ERICH3: vesicular association and antidepressant treatment response
Liu D, Zhuang Y, Zhang L, Gao H, Neavin D, Carrillo-Roa T, Wang Y, Yu J, Qin S, Kim D, Liu E, Nguyen T, Biernacka J, Kaddurah-Daouk R, Dunlop B, Craighead W, Mayberg H, Binder E, Frye M, Wang L, Weinshilboum R. ERICH3: vesicular association and antidepressant treatment response. Molecular Psychiatry 2020, 26: 2415-2428. PMID: 33230203, PMCID: PMC8141066, DOI: 10.1038/s41380-020-00940-y.Peer-Reviewed Original ResearchConceptsSingle-nucleotide polymorphismsAssociated with SSRI responseGenome-wide association studiesSSRI treatment outcomeAntidepressant treatment responseVesicular functionSerotonin reuptake inhibitorsClathrin heavy chainHuman iPSC-derived neuronsPlasma 5-HT concentrationsVesicle-like structuresSSRI responseSSRI trialMDD trialsMDD patientsDepressive disorderSSRI therapyReuptake inhibitorsGenome-wideIPSC-derived neuronsSK-N-SH cellsAssociation studiesInteracting proteinsERICH3Neuronal cell types
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