woundsBack of ratsLess improvementFactor expressionRNA levelsTissue expressionEpidermal keratinocytes
2001
Muscle contusion injuries: current treatment options.
Beiner J, Jokl P. Muscle contusion injuries: current treatment options. Journal Of The American Academy Of Orthopaedic Surgeons 2001, 9: 227-37. PMID: 11476532, DOI: 10.5435/00124635-200107000-00002.Peer-Reviewed Original ResearchConceptsMuscle contusionAnti-inflammatory medicationsTreatment of complicationsCurrent treatment optionsCause of morbiditySports-related injuriesExtent of injuryPresence of fatigueMagnetic resonance imagingScar tissue formationOperative repairMyositis ossificansTreatment optionsSite of impactClinical studiesNatural healing processClinical judgmentResonance imagingActivation statusInjuryMuscle repairHealing processNew modalityContusionAnimal research
2000
Intracoronary brachytherapy not associated with changes in major side branches
Cottin Y, Lansky A, Kim H, Kollum M, Abrahimi A, Mehran R, Bhargava B, Chan R, Waksman R. Intracoronary brachytherapy not associated with changes in major side branches. Catheterization And Cardiovascular Interventions 2000, 51: 154-158. PMID: 11025567, DOI: 10.1002/1522-726x(200010)51:2<154::aid-ccd5>3.0.co;2-v.Peer-Reviewed Original ResearchConceptsSide branch occlusionMajor side branchesIntravascular radiationIntracoronary brachytherapyIrradiated groupSide branchesLate coronary occlusionTreatment of restenosisBaseline patientConsecutive patientsCoronary occlusionPatency ratesTotal occlusionSignificant stenosisLesion characteristicsTarget lesionsControl groupLow dosesPatientsAdverse effectsOcclusionHealing processSignificant decreaseStenosisRestenosisAccelerated Healing of Full-Thickness Skin Wounds in a Wet Environment
Svensjö T, Pomahac B, Yao F, Slama J, Eriksson E. Accelerated Healing of Full-Thickness Skin Wounds in a Wet Environment. Plastic & Reconstructive Surgery 2000, 106: 602-612. DOI: 10.1097/00006534-200009030-00012.Peer-Reviewed Original ResearchFull-thickness skin woundsSkin woundsAccelerated healingSaline-treated woundsGranulation tissue formationYoung Yorkshire pigsSecondary intentionTreatment modalitiesWound healing processSkin wound repairGranulation tissueWound healing modelWound contractionStandardized fashionPorcine wound healing modelFast contractionHealing processWound repairWoundsCell layerYorkshire pigsMoist woundSkin repairHealing modelHealingAccelerated Healing of Full-Thickness Skin Wounds in a Wet Environment
Svensjö T, Pomahac B, Yao F, Slama J, Eriksson E. Accelerated Healing of Full-Thickness Skin Wounds in a Wet Environment. Plastic & Reconstructive Surgery 2000, 106: 602-612. PMID: 10987467, DOI: 10.1097/00006534-200009010-00012.Peer-Reviewed Original ResearchConceptsFull-thickness skin woundsSkin woundsAccelerated healingSaline-treated woundsGranulation tissue formationYoung Yorkshire pigsSecondary intentionTreatment modalitiesWound healing processSkin wound repairGranulation tissueWound healing modelWound contractionStandardized fashionPorcine wound healing modelFast contractionHealing processWound repairWoundsCell layerYorkshire pigsMoist woundSkin repairHealing modelHealingExperimental model for allograft incorporation and allograft fracture repair
Lee F, Hazan E, Gebhardt M, Mankin H. Experimental model for allograft incorporation and allograft fracture repair. Journal Of Orthopaedic Research® 2000, 18: 303-306. PMID: 10815832, DOI: 10.1002/jor.1100180219.Peer-Reviewed Original ResearchConceptsAllograft incorporationFracture repairHost-donor interfaceSprague-Dawley ratsSkeletal defectsAdult LewisImmediate ambulationIntercalary allograftsRat modelHistological examinationOsteotomy healingKirschner wiresMuscle layerOsteotomy siteTransverse osteotomyExperimental modelHealing processAllograftsRepair processRepairAmbulation
1999
Accelerated Wound Healing in Mice With a Disruption of the Thrombospondin 2 Gene
Kyriakides T, Tam J, Bornstein P. Accelerated Wound Healing in Mice With a Disruption of the Thrombospondin 2 Gene. Journal Of Investigative Dermatology 1999, 113: 782-787. PMID: 10571734, DOI: 10.1046/j.1523-1747.1999.00755.x.Peer-Reviewed Original ResearchConceptsGranulation tissueThrombospondin-2Late woundsControl woundsWound healingExtent of angiogenesisRe-epithelization rateAbnormal collagen fibrilsVascular densityLess scarringRete pegsHistologic analysisExcisional woundsControl epitheliumSuch woundsThrombospondin 2 geneTotal cellular contentAccelerated wound healingElevated levelsHealing processMiceWoundsBiopsy punchEarly woundsHealing
1993
Nonexcisional Treatment of Benign and Premalignant Cutaneous Lesions
Morganroth G, Leffell D. Nonexcisional Treatment of Benign and Premalignant Cutaneous Lesions. Clinics In Plastic Surgery 1993, 20: 91-104. PMID: 8420713, DOI: 10.1016/s0094-1298(20)30775-6.Peer-Reviewed Original Research
1989
The effect of radiation on the fracture repair process. A biomechanical evaluation of a closed fracture in a rat model
Markbreiter L, Pelker R, Friedlaender G, Peschel R, Panjabi M. The effect of radiation on the fracture repair process. A biomechanical evaluation of a closed fracture in a rat model. Journal Of Orthopaedic Research® 1989, 7: 178-183. PMID: 2918417, DOI: 10.1002/jor.1100070204.Peer-Reviewed Original ResearchConceptsRat modelFemoral midshaft fractureBiomechanical parametersFracture repair processFracture healing processOpen fracture modelSingle doseMidshaft fracturesIntramedullary pinningClosed fracturesNormal controlsFracture healingControl groupNormal levelsSimilar fracturesBiomechanical evaluationHealing processExperimental groupWeeksFracturesRepair processTemporal progressionGroupEffects of radiationPrevious studies
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