2025
Integrated control of leukocyte compartments as a feature of adaptive physiology
Jaschke N, Wang A. Integrated control of leukocyte compartments as a feature of adaptive physiology. Immunity 2025, 58: 279-294. PMID: 39909034, DOI: 10.1016/j.immuni.2025.01.013.Peer-Reviewed Original ResearchBiomechanics of soft biological tissues and organs, mechanobiology, homeostasis and modelling
Holzapfel G, Humphrey J, Ogden R. Biomechanics of soft biological tissues and organs, mechanobiology, homeostasis and modelling. Journal Of The Royal Society Interface 2025, 22: 20240361. PMID: 39876788, PMCID: PMC11775666, DOI: 10.1098/rsif.2024.0361.Peer-Reviewed Original ResearchConceptsSoft biological tissuesConstitutive relationsLoad-bearing soft tissuesNonlinear stress analysisMethods of continuum mechanicsInelastic constitutive relationsBiomechanics of soft biological tissueDiverse loading conditionsBiological tissuesConstitutive formulationLocal mechanical environmentMechanical behaviorStress analysisLoading conditionsContinuum mechanicsMechanical responseDiverse microstructuresMulti-axialMechanical environmentMechanobiologyTissue propertiesBiomechanical studiesClinical interventionsExperimental findingsMicrostructureSLC10A7 regulates O-GalNAc glycosylation and Ca2+ homeostasis in the secretory pathway: insights into SLC10A7-CDG
Durin Z, Layotte A, Morelle W, Houdou M, Folcher A, Legrand D, Lefeber D, Prevarskaya N, Von Blume J, Cormier-Daire V, Foulquier F. SLC10A7 regulates O-GalNAc glycosylation and Ca2+ homeostasis in the secretory pathway: insights into SLC10A7-CDG. Cellular And Molecular Life Sciences 2025, 82: 40. PMID: 39779512, PMCID: PMC11711720, DOI: 10.1007/s00018-024-05551-2.Peer-Reviewed Original ResearchConceptsCongenital disorders of glycosylationGlycan synthesisCa2+ homeostasisGolgi glycosylation defectsO-GalNAc glycosylationO-glycosylation defectRegulation of Ca2+ homeostasisGolgi transmembrane proteinCongenital disorders of glycosylation patientsDisorders of glycosylationGolgi homeostasisGolgi localizationGolgi compartmentSecretory pathwayHAP1 cellsProtein familyPatient fibroblastsGlycosylation defectsTransmembrane proteinsGalNAc residuesTransporter familyTight regulationGolgiGlycosylation abnormalitiesSLC10A7The other side of the incretin story: GIPR signaling in energy homeostasis
Nakandakari S, Fosam A, Perry R. The other side of the incretin story: GIPR signaling in energy homeostasis. Cell Metabolism 2025, 37: 1-3. PMID: 39778517, DOI: 10.1016/j.cmet.2024.12.003.Peer-Reviewed Original Research
2024
Suppression of neurons in circumventricular organs enables months-long survival without water in thirteen-lined ground squirrels
Junkins M, Feng N, Merriman D, Bagriantsev S, Gracheva E. Suppression of neurons in circumventricular organs enables months-long survival without water in thirteen-lined ground squirrels. Science 2024, 386: 1048-1055. PMID: 39607925, PMCID: PMC11853976, DOI: 10.1126/science.adp8358.Peer-Reviewed Original ResearchTranscription factor TCF1 binds to RORγt and orchestrates a regulatory network that determines homeostatic Th17 cell state
Mangani D, Subramanian A, Huang L, Cheng H, Krovi S, Wu Y, Yang D, Moreira T, Escobar G, Schnell A, Dixon K, Krishnan R, Singh V, Sobel R, Weiner H, Kuchroo V, Anderson A. Transcription factor TCF1 binds to RORγt and orchestrates a regulatory network that determines homeostatic Th17 cell state. Immunity 2024, 57: 2565-2582.e6. PMID: 39447575, PMCID: PMC11614491, DOI: 10.1016/j.immuni.2024.09.017.Peer-Reviewed Original ResearchConceptsCell statesRegulatory networksSpectrum of cell statesTh17 cellsTranscription factor TPro-inflammatory Th17 cellsHomeostatic tissue functionReceptor signalingMature T cellsAutoimmune tissue damageInterleukin (IL)-23Controlling tissue inflammationPro-inflammatory functionsPro-inflammatory cellsConditional deletionDevelopment of therapiesRestore homeostasisPro-inflammatory potentialTCF1T-helperT cellsRORgtTissue inflammationCellsInflammatory diseasesAstrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis
Ardanaz C, de la Cruz A, Minhas P, Hernández-Martín N, Pozo M, Valdecantos M, Valverde Á, Villa-Valverde P, Elizalde-Horcada M, Puerta E, Ramírez M, Ortega J, Urbiola A, Ederra C, Ariz M, Ortiz-de-Solórzano C, Fernández-Irigoyen J, Santamaría E, Karsenty G, Brüning J, Solas M. Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis. Science Advances 2024, 10: eadp1115. PMID: 39423276, PMCID: PMC11488540, DOI: 10.1126/sciadv.adp1115.Peer-Reviewed Original ResearchConceptsPeripheral glucose homeostasisBrain glucose metabolismGlucose metabolismAstrocytic glucose transporterGlucose homeostasisPeripheral glucose metabolismSystemic glucose metabolismATP releasePurinergic signalingBlood-borne glucoseBrain metabolismAstrocytesBrain energeticsInsulin signalingCognitive functionGlucose transportBrain functionMiceBrainGLUT1MetabolismHomeostasisObesityDendritic cells in a pinch: Migration during homeostasis.
Olson E, Eisenbarth S. Dendritic cells in a pinch: Migration during homeostasis. Science Immunology 2024, 9: eadt3806. PMID: 39365873, DOI: 10.1126/sciimmunol.adt3806.Peer-Reviewed Original ResearchConceptsDendritic cellsCellular stiffness sensing through talin 1 in tissue mechanical homeostasis
Chanduri M, Kumar A, Weiss D, Emuna N, Barsukov I, Shi M, Tanaka K, Wang X, Datye A, Kanyo J, Collin F, Lam T, Schwarz U, Bai S, Nottoli T, Goult B, Humphrey J, Schwartz M. Cellular stiffness sensing through talin 1 in tissue mechanical homeostasis. Science Advances 2024, 10: eadi6286. PMID: 39167642, PMCID: PMC11338229, DOI: 10.1126/sciadv.adi6286.Peer-Reviewed Original ResearchConceptsTissue mechanical homeostasisStiffness sensingExtracellular matrixTalin-1Mechanical homeostasisExtracellular matrix mechanicsIncreased cell spreadingCell spreadingTalinMutationsCellular sensingFibrillar collagenReduced axial stiffnessTissue mechanical propertiesMechanical propertiesAxial stiffnessCompliant substratesHomeostasisRupture pressureArp2/3ARPC5LStiffnessHomeostasis hypothesisResident cellsTissue stiffnessCommensal microbiome and gastrointestinal mucosal immunity: Harmony and conflict with our closest neighbor
Tian K, Jing D, Lan J, Lv M, Wang T. Commensal microbiome and gastrointestinal mucosal immunity: Harmony and conflict with our closest neighbor. Immunity Inflammation And Disease 2024, 12: e1316. PMID: 39023417, PMCID: PMC11256888, DOI: 10.1002/iid3.1316.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGastrointestinal MicrobiomeHomeostasisHumansImmunity, MucosalIntestinal MucosaSymbiosisConceptsMucosal immune networkMucosal immune systemImmune systemMaintenance of intestinal healthSite of pathogen invasionPresence of commensal microbiotaImmune responsePattern recognition receptorsGut mucosal immune systemAntigen-presenting cellsMucosal immune cellsGastrointestinal mucosal immunityGut-associated lymphoid tissuePathogen invasionCommensal microbiotaGut homeostasisMicrobial communitiesProtective immune responsesAdaptive immune responsesNon-self antigensCommensal bacteriaCommensal microbiomeIntestinal healthInflammatory bowel diseaseRecognition receptorsKLF2 enhancer variant rs4808485 increases lupus risk by modulating inflammasome machinery and cellular homoeostasis
Singh M, Rallabandi H, Zhou X, Qi Y, Zhao Z, Gan T, Zhang H, Looger L, Nath S. KLF2 enhancer variant rs4808485 increases lupus risk by modulating inflammasome machinery and cellular homoeostasis. Annals Of The Rheumatic Diseases 2024, 83: 1-10. PMID: 38373841, PMCID: PMC11168881, DOI: 10.1136/ard-2023-224953.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesEnhancer Elements, GeneticGenetic Predisposition to DiseaseGenome-Wide Association StudyHomeostasisHumansInflammasomesKruppel-Like Transcription FactorsLupus Erythematosus, SystemicLupus NephritisNLR Family, Pyrin Domain-Containing 3 ProteinPolymorphism, Single NucleotidePromoter Regions, GeneticQuantitative Trait LociConceptsCellular homoeostasisAllele-specific enhancer activityExpression quantitative trait loci analysisGenome-wide association studiesAsian-specific lociQuantitative trait loci analysisSystemic lupus erythematosusCell cycle progressionChromatin immunoprecipitation-qPCRInflammasome machineryPol IIRNA-seqActive chromatinAssociation studiesFunctional variant(sKnockout cellsEpigenetic editingFunctional variantsLocus analysisHealthy controlsWild typeGenome editingTarget gene(sLupus riskGene expressionSingle-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis
Wang H, Du Y, Huang S, Sun X, Ye Y, Sun H, Chu X, Shan X, Yuan Y, Shen L, Bi Y. Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis. Nature Communications 2024, 15: 4827. PMID: 38844451, PMCID: PMC11156882, DOI: 10.1038/s41467-024-48914-w.Peer-Reviewed Original ResearchConceptsAdipose progenitor cellsT2D patientsProgenitor cellsDiphtheria toxin A expressionHeterogeneous stromal cellsGlycemic disturbancesAdipose tissueInfluence of obesityGlucose homeostasisVisceral adipose tissueHuman visceral adipose tissueImpaired glucose homeostasisType 2 diabetesHunter-killer peptidesRegulating glucose homeostasisSingle-cell analysisAPC functionStromal cellsA expressionMetabolic homeostasisAdipocyte lipolysisT2D developmentPatientsT2DBioactive proteinsPopulation data evidence of interdependence of the limbs of hormonal feedback loops.
Fitzgerald S, Bean N, Falhammar H, Hoermann R, Korem Kohanim Y, Pohlabeln H, Grote Beverborg N, Tomassetti S. Population data evidence of interdependence of the limbs of hormonal feedback loops. Journal Of Endocrinology 2024, 262 PMID: 38727510, DOI: 10.1530/joe-23-0384.Peer-Reviewed Original ResearchRedefining intestinal stemness: The emergence of a new ISC population
Li M, Sumigray K. Redefining intestinal stemness: The emergence of a new ISC population. Cell 2024, 187: 2900-2902. PMID: 38848673, DOI: 10.1016/j.cell.2024.04.021.Peer-Reviewed Original ResearchTert-expressing cells contribute to salivary gland homeostasis and tissue regeneration after radiation therapy
Guan L, Viswanathan V, Jiang Y, Vijayakumar S, Cao H, Zhao J, Colburg D, Neuhöfer P, Zhang Y, Wang J, Xu Y, Laseinde E, Hildebrand R, Rahman M, Frock R, Kong C, Beachy P, Artandi S, Le Q. Tert-expressing cells contribute to salivary gland homeostasis and tissue regeneration after radiation therapy. Genes & Development 2024, 38: 569-582. PMID: 38997156, PMCID: PMC11293384, DOI: 10.1101/gad.351577.124.Peer-Reviewed Original ResearchConceptsSubmandibular glandSalivary gland homeostasisProgenitor cellsGland homeostasisResponse to radiotherapyAdult submandibular glandCell survivalSalivary gland regenerationSelf-renewal capacityEnhanced proliferative activityRadiation therapyDuctal regionsRadiotherapyModulate cell survivalTelomerase-expressingGland regenerationProliferative activityMouse strainsTERT expressionCreERT2 recombinaseSalivary gland biologyRadiation exposureTERT locusIn vitro cultureCell populationsDHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells
Ren X, Liu Q, Zhou P, Zhou T, Wang D, Mei Q, Flavell R, Liu Z, Li M, Pan W, Zhu S. DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells. Nature Communications 2024, 15: 3080. PMID: 38594251, PMCID: PMC11004185, DOI: 10.1038/s41467-024-47235-2.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseIntestinal stem cellsIntestinal epithelial cellsEpithelial homeostasisSusceptibility to experimental colitisIncreased susceptibility to experimental colitisImpaired ISC functionStem cellsEpithelial barrier dysfunctionGenomic instabilityInflammatory bowel disease patientsPathogenesis of inflammatory bowel diseaseR-loop-mediated genome instabilityHallmarks of inflammatory bowel diseaseContinuous self-renewalBarrier dysfunctionExperimental colitisCrypt destructionEpithelial cellsInflammatory responseSelf-renewalBowel diseaseRisk factorsIntestinal epitheliumProtein levelsA New Mitochondrial Uncoupler Improves Metabolic Homeostasis in Mice.
Ramshankar G, Perry R. A New Mitochondrial Uncoupler Improves Metabolic Homeostasis in Mice. Diabetes 2024, 73: 357-358. PMID: 38377448, DOI: 10.2337/dbi23-0033.Commentaries, Editorials and LettersMotion of VAPB molecules reveals ER–mitochondria contact site subdomains
Obara C, Nixon-Abell J, Moore A, Riccio F, Hoffman D, Shtengel G, Xu C, Schaefer K, Pasolli H, Masson J, Hess H, Calderon C, Blackstone C, Lippincott-Schwartz J. Motion of VAPB molecules reveals ER–mitochondria contact site subdomains. Nature 2024, 626: 169-176. PMID: 38267577, PMCID: PMC10830423, DOI: 10.1038/s41586-023-06956-y.Peer-Reviewed Original ResearchConceptsContact sitesExchange of signaling moleculesInterorganelle communicationOrganelle tetheringEukaryotic cellsSingle-molecule imagingCellular physiologyThree-dimensional electron microscopyMembrane curvatureSignaling moleculesExchange of moleculesDynamic subdomainsNanoscale organizationProtein BMetabolic needsSubdomainsCellsSitesMutationsMoleculesRemodelingSites1,2HomeostasisCommunication hubRegulationModulation of canonical Wnt signaling regulates peribiliary mesenchymal identity during homeostasis and injury
Singh S, Budiman T, Redmond D, Gupta V. Modulation of canonical Wnt signaling regulates peribiliary mesenchymal identity during homeostasis and injury. Hepatology Communications 2024, 8: e0368. PMID: 38251878, PMCID: PMC10805418, DOI: 10.1097/hc9.0000000000000368.Peer-Reviewed Original ResearchConceptsT-box transcription factorTranscription factorsMesenchymal gene expressionSignaling effectorsGene expressionGli transcription factorsGene transcription programUpregulation of TBX2Gain of functionSingle-cell sequencingExtrahepatic bile ductCellular identityTranscriptome analysisTranscriptional programsReceptor-ligand analysisMyofibroblast transdifferentiationIn vivo approachesB-cateninT-boxSignaling pathwayBile ductTbx3 expressionTbx3Primary sclerosing cholangitisBile duct ligation
2023
Autoregulation of the LIM kinases by their PDZ domain
Casanova-Sepúlveda G, Sexton J, Turk B, Boggon T. Autoregulation of the LIM kinases by their PDZ domain. Nature Communications 2023, 14: 8441. PMID: 38114480, PMCID: PMC10730565, DOI: 10.1038/s41467-023-44148-4.Peer-Reviewed Original Research
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