2024
Chemotherapy drives tertiary lymphoid structures that correlate with ICI-responsive TCF1+CD8+ T cells in metastatic ovarian cancer
Lanickova T, Hensler M, Kasikova L, Vosahlikova S, Angelidou A, Pasulka J, Griebler H, Drozenova J, Mojzisova K, Vankerckhoven A, Laco J, Ryška A, Dundr P, Kocian R, Cibula D, Brtnicky T, Skapa P, Jacob F, Kovar M, Praznovec I, McNeish I, Halaska M, Rob L, Coosemans A, Orsulic S, Galluzzi L, Spisek R, Fucikova J. Chemotherapy drives tertiary lymphoid structures that correlate with ICI-responsive TCF1+CD8+ T cells in metastatic ovarian cancer. Clinical Cancer Research 2024, 31: 164-180. PMID: 39163092, PMCID: PMC11701433, DOI: 10.1158/1078-0432.ccr-24-1594.Peer-Reviewed Original ResearchHigh-grade serous ovarian carcinomaImmune checkpoint inhibitorsTertiary lymphoid structuresT cellsLymphoid structuresRecruitment of immune effector cellsMature tertiary lymphoid structuresCD8+ T cellsMetastatic ovarian cancerT-cell phenotypeFollicular T cellsSerous ovarian carcinomaSignificant survival benefitNeo-adjuvant chemotherapyImmune effector cellsIndependent patient cohortTargeted anticancer agentsCombinatorial partnersTesting chemotherapyCheckpoint inhibitorsTfh cellsCalreticulin exposureOvarian carcinomaPaclitaxel-carboplatinSyngeneic model
2021
Effect of exercise on peritoneal microenvironment and progression of ovarian cancer.
Morrisson M, Bi F, Yang K, Cady S, Hartwich T, Cerchia A, Li Z, Kim J, Irwin M, Yang-Hartwich Y. Effect of exercise on peritoneal microenvironment and progression of ovarian cancer. American Journal Of Cancer Research 2021, 11: 5045-5062. PMID: 34765311, PMCID: PMC8569339.Peer-Reviewed Original ResearchEffects of exerciseOvarian cancerPeritoneal microenvironmentChemotherapy outcomesPatients' health-related qualityBlood urea nitrogen levelsMouse ovarian cancer modelIncidence of neutropeniaIntraperitoneal fat tissueProduction of CCL2Role of CCL2Health-related qualityDeadliest gynecological malignancyMetastatic ovarian cancerExercise-induced changesUrea nitrogen levelsOvarian cancer modelOvarian carcinoma progressionPotential beneficial effectsCancer cell viabilityPeritoneal colonizationCo-culture modelChronic exerciseClinical outcomesGynecological malignancies
2020
In vivo modeling of metastatic human high-grade serous ovarian cancer in mice
Kim O, Park EY, Klinkebiel DL, Pack SD, Shin YH, Abdullaev Z, Emerson RE, Coffey DM, Kwon SY, Creighton CJ, Kwon S, Chang EC, Chiang T, Yatsenko AN, Chien J, Cheon DJ, Yang-Hartwich Y, Nakshatri H, Nephew KP, Behringer RR, Fernández FM, Cho CH, Vanderhyden B, Drapkin R, Bast RC, Miller KD, Karpf AR, Kim J. In vivo modeling of metastatic human high-grade serous ovarian cancer in mice. PLOS Genetics 2020, 16: e1008808. PMID: 32497036, PMCID: PMC7297383, DOI: 10.1371/journal.pgen.1008808.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsCell Line, TumorChromosomal InstabilityCystadenocarcinoma, SerousDEAD-box RNA HelicasesDisease Models, AnimalDNA RepairDrug Resistance, NeoplasmDrug Screening Assays, AntitumorFeasibility StudiesFemaleHumansMiceMice, KnockoutMutationNeoplasm GradingNeoplasm MetastasisOvarian NeoplasmsPeritoneal NeoplasmsPrimary Cell CulturePTEN PhosphohydrolaseRibonuclease IIITumor Suppressor Protein p53ConceptsHigh-grade serous carcinomaHuman HGSCHigh-grade serous ovarian cancerSerous ovarian cancerOvarian cancerPeritoneal metastasisHuman high-grade serous ovarian cancerMetastatic ovarian cancerOvarian cancer typesHuman cancer metastasisHuman cancer mortalityHemorrhagic ascitesClinical metastasisHistopathological similaritiesSerous carcinomaCancer mortalityFallopian tubeMurine modelPeritoneal cavityMouse modelPotential therapyMouse deathMetastasisCancer typesCancer metastasis
2007
Gene expression profile of ovarian serous papillary carcinomas: identification of metastasis-associated genes
Bignotti E, Tassi RA, Calza S, Ravaggi A, Bandiera E, Rossi E, Donzelli C, Pasinetti B, Pecorelli S, Santin AD. Gene expression profile of ovarian serous papillary carcinomas: identification of metastasis-associated genes. American Journal Of Obstetrics And Gynecology 2007, 196: 245.e1-245.e11. PMID: 17346539, DOI: 10.1016/j.ajog.2006.10.874.Peer-Reviewed Original ResearchConceptsMetastasis-associated genesGene expressionOverexpression of CXCL12Gene expression profilesGene expression profilingMetastatic ovarian cancerNumber of invasionsHepsin geneHuman genesExpression profilingExpression profilesOligonucleotide microarraysQuantitative real-time polymerase chain reactionOvarian cancerGenesProbe setsPrimary ovarian serous carcinomaOvarian serous papillary carcinomaSerous papillary ovarian carcinomasProtein levelsSerous papillary carcinomaReal-time polymerase chain reactionOvarian serous carcinomaOspCPredictive genes
1994
Ectopic production of prostate specific antigen by a breast tumor metastatic to the ovary
Yu H, Diamandis E, Levesque M, Sismondi P, Zola P, Katsaros D. Ectopic production of prostate specific antigen by a breast tumor metastatic to the ovary. Journal Of Clinical Laboratory Analysis 1994, 8: 251-253. PMID: 7523638, DOI: 10.1002/jcla.1860080412.Peer-Reviewed Original ResearchConceptsProstate-specific antigenMetastatic ovarian cancerPrimary breast tumorsBreast tumorsOvarian cancerSpecific antigenPrimary ovarian cancer tumorsFavorable prognostic indicatorOvarian cancer tumorsMetastatic sitesTumor metastaticPrognostic indicatorBreast cancerPSA productionEctopic productionTumorsSteroid hormonesCancer tumorsCancerPatientsAntigenTreatmentLow levelsHigh levelsMetastatic
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