2024
Machine Learning Models for 3-Month Outcome Prediction Using Radiomics of Intracerebral Hemorrhage and Perihematomal Edema from Admission Head Computed Tomography (CT)
Dierksen F, Sommer J, Tran A, Lin H, Haider S, Maier I, Aneja S, Sanelli P, Malhotra A, Qureshi A, Claassen J, Park S, Murthy S, Falcone G, Sheth K, Payabvash S. Machine Learning Models for 3-Month Outcome Prediction Using Radiomics of Intracerebral Hemorrhage and Perihematomal Edema from Admission Head Computed Tomography (CT). Diagnostics 2024, 14: 2827. PMID: 39767188, PMCID: PMC11674633, DOI: 10.3390/diagnostics14242827.Peer-Reviewed Original ResearchIntegrated discrimination indexNet reclassification indexPerihematomal edemaHead computed tomographyIntracerebral hemorrhageComputed tomographyClinical variablesClinical predictors of poor outcomeOutcome predictionAcute supratentorial intracerebral hemorrhageAdmission head computed tomographyRadiomic featuresNon-contrast head computed tomographyPredictors of poor outcomeModified Rankin Scale scoreIntracerebral hemorrhage scoreSupratentorial intracerebral hemorrhageIntracerebral hemorrhage patientsClinical risk factorsRankin Scale scoreReceiver operating characteristic areaOperating characteristics areaSecondary brain injuryHematoma evacuationPatient selectionA Hybrid Transformer-Convolutional Neural Network for Segmentation of Intracerebral Hemorrhage and Perihematomal Edema on Non-Contrast Head Computed Tomography (CT) with Uncertainty Quantification to Improve Confidence
Tran A, Desser D, Zeevi T, Abou Karam G, Dierksen F, Dell'Orco A, Kniep H, Hanning U, Fiehler J, Zietz J, Sanelli P, Malhotra A, Duncan J, Aneja S, Falcone G, Qureshi A, Sheth K, Nawabi J, Payabvash S. A Hybrid Transformer-Convolutional Neural Network for Segmentation of Intracerebral Hemorrhage and Perihematomal Edema on Non-Contrast Head Computed Tomography (CT) with Uncertainty Quantification to Improve Confidence. Bioengineering 2024, 11: 1274. PMID: 39768092, PMCID: PMC11672977, DOI: 10.3390/bioengineering11121274.Peer-Reviewed Original ResearchNon-contrast head computed tomographyPerihematomal edemaHead computed tomographyIntracerebral hemorrhageComputed tomographyVolume similarityUniversity Medical Center Hamburg-EppendorfSecondary brain injuryYale cohortInfratentorial locationMulticentre trialCT scanTreatment planningNon-contrastHamburg-EppendorfImaging markersHemorrhagic strokeHemorrhageEdemaCohortBrain injuryDice coefficientPeri-hematomal edema shape features related to 3-month outcome in acute supratentorial intracerebral hemorrhage
Dierksen F, Tran A, Zeevi T, Maier I, Qureshi A, Sanelli P, Werring D, Malhotra A, Falcone G, Sheth K, Payabvash S. Peri-hematomal edema shape features related to 3-month outcome in acute supratentorial intracerebral hemorrhage. European Stroke Journal 2024, 9: 383-390. PMID: 38179883, PMCID: PMC11318427, DOI: 10.1177/23969873231223814.Peer-Reviewed Original ResearchNIH Stroke ScaleGlasgow Coma ScaleAssociation of baselineIntracerebral hemorrhagePerihematomal edemaHematoma volumeAcute supratentorial intracerebral hemorrhageNon-traumatic intracerebral hemorrhageSecondary brain injuryAcute ICH patientsIndependent prognostic factorSupratentorial intracerebral hemorrhageAdmission NIH Stroke ScalePotential treatment targetRankin scoreStroke ScaleIndependent predictorsPatient agePrognostic factorsComa ScaleMultivariable analysisICH patientsPrognostic valueBrain injuryFavorable outcome
2023
Clinical implications of Peri-hematomal edema microperfusion fraction in intracerebral hemorrhage intravoxel incoherent motion imaging – A pilot study
Abou Karam G, Tharmaseelan H, Aboian M, Malhotra A, Gilmore E, Falcone G, de Havenon A, Sheth K, Payabvash S. Clinical implications of Peri-hematomal edema microperfusion fraction in intracerebral hemorrhage intravoxel incoherent motion imaging – A pilot study. Journal Of Stroke And Cerebrovascular Diseases 2023, 32: 107375. PMID: 37738914, PMCID: PMC10591892, DOI: 10.1016/j.jstrokecerebrovasdis.2023.107375.Peer-Reviewed Original ResearchConceptsModified Rankin ScaleSecondary brain injuryIntracerebral hemorrhagePerihematomal edemaSubacute intracerebral hemorrhageIntravoxel incoherent motion imagingAdmission NIHSSBrain injuryMedian baseline National InstitutesPilot studyBaseline National InstitutesHealth Stroke ScalePerfusion fractionSupratentorial intracerebral hemorrhageIVIM metricsIncoherent motion imagingStroke ScaleNeuroprotective therapiesParenchymal injuryRankin ScaleRisk patientsConsecutive patientsUnivariable analysisPoor outcomeICH volume
2022
Association of Soluble ST2 With Functional Outcome, Perihematomal Edema, and Immune Response After Intraparenchymal Hemorrhage
Bevers M, Booraem C, Li K, Sreekrishnan A, Sastre C, Falcone G, Sheth K, Sansing L, Kimberly W. Association of Soluble ST2 With Functional Outcome, Perihematomal Edema, and Immune Response After Intraparenchymal Hemorrhage. Neurology 2022, 100: e1329-e1338. PMID: 36549913, PMCID: PMC10065211, DOI: 10.1212/wnl.0000000000206764.Peer-Reviewed Original ResearchConceptsSoluble ST2Deep intraparenchymal hemorrhageIntraparenchymal hemorrhagePerihematomal edemaImmune responseHematoma volumePoor outcomeFunctional outcomeMedian admission Glasgow Coma Scale scoreScale scoreAdmission Glasgow Coma Scale scorePeripheral innate immune responseModified Rankin Scale scoreGlasgow Coma Scale scoreHours of ictusPeripheral immune responseSecondary brain injuryRankin Scale scoreInnate immune cellsImmune cell populationsIntracerebral Hemorrhage ScoreSerial CT scansInnate immune responseHuman brain tissueSST2 levels
2019
Deep Learning for Automated Measurement of Hemorrhage and Perihematomal Edema in Supratentorial Intracerebral Hemorrhage
Dhar R, Falcone GJ, Chen Y, Hamzehloo A, Kirsch EP, Noche RB, Roth K, Acosta J, Ruiz A, Phuah CL, Woo D, Gill TM, Sheth KN, Lee JM. Deep Learning for Automated Measurement of Hemorrhage and Perihematomal Edema in Supratentorial Intracerebral Hemorrhage. Stroke 2019, 51: 648-651. PMID: 31805845, PMCID: PMC6993878, DOI: 10.1161/strokeaha.119.027657.Peer-Reviewed Original ResearchConceptsSupratentorial intracerebral hemorrhagePerihematomal edemaIntracerebral hemorrhagePHE volumeResults Two hundred twentyIntracerebral Hemorrhage (ERICH) studyMechanism of injuryIntracerebral hemorrhage patientsSpontaneous intracerebral hemorrhageLarge cohort studyComputed tomography scanSecondary outcomesCohort studyPrimary outcomeHemorrhage patientsSecondary injuryTomography scanHundred twentyMedian volumeLarge cohortHemorrhagePatientsQuantification of hemorrhageFirst cohortDisease biologyPerihematomal Edema After Intracerebral Hemorrhage in Patients With Active Malignancy
Gusdon AM, Nyquist PA, Torres-Lopez VM, Leasure AC, Falcone GJ, Sheth KN, Sansing LH, Hanley DF, Malani R. Perihematomal Edema After Intracerebral Hemorrhage in Patients With Active Malignancy. Stroke 2019, 51: 129-136. PMID: 31744426, PMCID: PMC7048624, DOI: 10.1161/strokeaha.119.027085.Peer-Reviewed Original ResearchConceptsBlood product transfusionThirty-day mortalityIntracerebral hemorrhagePerihematomal edemaActive malignancyProduct transfusionPHE volumeICH volumeActive cancerPHE growthPlatelet transfusionsCentral nervous system involvementRecurrence of malignancyNervous system involvementNontraumatic intracerebral hemorrhageCancer-specific dataPHE expansionRecent chemotherapyChart reviewConclusions PatientsControl patientsMost patientsHematoma volumeInstitutional databaseSystem involvement
2017
Perihematomal Edema is Associated with Poor Outcome in Patients with Cerebellar Intracerebral Hemorrhage (P2.262)
Leasure A, Sreekrishnan A, Zhou S, Sansing L, Greer D, Sheth K. Perihematomal Edema is Associated with Poor Outcome in Patients with Cerebellar Intracerebral Hemorrhage (P2.262). Neurology 2017, 88 DOI: 10.1212/wnl.88.16_supplement.p2.262.Peer-Reviewed Original Research
2016
Rate of Perihematomal Edema Expansion Predicts Outcome After Intracerebral Hemorrhage
Urday S, Beslow LA, Dai F, Zhang F, Battey TW, Vashkevich A, Ayres AM, Leasure AC, Selim MH, Simard JM, Rosand J, Kimberly WT, Sheth KN. Rate of Perihematomal Edema Expansion Predicts Outcome After Intracerebral Hemorrhage. Critical Care Medicine 2016, 44: 790-797. PMID: 26757167, PMCID: PMC4859217, DOI: 10.1097/ccm.0000000000001553.Peer-Reviewed Original ResearchConceptsRankin Scale scorePerihematomal edema volumeIntracerebral hemorrhageEdema volumePerihematomal edemaScale scoreOrdinal shift analysisPerihematomal edema expansionPatients 18 yearsRetrospective cohort studyTertiary medical centerIntracerebral Hemorrhage ScoreNeurologic outcomeCohort studyIndependent predictorsIntraventricular hemorrhageSecondary injuryWorse outcomesCurrent treatmentHemorrhage scoreMedical CenterCT scanDevastating disorderEdema expansionHemorrhageTreatment of Edema Associated With Intracerebral Hemorrhage
Leasure A, Kimberly WT, Sansing LH, Kahle KT, Kronenberg G, Kunte H, Simard JM, Sheth KN. Treatment of Edema Associated With Intracerebral Hemorrhage. Current Treatment Options In Neurology 2016, 18: 9. PMID: 26874842, DOI: 10.1007/s11940-015-0392-z.Peer-Reviewed Original ResearchPerihematomal edemaIntracerebral hemorrhageHypertonic salineFirst-line medical therapyTreatment of ICHWorse clinical outcomesLarge clinical trialsSubsequent continuous infusionTreatment of edemaEdema refractoryClinical deteriorationBrain herniationCommon complicationDecompressive craniectomyMedical therapyClinical outcomesContinuous infusionEdema formationClinical trialsBolus formClinical researchHemorrhageNext major advanceEdemaPilot study
2011
Anti-Adrenergic Medications and Edema Development after Intracerebral Hemorrhage
Sansing LH, Messe SR, Cucchiara BL, Lyden PD, Kasner SE. Anti-Adrenergic Medications and Edema Development after Intracerebral Hemorrhage. Neurocritical Care 2011, 14: 395-400. PMID: 21264527, DOI: 10.1007/s12028-010-9498-z.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-2 Receptor AgonistsAdrenergic beta-AntagonistsAgedAntihypertensive AgentsAntioxidantsBenzenesulfonatesBlood PressureBrain EdemaCerebral HemorrhageClonidineCohort StudiesCritical CareDouble-Blind MethodDrug Therapy, CombinationFemaleFree Radical ScavengersGlasgow Coma ScaleHumansMaleMiddle AgedMultivariate AnalysisProspective StudiesTreatment OutcomeConceptsIntracerebral hemorrhageClinical outcomesBlood pressure medication useAcute intracerebral hemorrhageSympathetic nervous systemAdrenergic medicationsAntihypertensive medicationsAntihypertensive treatmentMethodsThe patientsPlacebo armBlood pressureMedication useEdema volumePerihematomal edemaEdema developmentInflammatory responseLess edemaHemorrhage volumeAdrenergic activationMedicationsNervous systemMultivariate analysisEdemaHemorrhagePatients
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