2024
Rare Drivers at Low Prevalence with High Cancer Effects in T-Cell and B-Cell Pediatric Acute Lymphoblastic Leukemia
Mandell J, Diviti S, Xu M, Townsend J. Rare Drivers at Low Prevalence with High Cancer Effects in T-Cell and B-Cell Pediatric Acute Lymphoblastic Leukemia. International Journal Of Molecular Sciences 2024, 25: 6589. PMID: 38928295, PMCID: PMC11203805, DOI: 10.3390/ijms25126589.Peer-Reviewed Original ResearchGenomic analysisPediatric acute lymphoblastic leukemiaCancer effectsAcute lymphoblastic leukemiaT cellsTherapeutic targetSomatic substitutionsRare driversB-ALLLymphoblastic leukemiaEpistatic effectsT-cell ALL patientsMutational contributionsMutated genesCancer phenotypeMutated formDevelopment of leukemiaLow prevalenceB-cell lineageDisease mechanismsMutationsPrecision therapeuticsTherapeutic opportunitiesT-ALLALL patients
2023
Thromboembolic Disorders
Merriam A, Pettker C. Thromboembolic Disorders. 2023, 123-133. DOI: 10.1002/9781119636540.ch15.Peer-Reviewed Original ResearchVenous thromboembolismPulmonary embolismLeading causeDeep venous thrombosisCommon physical symptomsOperative vaginal deliveryPregnancy-specific risk factorsMaternal morbidityCesarean deliveryMultiple gestationsMaternal deathsVaginal deliveryVenous thrombosisPostpartum hemorrhageMaternal mortalityNonpregnant individualsThrombotic riskPostpartum periodRisk factorsThromboembolic disordersLow prevalencePhysical symptomsPregnancySymptomsThromboembolismSearch of a genomic sequence database for potential novel blood group antigens: Investigation into why some amino acid substitutions are not immunogenic
Howe J, Stack G. Search of a genomic sequence database for potential novel blood group antigens: Investigation into why some amino acid substitutions are not immunogenic. Transfusion 2023, 63: 1399-1411. PMID: 37386886, DOI: 10.1111/trf.17459.Peer-Reviewed Original ResearchConceptsBlood group antigensGroup antigensB-cell epitopesGenomic sequence databasesLinear B-cell epitopesLow prevalenceSequence databasesAtypical chemokine receptor 1Chemokine receptor 1New blood group antigensExtracellular domainHuman genome sequence databaseMissense mutationsGenome sequence databaseEpitope prediction programsTransfusion practiceProtein structural analysisPoor immunogenicityAmino acid substitutionsReceptor 1Phenotype prevalenceAntigenStudy designBlood groupPrevalenceCo-occurring Medical Multimorbidity, Mental Illness, and Substance Use Disorders Among Older Criminal Legal System-Involved Veterans
Han B, Bronson J, Washington L, Yu M, Kelton K, Tsai J, Finlay A. Co-occurring Medical Multimorbidity, Mental Illness, and Substance Use Disorders Among Older Criminal Legal System-Involved Veterans. Medical Care 2023, 61: 477-483. PMID: 37204150, PMCID: PMC10330246, DOI: 10.1097/mlr.0000000000001864.Peer-Reviewed Original ResearchConceptsMedical multimorbidityMental illnessOlder veteransCLS involvementCo-occurring mental illnessVeterans Health Administration facilitiesMultivariable logistic regression modelConcurrent mental illnessPatterns of multimorbidityDisease-specific carePoor health outcomesSubstance use disordersLogistic regression modelsHigh prevalenceHigh riskLow prevalenceMultimorbidityAppropriate careUse disordersHealth outcomesIllnessAdministration facilitiesPrevalenceHealth recordsVeteransData‐driven classification of health status of older adults with diabetes: The diabetes and aging study
Huang E, Liu J, Lipska K, Grant R, Laiteerapong N, Moffet H, Schumm L, Karter A. Data‐driven classification of health status of older adults with diabetes: The diabetes and aging study. Journal Of The American Geriatrics Society 2023, 71: 2120-2130. PMID: 36883732, PMCID: PMC10363208, DOI: 10.1111/jgs.18310.Peer-Reviewed Original ResearchConceptsOlder adultsBaseline comorbiditiesCardiovascular eventsHigh prevalenceClass 3Integrated healthcare delivery systemRisk of complicationsType 2 diabetesClass 1Population health managementRace-adjusted ratesClass 2Healthcare delivery systemIncident complicationsCause mortalityMicrovascular eventsCohort studyComplication ratePrevalent comorbiditiesComorbid conditionsFuture complicationsHypoglycemic eventsDiabetes careCardiovascular conditionsLow prevalenceValidated anxiety assessments among pediatric patients with peanut allergy on oral immunotherapy
Kaman K, Dhodapkar M, Shabanova V, McCollum S, Factor J, Leeds S. Validated anxiety assessments among pediatric patients with peanut allergy on oral immunotherapy. Annals Of Allergy Asthma & Immunology 2023, 130: 657-663. PMID: 36738780, DOI: 10.1016/j.anai.2023.01.028.Peer-Reviewed Original ResearchConceptsPeanut oral immunotherapyOral immunotherapyNon-white racePeanut allergyAnxiety scoresOlder cohortProspective cross-sectional cohort studyCross-sectional cohort studyHigher mean anxiety scoresMean anxiety scoreDiagnosable anxietyCohort studyMale patientsPediatric patientsFemale patientsFood allergySimilar patientsHigh prevalenceHigher scoresLife measuresLow prevalencePatientsSeparation anxiety scoresElectronic survey questionnaireAllergyObstructive sleep apnea (OSA) is associated with the impairment of beta-cell response to glucose in children and adolescents with obesity
Umano G, Galderisi A, Aiello F, Martino M, Camponesco O, Di Sessa A, Marzuillo P, Alfonso P, Miraglia del Giudice E. Obstructive sleep apnea (OSA) is associated with the impairment of beta-cell response to glucose in children and adolescents with obesity. International Journal Of Obesity 2023, 47: 257-262. PMID: 36670156, PMCID: PMC10113157, DOI: 10.1038/s41366-023-01257-w.Peer-Reviewed Original ResearchConceptsMild obstructive sleep apneaObstructive sleep apneaOral glucose tolerance testSevere obstructive sleep apneaInsulin secretionSleep apneaPlasma glucoseCardio-respiratory polygraphyTotal insulin secretionApnea-hypopnea indexOxygen desaturation indexBeta-cell responseGlucose tolerance testBeta-cell functionDynamic insulin secretionSpearman correlation testOral minimal modelOGTT studyReleasable insulinOSA severityDesaturation indexPediatric clinicTolerance testInsulin sensitivityLow prevalenceSmoking Disparities by Level of Educational Attainment and Birth Cohort in the U.S.
Cao P, Jeon J, Tam J, Fleischer N, Levy D, Holford T, Meza R. Smoking Disparities by Level of Educational Attainment and Birth Cohort in the U.S. American Journal Of Preventive Medicine 2023, 64: s22-s31. PMID: 36935129, PMCID: PMC10177656, DOI: 10.1016/j.amepre.2022.06.021.Peer-Reviewed Original ResearchConceptsBirth cohortSmoking patternsRecent cohortsEducation groupCurrent smoking prevalenceEducation levelGrade educationCessation probabilitiesSmoking prevalenceTobacco useLow prevalenceCohortSmoking disparitiesDemographic characteristicsPrevalenceCohort modelCollege degreeCalendar yearDemographic factorsCessationGroupSpecial considerationDisparitiesIndividualsImportant differences
2022
Mapping age- and sex-specific HIV prevalence in adults in sub-Saharan Africa, 2000–2018
Haeuser E, Serfes A, Cork M, Yang M, Abbastabar H, Abhilash E, Adabi M, Adebayo O, Adekanmbi V, Adeyinka D, Afzal S, Ahinkorah B, Ahmadi K, Ahmed M, Akalu Y, Akinyemi R, Akunna C, Alahdab F, Alanezi F, Alanzi T, Alene K, Alhassan R, Alipour V, Almasi-Hashiani A, Alvis-Guzman N, Ameyaw E, Amini S, Amugsi D, Ancuceanu R, Anvari D, Appiah S, Arabloo J, Aremu O, Asemahagn M, Jafarabadi M, Awedew A, Quintanilla B, Ayanore M, Aynalem Y, Azari S, Azene Z, Darshan B, Babalola T, Baig A, Banach M, Bärnighausen T, Bell A, Bhagavathula A, Bhardwaj N, Bhardwaj P, Bhattacharyya K, Bijani A, Bitew Z, Bohlouli S, Bolarinwa O, Boloor A, Bozicevic I, Butt Z, Cárdenas R, Carvalho F, Charan J, Chattu V, Chowdhury M, Chu D, Cowden R, Dahlawi S, Damiani G, Darteh E, Darwesh A, das Neves J, Weaver N, De Leo D, De Neve J, Deribe K, Deuba K, Dharmaratne S, Dianatinasab M, Diaz D, Didarloo A, Djalalinia S, Dorostkar F, Dubljanin E, Duko B, El Tantawi M, El-Jaafary S, Eshrati B, Eskandarieh S, Eyawo O, Ezeonwumelu I, Ezzikouri S, Farzadfar F, Fattahi N, Fauk N, Fernandes E, Filip I, Fischer F, Foigt N, Foroutan M, Fukumoto T, Gad M, Gaidhane A, Gebregiorgis B, Gebremedhin K, Getacher L, Ghadiri K, Ghashghaee A, Golechha M, Gubari M, Gugnani H, Guimarães R, Haider M, Haj-Mirzaian A, Hamidi S, Hashi A, Hassanipour S, Hassankhani H, Hayat K, Herteliu C, Ho H, Holla R, Hosseini M, Hosseinzadeh M, Hwang B, Ibitoye S, Ilesanmi O, Ilic I, Ilic M, Islam R, Iwu C, Jakovljevic M, Jha R, Ji J, Johnson K, Joseph N, Joshua V, Joukar F, Jozwiak J, Kalankesh L, Kalhor R, Kamyari N, Kanchan T, Matin B, Karimi S, Kayode G, Karyani A, Keramati M, Khan E, Khan G, Khan M, Khatab K, Khubchandani J, Kim Y, Kisa A, Kisa S, Kopec J, Kosen S, Laxminarayana S, Koyanagi A, Krishan K, Defo B, Kugbey N, Kulkarni V, Kumar M, Kumar N, Kusuma D, La Vecchia C, Lal D, Landires I, Larson H, Lasrado S, Lee P, Li S, Liu X, Maleki A, Malik P, Mansournia M, Martins-Melo F, Mendoza W, Menezes R, Mengesha E, Meretoja T, Mestrovic T, Mirica A, Moazen B, Mohamad O, Mohammad Y, Mohammadian-Hafshejani A, Mohammadpourhodki R, Mohammed S, Mohammed S, Mokdad A, Moradi M, Moraga P, Mubarik S, Mulu G, Mwanri L, Nagarajan A, Naimzada M, Naveed M, Nazari J, Ndejjo R, Negoi I, Ngalesoni F, Nguefack-Tsague G, Ngunjiri J, Nguyen C, Nguyen H, Nnaji C, Noubiap J, Nuñez-Samudio V, Nwatah V, Oancea B, Odukoya O, Olagunju A, Olakunde B, Olusanya B, Olusanya J, Bali A, Onwujekwe O, Orisakwe O, Otstavnov N, Otstavnov S, Owolabi M, Mahesh P, Padubidri J, Pana A, Pandey A, Pandi-Perumal S, Kan F, Patton G, Pawar S, Peprah E, Postma M, Preotescu L, Syed Z, Rabiee N, Radfar A, Rafiei A, Rahim F, Rahimi-Movaghar V, Rahmani A, Ramezanzadeh K, Rana J, Ranabhat C, Rao S, Rawaf D, Rawaf S, Rawassizadeh R, Regassa L, Rezaei N, Rezapour A, Riaz M, Ribeiro A, Ross J, Rubagotti E, Rumisha S, Rwegerera G, Moghaddam S, Sagar R, Sahiledengle B, Sahu M, Salem M, Kafil H, Samy A, Sartorius B, Sathian B, Seidu A, Shaheen A, Shaikh M, Shamsizadeh M, Shiferaw W, Shin J, Shrestha R, Singh J, Skryabin V, Skryabina A, Soltani S, Sufiyan M, Tabuchi T, Tadesse E, Taveira N, Tesfay F, Thapar R, Tovani-Palone M, Tsegaye G, Umeokonkwo C, Unnikrishnan B, Villafañe J, Violante F, Vo B, Vu G, Wado Y, Waheed Y, Wamai R, Wang Y, Ward P, Wickramasinghe N, Wilson K, Yaya S, Yip P, Yonemoto N, Yu C, Zastrozhin M, Zhang Y, Zhang Z, Hay S, Dwyer-Lindgren L. Mapping age- and sex-specific HIV prevalence in adults in sub-Saharan Africa, 2000–2018. BMC Medicine 2022, 20: 488. PMID: 36529768, PMCID: PMC9760541, DOI: 10.1186/s12916-022-02639-z.Peer-Reviewed Original ResearchConceptsHIV prevalenceAge groupsBackgroundHuman immunodeficiency virusJoint United Nations ProgrammeImmune deficiency syndromeHIV prevalence estimatesAdults ages 15HIV/AIDSClinic attendeesUnited Nations ProgrammeImmunodeficiency virusSentinel surveillanceDisease burdenDeficiency syndromePrevalence increasesSeroprevalence surveyPrevalence trendsLow prevalencePrevalence estimatesTreatment interventionsPrevalence differencesTargeted interventionsPrevalenceTreatment effortsAge 15The prevalence of mental health disorders in people with HIV and the effects on the HIV care continuum
Lang R, Hogan B, Zhu J, McArthur K, Lee J, Zandi P, Nestadt P, Silverberg M, Parcesepe A, Cook J, Gill M, Grelotti D, Closson K, Lima V, Goulet J, Horberg M, Gebo K, Camoens R, Rebeiro P, Nijhawan A, McGinnis K, Eron J, Althoff K. The prevalence of mental health disorders in people with HIV and the effects on the HIV care continuum. AIDS 2022, 37: 259-269. PMID: 36541638, PMCID: PMC9782734, DOI: 10.1097/qad.0000000000003420.Peer-Reviewed Original ResearchConceptsMental health disordersMore mental health disordersAdjusted prevalence ratiosViral suppressionBipolar disorderHealth disordersNorth American AIDS Cohort CollaborationPrevalence of MHDsHIV care continuum outcomesAnxiety disordersCare continuum outcomesMental health multimorbidityHIV care continuumPrevalence of depressiveCohort CollaborationContinuum outcomesPrevalence ratiosDepressive disorderCare continuumObservational studyLow prevalenceInternational ClassificationMultimorbidityPWHPrevalenceConcordance of SARS-CoV-2 Antibody Results during a Period of Low Prevalence
Miller C, Althoff K, Schlueter D, Anton-Culver H, Chen Q, Garbett S, Ratsimbazafy F, Thomsen I, Karlson E, Cicek M, Pinto L, Malin B, Ohno-Machado L, Williams C, Goldstein D, Kouame A, Ramirez A, Gebo K, Schully S. Concordance of SARS-CoV-2 Antibody Results during a Period of Low Prevalence. MSphere 2022, 7: e00257-22. PMID: 36173112, PMCID: PMC9599436, DOI: 10.1128/msphere.00257-22.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 antibody concentrationsLow prevalenceVaccine availabilitySARS-CoV-2 enzyme-linked immunosorbent assayFalse positivityLow SARS-CoV-2 prevalenceSARS-CoV-2 IgG assaysSARS-CoV-2 IgG testSARS-CoV-2 IgG antibodiesSevere acute respiratory syndrome coronavirus 2Coronavirus disease 2019 prevalenceAcute respiratory syndrome coronavirus 2Antibody concentrationsSARS-CoV-2 testDifferent antigensRespiratory syndrome coronavirus 2SARS-CoV-2 prevalenceSyndrome coronavirus 2SARS-CoV-2 pandemicConcordant positive resultsConcordant negative resultsEnzyme-linked immunosorbent assayPositive resultsFuture pandemic preparednessConcordance of resultsPhenome-wide Association Analysis of Substance Use Disorders in a Deeply Phenotyped Sample
Kember RL, Hartwell EE, Xu H, Rotenberg J, Almasy L, Zhou H, Gelernter J, Kranzler HR. Phenome-wide Association Analysis of Substance Use Disorders in a Deeply Phenotyped Sample. Biological Psychiatry 2022, 93: 536-545. PMID: 36273948, PMCID: PMC9931661, DOI: 10.1016/j.biopsych.2022.08.010.Peer-Reviewed Original ResearchConceptsSubstance use disordersAlcohol use disorderOpioid use disorderPolygenic risk scoresUse disordersCo-occurring psychiatric disordersComprehensive psychiatric interviewSemi-Structured AssessmentElectronic health recordsControl subjectsLow prevalencePsychiatric interviewRisk scorePsychiatric disordersPhenome-wide association analysisDrug dependenceEuropean individualsHealth recordsLifetime cannabisPhenome-wide association studyDisordersAfrican ancestry individualsDSM diagnosesPopulation sampleGenetic liabilityCorrelates of daytime sleepiness and insomnia among adults in Samoa
Heinsberg L, Carlson J, Pomer A, Cade B, Naseri T, Reupena M, Weeks D, McGarvey S, Redline S, Hawley N. Correlates of daytime sleepiness and insomnia among adults in Samoa. Sleep Epidemiology 2022, 2: 100042. PMID: 36338277, PMCID: PMC9635619, DOI: 10.1016/j.sleepe.2022.100042.Peer-Reviewed Original ResearchWomen's Health Initiative Insomnia Rating ScaleEpworth Sleepiness ScaleDaytime sleepinessDay shift workShift workExcessive daytimeESS scoreSleep healthMore physical activityInsomnia Rating ScaleCross-sectional analysisModifiable factorsHigh prevalenceHigh-income countriesSleepiness ScaleLow prevalencePhysical activitySleep measuresInsomniaRating ScaleSleepinessBehavioral factorsPrevalenceScoresAdultsTriggering of myocardial infarction by heat exposure is modified by medication intake
Chen K, Dubrow R, Breitner S, Wolf K, Linseisen J, Schmitz T, Heier M, von Scheidt W, Kuch B, Meisinger C, Peters A, Schneider A. Triggering of myocardial infarction by heat exposure is modified by medication intake. Nature Cardiovascular Research 2022, 1: 727-731. PMID: 39196082, DOI: 10.1038/s44161-022-00102-z.Peer-Reviewed Original ResearchMyocardial infarctionEffect modificationMI riskPre-existing coronary heart diseaseAnti-platelet medicationCertain cardiovascular medicationsBeta-receptor blockersCoronary heart diseaseAcute myocardial infarctionHeat exposureCardiovascular medicationsOlder patientsYounger patientsMedication useMedication intakeHeart diseaseHigh prevalenceLow prevalenceMI casesMedicationsPatientsInfarctionSignificant differencesCHDPrevalenceModeling pandemic to endemic patterns of SARS-CoV-2 transmission using parameters estimated from animal model data
Mullin S, Vander Wyk B, Asher JL, Compton SR, Allore HG, Zeiss CJ. Modeling pandemic to endemic patterns of SARS-CoV-2 transmission using parameters estimated from animal model data. PNAS Nexus 2022, 1: pgac096. PMID: 35799833, PMCID: PMC9254158, DOI: 10.1093/pnasnexus/pgac096.Peer-Reviewed Original ResearchSARS-CoV-2 transmissionNatural infectionDuration of immunitySARS-CoV-2 pandemicAnimal model dataEndemic stateHeterologous vaccinationMedian timeCoronaviral diseaseDeterministic compartmental modelNatural immunityLow prevalenceCoronaviral infectionVaccinationViral transmissionInfectionTransmissible variantsImmunityEndemic patternReinfection dataNatural exposureReinfectionEndemic stabilityVariable durationAnimalsThe Prognostic Value of CAC Zero Among Individuals Presenting With Chest Pain A Meta-Analysis
Agha AM, Pacor J, Grandhi GR, Mszar R, Khan SU, Parikh R, Agrawal T, Burt J, Blankstein R, Blaha MJ, Shaw LJ, Al-Mallah MH, Brackett A, Cainzos-Achirica M, Miller EJ, Nasir K. The Prognostic Value of CAC Zero Among Individuals Presenting With Chest Pain A Meta-Analysis. JACC Cardiovascular Imaging 2022, 15: 1745-1757. PMID: 36202453, DOI: 10.1016/j.jcmg.2022.03.031.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseAcute chest painCoronary artery calciumCoronary artery diseaseStable chest painNonobstructive coronary artery diseaseMajor adverse cardiac eventsAdverse cardiac eventsChest painCardiac eventsLow prevalenceAbsence of CACHealth care delivery modelsCare delivery modelsA Meta-AnalysisNegative predictive valueCAC assessmentArtery calciumCAC scoreIntermediate riskArtery diseaseCoronary CTACTA assessmentPrognostic valueTomography angiographyComparison of the Respiratory Resistomes and Microbiota in Children Receiving Short versus Standard Course Treatment for Community-Acquired Pneumonia
Pettigrew MM, Kwon J, Gent JF, Kong Y, Wade M, Williams DJ, Creech CB, Evans S, Pan Q, Walter EB, Martin JM, Gerber JS, Newland JG, Hofto ME, Staat MA, Fowler VG, Chambers HF, Huskins WC. Comparison of the Respiratory Resistomes and Microbiota in Children Receiving Short versus Standard Course Treatment for Community-Acquired Pneumonia. MBio 2022, 13: e00195-22. PMID: 35323040, PMCID: PMC9040816, DOI: 10.1128/mbio.00195-22.Peer-Reviewed Original ResearchConceptsCommunity-acquired pneumoniaShort-course strategyBeta-lactam therapyTreatment strategiesAntibiotic useRespiratory microbiomePediatric community-acquired pneumoniaDays of antibioticsShorter antibiotic coursesStandard-strategy groupDays of therapyStandard treatment strategyAntibiotic resistanceAdditional rationaleEffectiveness of interventionsImpact of durationAntibiotic coursesThroat swabsCourse strategyAntibiotic treatmentPediatric pneumoniaCourse treatmentLow prevalencePneumoniaAntibiotic resistance determinantsImpact of seasonal RTS,S/AS01E vaccination plus seasonal malaria chemoprevention on the nutritional status of children in Burkina Faso and Mali
Grant J, Sagara I, Zongo I, Cairns M, Yerbanga R, Diarra M, Zoungrana C, Issiaka D, Nikièma F, Sompougdou F, Tapily A, Kaya M, Haro A, Sanogo K, Sienou A, Traore S, Thera I, Yalcouye H, Kuepfer I, Snell P, Milligan P, Ockenhouse C, Ofori-Anyinam O, Tinto H, Djimde A, Chandramohan D, Greenwood B, Dicko A, Ouédraogo J. Impact of seasonal RTS,S/AS01E vaccination plus seasonal malaria chemoprevention on the nutritional status of children in Burkina Faso and Mali. Malaria Journal 2022, 21: 59. PMID: 35193608, PMCID: PMC8864823, DOI: 10.1186/s12936-022-04077-x.Peer-Reviewed Original ResearchConceptsSeasonal malaria chemopreventionMalaria chemopreventionSevere wastingHigh burdenTransmission seasonCombined groupNutritional statusMalaria transmission seasonNutritional status indicatorsPrevalence of stuntingIncidence of malariaCross-sectional surveyMalaria vaccinationSevere malariaRecent trialsStudy populationAS01ELow prevalenceAnthropometric measurementsChronic malnutritionTreatment groupsChance findingStudy childrenResultsIn 2017PrevalenceAssociations of online religious participation during COVID-19 lockdown with subsequent health and well-being among UK adults
Shiba K, Cowden RG, Gonzalez N, Ransome Y, Nakagomi A, Chen Y, Lee MT, VanderWeele TJ, Fancourt D. Associations of online religious participation during COVID-19 lockdown with subsequent health and well-being among UK adults. Psychological Medicine 2022, 53: 3887-3896. PMID: 35189993, PMCID: PMC10317791, DOI: 10.1017/s0033291722000551.Peer-Reviewed Original ResearchConceptsSubsequent healthBaseline socio-demographic characteristicsUK adultsReligious service attendanceService attendanceSocio-demographic characteristicsWeek 20Low prevalenceHealth behaviorsNon-pandemic situationsFavorable healthPsychological distressOutcomesInconsistent resultsMultiple testingStringent lockdownCOVID-19 lockdownWeeksAssociationHealthFuture studiesAttendancePerson attendanceAdultsLittle evidencePrevalence of Secondary Hypertension in Otherwise Healthy Youths with a New Diagnosis of Hypertension: A Meta-Analysis
Nugent JT, Young C, Funaro MC, Jiang K, Saran I, Ghazi L, Wilson FP, Greenberg JH. Prevalence of Secondary Hypertension in Otherwise Healthy Youths with a New Diagnosis of Hypertension: A Meta-Analysis. The Journal Of Pediatrics 2022, 244: 30-37.e10. PMID: 35120981, PMCID: PMC9086113, DOI: 10.1016/j.jpeds.2022.01.047.Peer-Reviewed Original ResearchConceptsSecondary hypertensionPrimary careLow prevalenceNew diagnosisTime of diagnosisClinical practice guidelinesCochrane Library databasesBlood pressure deviceSignificant subgroup differencesParticipants' age rangeWeb of ScienceHypertension definitionReferral clinicProspective studyRetrospective studyOutpatient settingHealthy childrenSecondary causesCurrent guidelinesDiagnostic evaluationHypertensionObservational studyPractice guidelinesLibrary databasesPrevalence estimates
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