2024
Mapping extrachromosomal DNA amplifications during cancer progression
Kim H, Kim S, Wade T, Yeo E, Lipsa A, Golebiewska A, Johnson K, An S, Ko J, Nam Y, Lee H, Kang S, Chung H, Niclou S, Moon H, Paek S, Bafna V, Luebeck J, Verhaak R. Mapping extrachromosomal DNA amplifications during cancer progression. Nature Genetics 2024, 56: 2447-2454. PMID: 39402156, PMCID: PMC11549044, DOI: 10.1038/s41588-024-01949-7.Peer-Reviewed Original ResearchConceptsPretreatment tumorsCancer progressionChemotherapy-pretreated patientsNewly diagnosed tumorsVariant allele fractionUntreated metastasesPrimary cancerUntreated cancerTreatment responseFocal amplificationTumor samplesChromosomal amplificationsDiagnosed cancerTumorExtrachromosomal DNA amplificationsAdvanced cancerCancerEcDNATime pointsMetastasisNewlyDNA amplificationProgressionExtrachromosomal DNAPatients
2018
Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma
Pectasides E, Stachler M, Derks S, Liu Y, Maron S, Islam M, Alpert L, Kwak H, Kindler H, Polite B, Sharma M, Allen K, O'Day E, Lomnicki S, Maranto M, Kanteti R, Fitzpatrick C, Weber C, Setia N, Xiao S, Hart J, Nagy R, Kim K, Choi M, Min B, Nason K, O'Keefe L, Watanabe M, Baba H, Lanman R, Agoston A, Oh D, Dunford A, Thorner A, Ducar M, Wollison B, Coleman H, Ji Y, Posner M, Roggin K, Turaga K, Chang P, Hogarth K, Siddiqui U, Gelrud A, Ha G, Freeman S, Rhoades J, Reed S, Gydush G, Rotem D, Davison J, Imamura Y, Adalsteinsson V, Lee J, Bass A, Catenacci D. Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma. Cancer Discovery 2018, 8: cd-17-0395. PMID: 28978556, PMCID: PMC5894850, DOI: 10.1158/2159-8290.cd-17-0395.Peer-Reviewed Original ResearchConceptsCell-free DNAGastroesophageal adenocarcinomaPrimary tumorMetastatic lesionsMetastatic tumorsTargeted therapyGenomic alterationsGenomic biomarkersAnalysis of cell-free DNACell-free DNA profilingSynchronous metastatic lesionsGenomic profiling resultsTargetable genomic alterationsSelection of therapyClinically relevant alterationsGenomic heterogeneityPrecision medicineUntreated metastasesDisseminated diseaseMultiregional sequencingMetastatic tissuesTargetable alterationsBiomarker testingRelevant alterationsTissue profile
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