2023
Quantitative Risk for Single-Positive Lupus Anticoagulant Results With Different Anticoagulants
Khan W, Tormey C, Rinder H, Siddon A. Quantitative Risk for Single-Positive Lupus Anticoagulant Results With Different Anticoagulants. American Journal Of Clinical Pathology 2023, 159: 417-419. PMID: 36940149, DOI: 10.1093/ajcp/aqac183.Peer-Reviewed Original ResearchMeSH KeywordsAnticoagulantsAntiphospholipid SyndromeBlood Coagulation TestsHumansLupus Coagulation InhibitorPartial Thromboplastin TimePhospholipidsProthrombin TimeWarfarin
2022
Direct Oral Anticoagulants vs Vitamin K Antagonists in Patients With Antiphospholipid Syndromes Meta-Analysis of Randomized Trials
Khairani C, Bejjani A, Piazza G, Jimenez D, Monreal M, Chatterjee S, Pengo V, Woller S, Cortes-Hernandez J, Connors J, Kanthi Y, Krumholz H, Middeldorp S, Falanga A, Cushman M, Goldhaber S, Garcia D, Bikdeli B. Direct Oral Anticoagulants vs Vitamin K Antagonists in Patients With Antiphospholipid Syndromes Meta-Analysis of Randomized Trials. Journal Of The American College Of Cardiology 2022, 81: 16-30. PMID: 36328154, PMCID: PMC9812926, DOI: 10.1016/j.jacc.2022.10.008.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnticoagulantsAntiphospholipid SyndromeFibrinolytic AgentsHemorrhageHumansRandomized Controlled Trials as TopicThrombosisVenous ThromboembolismVitamin KConceptsDirect oral anticoagulantsVitamin K antagonistsVenous thromboembolic eventsArterial thrombotic eventsSubsequent venous thromboembolic eventsThrombotic antiphospholipid syndromeMajor bleedingThrombotic eventsK antagonistsOral anticoagulantsAntiphospholipid syndromeUse of DOACsMain efficacy outcomeMain safety outcomeCochrane Central RegisterAdequate allocation concealmentRandom-effects modelRandom sequence generationThromboembolic eventsCentral RegisterEfficacy outcomesArterial thrombosisControlled TrialsRandomized trialsAllocation concealmentCOVID-19 and antiphospholipid antibodies
Butt A, Erkan D, Lee A. COVID-19 and antiphospholipid antibodies. Best Practice & Research Clinical Haematology 2022, 35: 101402. PMID: 36494152, PMCID: PMC9568270, DOI: 10.1016/j.beha.2022.101402.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, AntiphospholipidAntiphospholipid SyndromeCOVID-19COVID-19 VaccinesHumansLupus Coagulation InhibitorConceptsAntiphospholipid antibodiesCOVID-19 patientsAntiphospholipid syndromeCOVID-19Antiphospholipid antibody productionCOVID-19 coagulopathyCOVID-19 shareMechanism of thrombogenesisCOVID-19 vaccinationNeutrophil extracellular trapsActivation of plateletsPathophysiologic featuresClinical outcomesExtracellular trapsSuch antibodiesAntibody productionComplement pathwayPatientsSyndromeAntibodiesConflicting resultsCoagulopathyImmunothrombosisHypercoagulabilityVaccination
2021
Concomitant factor VIII inhibitor and lupus anticoagulant in an asymptomatic patient
Jacobs JW, Gisriel SD, Iyer K, Rinder HM. Concomitant factor VIII inhibitor and lupus anticoagulant in an asymptomatic patient. Journal Of Thrombosis And Thrombolysis 2021, 53: 945-949. PMID: 34697688, PMCID: PMC8544916, DOI: 10.1007/s11239-021-02591-4.Peer-Reviewed Original ResearchMeSH KeywordsAntiphospholipid SyndromeAutoantibodiesFactor VIIIHemophilia AHemorrhageHumansLupus Coagulation InhibitorPartial Thromboplastin TimePhospholipidsThrombosisConceptsPartial thromboplastin timeLupus anticoagulantFVIII inhibitorsAsymptomatic patientsFactor VIIIComprehensive hematologic evaluationLife-threatening hemorrhageTypical laboratory findingsDistinctive clinical presentationFactor VIII inhibitorsRisk of thrombosisSigns of hemorrhageSevere bleeding diathesisCoagulation factor VIIIImmunosuppressive therapyClinical presentationClinical symptomsPathologic antibodiesVIII inhibitorsLaboratory findingsHematologic evaluationUnique presentationBleeding diathesisThromboplastin timeAutoantibodiesDevelopment of a New International Antiphospholipid Syndrome Classification Criteria Phase I/II Report: Generation and Reduction of Candidate Criteria
Barbhaiya M, Zuily S, Ahmadzadeh Y, Amigo M, Avcin T, Bertolaccini M, Branch D, Jesus G, Devreese K, Frances C, Garcia D, Guillemin F, Levine S, Levy R, Lockshin M, Ortel T, Seshan S, Tektonidou M, Wahl D, Willis R, Naden R, Costenbader K, Erkan D, Agmon‐Levin N, Aguilar C, Alba P, Alpan O, Ambrozic A, Amoura Z, Andrade D, Andrade L, Appenzeller S, Esen B, Atsumi T, Berkun Y, Cabral A, Canaud G, Cervera R, Chen P, Chighizola C, Cimaz R, Cohen H, Costedoat‐Chalumeau N, Crowther M, Cuadrado M, de Groot P, de Moerloose P, Derksen R, Diz‐Kucukkaya R, Dörner T, Fortin P, Giannakopoulos B, Gómez‐Puerta J, Gonzalez E, Inanc M, Kenet G, Khamashta M, Kriegel M, Krilis S, Laskin C, Massicotte P, McCarty G, Meroni P, Mikdashi J, Myones B, Pengo V, Petri M, Roubey R, Sammaritano L, Sanna G, Sciascia S, Signorelli F, Soybilgic A, Tincani A, Woller S, Yelnik C. Development of a New International Antiphospholipid Syndrome Classification Criteria Phase I/II Report: Generation and Reduction of Candidate Criteria. Arthritis Care & Research 2021, 73: 1490-1501. PMID: 33253499, PMCID: PMC8966711, DOI: 10.1002/acr.24520.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAntiphospholipid SyndromeConsensusDelphi TechniqueHumansPredictive Value of TestsRheumatologySeverity of Illness IndexConceptsAntiphospholipid syndromeAPS classificationPhase IAPS classification criteriaCandidate criteriaPhase IIClassification criteriaItem reduction techniquesAmerican CollegeNominal group techniqueDelphi exerciseMultidisciplinary initiativeLaboratory domainHigher likelihoodRheumatologyCase collectionSystematic literature reviewPhysician scientistsPresent studyEuropean AllianceAggregate scoreLiterature reviewConsensus-based approach
2020
The Application of ROTEM in a Parturient With Antiphospholipid Syndrome in the Setting of Anticoagulation for Cesarean Delivery: A Case Report.
Fiol AG, Fardelmann KL, McGuire PJ, Merriam AA, Miller A, Alian A. The Application of ROTEM in a Parturient With Antiphospholipid Syndrome in the Setting of Anticoagulation for Cesarean Delivery: A Case Report. A&A Practice 2020, 14: e01182. PMID: 32224689, DOI: 10.1213/xaa.0000000000001182.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAdultAntiphospholipid SyndromeCesarean SectionFemaleHELLP SyndromeHeparinHumansPartial Thromboplastin TimePlasmaPregnancyThrombelastographyConceptsAntiphospholipid syndromeHeparin neutralizationDiagnosis of hemolysisElevated liver enzymesSetting of anticoagulationFresh frozen plasmaPartial thromboplastin timeCesarean deliveryLow plateletsTransfusion managementCase reportFrozen plasmaLiver enzymesThromboplastin timeParturientsSyndromeIntrinsic pathwayAnticoagulationROTEMDiagnosisNeutralizationHeparin
2019
The color of skin: purple diseases of the skin, nails, and mucosa
Steuer AB, Cohen JM. The color of skin: purple diseases of the skin, nails, and mucosa. Clinics In Dermatology 2019, 37: 528-547. PMID: 31896408, DOI: 10.1016/j.clindermatol.2019.07.016.Peer-Reviewed Original ResearchMeSH KeywordsAnticoagulantsAntiphospholipid SyndromeCalciphylaxisChurg-Strauss SyndromeColorCryoglobulinemiaDiagnosis, DifferentialGranulomatosis with PolyangiitisHumansLevamisoleMicroscopic PolyangiitisNecrosisPolyarteritis NodosaPurpura FulminansPurpura, Thrombotic ThrombocytopenicSkinVasculitisWarfarinConceptsCutaneous vasculitisCutaneous small vessel vasculitisLevamisole-induced vasculopathyAntiphospholipid antibody syndromeSmall vessel vasculitisThrombotic thrombocytopenic purpuraAntibody syndromeEosinophilic granulomatosisPolyarteritis nodosumEcthyma gangrenosumMicroscopic polyangiitisSkin necrosisInfectious dermatosesLichen planusPurpura fulminansThrombocytopenic purpuraInflammatory dermatosesSystemic diseaseClinical appearanceKaposi's sarcomaVasculitisPolyangiitisGranulomatosisVasculopathyDermatosesPathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity
Ruff WE, Dehner C, Kim WJ, Pagovich O, Aguiar CL, Yu AT, Roth AS, Vieira SM, Kriegel C, Adeniyi O, Mulla MJ, Abrahams VM, Kwok WW, Nussinov R, Erkan D, Goodman AL, Kriegel MA. Pathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity. Cell Host & Microbe 2019, 26: 100-113.e8. PMID: 31227334, PMCID: PMC8194364, DOI: 10.1016/j.chom.2019.05.003.Peer-Reviewed Original ResearchConceptsAntiphospholipid syndromePathogenic monoclonal antibodyHuman autoimmune diseasesGut commensalsB-cell autoepitopesHuman gut commensalGPI IgGAPS patientsIgG titersOral gavageMemory TSusceptible miceAntigenic loadAutoimmune diseasesAutoimmune pathologyTrigger autoimmunityHuman autoimmunityGlycoprotein IGPI autoantibodiesAutoimmunityMonoclonal antibodiesCell clonesCross reactMimotopesAutoantibodies
2018
Role of NOD2 in antiphospholipid antibody-induced and bacterial MDP amplification of trophoblast inflammation
Mulla MJ, Pasternak MC, Salmon JE, Chamley LW, Abrahams VM. Role of NOD2 in antiphospholipid antibody-induced and bacterial MDP amplification of trophoblast inflammation. Journal Of Autoimmunity 2018, 98: 103-112. PMID: 30594350, DOI: 10.1016/j.jaut.2018.12.003.Peer-Reviewed Original ResearchConceptsMuramyl dipeptideAbsence of aPLAnti-angiogenic profileNovel danger signalPresence of aPLRole of NOD2IL-1β expressionMaternal-fetal interfaceActivation of NOD2IL-1β productionBacterial muramyl dipeptideAntiphospholipid antibodiesCommon bacterial componentsPregnancy complicationsPregnancy outcomesAdverse outcomesIL-1βTrophoblast responsesExtravillous trophoblastsHigh riskPreeclampsiaDanger signalsBacterial infectionsVEGF secretionInflammationBilateral central retinal artery occlusion from catastrophic antiphospholipid syndrome
Joshi U, Afroz S, Ranka S, Mba B. Bilateral central retinal artery occlusion from catastrophic antiphospholipid syndrome. BMJ Case Reports 2018, 2018: bcr-2018-226463. PMID: 30420561, PMCID: PMC6254375, DOI: 10.1136/bcr-2018-226463.Peer-Reviewed Original ResearchConceptsCentral retinal artery occlusionCatastrophic antiphospholipid syndromeRetinal artery occlusionAntiphospholipid syndromeArtery occlusionBilateral central retinal artery occlusionHigh-dose steroidsIntravenous pulse steroidsLeft eye visionRight fifth toeSudden painless lossEnd of treatmentLeft index fingerPainless lossPulse steroidsTherapeutic anticoagulationAcute onsetLupus flareStroke workupSystemic lupusBlurry visionRight eyeOcular massageBluish discolorationDay 5
2017
Association of psychosis with antiphospholipid antibody syndrome: A systematic review of clinical studies
Hallab A, Naveed S, Altibi A, Abdelkhalek M, Ngo H, Le T, Hirayama K, Huy N. Association of psychosis with antiphospholipid antibody syndrome: A systematic review of clinical studies. General Hospital Psychiatry 2017, 50: 137-147. PMID: 29241089, DOI: 10.1016/j.genhosppsych.2017.11.005.Peer-Reviewed Original ResearchConceptsAntiphospholipid antibody syndromeSystematic reviewPreferred Reporting ItemsAntibody syndromeManually searched referencesPresence of antiphospholipid antibody syndromeSystematic review of clinical studiesPsychotic symptomsResolution of psychotic symptomsReview of clinical studiesAPS-associated thrombosisAssociation of psychosisReporting ItemsPotential articlesArticle qualityRelevant articlesFemale sexPsychiatric symptomsFavorable prognosisClinical presentationPatient ageCase seriesClinical outcomesClinical manifestationsTreatment optionsLow molecular weight heparin and aspirin exacerbate human endometrial endothelial cell responses to antiphospholipid antibodies
Quao ZC, Tong M, Bryce E, Guller S, Chamley LW, Abrahams VM. Low molecular weight heparin and aspirin exacerbate human endometrial endothelial cell responses to antiphospholipid antibodies. American Journal Of Reproductive Immunology 2017, 79 PMID: 29135051, PMCID: PMC5728699, DOI: 10.1111/aji.12785.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, AntiphospholipidAntiphospholipid SyndromeAspirinbeta 2-Glycoprotein ICells, CulturedChemokinesDisease ProgressionDrug Therapy, CombinationEndometriumEndothelial CellsFemaleHeparin, Low-Molecular-WeightHumansMembrane ProteinsNeovascularization, PhysiologicPregnancyPregnancy ComplicationsTrophoblastsVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1ConceptsLow molecular weight heparinHuman endometrial endothelial cellsMolecular weight heparinUterine endotheliumAntiphospholipid antibodiesWeight heparinInfluence of LMWHLow dose low molecular weight heparinAnti-angiogenic sFlt-1Chemokine MCP-1Endometrial endothelial cellsEffects of aPLSFlt-1 releaseAngiogenic factor secretionObstetric APSPregnancy complicationsControl IgGChemokine profilesEndothelium dysfunctionChemokine secretionPro-angiogenic VEGFCombination therapySFlt-1Impaired placentationMCP-1Cyanosis of the foot.
Shi VJ, Leventhal JS, Mensah KA, Galan A, Choate KA. Cyanosis of the foot. Cutis 2017, 100: 206;209;210. PMID: 29136053.Peer-Reviewed Original Research
2016
Antiphospholipid antibody-induced miR-146a-3p drives trophoblast interleukin-8 secretion through activation of Toll-like receptor 8
Gysler SM, Mulla MJ, Guerra M, Brosens JJ, Salmon JE, Chamley LW, Abrahams VM. Antiphospholipid antibody-induced miR-146a-3p drives trophoblast interleukin-8 secretion through activation of Toll-like receptor 8. Molecular Human Reproduction 2016, 22: 465-474. PMID: 27029214, PMCID: PMC4941806, DOI: 10.1093/molehr/gaw027.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, AntiphospholipidAntiphospholipid SyndromeFemaleHumansInterleukin-8MicroRNAsPregnancyPregnancy Trimester, FirstToll-Like Receptor 4Toll-Like Receptor 8TrophoblastsConceptsToll-like receptor 4IL-8 secretionAdverse pregnancy outcomesTrophoblast-derived exosomesHealthy pregnant controlsMiR-146aTrophoblast cellsMiR-155MiR-210Pregnancy complicationsAntiphospholipid syndromePregnant controlsTLR4 antagonistHTR8 cellsHuman first-trimester extravillous trophoblast cell lineFirst trimester extravillous trophoblast cell lineRelated adverse pregnancy outcomesAbsence of aPLMiR expression levelsPanel of miRsObstetric antiphospholipid syndromeExtravillous trophoblast cell lineToll-like receptor 8Pro-inflammatory effectsAmerican Heart Association
2015
Antiphospholipid Antibody Syndrome
Rudich DS, Yun SH, Liebling A, Silbert JE, Moeckel GW, Lesser RL. Antiphospholipid Antibody Syndrome. Journal Of Neuro-Ophthalmology 2015, 35: 396-399. PMID: 26049680, DOI: 10.1097/wno.0000000000000277.Peer-Reviewed Original Research
2014
Diet, microbiota and autoimmune diseases
Vieira S, Pagovich O, Kriegel M. Diet, microbiota and autoimmune diseases. Lupus 2014, 23: 518-526. PMID: 24763536, PMCID: PMC4009622, DOI: 10.1177/0961203313501401.Peer-Reviewed Original ResearchConceptsAutoimmune diseasesGut microbial communityGerm-free mouse modelDevelopment of autoimmunityDiet-derived metabolitesType 1 diabetesSeverity of diseaseLife-prolonging effectAdaptive immune systemAntiphospholipid syndromeAutoimmune modelSystemic lupusMultiple sclerosisGastrointestinal tractMurine modelMouse modelRodent modelsImmunomodulatory potentialCommensal bacteriaImmune systemCaloric restrictionGut microbiomeDietary changesLupusGut commensals
2013
A Role for Uric Acid and the Nalp3 Inflammasome in Antiphospholipid Antibody-Induced IL-1β Production by Human First Trimester Trophoblast
Mulla MJ, Salmon JE, Chamley LW, Brosens JJ, Boeras CM, Kavathas PB, Abrahams VM. A Role for Uric Acid and the Nalp3 Inflammasome in Antiphospholipid Antibody-Induced IL-1β Production by Human First Trimester Trophoblast. PLOS ONE 2013, 8: e65237. PMID: 23762324, PMCID: PMC3675211, DOI: 10.1371/journal.pone.0065237.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntiphospholipidAntiphospholipid Syndromebeta 2-Glycoprotein ICARD Signaling Adaptor ProteinsCarrier ProteinsCaspase 1Cell LineCytoskeletal ProteinsFemaleGene Expression RegulationHumansInflammasomesInterleukin-1betaMiceNLR Family, Pyrin Domain-Containing 3 ProteinPregnancyPregnancy Trimester, FirstProtein PrecursorsSignal TransductionToll-Like Receptor 4TrophoblastsUric AcidConceptsIL-1β productionIntrauterine growth restrictionIL-1β secretionAntiphospholipid syndromeIL-1β processingAntiphospholipid antibodiesIL-1βHuman first trimester trophoblast cell lineFirst trimester trophoblast cell lineUric acidNalp3/ASC inflammasomeHuman first trimester trophoblast cellsToll-like receptor 4Human first-trimester trophoblastsFirst trimester trophoblast cellsAnti-β2GPI AbsAdverse pregnancy outcomesAnti-β2GPI antibodiesRecurrent pregnancy lossTLR4-dependent mannerApoptosis-associated speck-like proteinMaternal-fetal interfaceFirst trimester trophoblastsSpeck-like proteinTrophoblast cell line
2011
Hydroxychloroquine reduces binding of antiphospholipid antibodies to syncytiotrophoblasts and restores annexin A5 expression
Wu XX, Guller S, Rand JH. Hydroxychloroquine reduces binding of antiphospholipid antibodies to syncytiotrophoblasts and restores annexin A5 expression. American Journal Of Obstetrics And Gynecology 2011, 205: 576.e7-576.e14. PMID: 21871597, PMCID: PMC3224185, DOI: 10.1016/j.ajog.2011.06.064.Peer-Reviewed Original ResearchConceptsAntiphospholipid antibodiesHuman placental syncytiotrophoblastPlacental syncytiotrophoblastAnnexin A5 anticoagulant shieldA5 expressionEffect of hydroxychloroquineAnnexin A5 expressionFirst morphologic evidenceAntibody-mediated disruptionAntiphospholipid syndromeComputer-based morphometric analysisThrombogenic mechanismsBeWo trophoblastsImmune complexesNovel treatmentsHydroxychloroquineAntimalarial drugsImmunoglobulin G (IgG) bindingMorphologic evidenceSyncytiotrophoblastImmunoglobulin GsPrimary culturesAntibodiesAnnexin A5Laser confocal microscopy
2010
Anti-phospholipid antibody syndrome in the kidney
Nikiforow S, Moeckel G, Brewster UC. Anti-phospholipid antibody syndrome in the kidney. Kidney International 2010, 77: 473. PMID: 20150948, DOI: 10.1038/ki.2009.484.Peer-Reviewed Case Reports and Technical NotesAdultAnticoagulantsAntiphospholipid SyndromeAutoantibodiesBiopsyHumansKidneyMalePlasmapheresisSteroidsTreatment Outcome
2008
Thrombotic Microangiopathy and Renal Failure Exacerbated by ε-Aminocaproic Acid
Mutter WP, Stillman IE, Dahl NK. Thrombotic Microangiopathy and Renal Failure Exacerbated by ε-Aminocaproic Acid. American Journal Of Kidney Diseases 2008, 53: 346-350. PMID: 18805613, DOI: 10.1053/j.ajkd.2008.07.023.Peer-Reviewed Original Research
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