Bromodomains regulate dynamic targeting of the PBAF chromatin-remodeling complex to chromatin hubs
Kenworthy C, Haque N, Liou S, Chandris P, Wong V, Dziuba P, Lavis L, Liu W, Singer R, Coleman R. Bromodomains regulate dynamic targeting of the PBAF chromatin-remodeling complex to chromatin hubs. Biophysical Journal 2022, 121: 1738-1752. PMID: 35364106, PMCID: PMC9117891, DOI: 10.1016/j.bpj.2022.03.027.Peer-Reviewed Original ResearchConceptsChromatin remodelersChromatin statePBAF chromatin-remodeling complexSingle-molecule fluorescence microscopy studiesDifferent chromatin statesChromatin-remodeling complexRNA polymerase IIChromatin hubTranscriptional burstingPolymerase IIAcetylated nucleosomesFluorescence microscopy studiesPBAFBromodomainsNucleosomesChromatin stabilityLive cellsStable engagementRemodelersDynamic targetingDirect roleChromatinImaging revealsTargetingGenome
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