2024
Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis
Fu W, Vasylyev D, Bi Y, Zhang M, Sun G, Khleborodova A, Huang G, Zhao L, Zhou R, Li Y, Liu S, Cai X, He W, Cui M, Zhao X, Hettinghouse A, Good J, Kim E, Strauss E, Leucht P, Schwarzkopf R, Guo E, Samuels J, Hu W, Attur M, Waxman S, Liu C. Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis. Nature 2024, 625: 557-565. PMID: 38172636, PMCID: PMC10794151, DOI: 10.1038/s41586-023-06888-7.Peer-Reviewed Original ResearchVoltage-gated sodium channelsOA progressionDorsal root ganglion neuronsStructural joint damagePain relief treatmentHuman OA chondrocytesCommon joint diseaseMultiple mouse modelsNav1.7 blockersPain behaviorGanglion neuronsPharmacological blockadeJoint damageJoint degenerationChannel blockersJoint diseaseOA chondrocytesMouse modelTherapeutic targetOsteoarthritisIntracellular Ca2Nav1.7Nav1.7 channelsGenetic ablationLimited evidence
2023
Observational cohort study of long‐term outcomes of liver transplantation in haemophilia
Ragni M, Callis J, Daoud N, Hu B, Manuel M, Santos J, Schwartz J, Friedman K, Kouides P, Kuriakose P, Leavitt A, Lim M, Machin N, Recht M, Chrisentery‐Singleton T. Observational cohort study of long‐term outcomes of liver transplantation in haemophilia. Haemophilia 2023, 30: 87-97. PMID: 38111071, DOI: 10.1111/hae.14910.Peer-Reviewed Original ResearchConceptsHaem-A-QoLPROMIS-29Hemophilia treatment centersYears post-OLTXQuality of lifeQuality-of-life impactObservational cohort studyHemophilia ALiver transplantationPost-OLTxHigher sportsHemophilia B (HBLong-term outcome of liver transplantationUnivariate regression modelsCohort studyOutcome of liver transplantationTotal scoreB (HBJoint diseaseLong-term outcomesNon-severe diseaseNon-CaucasiansRegression modelsStudent's t-testDemographic dataCircIRAK3 exerts negative feedback regulation on inflammation by binding to HNRNP U and destabilizing proinflammatory cytokine mRNA in osteoarthritis and chondrogenesis
Wen X, Fang G, Li H, Jiang Z, Du X, Liao Z, Liu R, Huang G, Meng F, Liao W, Zhang Z. CircIRAK3 exerts negative feedback regulation on inflammation by binding to HNRNP U and destabilizing proinflammatory cytokine mRNA in osteoarthritis and chondrogenesis. International Journal Of Biological Macromolecules 2023, 256: 128453. PMID: 38016613, DOI: 10.1016/j.ijbiomac.2023.128453.Peer-Reviewed Original ResearchTherapeutic effectCartilage degenerationMesenchymal stem cell therapyLimited treatment optionsIntra-articular injectionMSC therapeutic effectsProinflammatory cytokine mRNADegenerative joint diseaseDMM mouse modelNew therapeutic targetsHigher OARSI scoresStem cell therapyChronic inflammationIL-1βTreatment optionsOARSI scoresJoint diseaseCytokine mRNAMouse modelCombination of MSCTherapeutic targetIL6 mRNAOA cartilageOsteoarthritisInflammation
2022
Construction and evaluation of a clinically relevant model of septic arthritis
Kwon H, Yu K, Lee F. Construction and evaluation of a clinically relevant model of septic arthritis. Lab Animal 2022, 52: 11-26. PMID: 36564668, DOI: 10.1038/s41684-022-01089-7.Peer-Reviewed Original ResearchConceptsSeptic arthritisAnimal modelsMethicillin-resistant Staphylococcus aureus culturesIntra-articular inflammationReproducible animal modelRelevant mouse modelExperimental animal modelsMRSA infectionCartilage destructionC57BL/6J miceInflammatory pathologyJoint diseaseTherapeutic medicationsMouse modelArthritisSynovial fluidClinical relevancePotential treatmentHuman patientsKnee jointDirect inoculationAureus culturesMRSAMiceStaphylococcus aureus culturesAB0924 Individual Digit Level Nail Involvement and Joint Assessment in Patients with Nail Psoriasis
Ritchlin C, Kristensen L, Strober B, Kavanaugh A, Bolce R, Lisse J, Pustizzi J, Somani N, Sapin C, Merola J. AB0924 Individual Digit Level Nail Involvement and Joint Assessment in Patients with Nail Psoriasis. Annals Of The Rheumatic Diseases 2022, 81: 1590-1591. DOI: 10.1136/annrheumdis-2022-eular.711.Peer-Reviewed Original ResearchNail Psoriasis Severity IndexNail involvementDIP jointJoint involvementSanofi GenzymeNail psoriasisInterphalangeal jointJoint diseaseEli LillyExact testAssessor-blinded studyDIP joint involvementJoint count scoresSpeakers bureauPsoriasis Severity IndexProximal interphalangeal jointsDistal interphalangeal jointMetacarpophalangeal joint levelFisher's exact testGrant/research supportChi-square testImportant clinical parametersJoint assessmentNail assessmentPsoriasis RegistryAcid-sensitive ion channel 1a mediates osteoarthritis chondrocyte senescence by promoting Lamin B1 degradation
Ding J, Chen Y, Zhao Y, Chen F, Dong L, Zhang H, Hu W, Li S, Zhou R, Hu W. Acid-sensitive ion channel 1a mediates osteoarthritis chondrocyte senescence by promoting Lamin B1 degradation. Biochemical Pharmacology 2022, 202: 115107. PMID: 35643339, DOI: 10.1016/j.bcp.2022.115107.Peer-Reviewed Original ResearchConceptsAcid-sensitive ion channel 1aChondrocyte senescenceIon channel 1aChannel 1aBeclin-1Chronic joint diseaseBeclin-1 protein expressionRat OA modelProtein Beclin 1Senescence-related markersJoint diseaseOA modelAging of chondrocytesJoint cavityPsalmotoxin-1Chondrocyte autophagyOsteoarthritisB1 expressionProtein expressionCationic channelsHairpin RNALamin B1Autophagy pathwayArticular cartilageLamin B1 expression
2021
14-3-3 epsilon is an intracellular component of TNFbib2 receptor complex and its activation protects against osteoarthritis
Fu W, Hettinghouse A, Chen Y, Hu W, Ding X, Chen M, Ding Y, Mundra J, Song W, Liu R, Yi Y, Attur M, Samuels J, Strauss E, Leucht P, Schwarzkopf R, Liu C. 14-3-3 epsilon is an intracellular component of TNFbib2 receptor complex and its activation protects against osteoarthritis. Annals Of The Rheumatic Diseases 2021, 80: 1615-1627. PMID: 34226187, PMCID: PMC8595573, DOI: 10.1136/annrheumdis-2021-220000.Peer-Reviewed Original ResearchConceptsPathogenesis of osteoarthritisTNFR2 complexTherapeutic effectSingle-cell RNA-seqIntracellular componentsReceptor complexExtracellular signal-regulated kinaseNuclear factor kappa BSignal-regulated kinaseCommon joint diseaseFactor kappa BChondrocyte-specific deletionProteomic screenElk-1RNA-seqTranscription factorsCell-based assaysTNF signalingTNFR2 pathwayInducible componentJoint diseaseActivity screenTherapeutic targetKappa BOsteoarthritis
2019
Bariatric Surgery: Safety, Efficacy, Disease State, Collaboration, Future
Morton JM, Rosenthal RJ. Bariatric Surgery: Safety, Efficacy, Disease State, Collaboration, Future. The Journal Of Arthroplasty 2019, 34: s36-s37. PMID: 31003783, DOI: 10.1016/j.arth.2019.03.040.Peer-Reviewed Original ResearchObesity Disease Pandemic on Joint Disease and Longevity
Milla C, Lo Menzo E, Morton J, Rosenthal RJ. Obesity Disease Pandemic on Joint Disease and Longevity. The Journal Of Arthroplasty 2019, 34: s33-s35. PMID: 30954412, DOI: 10.1016/j.arth.2019.03.004.Peer-Reviewed Original Research
2017
Effects of autophagy on acid-sensing ion channel 1a-mediated apoptosis in rat articular chondrocytes
Xie Y, Li Y, Zhou R, Dai B, Qian Y, Wu X, Ge J, Hu W, Chen F. Effects of autophagy on acid-sensing ion channel 1a-mediated apoptosis in rat articular chondrocytes. Molecular And Cellular Biochemistry 2017, 443: 181-191. PMID: 29273849, DOI: 10.1007/s11010-017-3223-6.Peer-Reviewed Original ResearchConceptsRat articular chondrocytesRheumatoid arthritisEffect of autophagyPathogenesis of RAArticular chondrocytesProgression of RAInhibition of ASIC1aAcid-sensing ion channel 1aMultiple pathogenic factorsDegenerative joint diseaseArticular chondrocyte apoptosisRat knee jointsIon channel 1aShort hairpin RNAPrecise etiologyJoint diseasePathogenic factorsKnee jointPsalmotoxin-1Chondrocyte apoptosisPrimary articular chondrocytesChannel 1aASIC1aAutophagy fluxBeclin-1Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models
Wei J, Fu W, Ding Y, Hettinghouse A, Lendhey M, Schwarzkopf R, Kennedy O, Liu C. Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models. Arthritis Research & Therapy 2017, 19: 280. PMID: 29258611, PMCID: PMC5735869, DOI: 10.1186/s13075-017-1485-8.Peer-Reviewed Original ResearchConceptsTherapeutic effectOA modelPain-related markersAnti-catabolic effectsRole of progranulinDegenerative joint diseaseMurine OA modelMultiple murine modelsNew therapeutic alternativesTumor necrosis factor receptorIntra-articular deliveryNecrosis factor receptorInflammatory arthritisPGRN deficiencyOA phenotypeSafranin O stainingTherapeutic alternativeRat modelJoint diseaseOsteoarthritis progressionPreventative effectMurine modelCartilage degradationDegenerative factorsEarly osteoarthritisSeptic Arthritis of Native Joints: Are Outcomes Better with Medical or Surgical Management?
McConnell I, Baghban A, Holleck J, Gupta S. Septic Arthritis of Native Joints: Are Outcomes Better with Medical or Surgical Management? Open Forum Infectious Diseases 2017, 4: s92-s92. PMCID: PMC5631936, DOI: 10.1093/ofid/ofx163.058.Peer-Reviewed Original ResearchDuration of antibioticsNative joint septic arthritisSeptic arthritisSurgical groupSurgical managementFull recoveryPoor outcomeInclusion criteriaSingle-center retrospective chart reviewCulture-negative septic arthritisMedical groupSixty one casesRetrospective chart reviewLength of staySignificant differencesCorrelation of outcomesChart reviewJoint drainageSurgical treatmentRisk factorsOdds ratioJoint diseaseEvaluated outcomesOutcome dataCommon pathogens
2016
Clavicle Fractures are Associated With Arthritis of the Glenohumeral Joint in a Large Osteological Collection
Weinberg DS, Vallier HA, Gaumer GA, Cooperman DR, Liu RW. Clavicle Fractures are Associated With Arthritis of the Glenohumeral Joint in a Large Osteological Collection. Journal Of Orthopaedic Trauma 2016, 30: 605-611. PMID: 27525633, DOI: 10.1097/bot.0000000000000654.Peer-Reviewed Original ResearchConceptsClavicle fracturesGlenohumeral jointIpsilateral clavicle fractureDegenerative joint diseaseFuture clinical studiesLarge osteological collectionEvidence of fractureJoint contact forcesNonoperative careMale genderClinical studiesJoint diseaseLong-term consequencesLong-term effectsControl groupCadaveric skeletonsArthritisOsteoarthritisBiomechanical studyDemographic informationMultiple regression analysisRegression analysisRecent dataClavicleLateralityHip-related toxicity after prostate radiotherapy: Treatment related or coincidental?
Zelefsky M, Kollmeier M, Gorshein E, Pei X, Torres M, McBride S, Happersett L, Cohen G, Yamada Y. Hip-related toxicity after prostate radiotherapy: Treatment related or coincidental? Radiotherapy And Oncology 2016, 121: 109-112. PMID: 27756494, PMCID: PMC5546832, DOI: 10.1016/j.radonc.2016.08.010.Peer-Reviewed Original ResearchConceptsDegenerative joint diseaseHip painPersistent hip painSevere hip painLocalized prostate cancerOnly variableProstate cancer patientsExternal beam radiotherapyHip revision surgerySalvage therapySevere painCancer patientsProstate cancerJoint diseaseLower incidenceBeam radiotherapyHip replacementConcurrent ADTMultivariate analysisPatientsRadiotherapyPainProstate radiotherapyIncidenceAmbulation
2012
Chapter 26 Familial Hypophosphatemia and Related Disorders
Holm I, Econs M, Carpenter T. Chapter 26 Familial Hypophosphatemia and Related Disorders. 2012, 699-726. DOI: 10.1016/b978-0-12-382040-2.10026-7.Peer-Reviewed Original ResearchAutosomal dominant hypophosphatemic ricketsTumor-induced osteomalaciaRelated disordersClinical featuresHypophosphatemic ricketsPathophysiology of XLHLong-term morbidityDevelopment of ricketsDegenerative joint diseaseHereditary hypophosphatemic ricketsCommon bone diseaseDominant hypophosphatemic ricketsFGF-23Joint painDental abscessDihydroxyvitamin DAvailable therapiesFamilial hypophosphatemiaHypophosphatemic diseasesDental diseaseJoint diseaseBone diseaseChronic featuresTherapeutic approachesRenal phosphate
2006
Use of etanercept for psoriatic arthritis in the dermatology clinic: The Experience Diagnosing, Understanding Care, and Treatment with Etanercept (EDUCATE) study
Gottlieb A, Kircik L, Eisen D, Jackson J, Boh E, Strober B, Frankel E, Xia H, Stevens S. Use of etanercept for psoriatic arthritis in the dermatology clinic: The Experience Diagnosing, Understanding Care, and Treatment with Etanercept (EDUCATE) study. Journal Of Dermatological Treatment 2006, 17: 343-352. PMID: 17853307, DOI: 10.1080/09546630600967166.Peer-Reviewed Original ResearchConceptsPsoriatic arthritisDermatology clinicBody surface area involvementGlobal assessmentTolerability of etanerceptPatient global assessmentPhysician global assessmentSerious adverse eventsUse of etanerceptSurface area involvementActive psoriatic arthritisWeeks of treatmentBody surface areaEtanercept treatmentExperience diagnosingEtanercept therapyPlaque psoriasisAdverse eventsJoint painArea involvementJoint diseaseDisease scorePatientsArthritisPsoriasis
2003
Charcot Joint Disease in Diabetes Mellitus
Lee L, Blume PA, Sumpio B. Charcot Joint Disease in Diabetes Mellitus. Annals Of Vascular Surgery 2003, 17: 571-580. PMID: 14508661, DOI: 10.1007/s10016-003-0039-5.Peer-Reviewed Original ResearchConceptsCharcot joint diseaseDiabetes mellitusJoint diseaseCharcot neuropathic arthropathyDiabetic foot ulcerationStructural foot deformitiesDevastating deformitiesNeuropathic arthropathyCharcot arthropathyDiabetic patientsFoot ulcerationClinical presentationDegenerative arthropathyPedal ulcerationFoot deformityFoot problemsTreatment modalitiesImmediate treatmentVascular surgeonsNeuropathic diseasePatientsMellitusArthropathyEarly signsStructural deformityChapter 25 Familial Hypophosphatemia and Related Disorders
Holm I, Econs M, Carpenter T. Chapter 25 Familial Hypophosphatemia and Related Disorders. 2003, 603-xvi. DOI: 10.1016/b978-012286551-0/50027-0.Peer-Reviewed Original ResearchAutosomal dominant hypophosphatemic ricketsTumor-induced osteomalaciaRelated disordersHypophosphatemic ricketsPathophysiology of XLHDevelopment of ricketsDegenerative joint diseaseHereditary hypophosphatemic ricketsCommon bone diseaseJoint painDental abscessClinical featuresDihydroxyvitamin DFamilial hypophosphatemiaHypophosphatemic diseasesDental diseaseJoint diseaseBone diseaseRenal phosphateEndopeptidase PHEXShort statureHypophosphatemiaXLHDiseaseRickets
2001
Molecular Mimicry in Lyme Arthritis Demonstrated at the Single Cell Level: LFA-1αL Is a Partial Agonist for Outer Surface Protein A-Reactive T Cells
Trollmo C, Meyer A, Steere A, Hafler D, Huber B. Molecular Mimicry in Lyme Arthritis Demonstrated at the Single Cell Level: LFA-1αL Is a Partial Agonist for Outer Surface Protein A-Reactive T Cells. The Journal Of Immunology 2001, 166: 5286-5291. PMID: 11290815, DOI: 10.4049/jimmunol.166.8.5286.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferi GroupClone CellsHumansHybridomasLipoproteinsLyme DiseaseLyme Disease VaccinesLymphocyte ActivationLymphocyte Function-Associated Antigen-1MiceMice, TransgenicMolecular MimicryPeptide FragmentsT-Lymphocyte SubsetsConceptsIL-13Antibiotic treatment-resistant Lyme arthritisPartial agonistTreatment-resistant Lyme arthritisChronic inflammatory joint diseaseT cell hybridsDR4 transgenic miceHuman T cell clonesClass II tetramersInflammatory joint diseaseSymptoms of arthritisT cell responsesT cell levelsEpisodes of arthritisT cell clonesSurface protein AAutoimmune mechanismsOuter surface protein ALyme arthritisJoint diseaseT cellsIFN-gammaImmunodominant epitopesCell levelTransgenic mice
1995
Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established disease.
Wang Y, Rollins S, Madri J, Matis L. Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 8955-8959. PMID: 7568051, PMCID: PMC41086, DOI: 10.1073/pnas.92.19.8955.Peer-Reviewed Original ResearchConceptsCollagen-induced arthritisRheumatoid arthritisComplement activationAnti-C5 mAbInflammatory joint diseaseOnset of arthritisMonoclonal antibody therapyTerminal complement activationAttractive therapeutic targetJoint inflammationAntibody therapySystemic administrationJoint diseaseNumerous disease statesImmunized animalsArthritisAnimal modelsTherapeutic targetPotent mediatorTerminal complement componentsActivated componentsComplement cascadeComplement componentsComplement systemMonoclonal antibodies
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