2025
Lipid Peroxidation and Glutathione Levels Among People Living With HIV Co‐infected With Human Coronaviruses in Ghana
Amegashie E, Kwayisi‐Darkwah C, Adusei‐Poku M, Sikeola R, Ativi L, Ahene A, Atampugbire G, Tagoe E, Paintsil E, Torpey K, Quaye O. Lipid Peroxidation and Glutathione Levels Among People Living With HIV Co‐infected With Human Coronaviruses in Ghana. Journal Of Medical Virology 2025, 97: e70301. PMID: 40110873, DOI: 10.1002/jmv.70301.Peer-Reviewed Original ResearchMeSH KeywordsAdultCoinfectionCoronavirus InfectionsCross-Sectional StudiesCyclopropanesDideoxyadenosineDideoxynucleosidesFemaleGhanaGlutathioneHeterocyclic Compounds, 3-RingHIV InfectionsHumansLipid PeroxidationMaleMalondialdehydeMiddle AgedOxazinesOxidative StressPiperazinesProspective StudiesPyridonesYoung AdultConceptsHuman immunodeficiency virusHuman immunodeficiency virus co-infectionCo-infectionGSH levelsART-experienced individualsPLWH co-infectedHuman coronavirusesHIV co-infectionHIV-negative individualsMalondialdehyde levelsOxidative stressOxidative stress markersIncreased MDA levelsCross-sectional studyOro-pharyngeal swabsImmunodeficiency virusGhanaian patientsMono-infectionReduced GSH levelsTreatment strategiesPlasma samplesDisease severityMDA levelsStress markersTailored monitoring
2024
Plasma oxidative stress marker levels related to functional brain abnormalities in first-episode drug-naive major depressive disorder
Liu Y, Zhang B, Zhou Y, Li M, Gao Y, Qin W, Xie Y, Liu W, Jing Y, Li J. Plasma oxidative stress marker levels related to functional brain abnormalities in first-episode drug-naive major depressive disorder. Psychiatry Research 2024, 333: 115742. PMID: 38232568, DOI: 10.1016/j.psychres.2024.115742.Peer-Reviewed Original ResearchConceptsMajor depressive disorderMajor depressive disorder patientsAmplitude of low-frequency fluctuationDepressive disorderSuicidal ideationWhole-brain functional connectivity analysisMDD pathophysiologyDrug-naive MDD patientsResting-state fMRI scansAmplitude of low-frequency fluctuation valuesFunctional brain abnormalitiesAnterior cingulate gyrusSuperior frontal gyrusFunctional connectivity analysisOxidative stress markersAbnormal brain functionLow-frequency fluctuationsPlasma oxidative stress markersMDD patientsFrontal gyrusFMRI scanningFirst-episodeCingulate gyrusBrain regionsConnectivity analysis
2020
Thiol/Disulfide Homeostasis in Bipolar and Unipolar Depression
Erzin G, Özkaya G, Topçuoğlu C, Yüksel R, Erel Ö, Yurt E, Göka E, Gülöksüz S. Thiol/Disulfide Homeostasis in Bipolar and Unipolar Depression. Clinical Psychopharmacology And Neuroscience 2020, 18: 395-401. PMID: 32702218, PMCID: PMC7383011, DOI: 10.9758/cpn.2020.18.3.395.Peer-Reviewed Original ResearchDisulfide/total thiol ratiosTotal thiol ratiosThiol-disulfide homeostasisBipolar depressionHealthy controlsUnipolar depressionNative thiol ratioBipolar disorderDisulfide levelsThiol ratioDepressive disorderNative thiolAnkara Numune TrainingThiol/disulfide homeostasisDisulfide/native thiol ratioOxidative stress markersUnipolar depressive disorderDSM-5 criteriaLevels of disulfideUD groupOutpatient clinicClinical entityDepressive episodeResearch HospitalTherapeutic differences
2019
Prediction and associations of preterm birth and its subtypes with eicosanoid enzymatic pathways and inflammatory markers
Aung M, Yu Y, Ferguson K, Cantonwine D, Zeng L, McElrath T, Pennathur S, Mukherjee B, Meeker J. Prediction and associations of preterm birth and its subtypes with eicosanoid enzymatic pathways and inflammatory markers. Scientific Reports 2019, 9: 17049. PMID: 31745121, PMCID: PMC6863859, DOI: 10.1038/s41598-019-53448-z.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPreterm birthMultiple logistic regressionCross-sectional study of pregnant womenAssociation of preterm birthCases of preterm birthStudy of pregnant womenOverall preterm birthPreterm birth casesPreterm birth outcomesCytochrome P450 metabolitesLogistic regressionOxidative stress markersAberrant placentationCross-sectional studyDelivered termCytochrome P450 productPredictive biomarkersPregnant womenPretermEicosanoid metabolitesImmune biomarkersLipoxygenase metabolitesBirth casesResolvin D1
2018
Associations between repeated ultrasound measures of fetal growth and biomarkers of maternal oxidative stress and inflammation in pregnancy
Ferguson K, Kamai E, Cantonwine D, Mukherjee B, Meeker J, McElrath T. Associations between repeated ultrasound measures of fetal growth and biomarkers of maternal oxidative stress and inflammation in pregnancy. American Journal Of Reproductive Immunology 2018, 80: e13017. PMID: 29984454, PMCID: PMC6160349, DOI: 10.1111/aji.13017.Peer-Reviewed Original ResearchConceptsAssociated with reduced fetal growthFetal growthAssociated with poorer childAdult health outcomesOxidative stress markersBirth cohort studyInterquartile rangeAssociated with head circumferenceRepeated-measures modelFetal weight z-scoreAssociated with fetal weightOxidative stressHealth outcomesStandard deviation decreaseWeight z-scoreStress markersSecondary analysisMaternal oxidative stressCohort studyZ-scoreFetal weightMaternal inflammationDeviation decreasePreterm birthHead circumference
2016
Socioeconomic Disadvantage Moderates the Association between Peripheral Biomarkers and Childhood Psychopathology
Mansur R, Cunha G, Asevedo E, Zugman A, Zeni-Graiff M, Rios A, Sethi S, Maurya P, Levandowski M, Gadelha A, Pan P, Stertz L, Belangero S, Anna M, Teixeira A, Mari J, Rohde L, Miguel E, McIntyre R, Grassi-Oliveira R, Bressan R, Brietzke E. Socioeconomic Disadvantage Moderates the Association between Peripheral Biomarkers and Childhood Psychopathology. PLOS ONE 2016, 11: e0160455. PMID: 27489945, PMCID: PMC4973983, DOI: 10.1371/journal.pone.0160455.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorThiobarbituric acid reactive substancesMental health problemsInterleukin-6Serum levelsHealth problemsSocioeconomic disadvantagePeripheral biomarkersSerum biomarkersOxidative stress markersAcid reactive substancesCross-sectional designChild Behavior Checklist DSMNeurotrophic factorHigher socioeconomic disadvantageSocio-demographic characteristicsBiomarker levelsNeurotrophic proteinsDomains of psychopathologyStress markersSpecific SubscaleCumulative risk modelBiomarkersMultiple biological systemsPathological neurodevelopmentMurine precision-cut lung slices exhibit acute responses following exposure to gasoline direct injection engine emissions
Maikawa CL, Zimmerman N, Rais K, Shah M, Hawley B, Pant P, Jeong CH, Delgado-Saborit JM, Volckens J, Evans G, Wallace JS, Pollitt K. Murine precision-cut lung slices exhibit acute responses following exposure to gasoline direct injection engine emissions. The Science Of The Total Environment 2016, 568: 1102-1109. PMID: 27369091, DOI: 10.1016/j.scitotenv.2016.06.173.Peer-Reviewed Original ResearchConceptsLung slicesPulmonary responseBALB/c miceMurine precision-cut lung slicesOxidative stressPrecision-cut lung slicesOxidative stress markersOne-hour exposurePulmonary effectsC miceGDI engine exhaustAcute responseCYP1B1 expressionStress markersVivo modelPolycyclic aromatic hydrocarbon metabolismUpregulation of genesElectrostatic aerosolParticulate fractionAromatic hydrocarbon metabolismExposureUpregulated genesMRNA productionMetabolismAir-liquid interfaceRole of Nitric Oxide Isoforms in Vascular and Alveolar Development and Lung Injury in Vascular Endothelial Growth Factor Overexpressing Neonatal Mice Lungs
Syed MA, Choo-Wing R, Homer RJ, Bhandari V. Role of Nitric Oxide Isoforms in Vascular and Alveolar Development and Lung Injury in Vascular Endothelial Growth Factor Overexpressing Neonatal Mice Lungs. PLOS ONE 2016, 11: e0147588. PMID: 26799210, PMCID: PMC4723240, DOI: 10.1371/journal.pone.0147588.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorEndothelial growth factorVascular markersRoom airVascular permeabilityMouse lungLung developmentVEGF overexpressionDifferent nitric oxide synthase isoformsNitric oxide synthase isoformsGrowth factorInhibition of NOS1Inhibition of NOS2Nitric oxide isoformsOxidative stress markersNeonatal mouse lungNOS1 inhibitionNOS1 inhibitorInjury markersLung injuryLung vascularNewborn lungNOS pathwayAlveolar developmentPostnatal day
2015
Chapter 49 Antioxidant Status in Vascular Dementia
Zito G, Squitti R, Polimanti R. Chapter 49 Antioxidant Status in Vascular Dementia. 2015, 529-537. DOI: 10.1016/b978-0-12-407824-6.00049-5.Peer-Reviewed Original ResearchVascular dementiaSystemic oxidative stress markersAdministration of antioxidantsOxidative stress markersVaD patientsPathological featuresSupplementation therapyAntioxidant statusStress markersCognitive declineOxidative stressEffectiveness of antioxidantsDementiaVADCommon formClinical experimentsPatientsAntioxidantsDifferent studiesPathogenesisTherapyAdministrationCaregivers
2014
Pharmacologic overview of systemic chlorogenic acid therapy on experimental wound healing
Bagdas D, Gul N, Topal A, Tas S, Ozyigit M, Cinkilic N, Gul Z, Etoz B, Ziyanok S, Inan S, Turacozen O, Gurun M. Pharmacologic overview of systemic chlorogenic acid therapy on experimental wound healing. Naunyn-Schmiedeberg's Archives Of Pharmacology 2014, 387: 1101-1116. PMID: 25129377, DOI: 10.1007/s00210-014-1034-9.Peer-Reviewed Original ResearchConceptsSide effectsWound healingHigh doseBone marrowEffects of CGAAnti-inflammatory effectsDietary chlorogenic acidNitric oxide levelsMatrix metalloproteinase-9Oxidative stress markersPossible side effectsDose-dependent mannerChlorogenic acidCGA supplementationPharmacologic overviewFree radical scavengerAcid therapyCGA treatmentLeukocyte infiltrationPivotal organImmunohistochemical examinationRat bone marrowMetalloproteinase-9Oxide levelsStress markersUrinary Phthalate Metabolite Associations with Biomarkers of Inflammation and Oxidative Stress Across Pregnancy in Puerto Rico
Ferguson K, Cantonwine D, Rivera-González L, Loch-Caruso R, Mukherjee B, Del Toro L, Jiménez-Vélez B, Calafat A, Ye X, Alshawabkeh A, Cordero J, Meeker J. Urinary Phthalate Metabolite Associations with Biomarkers of Inflammation and Oxidative Stress Across Pregnancy in Puerto Rico. Environmental Science And Technology 2014, 48: 7018-7025. PMID: 24845688, PMCID: PMC4066910, DOI: 10.1021/es502076j.Peer-Reviewed Original ResearchConceptsMono-n-butyl phthalateBiomarkers of inflammationIL-10Prospective cohort study of pregnant womenDi-2-ethylhexyl phthalate metabolitesCohort study of pregnant womenIL-6Study of pregnant womenAssociated with increased IL-6Oxidative stressUrinary phthalate metabolitesC-reactive proteinProspective cohort studyAdverse birth outcomesMetabolites of di-2-ethylhexyl phthalateOxidative stress markersPreterm birthMetabolite associationsPregnant womenMono-n-butylDi-2-ethylhexyl phthalateOxidative stress biomarkersBirth outcomesTNF-aInflammation biomarkersPathological Changes in Pulmonary Circulation in Carbon Tetrachloride (ccl4)-Induced Cirrhotic Mice
Das M, Boerma M, Goree JR, Lavoie EG, Fausther M, Gubrij IB, Pangle AK, Johnson LG, Dranoff JA. Pathological Changes in Pulmonary Circulation in Carbon Tetrachloride (ccl4)-Induced Cirrhotic Mice. PLOS ONE 2014, 9: e96043. PMID: 24763616, PMCID: PMC3999097, DOI: 10.1371/journal.pone.0096043.Peer-Reviewed Original ResearchConceptsPulmonary acceleration timeCirrhotic micePortopulmonary hypertensionPulmonary circulationPathological changesSpleen weight/body weight ratioVentricle weight/body weightWeight/body weight ratioChronic CCl4 treatmentPulmonary vascular diseaseMale C57BL/6 miceBody weight ratioTimes/weekOxidative stress markersNovel therapeutic interventionsPicrosirius red stainingSterile olive oilPortal hypertensionEffects of CCl4Pulmonary arteryC57BL/6 micePathophysiological mechanismsPulmonary vasculaturePerivascular collagenVascular diseaseEffect of advancing paternal age on semen parameters and seminal oxidative stress markers in infertile men
Alshahrani S, Agarwal A, Assidi M, Abuzenadah A, Durairajanayagam D, Ayaz A, Sharma R, Sabanegh E. Effect of advancing paternal age on semen parameters and seminal oxidative stress markers in infertile men. BMC Genomics 2014, 15: p42. PMCID: PMC4075617, DOI: 10.1186/1471-2164-15-s2-p42.Peer-Reviewed Original Research
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