2014
Adolescent cocaine exposure simplifies orbitofrontal cortical dendritic arbors
DePoy LM, Perszyk RE, Zimmermann KS, Koleske AJ, Gourley SL. Adolescent cocaine exposure simplifies orbitofrontal cortical dendritic arbors. Frontiers In Pharmacology 2014, 5: 228. PMID: 25452728, PMCID: PMC4233985, DOI: 10.3389/fphar.2014.00228.Peer-Reviewed Original ResearchDendritic arborsCocaine exposureDendritic spinesPre-existing structural abnormalitiesAdolescent cocaine exposurePostnatal day 31Prior cocaine exposureCocaine-induced modificationsDrugs of abuseDosing protocolDrug-naïveDrug exposureLocomotor activationExcitatory neuronsLong-term effectsAnimal modelsDay 31Structural abnormalitiesOrbitofrontal cortexBehavioral effectsBrain structuresMiceNeurobehavioral phenotypesCocaine vulnerabilityCell populations
2008
Sex differences in anxiety-like behavior and locomotor activity following chronic nicotine exposure in mice
Caldarone BJ, King SL, Picciotto MR. Sex differences in anxiety-like behavior and locomotor activity following chronic nicotine exposure in mice. Neuroscience Letters 2008, 439: 187-191. PMID: 18524488, PMCID: PMC2491450, DOI: 10.1016/j.neulet.2008.05.023.Peer-Reviewed Original ResearchConceptsAnxiogenic-like responseChronic nicotineAnxiety-like behaviorLocomotor activationFemale miceLocomotor activityPsychostimulant propertiesChronic nicotine exposureFemale C57BL/6J miceSymptoms of anxietyNicotine variesNicotine exposureOverall incidenceC57BL/6J miceMale miceWildtype miceNicotine intakeNicotinic receptorsOpen armsHigh doseMiceNicotineAnxiety disordersBeta2 subunitBehavioral sensitivity
2007
Galanin Protects Against Behavioral and Neurochemical Correlates of Opiate Reward
Hawes JJ, Brunzell DH, Narasimhaiah R, Langel Ű, Wynick D, Picciotto MR. Galanin Protects Against Behavioral and Neurochemical Correlates of Opiate Reward. Neuropsychopharmacology 2007, 33: 1864-1873. PMID: 17957220, PMCID: PMC2504505, DOI: 10.1038/sj.npp.1301579.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalBlotting, WesternBrain ChemistryConditioning, OperantCyclic AMP Response Element-Binding ProteinDose-Response Relationship, DrugExtracellular Signal-Regulated MAP KinasesGalaninGenotypeMiceMice, KnockoutMorphineMorphine DependenceMotor ActivityNarcoticsRewardSignal TransductionConceptsGKO miceMorphine place preferenceOpiate rewardGalanin agonistsMorphine administrationPlace preferenceGalanin knockout miceSingle systemic injectionEndogenous negative regulatorDrugs of abuseAcute administrationNeurochemical effectsNeuropeptide galaninPeripheral injectionWithdrawal signsLocomotor activationSystemic injectionNeurochemical correlatesNucleus accumbensGalaninKnockout miceTherapeutic targetBrain areasDrug reinforcementGalnon
2004
β2-subunit-containing nicotinic acetylcholine receptors are critical for dopamine-dependent locomotor activation following repeated nicotine administration
King SL, Caldarone BJ, Picciotto MR. β2-subunit-containing nicotinic acetylcholine receptors are critical for dopamine-dependent locomotor activation following repeated nicotine administration. Neuropharmacology 2004, 47: 132-139. PMID: 15464132, DOI: 10.1016/j.neuropharm.2004.06.024.Peer-Reviewed Original ResearchConceptsLocomotor activationNicotine administrationDopamine systemNicotinic acetylcholine receptorsAcetylcholine receptorsHigh-affinity nicotinic acetylcholine receptorsDopamine receptor antagonist pimozideBeta2 subunitRole of beta2Chronic nicotine administrationChronic nicotine exposureMesolimbic dopamine systemChronic nicotineNicotine exposureAntagonist pimozideB6 miceC57BL/6J miceOral administrationDopaminergic activationOngoing activationKnockout miceLocomotor activityMiceAdministrationNicotine
1995
R-(+)-HA-966, an antagonist for the glycine/NMDA receptor, prevents locomotor sensitization to repeated cocaine exposures
Morrow B, Taylor J, Roth R. R-(+)-HA-966, an antagonist for the glycine/NMDA receptor, prevents locomotor sensitization to repeated cocaine exposures. Brain Research 1995, 673: 165-169. PMID: 7757472, DOI: 10.1016/0006-8993(94)01456-r.Peer-Reviewed Original ResearchConceptsGlycine/NMDA receptorHA-966Locomotor sensitizationLocomotor activationNMDA receptorsCocaine administrationSubsequent challenge doseLocomotor stimulant propertiesNMDA receptor complexAcute stimulant effectsChallenge doseReverse toleranceRepeated administrationAcute doseCocaine exposureStimulant effectsGlycine receptorsStimulant propertiesCocaineSensitizationAdministrationReceptorsReceptor complexAntagonistDose
1994
Preexposure to, but Not Cotreatment with, the Neurotensin Antagonist SR 48692 Delays the Development of Cocaine Sensitization
Horger B, Taylor J, Elsworth J, Roth R. Preexposure to, but Not Cotreatment with, the Neurotensin Antagonist SR 48692 Delays the Development of Cocaine Sensitization. Neuropsychopharmacology 1994, 11: 215-222. PMID: 7865101, DOI: 10.1038/sj.npp.1380108.Peer-Reviewed Original ResearchConceptsCocaine challenge injectionSR 48692Role of neurotensinDevelopment of sensitizationEffects of cocaineCocaine sensitizationChallenge injectionDay drug-free periodMale Sprague-Dawley ratsCocaine-induced locomotor activityDrug-free periodSprague-Dawley ratsCocaine-induced locomotor activationCocaine-induced activityDrug-free daysEffects of cotreatmentPreexposure injectionsDaily administrationLocomotor activationCocaine testLocomotor deficitsLocomotor activityActivity countsChronic preexposureCocaine testing
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