2023
Endotheliopathy of liver sinusoidal endothelial cells in liver disease
Kondo R, Iwakiri Y, Kage M, Yano H. Endotheliopathy of liver sinusoidal endothelial cells in liver disease. Pathology International 2023, 73: 381-393. PMID: 37589433, DOI: 10.1111/pin.13361.Peer-Reviewed Original ResearchConceptsLiver diseaseSinusoidal endothelial cellsEndothelial cellsLiver injuryLiver tissueIntercellular adhesion molecule-1Improvement of thrombocytopeniaNeutrophil chemotactic mediatorsChronic hepatitis CLiver sinusoidal endothelial cellsSetting of inflammationSevere hepatic inflammationAdhesion molecule-1Largest solid organPotential therapeutic strategyVascular endothelial cellsVon Willebrand factorHepatitis CNeutrophil accumulationHepatic inflammationChemotactic mediatorsIL-6Antithrombotic factorsChemokine ligandSolid organsCrusted Scabies Presenting as Erythroderma in a Patient With Iatrogenic Immunosuppression for Treatment of Granulomatosis With Polyangiitis.
Olamiju B, Leventhal J, Vesely M. Crusted Scabies Presenting as Erythroderma in a Patient With Iatrogenic Immunosuppression for Treatment of Granulomatosis With Polyangiitis. Cutis 2023, 111: e44-e47. PMID: 37406327, DOI: 10.12788/cutis.0794.Peer-Reviewed Original ResearchConceptsCrusted scabiesMedication-induced immunosuppressionTreatment of granulomatosisBone marrow transplantationDiagnosis of scabiesVar hominisIatrogenic immunosuppressionBroad differentialMarrow transplantationAutoimmune diseasesSolid organsRare caseSevere formPatientsImmunosuppressionErythrodermaScabiesInfectionEctoparasitic infectionsPolyangiitisGranulomatosisTreatmentMyelosuppressionTransplantationDisease
2021
Emerging Diagnostics for Transplant Infectious Diseases
Azar M, Gaston D, Malinis M. Emerging Diagnostics for Transplant Infectious Diseases. 2021, 1535-1576. DOI: 10.1007/978-3-030-25869-6_69.Peer-Reviewed Original ResearchTransplant infectious diseasesInfectious diseasesPolymerase chain reaction panelHematopoietic stem cell transplantationCommunity-acquired infectionsStem cell transplantationMultidrug-resistant organismsTest performance characteristicsTransplant patientsUncommon pathogenCell transplantationSerious infectionsPatient outcomesClinical impactDiagnostic modalitiesSolid organsMolecular testingClinical specimensPatientsDiseaseDiagnostic advantageInfectionResistance detectionDiagnostic methodsDiagnostic capabilitiesBartonellosis in transplant recipients: A retrospective single center experience
Pischel L, Radcliffe C, Vilchez GA, Charifa A, Zhang XC, Grant M. Bartonellosis in transplant recipients: A retrospective single center experience. World Journal Of Transplantation 2021, 11: 244-253. PMID: 34164299, PMCID: PMC8218350, DOI: 10.5500/wjt.v11.i6.244.Peer-Reviewed Original ResearchStem cell transplant recipientsTransplant recipientsCell transplant recipientsClinical presentationDifferential diagnosisAutologous stem cell transplant recipientsHematopoietic stem cell transplant recipientsPost-transplant lymphoproliferative disorderRetrospective single-center experienceSingle-center retrospective studyRenal transplant recipientsSingle-center experienceCat-scratch diseaseCenter experienceClinical courseImmunocompromised hostLymphoproliferative disordersRetrospective studySingle institutionScratch diseaseSolid organsUnknown originDiagnostic testsRecipientsInfection
2020
The effect of anticoagulation on outcomes after liver and spleen injuries: A research consortium of New England centers for trauma (ReCONECT) study
Bhattacharya B, Askari R, Davis KA, Dorfman J, Eid AI, Elsharkawy AE, Kasotakis G, Mackey S, Odom S, Okafor BU, Rosenblatt M, Ruditsky A, Velmahos G, Maung AA. The effect of anticoagulation on outcomes after liver and spleen injuries: A research consortium of New England centers for trauma (ReCONECT) study. Injury 2020, 51: 1994-1998. PMID: 32482426, DOI: 10.1016/j.injury.2020.05.002.Peer-Reviewed Original ResearchConceptsNon-ACS patientsEffect of anticoagulationNon-operative managementSpleen injurySplenic injuryLiver injuryInitial non-operative managementSignificant differencesUse of anticoagulationBlood product transfusionMulticenter retrospective studyAC drugsMore PRBCsInjury gradeProduct transfusionCommon indicationAC patientsAtrial fibrillationRetrospective studyAnticoagulationSolid organsPatientsInjuryStudy periodLiverEmerging Diagnostics for Transplant Infectious Diseases
Azar M, Gaston D, Malinis M. Emerging Diagnostics for Transplant Infectious Diseases. 2020, 1-44. DOI: 10.1007/978-3-030-01751-4_69-1.Peer-Reviewed Original ResearchTransplant infectious diseasesInfectious diseasesPolymerase chain reaction panelHematopoietic stem cell transplantationCommunity-acquired infectionsStem cell transplantationMultidrug-resistant organismsTest performance characteristicsTransplant patientsUncommon pathogenCell transplantationSerious infectionsPatient outcomesClinical impactDiagnostic modalitiesSolid organsMolecular testingClinical specimensPatientsDiseaseDiagnostic advantageInfectionResistance detectionDiagnostic methodsDiagnostic capabilitiesEmerging Microbiology Diagnostics for Transplant Infections: On the Cusp of a Paradigm Shift.
Azar MM, Gaston DC, Kotton CN, Malinis MF. Emerging Microbiology Diagnostics for Transplant Infections: On the Cusp of a Paradigm Shift. Transplantation 2020, 104: 1358-1384. PMID: 31972701, DOI: 10.1097/tp.0000000000003123.BooksConceptsHematopoietic stem cell transplantationInfected transplant recipientsInfectious disease specialistsStem cell transplantationBlood culture specimensArray of pathogensTransplant recipientsTransplant cliniciansClinical outcomesDisease specialistsCell transplantationTransplant infectionsMagnetic resonance-based methodsMicrobiology diagnosticsSolid organsCulture specimensMolecular testingMolecular panelResistance determinantsInfectionOutcomesDiagnostic microbiologyResonance-based methodsPatientsTransplantationChapter 2 Methods of RBC Alloimmunization to ABO and Non-ABO Antigens, and Test Methodologies
Stendahl K, Tormey C, Baine I. Chapter 2 Methods of RBC Alloimmunization to ABO and Non-ABO Antigens, and Test Methodologies. 2020, 15-33. DOI: 10.1016/b978-0-323-67509-3.00002-0.ChaptersRBC alloimmunizationRBC transfusionRBC antigensHematopoietic progenitor cell transplantCompatible blood productsCompatible RBC unitsIncompatible RBC transfusionHemolytic transfusion reactionsProgenitor cell transplantABO blood groupComplex clinical scenariosCell transplantABO compatibilityMolecular typing methodsTransfusion reactionsBlood productsSolid organsImmunologic conceptsClinical scenariosAntibody detectionRBC unitsAntigenPatientsBlood groupTransfusion medicine
2018
Perioperative Psychiatric Problems in Organ Transplantation
Zimbrean P, Proops N. Perioperative Psychiatric Problems in Organ Transplantation. 2018, 173-193. DOI: 10.1007/978-3-319-99774-2_11.Peer-Reviewed Original ResearchOrgan transplantationPsychiatric problemsImportant psychiatric aspectsTransplantation listingTransplant candidatesTransplantation outcomesPostsurgical carePsychiatric presentationsSolid organsOrgan donorsPatient journeyPsychiatric aspectsPsychiatric implicationsTransplantationRecipientsHuman tissuesReviewLungKidneyPancreasPrevalenceDonorsLiverIntestineCareTransplant Virus Detection Using Multiplex Targeted Sequencing
Tan SK, Shen P, Lefterova MI, Sahoo MK, Fung E, Odegaard JI, Davis RW, Pinsky BA, Scharfe C. Transplant Virus Detection Using Multiplex Targeted Sequencing. The Journal Of Applied Laboratory Medicine 2018, 2: 757-769. PMID: 31245786, PMCID: PMC6594177, DOI: 10.1373/jalm.2017.024521.Peer-Reviewed Original ResearchTransplant recipientsClinical sensitivityEpstein-Barr virus infectionQuantitative PCRImmunocompromised transplant recipientHematopoietic cell transplantationHuman herpesvirus 7Bronchoalveolar lavageCell transplantationVirus infectionBK virusSolid organsCerebrospinal fluidPatient plasmaViral infectionViral sequencingClinical specimensMajor causeClinical performanceSmall clinical samplesReference virusesClinical samplesSpecific virusesVirusVirus of interest
2017
Outcomes of Solid Organ Transplants After Simultaneous Solid Organ and Vascularized Composite Allograft Procurements
Aycart M, Alhefzi M, Sharma G, Krezdorn N, Bueno E, Talbot S, Carty M, Tullius S, Pomahac B. Outcomes of Solid Organ Transplants After Simultaneous Solid Organ and Vascularized Composite Allograft Procurements. Transplantation 2017, 101: 1381-1386. PMID: 27140518, PMCID: PMC6347371, DOI: 10.1097/tp.0000000000001262.Peer-Reviewed Original ResearchMeSH KeywordsAdultComposite Tissue AllograftsFacial TransplantationFemaleGraft SurvivalHumansMaleMiddle AgedOperative TimeOrgan TransplantationPostoperative ComplicationsRegistriesRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTissue and Organ HarvestingTissue DonorsTreatment OutcomeUnited StatesYoung AdultConceptsGraft survival ratesSolid organsSurvival rateLiver recipientsTransplant recipientsAllograft procurementSolid organ allograftsSolid organ transplantsBrain-dead donorsLong-term outcomesShort-term resultsHeart recipientsIntraoperative parametersDonor surgeryOperative durationOrgan allograftsPostoperative outcomesScientific RegistryTransplantation outcomesPopulation of subjectsCase reportOperative characteristicsUnknown causeNationwide analysisOrgan transplants
2016
A resilience intervention involving mindfulness training for transplant patients and their caregivers
Stonnington CM, Darby B, Santucci A, Mulligan P, Pathuis P, Cuc A, Hentz JG, Zhang N, Mulligan D, Sood A. A resilience intervention involving mindfulness training for transplant patients and their caregivers. Clinical Transplantation 2016, 30: 1466-1472. PMID: 27618687, DOI: 10.1111/ctr.12841.Peer-Reviewed Original ResearchConceptsTransplant patientsCell transplant patientsNegative affectNeuroscience of stressMindfulness-based stress reductionMindfulness-based interventionsStem cell transplant patientsHealth-related qualityKidney/pancreasMeasures of stressPositive affectMindfulness trainingResilience interventionsMindfulness practiceMonths postinterventionMayo ClinicCaregiver interventionsMental componentSolid organsPatientsStress reductionAffectCaregiversMost participantsAnxietyRisks and Epidemiology of Infections After Liver Transplantation
Patron R, Kusne S, Mulligan D. Risks and Epidemiology of Infections After Liver Transplantation. 2016, 215-233. DOI: 10.1007/978-3-319-28797-3_14.Peer-Reviewed Original ResearchInfectious complicationsAppropriate antimicrobial prophylaxisDonor-transmitted infectionLiver transplant recipientsSerious infectious complicationsPrevention of recurrenceEpidemiology of infectionGraft lossHIV coinfectionAntimicrobial prophylaxisLiver transplantLiver transplantationTransplant recipientsOperative timeViral hepatitidesImmune competencePrompt interventionRisk factorsDiligent surveillanceSurgical techniqueSolid organsHigh riskTherapeutic strategiesAnti-infective agentsEarly signsChronic miR‐29 antagonism promotes favorable plaque remodeling in atherosclerotic mice
Ulrich V, Rotllan N, Araldi E, Luciano A, Skroblin P, Abonnenc M, Perrotta P, Yin X, Bauer A, Leslie KL, Zhang P, Aryal B, Montgomery RL, Thum T, Martin K, Suarez Y, Mayr M, Fernandez-Hernando C, Sessa WC. Chronic miR‐29 antagonism promotes favorable plaque remodeling in atherosclerotic mice. EMBO Molecular Medicine 2016, 8: 643-653. PMID: 27137489, PMCID: PMC4888854, DOI: 10.15252/emmm.201506031.Peer-Reviewed Original ResearchConceptsPlaque morphologyReduced lesion sizeAcute myocardial infarctionAtherosclerotic mouse modelVulnerable atherosclerotic lesionsFibrous cap thicknessPlaque extracellular matrixChronic administrationExtracellular matrixAtherosclerotic miceMyocardial infarctionPlaque remodelingSolid organsAbnormal remodelingMouse modelAtherosclerotic lesionsAtherosclerotic plaquesBlood chemistryLesion sizeMiR-29Necrotic zoneLesionsPlaquesCap thicknessMiR-29 target genesNuances in the Care of Emergent Splenic Injury in the Elderly Patient
Bhattacharya B, Davis K. Nuances in the Care of Emergent Splenic Injury in the Elderly Patient. Current Geriatrics Reports 2016, 5: 31-37. DOI: 10.1007/s13670-016-0153-1.Peer-Reviewed Original ResearchSplenic injuryGeriatric populationNon-operative managementAbdominal solid organsElderly patientsSplenic preservationTrauma admissionsGeriatric patientsSpleen traumaTreatment optionsPossible complicationsSolid organsAltered physiologySame time periodInjuryPatientsSpecial considerationComorbiditiesComplicationsAdmissionUnique challengesPopulationSpleenManagementTrauma
2012
Behavior of Tip-Steerable Needles in Ex Vivo and In Vivo Tissue
Majewicz A, Marra S, van Vledder M, Lin M, Choti M, Song D, Okamura A. Behavior of Tip-Steerable Needles in Ex Vivo and In Vivo Tissue. IEEE Transactions On Biomedical Engineering 2012, 59: 2705-2715. PMID: 22711767, PMCID: PMC3448818, DOI: 10.1109/tbme.2012.2204749.Peer-Reviewed Original Research
2011
A small molecule AMPK activator protects the heart against ischemia–reperfusion injury
Kim AS, Miller EJ, Wright TM, Li J, Qi D, Atsina K, Zaha V, Sakamoto K, Young LH. A small molecule AMPK activator protects the heart against ischemia–reperfusion injury. Journal Of Molecular And Cellular Cardiology 2011, 51: 24-32. PMID: 21402077, PMCID: PMC4005884, DOI: 10.1016/j.yjmcc.2011.03.003.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAMP-Activated Protein KinasesAnimalsApoptosisBiphenyl CompoundsCardiotonic AgentsEnzyme ActivatorsHeartIschemic PreconditioningMiceMice, Inbred C57BLMice, TransgenicMyocardial InfarctionMyocardial Reperfusion InjuryNecrosisNitric Oxide Synthase Type IIIPeptide Elongation Factor 2PyronesThiophenesConceptsIschemia-reperfusion injuryLeft ventricular contractile functionMyocardial ischemia-reperfusion injuryMouse heartsEndothelial nitric oxide synthase activationNitric oxide synthase activationLess myocardial necrosisCoronary artery occlusionIschemia-reperfusion damageVentricular contractile functionEukaryotic elongation factor 2Isolated mouse heartsPost-ischemic reperfusionAMPK activatorArtery occlusionIschemic contractureIschemic injuryInfarct sizeMyocardial stunningMyocardial necrosisCardioprotective mechanismsContractile functionSolid organsTherapeutic targetMyocardial apoptosis
2009
Deceased Donor Kidney Transplantation from Donors with Acute Renal Failure due to Rhabdomyolysis
Mekeel KL, Moss AA, Mulligan DC, Chakkera HA, Hamawi K, Mazur MJ, Heilman RL, Reddy KS. Deceased Donor Kidney Transplantation from Donors with Acute Renal Failure due to Rhabdomyolysis. American Journal Of Transplantation 2009, 9: 1666-1670. PMID: 19459799, DOI: 10.1111/j.1600-6143.2009.02663.x.Peer-Reviewed Original ResearchConceptsAcute renal failureGraft functionRenal failureDeceased donor kidney transplantationFull renal functionGood graft functionSlow graft functionDelayed graft functionDonor kidney transplantationCreatinine kinase levelsUrine hemoglobinKidney transplantationMost patientsRenal functionMean creatinineDead patientsImmediate functionKinase levelsSolid organsTransplant communityOrgan donorsRhabdomyolysisPatientsGraftPotential donors
2007
Limitations of Green Fluorescent Protein as a Cell Lineage Marker
Swenson ES, Price JG, Brazelton T, Krause DS. Limitations of Green Fluorescent Protein as a Cell Lineage Marker. Stem Cells 2007, 25: 2593-2600. PMID: 17615263, DOI: 10.1634/stemcells.2007-0241.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood CellsCattleCell LineageChickensCytomegalovirusFemaleFluorescent Antibody TechniqueGene ExpressionGenes, ReporterGenes, SyntheticGreen Fluorescent ProteinsHumansImmunoenzyme TechniquesMaleMiceMice, Inbred C57BLOrgan SpecificityRegulatory Sequences, Nucleic AcidTissue DistributionTransgenesVisceraConceptsSmall intestineMouse strainsPeripheral blood cellsTransgenic mouse strainReporter mouse strainPrimary rabbit antibodiesDonor originHuman ubiquitin C promoterImmunohistochemical stainingSolid organsCell lineage markersCell lineagesUBC-GFP miceUbiquitin C promoterChicken beta-actinFlow cytometryBlood cellsEnhanced green fluorescent protein (EGFP) reporterMiceOne-tissueAdult liverTissue sectionsIntestineLineage markersRabbit antibodies
2002
Primitive Neuroectodermal Tumors of the Pancreas
Movahedi-Lankarani S, Hruban R, Westra W, Klimstra D. Primitive Neuroectodermal Tumors of the Pancreas. The American Journal Of Surgical Pathology 2002, 26: 1040-1047. PMID: 12170091, DOI: 10.1097/00000478-200208000-00009.Peer-Reviewed Original ResearchConceptsPrimitive neuroectodermal tumorPatient diedNeuroectodermal tumorPatients died of postoperative complicationsPancreatic primitive neuroectodermal tumorNeoplastic cellsSmall round cell tumorHead of the pancreasDisease 4 yearsClinical follow-upPancreatic endocrine tumorsRound cell tumorAbdominal painNeuroendocrine differentiationPostoperative complicationsPrimary neoplasmsCell tumorsImmunohistochemical featuresEndocrine tumorsDifferential diagnosisExpressed cytokeratinEpithelial featuresFollow-upSolid organsTumor
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