2025
Oxytocin improves maternal licking behavior deficits in autism-associated Shank3 mutant dogs
Lyu W, Li Y, Yao A, Tan Q, Zhang R, Zhao J, Guo K, Jiang Y, Tian R, Zhang Y. Oxytocin improves maternal licking behavior deficits in autism-associated Shank3 mutant dogs. Translational Psychiatry 2025, 15: 76. PMID: 40050270, DOI: 10.1038/s41398-025-03296-5.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderMutant damsWild-typeMaternal behaviorASD risk genesLicking behaviorAbundant scaffolding proteinImpaired social interactionEffects of oxytocinCRISPR/Cas9 methodologyRisk genesMutant dogsNursing frequencyOXT treatmentBehavioral deficitsRepetitive behaviorsPotential therapeutic strategySpectrum disorderNeurobiology of Autism Spectrum Disorder and Intellectual Disability
Massa A, Costales J, Rubeis S, Foss-Feig J, Hof P, Kolevzon A. Neurobiology of Autism Spectrum Disorder and Intellectual Disability. 2025, 855-864. DOI: 10.1093/med/9780197640654.003.0063.Peer-Reviewed Original ResearchAbstract Autism spectrum disorderIntellectual disabilityAutism spectrum disorderSpectrum disorderNeurobiology of autism spectrum disordersAssociated with IDRepetitive behaviorsNeurodevelopmental disordersSocial communicationNeurobiologyInhibitory neurotransmissionSynaptic dysfunctionDisordersEarly childhoodASD riskGenetic factorsAnimal studiesASD genesNeurotransmissionGenetic studiesImpairmentDisability
2024
Maternal Serotonin Levels and Neurodevelopmental Severity in Autistic Children: A Partial Replication and Extension
Jutla A, Shuffrey L, Guter S, Anderson G, O’Reilly K, Montgomery A, Sutcliffe J, Cook E, Veenstra-VanderWeele J. Maternal Serotonin Levels and Neurodevelopmental Severity in Autistic Children: A Partial Replication and Extension. JAACAP Open 2024 DOI: 10.1016/j.jaacop.2024.09.005.Peer-Reviewed Original ResearchLatent profile analysisSevere profileAdaptive functioningAssociated with social impairmentAutistic childrenAutism symptom severityAutism spectrum disorderNonverbal IQSerotonin systemSocial impairmentAutistic traitsRepetitive behaviorsSerotonin levelsSymptom severityHigh-severity groupSpectrum disorderPartial replicationGroup levelSevere groupExploratory modelProfile analysisChildrenStratified participantsSeveritySerotoninAssociation of Irritability with Restricted, Repetitive Behaviors and Social Communication Challenges in Autistic Youth
Menezes M, Rutten M, Anderson S, Linde J, Ibrahim K, Sukhodolsky D. Association of Irritability with Restricted, Repetitive Behaviors and Social Communication Challenges in Autistic Youth. Journal Of Autism And Developmental Disorders 2024, 1-8. PMID: 39141271, DOI: 10.1007/s10803-024-06505-0.Peer-Reviewed Original ResearchSocial communication challengesRestricted/repetitive behaviorsAutistic youthSocial communicationRepetitive behaviorsAutism characteristicsAffective Reactivity IndexAssociations of irritabilitySelf-injurious behaviorSocial Responsiveness ScaleHierarchical multiple regressionMental health concernsAssociated with several categoriesCompulsive behaviorsStereotyped behaviorExamined relationsRitualistic behaviorRestrictive behaviorsSame behaviorSocial motivationResponse scaleAutistic childrenInteraction challengesReactivity indexClinical research programObsessive Compulsive Disorder and Hoarding Disorder
Khasnavis S, Asghar-Ali A. Obsessive Compulsive Disorder and Hoarding Disorder. 2024, 299-308. DOI: 10.1007/978-3-031-55711-8_23.Peer-Reviewed Original ResearchObsessive compulsive disorderCompulsive disorderManifestation of obsessive compulsive disorderClinically significant impairmentStructured psychotherapyEgo-dystonicCognitive intrusionsRepetitive behaviorsBehavioral manifestationsSignificant impairmentApproach to treatmentDaily functioningObsessionMultimodal approach to treatmentPsychotherapyOlder adultsCompulsionDisordersSelf-imageOnset diagnosisPharmacological therapyImpairmentSystem of rulesAdultsMedicationAutism Spectrum Disorder (ASD)
Rutten M, Zhong J, Rolison M, Sukhodolsky D. Autism Spectrum Disorder (ASD). 2024 DOI: 10.1016/b978-0-323-95702-1.00076-2.ChaptersAutism spectrum disorderSeverity of core symptomsIdentity-first languagePerson-first languageCore symptomsPsychiatric disordersRestricted interestsIntellectual disabilityRepetitive behaviorsSpectrum disorderSensory sensitivityNeurodevelopmental disordersSocial communicationAutismEnvironmental risk factorsAutism communityPharmacological interventionsDisordersAdvanced parental ageParental ageADHDAnxietyLanguagePhenotypic presentationDisabilityChapter 13 Data-driven learning strategies for biomarker detection and outcome prediction in Autism from task-based fMRI
Duncan J, Staib L, Dvornek N, Li X, Zhuang J, Wang J, Ventola P. Chapter 13 Data-driven learning strategies for biomarker detection and outcome prediction in Autism from task-based fMRI. 2024, 357-393. DOI: 10.1016/b978-0-32-385124-4.00024-6.Peer-Reviewed Original ResearchLong short-term memoryGraph neural networksFunctional magnetic resonance imagingAutism spectrum disorderNeural ordinary differential equationsData-driven learning strategyDeep learning techniquesTask-based functional magnetic resonance imagingShort-term memoryNeural networkLearning techniquesImpaired social interactionTerm memoryBehavioral therapyRepetitive behaviorsSpectrum disorderDevelopmental disordersLearning strategiesSpatio-temporal characteristicsInherent dynamicsCharacterization of individualsModel of causalitySocial interactionNetworkPersonalized outcome predictions
2023
The association between autistic traits and quality of social interactions in the daily life of adolescents and young adults
Fusar-Poli L, Investigators T, van Os J, Rutten B, Guloksuz S. The association between autistic traits and quality of social interactions in the daily life of adolescents and young adults. European Psychiatry 2023, 66: s76-s76. PMCID: PMC10596031, DOI: 10.1192/j.eurpsy.2023.246.Peer-Reviewed Original ResearchHigh autistic traitsAutism Spectrum QuotientAutistic traitsAutism spectrum disorderSocial interactionLow senseExperience sampling periodEveryday social interactionsNon-autistic subjectsDisclosure of interestDaily lifePsychosocial interventionsSpectrum disorderRepetitive behaviorsSocial communicationSocial functioningNeurodevelopmental conditionsHigh senseYoung adultsYouthParticipantsTraitsGeneral populationSenseHigher preferenceCharacteristics of trichotillomania and excoriation disorder across the lifespan
Lin A, Farhat L, Flores J, Levine J, Fernandez T, Bloch M, Olfson E. Characteristics of trichotillomania and excoriation disorder across the lifespan. Psychiatry Research 2023, 322: 115120. PMID: 36842397, PMCID: PMC10023474, DOI: 10.1016/j.psychres.2023.115120.Peer-Reviewed Original ResearchConceptsExcoriation disorderClinical characteristicsSkin-picking severityAttention-deficit/hyperactivity disorderCo-occurring conditionsBody-focused repetitive behaviorsObsessive-compulsive disorderSeverity scoreCurrent symptomsSignificant positive correlationTrichotillomaniaHyperactivity disorderDisordersSelf-reported anxietyAge 4High rateSubtypesSelf-report measuresSeverityCross-sectional survey responsesRepetitive behaviorsAdulthoodPositive correlation
2022
Network Structure of Autism Spectrum Disorder Behaviors and Its Evolution in Preschool Children: Insights from a New Longitudinal Network Analysis Method
Montazeri F, Buitelaar JK, Oosterling IJ, de Bildt A, Anderson GM. Network Structure of Autism Spectrum Disorder Behaviors and Its Evolution in Preschool Children: Insights from a New Longitudinal Network Analysis Method. Journal Of Autism And Developmental Disorders 2022, 53: 4293-4307. PMID: 36066728, DOI: 10.1007/s10803-022-05723-8.Peer-Reviewed Original ResearchConceptsAutism spectrum disorder behaviorsAutism spectrum disorderCross-sectional networksDisorder behaviorsAutism DiagnosticSpectrum disorderRepetitive behaviorsPreschool childrenBehavioral itemsLongitudinal networkEfficient therapeutic interventionsCentral behaviorRRBsBehaviorChildrenItemsTherapeutic interventionsDisordersInterventionADIDistinct Symptom Network Structure and Shared Central Social Communication Symptomatology in Autism and Schizophrenia: A Bayesian Network Analysis
Han GT, Trevisan DA, Foss-Feig J, Srihari V, McPartland JC. Distinct Symptom Network Structure and Shared Central Social Communication Symptomatology in Autism and Schizophrenia: A Bayesian Network Analysis. Journal Of Autism And Developmental Disorders 2022, 53: 3636-3647. PMID: 35752729, PMCID: PMC10202012, DOI: 10.1007/s10803-022-05620-0.Peer-Reviewed Original ResearchConceptsSchizophrenia spectrum disordersSocial communication difficultiesSymptom networksCognitive-perceptual symptomsSpectrum disorderRepetitive behaviorsNeurodevelopmental conditionsCommunication difficultiesASDPotential treatment targetAutismSymptom network structureDiagnostic groupsTreatment targetsNetwork analysis approachHigh centralitySymptomatologySchizophreniaSymptomsOrganizationAdultsDisordersBayesian network analysisDifficultiesAnalysis approach
2021
Sex-dependent role for EPHB2 in brain development and autism-associated behavior
Assali A, Cho JY, Tsvetkov E, Gupta AR, Cowan CW. Sex-dependent role for EPHB2 in brain development and autism-associated behavior. Neuropsychopharmacology 2021, 46: 2021-2029. PMID: 33649502, PMCID: PMC8429442, DOI: 10.1038/s41386-021-00986-8.Peer-Reviewed Original ResearchConceptsLayer V pyramidal neuronsAutism spectrum disorderSex-dependent roleAutism-associated behaviorsAttention deficit hyperactivity disorderPathophysiology of ASDSex-specific effectsNovo nonsense mutationFemale patientsPyramidal neuronsMotor hyperactivityIntrinsic excitabilityCortical functionRepetitive behaviorsSynaptic plasticityRelated disordersMemory deficitsBrain developmentHypofunctionReceptor tyrosine kinasesMiceHyperactivity disorderIntellectual disabilityDisordersEphB2
2020
Autism Spectrum Disorder and Schizophrenia Are Better Differentiated by Positive Symptoms Than Negative Symptoms
Trevisan DA, Foss-Feig JH, Naples AJ, Srihari V, Anticevic A, McPartland JC. Autism Spectrum Disorder and Schizophrenia Are Better Differentiated by Positive Symptoms Than Negative Symptoms. Frontiers In Psychiatry 2020, 11: 548. PMID: 32595540, PMCID: PMC7301837, DOI: 10.3389/fpsyt.2020.00548.Peer-Reviewed Original ResearchAutism spectrum disorderSpectrum disorderNegative symptomsAutism Diagnostic Observation SchedulePositive symptomsGold standard diagnostic assessmentHeterogenous neurodevelopmental disorderAnalysis of covarianceDSM-5 criteriaStereotyped languageTD adultsASD symptomsTypical developmentObservation ScheduleRepetitive behaviorsCommunicative behaviorNegative Syndrome ScaleStandardized measuresSZ groupSymptom domainsGroup differencesParticipant groupsSymptom overlapSZ symptomsNeurodevelopmental disordersMeta-analysis: Pharmacologic Treatment of Restricted and Repetitive Behaviors in Autism Spectrum Disorders
Zhou MS, Nasir M, Farhat LC, Kook M, Artukoglu BB, Bloch MH. Meta-analysis: Pharmacologic Treatment of Restricted and Repetitive Behaviors in Autism Spectrum Disorders. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 60: 35-45. PMID: 32387445, DOI: 10.1016/j.jaac.2020.03.007.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsPlacebo-controlled trialPharmacological treatmentPharmacological agentsAvailable pharmacological agentsAutism spectrum disorderSerotonin reuptake inhibitorsStandardized mean differenceStandardized study designsTreatment of ASDPharmacologic treatmentPrimary outcomeReuptake inhibitorsAntipsychotic medicationSpecific assessment toolsFolinic acidSpectrum disorderModest benefitRepetitive behaviorsMean differenceStudy designSmall effect sizesIndividual studiesTrialsPlacebo
2019
Anger Rumination is Associated with Restricted and Repetitive Behaviors in Children with Autism Spectrum Disorder
Ibrahim K, Kalvin C, Marsh CL, Anzano A, Gorynova L, Cimino K, Sukhodolsky DG. Anger Rumination is Associated with Restricted and Repetitive Behaviors in Children with Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2019, 49: 3656-3668. PMID: 31144231, PMCID: PMC7035789, DOI: 10.1007/s10803-019-04085-y.Peer-Reviewed Original ResearchFamily Accommodation in Autism Spectrum Disorder
Feldman I, Koller J, Lebowitz ER, Shulman C, Ben Itzchak E, Zachor DA. Family Accommodation in Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2019, 49: 3602-3610. PMID: 31134428, DOI: 10.1007/s10803-019-04078-x.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderFamily accommodationSpectrum disorderAnxiety disordersParent-based interventionsFamilies of childrenParents of childrenParental accommodationChild's RRBsRRB severityGreater symptom severityRepetitive behaviorsLower functioningHighlight avenuesPoor treatment outcomesRRBsSymptom severityChildrenMost participantsDisordersTreatment outcomesOCDHigh levelsFunctioningAccommodation
2018
Autism Spectrum Disorder
Lerner M, Rosen T, Kang E, Keifer C, Gerber A. Autism Spectrum Disorder. 2018, 223-234. DOI: 10.1093/oxfordhb/9780190634841.013.15.Peer-Reviewed Original ResearchAbstract Autism spectrum disorderAutism spectrum disorderComplex clinical presentationSymptom reductionRepetitive behaviorsProportion of youthSpectrum disorderPsychosocial interventionsNeurodevelopmental conditionsSocial communicationCase examplePercentage of youthIntervention practicesReview keyYouthClinical practiceInterventionDeficitsAdolescentsDisordersSymptomsExternalitiesAssessmentComorbid autism spectrum disorder and anxiety disorders: a brief review
Zaboski B, Storch E. Comorbid autism spectrum disorder and anxiety disorders: a brief review. Future Neurology 2018, 13: 31-37. PMID: 29379397, PMCID: PMC5772195, DOI: 10.2217/fnl-2017-0030.Peer-Reviewed Original ResearchAutism spectrum disorderCognitive behavioral therapyBehavioral therapySpectrum disorderComorbid autism spectrum disorderSocial skills deficitsCognitive variablesSkill deficitsComprehensive assessment approachParental stressRepetitive behaviorsProblem behaviorNeurobiological interactionsAnxiety disordersAnxietyFamilial relationshipsDisordersPharmacological treatmentPharmacological interventionsDeficitsAssessment approachFocused reviewUnique challengesBehaviorInterventionChapter 49 Genetic susceptibility in obsessive-compulsive disorder
Fernandez TV, Leckman JF, Pittenger C. Chapter 49 Genetic susceptibility in obsessive-compulsive disorder. Handbook Of Clinical Neurology 2018, 148: 767-781. PMID: 29478613, DOI: 10.1016/b978-0-444-64076-5.00049-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsObsessive-compulsive disorderPotential novel therapeutic avenuesNovel therapeutic avenuesSpecific risk allelesUnderlying pathophysiologyLarge cohortLifelong disabilityImmune pathwaysTherapeutic avenuesNew treatmentsGenetic susceptibilityRisk allelesCandidate gene association studiesMouse knockout modelsGenetic findingsGene association studiesKnockout modelsOCD pathologyRisk variantsNotable inroadsGenetic variantsDisordersVulnerable pathwaysSubstantial genetic contributionRepetitive behaviors
2017
Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior
Shonesy BC, Parrish WP, Haddad HK, Stephenson JR, Báldi R, Bluett RJ, Marks CR, Centanni SW, Folkes OM, Spiess K, Augustin SM, Mackie K, Lovinger DM, Winder DG, Patel S, Colbran RJ. Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior. Biological Psychiatry 2017, 84: 304-315. PMID: 29458998, PMCID: PMC6023784, DOI: 10.1016/j.biopsych.2017.11.036.Peer-Reviewed Original ResearchConceptsDirect pathway medium spiny neuronsMedium spiny neuronsDorsal striatumIndirect pathway medium spiny neuronsReceptor-expressing medium spiny neuronsStriatal direct pathwayAutism spectrum disorderDiacylglycerol lipase αConditional knockout miceSpectrum disorderGlutamatergic driveSpiny neuronsEndocannabinoid signalingRepetitive groomingSynaptic transmissionMouse modelRepetitive behaviorsKnockout miceExcessive groomingDopamine DBrain regionsStriatumVentral striatumBehavioral effectsTargeted deletion
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