2021
Genetic variants are identified to increase risk of COVID-19 related mortality from UK Biobank data
Hu J, Li C, Wang S, Li T, Zhang H. Genetic variants are identified to increase risk of COVID-19 related mortality from UK Biobank data. Human Genomics 2021, 15: 10. PMID: 33536081, PMCID: PMC7856608, DOI: 10.1186/s40246-021-00306-7.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenetic variantsPower of GWASTraditional genome-wide association studiesTraits of interestMulti-locus interactionsHuman bronchial epithelial cellsSignificant genetic variantsDownregulated genesChromosome 2Genetic basisGenetic factorsAssociation studiesBronchial epithelial cellsCilia dysfunctionSusceptibility lociMitochondrial dysfunctionGenome-wide significant genetic variantsEpithelial cellsGenesMolecular pathogenesisHost genetic factorsUK Biobank dataUK BiobankVariants
2009
Pharmacogenetics of a PARP inhibitor ABT-888 metabolic pathway
Li J, Sha X, LoRusso P. Pharmacogenetics of a PARP inhibitor ABT-888 metabolic pathway. Journal Of Clinical Oncology 2009, 27: e14556-e14556. DOI: 10.1200/jco.2009.27.15_suppl.e14556.Peer-Reviewed Original ResearchGenetic variantsMetabolic pathwaysDNA break repairABT-888Significant genetic variantsTherapeutic outcomesBreak repairCytochrome P450Ongoing phase I trialMolecular basisWild-type CYP2D6Advanced solid tumorsPhase I trialRecombinant human cytochrome P450DNA damageHuman liver microsomesMetabolite formationVariant enzymeMultiple cytotoxic agentsTumor drug concentrationsPARP activityFunctional significanceMajor enzymePredominant enzymeHuman cytochrome P450
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