2025
Cerebrospinal Fluid Biomarkers and Cognition in Alzheimer Disease and Frontotemporal Dementia in a Memory Clinic Setting
Cayir S, Sadabad F, Mecca A, Matuskey D, Fesharaki-Zadeh A. Cerebrospinal Fluid Biomarkers and Cognition in Alzheimer Disease and Frontotemporal Dementia in a Memory Clinic Setting. Alzheimer Disease & Associated Disorders 2025, 39: 22-27. DOI: 10.1097/wad.0000000000000656.Peer-Reviewed Original ResearchMoCA scoresMemory clinic settingHospital memory clinicCognitive performanceMontreal Cognitive AssessmentFrontotemporal dementiaAlzheimer's diseaseCognitive test scoresP-tauMemory clinicElectronic records of patientsRetrospective cohort studyT-tauCohort studyCognitive AssessmentElectronic recordsMoCACerebrospinal fluidRecords of patientsIndex scoreTau-related pathologyClinical settingDementiaConcentrations of T-tauScores
2024
Gender differences in the associations of circadian function with cognition among older persons with sleep disturbances
Pan Y, Cho G, Doyle M, Polisetty L, Burzynski C, Iannone L, Knauert M, Yaggi H, Gill T, Miner B. Gender differences in the associations of circadian function with cognition among older persons with sleep disturbances. Alzheimer's & Dementia 2024, 20: e089617. PMCID: PMC11716249, DOI: 10.1002/alz.089617.Peer-Reviewed Original ResearchMoCA scoresOlder adultsCognitive functionCommunity-dwelling older adultsCommunity-living adultsSleep disturbanceMontreal Cognitive AssessmentNo significant associationSleep-related factorsDays of actigraphyOlder personsActivity countsGender differencesPearson correlation coefficientMinority raceScore associationsInvestigate gender differencesCognitive AssessmentCircadian functionSlow wave sleepSignificant associationTotal sleep timeMoCANight of polysomnographyOlder menRelationship between neuroimaging and cognition in frontotemporal dementia: An FDG‐PET and structural MRI study
Cayir S, Volpi T, Toyonaga T, Gallezot J, Yang Y, Sadabad F, Mulnix T, Mecca A, Fesharaki‐Zadeh A, Matuskey D. Relationship between neuroimaging and cognition in frontotemporal dementia: An FDG‐PET and structural MRI study. Journal Of Neuroimaging 2024, 34: 627-634. PMID: 38676301, PMCID: PMC11511789, DOI: 10.1111/jon.13206.Peer-Reviewed Original ResearchMoCA scoresFDG-PETAssociation of cognitionStandardized uptake value ratioMontreal Cognitive AssessmentSignificant positive associationFrontotemporal dementiaPrimary outcome measurePosterior cingulate cortexDecline of cognitive functionYears of ageGM volumeFrontal cortexOutcome measuresCognitive dysfunctionGray matterCognitive AssessmentMoCAAssociated with cognitive dysfunctionFluorodeoxyglucose (FDG)-PETPositive associationMagnetic resonance imagingPartial volume correctionCognitive functionDementia
2023
Digital Elder Abuse Intervention for Older People Living with Dementia
Abujarad F, Edwards C, Neugroschl J, Hwang U, Marottoli R. Digital Elder Abuse Intervention for Older People Living with Dementia. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.082224.Peer-Reviewed Original ResearchElder abuseOlder adultsMoCA scoresCognition of participantsMemory clinicElder abuse interventionSelf-administered interventionSelf-reported abuseMontreal Cognitive AssessmentTablet-based interventionCognitive challengesCognitive AssessmentIntact participantsAbuse interventionsGeriatric memory clinicCognitive impairmentEmergency departmentParticipantsEA interventionED settingAbuseHigh riskYale New Haven Health SystemMultimedia elementsInterventionDigital Elder Abuse Intervention for Older People Living with Dementia
Abujarad F, Edwards C, Neugroschl J, Hwang U, Marottoli R. Digital Elder Abuse Intervention for Older People Living with Dementia. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.080071.Peer-Reviewed Original ResearchElder abuseOlder adultsMoCA scoresCognition of participantsMemory clinicElder abuse interventionSelf-administered interventionSelf-reported abuseMontreal Cognitive AssessmentTablet-based interventionCognitive challengesCognitive AssessmentIntact participantsAbuse interventionsGeriatric memory clinicCognitive impairmentEmergency departmentParticipantsEA interventionED settingAbuseHigh riskYale New Haven Health SystemMultimedia elementsInterventionAutophagy markers, cognitive deficits and depressive symptoms in Parkinson’s disease
Li Y, Yang H, Zhao P, Yang J, Yao C, Zhou C, Yang C, Sun X, Li S, Li J. Autophagy markers, cognitive deficits and depressive symptoms in Parkinson’s disease. Journal Of Neural Transmission 2023, 131: 73-81. PMID: 37801108, DOI: 10.1007/s00702-023-02702-w.Peer-Reviewed Original ResearchConceptsDepressed PD patientsDepressive symptomsNaming abilityPD patientsHamilton Depression Rating Scale-17Cognitive impairmentNon-depressed PD patientsLC3-II/LC3-IAssociated with delayed recallParkinson's diseaseAssociated with cognitive functionAssociated with MoCA scoresHAMD-17Cognitive deficitsMontreal Cognitive AssessmentDelayed recallCognitive functionCognitive AssessmentGlycolipid parametersAutophagy markersMoCA scoresSymptomsMotor functionImpairmentRecallImprovements in Montreal Cognitive Assessment scores after neurobehavioral therapy in adults with functional (nonepileptic) seizures and traumatic brain injury
Van Patten R, Chan L, Tocco K, Mordecai K, Altalib H, Twamley E, Gaston T, Grayson L, Martin A, Fry S, Goodman A, Allendorfer J, Correia S, Szaflarski J, LaFrance W. Improvements in Montreal Cognitive Assessment scores after neurobehavioral therapy in adults with functional (nonepileptic) seizures and traumatic brain injury. Journal Of Psychiatric Research 2023, 165: 282-289. PMID: 37549503, DOI: 10.1016/j.jpsychires.2023.07.038.Peer-Reviewed Original ResearchTraumatic brain injuryMental health symptomsNeurobehavioral therapyHealth symptomsSubjective cognitive difficultiesCo-occurring traumatic brain injuryEvidence-based psychotherapiesBrain injuryPre-post assessmentExecutive functionCognitive difficultiesCognitive performanceBaseline cognitive impairmentMontreal Cognitive Assessment scoreCognitive symptomsCognitionNES participantsCognitive Assessment scoreCognitive impairmentPositive changesMoCA scoresTotal score improvementBaseline sociodemographic factorsParticipantsAdultsEvaluation of the default mode network using nonnegative matrix factorization in patients with cognitive impairment induced by occupational aluminum exposure
Zhang F, Liu B, Shao Y, Tan Y, Niu Q, Wang X, Zhang H. Evaluation of the default mode network using nonnegative matrix factorization in patients with cognitive impairment induced by occupational aluminum exposure. Cerebral Cortex 2023, 33: 9815-9821. PMID: 37415087, DOI: 10.1093/cercor/bhad246.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentGray matter volumeDefault mode networkMatter volumePlasma Al concentrationMoCA scoresCognitive impairmentOccupational aluminium exposureMode networkRey Auditory Verbal Learning Test scoreAVLT scoresEnvironmental pathogenic factorsMontreal Cognitive AssessmentStructural covariance networksPathogenic factorsAluminum exposureMale subjectsPatientsNetwork alterationsNeurodegenerative diseasesCognitive AssessmentGroup comparisonsCovariance networksVerbal memoryNeural mechanismsVitamin D Status Over Time and Cognitive Function in Norwegian Older Adults: A Prospective Cohort of the HUNT Study
Asante E, Mai X, Eldholm R, Skjellegrind H, Kolberg M, Brumpton B, Selbœk G, Chen Y, Sun Y. Vitamin D Status Over Time and Cognitive Function in Norwegian Older Adults: A Prospective Cohort of the HUNT Study. The Journal Of Nutrition, Health & Aging 2023, 27: 30-37. PMID: 36651484, DOI: 10.1007/s12603-022-1867-8.Peer-Reviewed Original ResearchConceptsRisk of neurocognitive disordersNorwegian older adultsMild cognitive impairmentOlder adultsOdds ratioRisk of mild cognitive impairmentVitamin D statusOlder Norwegian adultsConfidence intervalsEstimate odds ratiosNeurocognitive disordersLong-term vitamin D statusSubsample of participantsVitamin D measurementsMontreal Cognitive AssessmentCognitive functionD statusHUNT StudyHealth StudyLinear regression modelsNorwegian adultsHUNT4Clinical expertsCognitive AssessmentMoCA scores
2022
Cognitive dysfunction following COVID-19 infection
Hadad R, Khoury J, Stanger C, Fisher T, Schneer S, Ben-Hayun R, Possin K, Valcour V, Aharon-Peretz J, Adir Y. Cognitive dysfunction following COVID-19 infection. Journal Of NeuroVirology 2022, 28: 430-437. PMID: 35618983, PMCID: PMC9134977, DOI: 10.1007/s13365-022-01079-y.Peer-Reviewed Original ResearchConceptsDisease severityPulmonary function testsDetailed medical historyLong-term sequelaeCOVID-19 infectionTotal MoCA scoreMontreal Cognitive AssessmentNormal laboratory testsCognitive performancePhonemic fluencyExecutive functionAge 49.5Neurologic consultationNeurological examinationBrain CTFunction testsNeurological consultationHealthy patientsNeurologic syndromeCOVID clinicMedical historyPremorbid conditionsCognitive dysfunctionMoCA scoresMoCA test
2020
Increased connectivity in several bilateral frontal and fronto‐parietal networks predicts depressive symptoms in mid‐ to late‐life diabetics
Salardini A, Shen X, Hashemi‐Aghdam A, Laltoo E, Savoia S, Tokoglu F, Constable T. Increased connectivity in several bilateral frontal and fronto‐parietal networks predicts depressive symptoms in mid‐ to late‐life diabetics. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.043619.Peer-Reviewed Original ResearchDepressive symptomsBeck Depression InventoryDiabetic individualsBDI scoresDepression InventoryPrefrontal cortexBackground Depressive symptomsLate-life diabetesVascular cognitive impairmentDiagnosis of diabetesHigher BDI scoresComprehensive neuropsychological testingDorsal prefrontal cortexBilateral ventromedial prefrontal cortexRs-fMRI dataDiabetic patientsFazekas scoreMoCA scoresNeuropsychological testingFunctional connectivity matricesCognitive impairmentDepression symptomsVentromedial prefrontal cortexSymptomsRs-fMRI
2018
Slower saccadic reading in Parkinson’s disease
Jehangir N, Yu CY, Song J, Shariati MA, Binder S, Beyer J, Santini V, Poston K, Liao YJ. Slower saccadic reading in Parkinson’s disease. PLOS ONE 2018, 13: e0191005. PMID: 29364897, PMCID: PMC5783375, DOI: 10.1371/journal.pone.0191005.Peer-Reviewed Original ResearchConceptsUnified Parkinson's Disease Rating ScaleDuration of diseasePD patientsDisease Rating ScaleParkinson's diseaseQuality of lifeConvergence insufficiencyVisual Functioning Questionnaire-25Parkinson's Disease Rating ScaleDegeneration of dopaminergicVFQ-25 scoresMontreal Cognitive Assessment (MoCA) testAbnormal eye movementsNon-motor deficitsIdiopathic Parkinson's diseaseNational Eye InstituteAge-matched controlsKing-Devick testCognitive Assessment testEye InstituteMoCA scoresPatientsControl groupClinical settingMotor difficulties
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