2025
N-acetylcysteine (NAC) supplementation improves dyspnea and may normalize von Willebrand plasma levels in gynecologic patients with Post-Acute-COVID-Sequela (PASC)/Long COVID
Bellone S, Siegel E, Santin A. N-acetylcysteine (NAC) supplementation improves dyspnea and may normalize von Willebrand plasma levels in gynecologic patients with Post-Acute-COVID-Sequela (PASC)/Long COVID. Gynecologic Oncology Reports 2025, 57: 101682. PMID: 39944180, PMCID: PMC11814706, DOI: 10.1016/j.gore.2025.101682.Peer-Reviewed Original ResearchVon Willebrand factorN-acetylcysteinePost-acute sequelae of COVID-19Gynecologic patientsVWF levelsLevels of clotting factorsVon Willebrand factor levelsOral N-acetylcysteineProspective randomized studyShortness of breathGynecologic oncology clinicChronically elevated levelsLong COVIDCOVID-19 patientsN-acetylcysteine supplementationSequelae of COVID-19Microvascular inflammationSubjective improvementThrombotic complicationsRandomized studyRed blood cellsControl patientsPrecursor of glutathionePlasma levelsCancer patients
2022
Neurofeedback-guided kinesthetic motor imagery training in Parkinson’s disease: Randomized trial
Tinaz S, Kamel S, Aravala SS, Elfil M, Bayoumi A, Patel A, Scheinost D, Sinha R, Hampson M. Neurofeedback-guided kinesthetic motor imagery training in Parkinson’s disease: Randomized trial. NeuroImage Clinical 2022, 34: 102980. PMID: 35247729, PMCID: PMC8897714, DOI: 10.1016/j.nicl.2022.102980.Peer-Reviewed Original ResearchConceptsKinesthetic motor imageryMotor function scoresMild Parkinson's diseaseParkinson's diseaseFunctional connectivityFunction scoresMI trainingSecondary clinical outcomesClinical outcome measuresRandomized clinical trialsWhole-brain functional connectivityPost-training changeFunctional connectivity strengthMotor imageryMotor imagery trainingDorsomedial frontal cortexDistinct neural circuitsClinical outcomesImaging outcomesSubjective improvementClinical trialsMotor functionMotor examFrontal cortexOutcome measures
2020
Cannabidiol in treatment of refractory epileptic spasms: An open-label study
Herlopian A, Hess EJ, Barnett J, Geffrey AL, Pollack SF, Skirvin L, Bruno P, Sourbron J, Thiele EA. Cannabidiol in treatment of refractory epileptic spasms: An open-label study. Epilepsy & Behavior 2020, 106: 106988. PMID: 32169600, DOI: 10.1016/j.yebeh.2020.106988.Peer-Reviewed Original ResearchConceptsRefractory epileptic spasmsEpileptic spasmsResponder rateAdjunctive therapyCBD treatmentInvestigational new drug trialsOpen-label studyMonths of treatmentSafe adjunctive therapyNew drug trialsInstitutional review boardSubjective reportsBaseline medicationsCBD initiationElectrographic findingsHypsarrhythmia patternClinical responseSeizure frequencyAdverse eventsClinical efficacyElectrographic changesSubjective improvementTarget dosageDrug trialsInitial dosage
2014
Use of a Novel Visual Aid to Improve Estimation of Obstetric Blood Loss
Zuckerwise LC, Pettker CM, Illuzzi J, Raab CR, Lipkind HS. Use of a Novel Visual Aid to Improve Estimation of Obstetric Blood Loss. Obstetrics And Gynecology 2014, 123: 982-986. PMID: 24785850, DOI: 10.1097/aog.0000000000000233.Peer-Reviewed Original ResearchConceptsObstetric blood lossBlood lossObstetric providersProvider typeBlood volume estimationYears of experienceVolume of bloodMaternal morbidityObstetric bleedingSubjective improvementDelivery kitsClinical rolePocket cardBlood volumeExpedient identificationBloodInterventionVisual aidsArtificial bloodVisual estimationAccurate assessmentPosttest surveysSignificant improvementParticipantsYears
2011
One-year objective and functional outcomes of a randomized clinical trial of vaginal mesh for prolapse
Sokol AI, Iglesia CB, Kudish BI, Gutman RE, Shveiky D, Bercik R, Sokol ER. One-year objective and functional outcomes of a randomized clinical trial of vaginal mesh for prolapse. American Journal Of Obstetrics And Gynecology 2011, 206: 86.e1-86.e9. PMID: 21974992, DOI: 10.1016/j.ajog.2011.08.003.Peer-Reviewed Original ResearchConceptsVaginal prolapse repairQuality of lifeReoperation rateMesh exposureProlapse repairSimilar recurrence ratesHigher reoperation rateRandomized clinical trialsProlapse stageEvaluable participantsPrimary outcomeSecondary outcomesBulge symptomsVaginal repairRecurrence rateFunctional outcomeSubjective improvementClinical trialsMesh repairVaginal meshTraditional repairMonthsOutcomesWomenProlapse
2007
Septectomy and Septal Dermoplasty for the Treatment of Severe Transfusion-Dependent Epistaxis in Patients with Hereditary Hemorrhagic Telangiectasia and Septal Perforation
Lesnik GT, Ross DA, Henderson KJ, Joe JK, Leder SB, White RI. Septectomy and Septal Dermoplasty for the Treatment of Severe Transfusion-Dependent Epistaxis in Patients with Hereditary Hemorrhagic Telangiectasia and Septal Perforation. American Journal Of Rhinology And Allergy 2007, 21: 312-315. PMID: 17621815, DOI: 10.2500/ajr.2007.21.3017.Peer-Reviewed Original ResearchConceptsHereditary hemorrhagic telangiectasiaSeptal dermoplastySeptal perforationQuality of lifeTransfusion requirementsHHT patientsHemorrhagic telangiectasiaMainstay of treatmentCentral nervous systemAutosomal dominant disorderMonopolar cauterizationGraft uptakeCommon manifestationMucocutaneous tissuesSubjective improvementEffective treatmentEpistaxisVisceral organsPatientsSeptectomyNervous systemAbnormal angiogenesisPatient resultsTelangiectasia formationCombined procedure
1998
Effect of Pergolide on Restless Legs and Leg Movements in Sleep in Uremic Patients
Pieta J, Miliar T, Zacharias J, Fine A, Kryger M. Effect of Pergolide on Restless Legs and Leg Movements in Sleep in Uremic Patients. Sleep 1998, 21: 617-622. PMID: 9779521, DOI: 10.1093/sleep/21.6.617.Peer-Reviewed Original ResearchConceptsRestless legs syndromeLeg movementsRestless legsUremic patientsSubjective improvementTreatment of RLSDouble-blind placebo-controlled crossover studyPlacebo-controlled crossover studyRestless legs symptomsEffects of pergolideContinuous peritoneal dialysisPeriodic limb movementsSmall patient groupsHours of sleepQuality of sleepFirst hourChronic hemodialysisLeg symptomsCrossover studyLegs syndromePeritoneal dialysisIncremental dosesPatient groupSleep architectureSleep disruptionMidodrine is effective and safe therapy for intradialytic hypotension over 8 months of follow-up.
Cruz D, Mahnensmith R, Brickel H, Perazella M. Midodrine is effective and safe therapy for intradialytic hypotension over 8 months of follow-up. Clinical Nephrology 1998, 50: 101-7. PMID: 9725781.Peer-Reviewed Original ResearchConceptsSymptomatic intradialytic hypotensionIntradialytic hypotensionMidodrine therapyHD sessionSafe therapyEnd-stage renal disease patientsStage renal disease patientsAlpha-1 adrenergic agonistMean ultrafiltration volumeSignificant causative roleRenal disease patientsTreatment-related factorsPatient-specific factorsMost therapeutic interventionsKt/VHypotensive symptomsBlood pressureHemodialysis patientsHD patientsDisease patientsSubjective improvementAdverse reactionsFrustrating complicationMean albuminSafe treatment
1992
The importance of nasal resistance in obstructive sleep apnea syndrome.
Kerr P, Millar T, Buckle P, Kryger M. The importance of nasal resistance in obstructive sleep apnea syndrome. Journal Of Otolaryngology 1992, 21: 189-95. PMID: 1404570.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeUpper airway collapseSleep apnea syndromeNasal resistanceOSAS patientsApnea syndromeAirway collapseAmount of apneaArousals/hourChronic nasal obstructionNasal airflow resistanceBaseline data collectionNocturnal oxygenationOSAS populationTopical vasoconstrictorOSAS severityNasal obstructionClinical evidenceNocturnal polysomnographyPSG studiesSubjective improvementPosterior rhinomanometryElevated nasal resistanceConditions of baselineSleep architecture
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply