2025
Antiseizure Medications in Poststroke Seizures
Misra S, Wang S, Quinn T, Dawson J, Zelano J, Tanaka T, Grotta J, Khan E, Beriwal N, Funaro M, Perla S, Dev P, Larsson D, Hussain T, Liebeskind D, Yasuda C, Altalib H, Zaveri H, Elshahat A, Hitawala G, Wang E, Kitagawa R, Pathak A, Scalzo F, Ihara M, Sunnerhagen K, Walters M, Zhao Y, Jette N, Kasner S, Kwan P, Mishra N. Antiseizure Medications in Poststroke Seizures. Neurology 2025, 104: e210231. PMID: 39808752, DOI: 10.1212/wnl.0000000000210231.Peer-Reviewed Original ResearchConceptsRisk of biasLow-certainty evidenceModerate to high certainty evidenceNon-randomized Studies of Interventions toolDrug discontinuation ratesCochrane risk of bias toolRisk of bias toolAntiseizure medicationsSeizure recurrenceHigh risk of biasAdverse eventsCertainty of evidenceHigh-certainty evidencePoststroke seizuresModerate-certainty evidenceMortality rateRandomized controlled trialsDiscontinuation ratesAntiseizure medication useRecommendations AssessmentCochrane riskBias toolElectronic databasesNon-randomized studiesAssociated with high mortality rates
2024
Anticoagulation Therapy for Venous Thromboembolism in the Pediatric Population: A Systematic Review and Meta-Analysis
Azzam M, Kawtharany H, Monagle P, Bercovitz R, Hamarsha Q, Alkhader A, Abou Zeid H, Mansour R, Patel P, Tabak C, Baghdadi S, Betensky M, Bhat R, Biss T, Branchford B, Brandao L, Chan A, Faustino E, Jaffray J, Jones S, Kerlin B, Kucine N, Kumar R, Male C, Pelland-Marcotte M, Raffini L, Raulji C, Sartain S, Takemoto C, Tarango C, Van Ommen H, Velez-Yanguas M, Vesely S, Wiernikowski J, Williams S, Wilson H, Woods G, Zia A, Mustafa R. Anticoagulation Therapy for Venous Thromboembolism in the Pediatric Population: A Systematic Review and Meta-Analysis. Blood 2024, 144: 1257-1257. DOI: 10.1182/blood-2024-212150.Peer-Reviewed Original ResearchRisk of biasCertainty of evidenceVenous thromboembolismPediatric patientsThrombus resolutionAll-cause mortalityThrombus recurrenceAC therapyAnticoagulant therapyAbsolute effectEvents of all-cause mortalityPediatric populationSystematic reviewNon-randomized Studies of InterventionsManagement of venous thromboembolismMeta-analysisStudies of interventionsConcerns related to riskNon-randomized observational studyNon-randomized studiesRecommendations AssessmentThrombus progressionBleeding eventsBleeding riskPortal hypertensionNeurologic Complications Following Peripheral Nerve Block in Foot and Ankle Surgery
Balboni J, Gianakos A, Fram B, Kregling C, Kermanshahi N, Webber K. Neurologic Complications Following Peripheral Nerve Block in Foot and Ankle Surgery. Foot & Ankle Orthopaedics 2024, 9: 2473011424s00378. PMCID: PMC11686789, DOI: 10.1177/2473011424s00378.Peer-Reviewed Original ResearchPeripheral nerve blocksComplex regional pain syndromeComplication rateNeurological complicationsNerve blockAnkle surgeryNerve injuryBlock administrationIncidence of postoperative neurological complicationsEvaluated risk of biasNeurological complication rateRegional pain syndromeSecondary outcome measuresPostoperative neurological complicationsMotor nerve dysfunctionRisk of biasInvestigate possible risk factorsReflex sympathetic dystrophyGuillain-Barre syndromeAt-risk patientsPrevalence of comorbid mood disordersNon-randomized studiesFoot dropLevel of conscious sedationLong-lasting symptomsEvaluation and Management of Biliary Dyskinesia in Children and Adolescents: A Systematic Review From the APSA Outcomes and Evidence-Based Committee
Kulaylat A, Lucas D, Chang H, Derderian S, Beres A, Ham P, Huerta C, Sulkowski J, Wakeman D, Englum B, Gulack B, Acker S, Gonzalez K, Levene T, Christison-Lagay E, Mansfield S, Yousef Y, Pennell C, Russell K, Rentea R, Tashiro J, Diesen D, Alemayehu H, Ricca R, Kelley-Quon L, Rialon K. Evaluation and Management of Biliary Dyskinesia in Children and Adolescents: A Systematic Review From the APSA Outcomes and Evidence-Based Committee. Journal Of Pediatric Surgery 2024, 59: 161678. PMID: 39227244, DOI: 10.1016/j.jpedsurg.2024.08.018.Peer-Reviewed Original ResearchSystematic reviewBiliary dyskinesiaOxford Levels of EvidencePreferred Reporting ItemsGrading of RecommendationsAmerican Pediatric Surgical Association OutcomesRisk of biasEvidence-based recommendationsDiagnostic criteriaPredictors of symptom reliefLevel of evidenceNon-operative managementResolution of symptomsPediatric-specific guidelinesOutcome of medical managementLong-term outcomesReporting ItemsNon-randomized studiesOxford LevelsMeta-analysesMethodological IndexAssociated outcomesClinical entityProspective studySymptom relief
2023
Positive psychology psychoeducation makes a small impact on undergraduate student mental health: Further curriculum innovation and better well-being research needed
Schlechter A, McDonald M, Lerner D, Yaden D, Clifton J, Moerdler-Green M, Horwitz S. Positive psychology psychoeducation makes a small impact on undergraduate student mental health: Further curriculum innovation and better well-being research needed. Journal Of American College Health 2023, 73: 563-568. PMID: 37437180, DOI: 10.1080/07448481.2023.2227719.Peer-Reviewed Original ResearchPERMA-ProfilerDASS-21Depression Anxiety and Stress ScaleMental healthUndergraduate students' mental healthWell-being measuresWell-beingStudents' mental healthPromote mental healthAdolescent psychopathologyMeasure psychopathologyStudent well-beingStress ScalePsychoeducationEffect sizePsychopathologyNon-randomized studiesDepressionSWLSUndergraduatePERMAHealthAnxietyAdolescentsCurriculum innovation
2022
The association between acute kidney injury and outcomes in cancer patients receiving immune checkpoint inhibitor therapy: a systematic review and meta-analysis
Kanbay M, Copur S, Siriopol D, Yildiz A, Berkkan M, Popa R, Hasbal N, Ortiz A, Perazella M. The association between acute kidney injury and outcomes in cancer patients receiving immune checkpoint inhibitor therapy: a systematic review and meta-analysis. Clinical Kidney Journal 2022, 16: 817-826. PMID: 37151409, PMCID: PMC10157786, DOI: 10.1093/ckj/sfac194.Peer-Reviewed Original ResearchAcute kidney injuryImmune checkpoint inhibitorsEffect of AKICheckpoint inhibitorsCancer patientsKidney injuryDevelopment of AKISystematic reviewImmune checkpoint inhibitor therapySevere acute kidney injuryPersistent kidney dysfunctionSevere AKI patientsCheckpoint inhibitor therapyRisk of deathNon-randomized studiesCochrane Library databasesRisk of mortalityNovel therapeutic approachesWeb of ScienceAKI patientsICPI treatmentCause mortalityInhibitor therapyKidney dysfunctionMortality outcomes
2021
Safety and efficacy of endovenous laser ablation (EVLA) using 1940 nm and radial emitting fiber: 3‐year results of a prospective, non‐randomized study and comparison with 1470 nm
Setia A, Schmedt C, Beisswenger A, Dikic S, Demhasaj S, Setia O, Schmitz‐Rixen T, Sroka R. Safety and efficacy of endovenous laser ablation (EVLA) using 1940 nm and radial emitting fiber: 3‐year results of a prospective, non‐randomized study and comparison with 1470 nm. Lasers In Surgery And Medicine 2021, 54: 511-522. PMID: 34865236, DOI: 10.1002/lsm.23500.Peer-Reviewed Original ResearchConceptsEndovenous laser ablationTruncal vein insufficiencyDuplex ultrasound examinationVein insufficiencyStump lengthDeep veinsSingle-center clinical studyAverage linear endovenous energy densityLower analgesic requirementsPostoperative pain levelsLower postoperative painNon-randomized studiesFrequency of recurrenceShort saphenous veinLinear endovenous energy densityRadial fibersEndovenous energy densityAnalgesic requirementsDuplex monitoringGreat saphenousLocal ecchymosisPersistent paresthesiaSimultaneous phlebectomyMonth outcomesPostoperative pain
2020
Trial in progress: A phase I/II, open-label, dose-escalation, safety and tolerability study of NC318 in subjects with advanced or metastatic solid tumors.
Gutierrez M, Hamid O, Shum E, Wise D, Balar A, Weber J, LoRusso P, Shafi S, Rimm D, Tolcher A, Basudhar D, Dujka M, Heller K. Trial in progress: A phase I/II, open-label, dose-escalation, safety and tolerability study of NC318 in subjects with advanced or metastatic solid tumors. Journal Of Clinical Oncology 2020, 38: tps3166-tps3166. DOI: 10.1200/jco.2020.38.15_suppl.tps3166.Peer-Reviewed Original ResearchMetastatic solid tumorsT cell functionSolid tumorsPD-L1 tumor proportion scoreAnti-tumor immune responseNon-small cell lungPhase I/IIPhase 2 doseTumor proportion scoreAnti-tumor immunityKey eligibility criteriaCell functionDose-escalation designBreast cancer subjectsNon-randomized studiesT cell proliferationPrevents tumor growthClass monoclonal antibodyCollection of biopsiesMeasurable diseaseRECIST v1.1Phase 1/2Escalation designTolerability studyImmune suppression
2019
Feasibility Studies of an Insulin-Only Bionic Pancreas in a Home-Use Setting
Ekhlaspour L, Nally LM, El-Khatib FH, Ly TT, Clinton P, Frank E, Tanenbaum ML, Hanes SJ, Selagamsetty RR, Hood K, Damiano ER, Buckingham BA. Feasibility Studies of an Insulin-Only Bionic Pancreas in a Home-Use Setting. Journal Of Diabetes Science And Technology 2019, 13: 1001-1007. PMID: 31470740, PMCID: PMC6835195, DOI: 10.1177/1932296819872225.Peer-Reviewed Original ResearchConceptsUsual care armStudy armsOpen-label non-randomized studyHome-use settingDaily insulin doseNon-randomized studiesCare armUsual careInsulin doseIncreased riskMean ageDiabetes burdenGlycemic outcomesHypoglycemic riskIntervention periodAverage glucoseBody weightConsecutive weeksBionic pancreasDynamic glucoseSignificant differencesDlInsulinFactor testingRisk
2018
Guidelines for enhanced recovery after lung surgery: recommendations of the Enhanced Recovery After Surgery (ERAS®) Society and the European Society of Thoracic Surgeons (ESTS)
Batchelor TJP, Rasburn NJ, Abdelnour-Berchtold E, Brunelli A, Cerfolio RJ, Gonzalez M, Ljungqvist O, Petersen RH, Popescu WM, Slinger PD, Naidu B. Guidelines for enhanced recovery after lung surgery: recommendations of the Enhanced Recovery After Surgery (ERAS®) Society and the European Society of Thoracic Surgeons (ESTS). European Journal Of Cardio-Thoracic Surgery 2018, 55: 91-115. PMID: 30304509, DOI: 10.1093/ejcts/ezy301.Peer-Reviewed Original ResearchConceptsEnhanced recoveryPerioperative managementLung surgeryThoracic surgeryConsensus recommendationsSurgery SocietyEarlier chest drain removalAvailable evidenceOpioid-sparing analgesiaPostoperative organ dysfunctionRetrospective cohort studyVenous thromboembolism prophylaxisEuropean SocietyHigh-risk patientsOptimal perioperative managementPerioperative care pathwaysChest drain removalHigh-level evidenceShort-acting anestheticsNon-randomized studiesPrevention of hypothermiaLarge non-randomized studiesGood quality studiesBest available evidenceAvoidance of fastingSerial intravascular ultrasound evaluation of the DESolve™ novolimus‐eluting bioresorbable coronary scaffold system
Barreira G, Costa J, Costa R, Staico R, Chamie D, Slhessarenko J, Tanajura L, Abizaid A, Sousa A, Abizaid A. Serial intravascular ultrasound evaluation of the DESolve™ novolimus‐eluting bioresorbable coronary scaffold system. Catheterization And Cardiovascular Interventions 2018, 92: e368-e374. PMID: 29521477, DOI: 10.1002/ccd.27591.Peer-Reviewed Original ResearchMeSH KeywordsAbsorbable ImplantsAgedCardiovascular AgentsCoated Materials, BiocompatibleCoronary AngiographyCoronary Artery DiseaseCoronary VesselsFemaleHumansMacrolidesMaleMiddle AgedPercutaneous Coronary InterventionPredictive Value of TestsProspective StudiesTime FactorsTreatment OutcomeUltrasonography, InterventionalConceptsBioresorbable coronary scaffoldsSafety of coronary angioplastySuppression of neointimal proliferationAdverse cardiac eventsTime pointsLate lumen lossNon-randomized studiesPercutaneous coronary interventionDevice dimensionsIntravascular ultrasound evaluationScaffold systemConsecutive patientsCoronary scaffoldsPrimary endpointSingle-centerCardiac eventsAngiographic successUltrasound evaluationFollow-upLumen lossCoronary interventionSerial evaluationNeointimal proliferationScaffold areaCoronary angioplasty
2017
The Use of Implantable Cardioverter-defibrillators in the Prevention of Sudden Cardiac Death: A Focus on Congenital Heart Disease and Inherited Arrhythmia Syndromes
Goldstein S, Ward C, Al-Khatib S. The Use of Implantable Cardioverter-defibrillators in the Prevention of Sudden Cardiac Death: A Focus on Congenital Heart Disease and Inherited Arrhythmia Syndromes. Journal Of Innovations In Cardiac Rhythm Management 2017, 9: 2996-3005. PMID: 32494470, PMCID: PMC7252881, DOI: 10.19102/icrm.2018.090103.Peer-Reviewed Original ResearchCongenital heart diseaseInherited arrhythmia syndromesSudden cardiac deathArrhythmia syndromesCardiac deathIncreased risk of sudden cardiac deathPrevention of sudden cardiac deathRisk of sudden cardiac deathHeart diseaseImplantable cardioverter-defibrillator (ICDCardioverter-defibrillator (ICDRisk stratification methodsNon-randomized studiesImplantable cardioverter-defibrillatorRandomized clinical trialsCardioverter-defibrillatorClinical trialsIncreased riskPatientsSyndromeDiseaseImplantationStratification methodICDDeathPrevalence of Specific Types of Pain Diagnoses in a Sample of United States Adults.
Murphy KR, Han JL, Yang S, Hussaini SM, Elsamadicy AA, Parente B, Xie J, Pagadala P, Lad SP. Prevalence of Specific Types of Pain Diagnoses in a Sample of United States Adults. Pain Physician 2017, 20: e257-e268. PMID: 28158163, DOI: 10.36076/ppj.2017.e268.Peer-Reviewed Original ResearchConceptsDegenerative spine diseasePain diagnosisPain conditionsLimb painBack painChronic painSpine diseaseComplex regional pain syndromePost-laminectomy painPost-laminectomy syndromeUnited States patient populationMedicare Supplemental databasesChronic pain conditionsRegional pain syndromeNon-randomized studiesSpecific pain diagnosesUnited States adultsHealth care servicesPain syndromePain patientsPatient populationTruven MarketScanPatient cohortRetrospective analysisPain
2003
Peripheral T- cell lymphomas: diagnosis and management
Dearden CE, Foss FM. Peripheral T- cell lymphomas: diagnosis and management. Hematology/Oncology Clinics Of North America 2003, 17: 1351-1366. PMID: 14710889, DOI: 10.1016/s0889-8588(03)00119-9.Peer-Reviewed Original ResearchConceptsFirst-line therapyT-cell lymphomaCampath-1HResponse rateLine therapyPurine analoguesT-PLLAllogeneic bone marrow transplantationPeripheral T-cell lymphomaThird of patientsFavorable prognostic factorBone marrow transplantationMonoclonal antibody therapyStem cell transplantationNon-randomized studiesMature T-cell neoplasmsMinimal residual diseaseT-cell neoplasmsHigh response rateT-cell malignanciesLargest disease groupRisk of toxicityDurable remissionsRefractory patientsPreparative regimens
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