2025
Collagen Hybridizing Peptide-Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis.
Ahmad A, Ghim M, Kukreja G, Neishabouri A, Zhang Z, Li J, Salarian M, Toczek J, Gona K, Hedayatyanfard K, Morrison T, Zhang J, Huang Y, Liu C, Yu S, Sadeghi M. Collagen Hybridizing Peptide-Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis. Journal Of Nuclear Medicine 2025, 66: 425-433. PMID: 39915119, PMCID: PMC11876730, DOI: 10.2967/jnumed.124.268832.Peer-Reviewed Original ResearchConceptsPulmonary fibrosisTracer uptakeLung uptakeMurine model of pulmonary fibrosisModel of pulmonary fibrosisMice 3 wkEffect of antifibrotic therapyCollagen turnoverInterstitial lung diseaseClinical diagnostic methodsSPECT/CT imagingHybrid tracersLung histologyAntifibrotic therapyControl miceDisease activityMurine modelLung diseaseMice 8Tissue fibrosisPatient managementLiver uptakeSPECT/CTFibrosisSPECT images
2024
Reproducibility of Semi-automated Quantitative Analyses of Tc-99m Pyrophosphate Uptake from Myocardial Perfusion Planar and SPECT Images
Goyal D, Sandoval V, Weyman C, Miller E, Liu Y. Reproducibility of Semi-automated Quantitative Analyses of Tc-99m Pyrophosphate Uptake from Myocardial Perfusion Planar and SPECT Images. Journal Of Medical And Biological Engineering 2024, 45: 84-91. DOI: 10.1007/s40846-024-00924-1.Peer-Reviewed Original ResearchStandardized uptake valueTc-99SPECT imagesStandard uptake value quantificationTransthyretin cardiac amyloidosisH/CL ratioTc-99m PYP uptakeMethodsOur study cohortInter-observer reproducibilityPlanar imagingTechnetium-99mCardiac amyloidosisClinical suspicionSPECT/CT imagingTc-99m PYP imagingTc-99m PYPConsecutive subjectsUptake valueObserver reproducibilityStudy cohortInter-observerPurposeThe aimResultsIntra-observerMyocardial uptakeSPECTDose-aware Diffusion Model for 3D Low-count Cardiac SPECT Image Denoising with Projection-domain Consistency
Xie H, Gan W, Chen X, Zhou B, Liu Q, Xia M, Guo X, Liu Y, An H, Kamilov U, Wang G, Sinusas A, Liu C. Dose-aware Diffusion Model for 3D Low-count Cardiac SPECT Image Denoising with Projection-domain Consistency. 2024, 00: 1-1. DOI: 10.1109/nss/mic/rtsd57108.2024.10655170.Peer-Reviewed Original ResearchImage denoisingImage denoising performanceDeep learning techniquesNoise-levelDenoising performanceDenoising resultsNeural networkLearning techniquesSPECT imagesLow count levelsSPECT scansDenoisingSampling stepIterative reconstructionNoise amplitudeImagesInjected dosePatient studiesDiffusion modelRadiation exposureCardiology studiesSPECTNetworkStochastic natureMLEMThe Diagnostic Accuracy of SPECT Imaging in Patients With Suspected Pulmonary Embolism
Bang J, Lee W, Cho S, Choi M, Song Y. The Diagnostic Accuracy of SPECT Imaging in Patients With Suspected Pulmonary Embolism. Clinical Nuclear Medicine 2024, 49: 637-643. PMID: 38831512, DOI: 10.1097/rlu.0000000000005167.Peer-Reviewed Original ResearchConceptsChronic thromboembolic pulmonary hypertensionThromboembolic pulmonary hypertensionPulmonary embolismV/Q SPECT/CTDiagnostic accuracyPulmonary hypertensionQ-SPECT/CTSPECT imaging modalitiesDiagnostic accuracy of SPECT imagingSuspected chronic thromboembolic pulmonary hypertensionSuspected acute pulmonary embolismSPECT imagesPlanar imagingSpecificity of SPECTSuspected acute PEImaging modalitiesSuspected pulmonary embolismAcute pulmonary embolismAccuracy of SPECTAccuracy of SPECT imagesMeta-analysesSearch of MEDLINEDiagnostic accuracy of SPECTQ-SPECTNetwork meta-analysesPrototype catheter-based device for real time dual-isotope myocardial mapping
Stendahl J, Vermillion B, Daghighian F, Sinusas A. Prototype catheter-based device for real time dual-isotope myocardial mapping. European Heart Journal - Cardiovascular Imaging 2024, 25: jeae142.049. DOI: 10.1093/ehjci/jeae142.049.Peer-Reviewed Original ResearchReproducibility for quantification of myocardial Tc-99m PYP amyloid uptake in grade 1 patients
Sandoval V, Goyal D, Miller E, Liu Y. Reproducibility for quantification of myocardial Tc-99m PYP amyloid uptake in grade 1 patients. European Heart Journal - Cardiovascular Imaging 2024, 25: jeae142.047. DOI: 10.1093/ehjci/jeae142.047.Peer-Reviewed Original ResearchStandardized uptake valueTc-99m PYP uptakeTc-99Cardiac amyloidosisHeart failureStandard uptake value quantificationStandardized uptake value calculationSPECT imagesIntractable heart failureSystolic heart failureIntroduction of therapyPlanar imagingTc-99m pyrophosphateAmyloid patientsSPECT/CT imagingInter-reproducibilityUptake valueContralateral ratioCoefficient of variationDisease progressionH/M ratioGrade 1Blood poolPatientsH/CL ratio
2022
Mitigating bias in deep learning for diagnosis of coronary artery disease from myocardial perfusion SPECT images
Miller RJH, Singh A, Otaki Y, Tamarappoo BK, Kavanagh P, Parekh T, Hu LH, Gransar H, Sharir T, Einstein AJ, Fish MB, Ruddy TD, Kaufmann PA, Sinusas AJ, Miller EJ, Bateman TM, Dorbala S, Di Carli MF, Liang JX, Dey D, Berman DS, Slomka PJ. Mitigating bias in deep learning for diagnosis of coronary artery disease from myocardial perfusion SPECT images. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 50: 387-397. PMID: 36194270, PMCID: PMC10042590, DOI: 10.1007/s00259-022-05972-w.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseMyocardial perfusion imagingArtery diseaseInvasive angiographyObstructive coronary artery diseaseDisease probabilityLow-risk patientsLow-risk populationHigh-risk populationTotal perfusion deficitHigh diagnostic accuracyS-TPDPerfusion deficitsPatient managementPatientsPerfusion imagingDiagnostic accuracyPerfusion SPECT imagesLower likelihoodGood calibrationCharacteristic curveAngiographySPECT imagesSelection biasDiseaseDuDoSS: Deep‐learning‐based dual‐domain sinogram synthesis from sparsely sampled projections of cardiac SPECT
Chen X, Zhou B, Xie H, Miao T, Liu H, Holler W, Lin M, Miller EJ, Carson RE, Sinusas AJ, Liu C. DuDoSS: Deep‐learning‐based dual‐domain sinogram synthesis from sparsely sampled projections of cardiac SPECT. Medical Physics 2022, 50: 89-103. PMID: 36048541, PMCID: PMC9868054, DOI: 10.1002/mp.15958.Peer-Reviewed Original ResearchConceptsLow reconstruction accuracySynthetic projectionsAbsolute percent errorImage predictionSPECT image reconstructionImage domainSinogram synthesisGround truthReconstruction accuracyImage reconstructionSinogram domainProjection angleData acquisitionMean square errorFast data acquisitionImagesReconstruction artifactsSPECT imagesSquare error
2016
SPECT Imaging of 2-D and 3-D Distributed Sources with Near-Field Coded Aperture Collimation: Computer Simulation and Real Data Validation
Mu Z, Dobrucki LW, Liu YH. SPECT Imaging of 2-D and 3-D Distributed Sources with Near-Field Coded Aperture Collimation: Computer Simulation and Real Data Validation. Journal Of Medical And Biological Engineering 2016, 36: 32-43. PMID: 27069461, PMCID: PMC4791458, DOI: 10.1007/s40846-016-0111-6.Peer-Reviewed Original ResearchMaximum likelihood expectation maximizationReconstruction approachImage resolutionLarge projection angleIterative image reconstructionNoise artifactsMicro-SPECT systemComputer simulationsReal data validationImage reconstructionDigital phantomExpectation maximizationData validationCA moduleMLEM algorithmImage qualityPinhole imagesProjection angleCommercial softwareImagesPhantom imagesSquared errorSPECT imagesCA imagesImage contrast
2014
Novel Cost-Effective and High-Performance Modular Detectors for Emission Tomography Systems
Sabet H, El-Fakhri G. Novel Cost-Effective and High-Performance Modular Detectors for Emission Tomography Systems. 2014, 1-3. DOI: 10.1109/nssmic.2014.7430755.Peer-Reviewed Original ResearchLaser induced optical barriersScintillation light spreadIncident gamma raysInter-pixel gapEmission tomography systemSpatial resolutionScintillator arrayGamma raysOptical barrierMechanical pixelationAnimal PETCE arrayLow packing fractionScintillationSmall-animal PETTomography systemSPECT imagesCross-sectionPixel separationArray fabricationLYSOPacking fractionRaysResolutionProcess yield
2011
Cerebral perfusion and automated individual analysis using SPECT among an obsessive-compulsive population
da Rocha E, Buchpiguel C, Miguel E, Peres S, Filho G. Cerebral perfusion and automated individual analysis using SPECT among an obsessive-compulsive population. Jornal Brasileiro De Psiquiatria 2011, 60: 1-6. DOI: 10.1590/s0047-20852011000100001.Peer-Reviewed Original ResearchStatistical parametric mappingBrain SPECT imagesCerebral perfusionPerfusion abnormalitiesPerfusional abnormalitiesSPECT examinationNormal groupNormal subjectsClinical practiceSample of subjectsParametric mappingAbnormalitiesPatientsSPECT imagesIndividual assessmentVoxel levelSubjectsOCDStatistical thresholdPerfusionIndividual analysis
2010
Comparison of simultaneous and sequential SPECT imaging for discrimination tasks in assessment of cardiac defects
Trott C, Ouyang J, Fakhri G. Comparison of simultaneous and sequential SPECT imaging for discrimination tasks in assessment of cardiac defects. Physics In Medicine And Biology 2010, 55: 6897-6910. PMID: 21048290, PMCID: PMC3117301, DOI: 10.1088/0031-9155/55/22/019.Peer-Reviewed Original Research
2009
A quantitative evaluation study of four-dimensional gated cardiac SPECT reconstruction
Jin M, Yang Y, Niu X, Marin T, Brankov J, Feng B, Pretorius P, King M, Wernick M. A quantitative evaluation study of four-dimensional gated cardiac SPECT reconstruction. Physics In Medicine And Biology 2009, 54: 5643-5659. PMID: 19724094, PMCID: PMC3690946, DOI: 10.1088/0031-9155/54/18/019.Peer-Reviewed Original ResearchConceptsGated cardiac SPECT imagesNURBS-based cardiac-torso (NCATMotion-compensated temporal regularizationCardiac SPECT imagingBias-variance analysisDistance-dependent blurringGated cardiac SPECTMotion compensation approachReconstructed myocardiumSPECT imagesDetection of perfusion defectsSPECT reconstructionCardiac SPECTIntensity uniformityTemporal smoothnessPatient dataLeft ventricular myocardiumReconstructed imagesReconstruction processSpatial smoothingPerfusion defectsScatteringDegradation factorsTemporal regularityVentricular myocardiumMotion-compensated temporal summation of cardiac gated SPECT images using a deformable mesh model
Marin T, Wernick M, Yang Y, Brankov J. Motion-compensated temporal summation of cardiac gated SPECT images using a deformable mesh model. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2009, 2009: 3657-3660. PMID: 19964313, PMCID: PMC2810283, DOI: 10.1109/iembs.2009.5333693.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsCardiac-Gated Imaging TechniquesCardiac-Gated Single-Photon Emission Computer-Assisted TomographyComputer SimulationHeartHumansImage Processing, Computer-AssistedImaging, Three-DimensionalModels, StatisticalMotionPhantoms, ImagingRadiographic Image Interpretation, Computer-AssistedTomography, Emission-Computed, Single-PhotonConceptsDeformable mesh modelMotion blurring artifactsMesh modelCardiac gated SPECT imagingCardiac gated SPECTEstimating heart motionHeart motionNoisy imagesMotion estimationNoise reduction performanceTime dimensionEstimated motionBlurring artifactsIndividual framesPartial volume effectsNoise reductionQuantitative evaluationReduction performanceImagesNoiseSPECT imagesStatic SPECT imagesArtifactsFrameGate sequencesIMAGING | SPECT in Epilepsy Research
Purcaro M, Blumenfeld H. IMAGING | SPECT in Epilepsy Research. 2009, 558-564. DOI: 10.1016/b978-012373961-2.00024-2.Peer-Reviewed Original ResearchEpilepsy researchUseful imaging modalityInterictal SPECT imagesSingle photon emissionIctal dystoniaExtratemporal epilepsyPresurgical localizationHypothalamic hamartomaSurgical interventionInfantile spasmsSurgical successEpileptogenic focusPostsurgical outcomesSeizure localizationNeurological disordersEpilepsyImaging modalitiesMillions of peoplePhoton emissionSPECT imagesSPECTMedicationsSpasmDystoniaHamartoma
2007
Comparison of Brain PET and Sequential and Simultaneous Dual-isotope SPECT for Estimation Tasks in Normal and Parkinson Subjects
Trott C, Fakhri G. Comparison of Brain PET and Sequential and Simultaneous Dual-isotope SPECT for Estimation Tasks in Normal and Parkinson Subjects. 2007, 5: 3616-3620. DOI: 10.1109/nssmic.2007.4436906.Peer-Reviewed Original ResearchDopamine transporterEarly stages of PDDual-isotope SPECTStages of PDSequential SPECTDisease stageSimultaneous dual-isotope studyStriatal sizeBrain functionImprove patient managementEstimation taskDual-isotope studiesBrain PETDopamineClinical symptomsParkinson's diseasePatient managementSPECT imagesSpecific bindingMotor functionSPECTBrainEarly detectionActivity concentrationsIdentical physiological conditions
2004
A general-spectral method for improved quantitative SPECT imaging of indium-111
Moore S, Park M, Fakhri G, Gerbaudo V, Zimmerman R. A general-spectral method for improved quantitative SPECT imaging of indium-111. 2004, 6: 3682-3684. DOI: 10.1109/nssmic.2004.1466680.Peer-Reviewed Original ResearchRadiotherapy treatment planningList-mode dataFree of scatterQuantitative SPECT imagingScatter compensation methodsList-mode acquisitionDown-scatterScattered photonsPhoton scatteringPhotopeakQuantitative SPECTOSEM reconstructionSPECT imagesLeastsquares procedureDose specificationAttenuation projectionNoisy projectionsScatteringTreatment planningSphere activitySphere locationIndium-111PhotonsContrast valuesSphere position
2003
Performance of Simultaneous and Sequential Tc-99m/I-123 SPECT Imaging in Estimation of Striatal Activity
Kijewski M, Fakhri G, Moore S. Performance of Simultaneous and Sequential Tc-99m/I-123 SPECT Imaging in Estimation of Striatal Activity. 2003, 5: 3134-3136. DOI: 10.1109/nssmic.2003.1352561.Peer-Reviewed Original Research
2002
Correlation of myocardial p-(123)I-iodophenylpentadecanoic acid retention with (18)F-FDG accumulation during experimental low-flow ischemia.
Shi CQ, Young LH, Daher E, DiBella EV, Liu YH, Heller EN, Zoghbi S, Wackers FJ, Soufer R, Sinusas AJ. Correlation of myocardial p-(123)I-iodophenylpentadecanoic acid retention with (18)F-FDG accumulation during experimental low-flow ischemia. Journal Of Nuclear Medicine 2002, 43: 421-31. PMID: 11884504.Peer-Reviewed Original Research
2001
Realistic Monte Carlo Simulation of Ga-67 SPECT Imaging
Moore S, El Fakhri G. Realistic Monte Carlo Simulation of Ga-67 SPECT Imaging. IEEE Transactions On Nuclear Science 2001, 48: 720. DOI: 10.1109/23.940153.Peer-Reviewed Original ResearchRealistic Monte Carlo simulationsNumerical torso phantomLead X-raysMonte Carlo programPhoton emission energyPoisson noise realizationsGa-67 SPECT imagingCollimator penetrationDetector resolutionEnergy windowRSD phantomPhoton propagationPhoton scatteringTorso phantomHeart/thorax phantomAttenuation mapEnergy distributionEmission energyImproved variance reductionSPECT imagesPhantomGa-67 studiesNoise realizationsScatteringAxillary lymph nodes
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