2025
The Role of Artificial Intelligence Combined With Digital Cholangioscopy for Indeterminant and Malignant Biliary Strictures: A Systematic Review and Meta-analysis.
McCarty T, Shah R, Allencherril R, Moon N, Njei B. The Role of Artificial Intelligence Combined With Digital Cholangioscopy for Indeterminant and Malignant Biliary Strictures: A Systematic Review and Meta-analysis. Journal Of Clinical Gastroenterology 2025 PMID: 39998988, DOI: 10.1097/mcg.0000000000002148.Peer-Reviewed Original ResearchConvolutional neural networkMalignant biliary stricturesAI-based systemsArtificial intelligence (AI)-based algorithmImage processing speedEndoscopic retrograde cholangiopancreatographyBiliary stricturesComputer visionPooled sensitivityNeural networkMachine learningDiagnostic performanceMeta-analysisIntelligent combinationIndeterminate biliary stricturesDiagnostic odds ratioImprove diagnostic yieldReceiver operating characteristic curveSystematic reviewOperating characteristics curveProcessing speedDiagnostic yieldRetrograde cholangiopancreatographyDiagnostic accuracyWorking group methodology
2024
PPAR agonists for the treatment of cholestatic liver diseases: Over a decade of clinical progress
Hayes C, Gallucci G, Boyer J, Assis D, Ghonem N. PPAR agonists for the treatment of cholestatic liver diseases: Over a decade of clinical progress. Hepatology Communications 2024, 9: e0612. PMID: 39699308, PMCID: PMC11661771, DOI: 10.1097/hc9.0000000000000612.Peer-Reviewed Original ResearchConceptsPeroxisome proliferator-activated receptor agonistsPrimary biliary cholangitisPrimary sclerosing cholangitisPeroxisome proliferator-activated receptorUnited States Food and Drug Administration approvalHepatic accumulation of bile acidsRisk of progression to cirrhosisFood and Drug Administration approvalPeroxisome proliferator-activator receptor agonismSecond-line therapyFirst-line therapySymptoms of cholestasisDrug Administration approvalTreatment of cholestatic liver diseasesCholestatic liver diseaseAccumulation of bile acidsProgression to cirrhosisTreatment of cholestasisSignificant clinical interestSmall bile ductsProliferator-activated receptorsBile acid metabolismIncomplete respondersBiliary cholangitisBiliary stricturesPathophysiology of Cystic Fibrosis Liver Disease
Kasper V, Assis D. Pathophysiology of Cystic Fibrosis Liver Disease. Pediatric Pulmonology 2024, 59: s98-s106. PMID: 39105342, DOI: 10.1002/ppul.26869.Peer-Reviewed Original ResearchConceptsComplication of cystic fibrosisCF liver diseaseHeterogeneity of clinical manifestationsManifestations of CFDisease-modifying factorsCFTR mutationsHepatobiliary complicationsBiliary stricturesBiliary cholestasisClinical manifestationsCystic fibrosisLiver diseaseTherapeutic approachesCF careDisease modelsDiseaseROLE OF ARTIFICAL INTELLIGENCE COMBINED WITH DIGITAL CHOLANGIOSCOPY FOR INDETERMINANT AND MALIGNANT BILIARY STRICTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS
McCarty T, Shah R, Moon N, Njei B. ROLE OF ARTIFICAL INTELLIGENCE COMBINED WITH DIGITAL CHOLANGIOSCOPY FOR INDETERMINANT AND MALIGNANT BILIARY STRICTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Gastrointestinal Endoscopy 2024, 99: ab39. DOI: 10.1016/j.gie.2024.04.709.Peer-Reviewed Original Research
2022
Research Priorities in Percutaneous Image- and Endoscopy-Guided Interventions for Biliary and Gallbladder Diseases: Proceedings from the Society of Interventional Radiology Foundation Multidisciplinary Research Consensus Panel
Riaz A, Trivedi P, Aadam AA, Katariya N, Matsuoka L, Malik A, Gunn AJ, Vezeridis A, Sarwar A, Schlachter T, Harmath C, Srinivasa R, Abi-Jaoudeh N, Singh H. Research Priorities in Percutaneous Image- and Endoscopy-Guided Interventions for Biliary and Gallbladder Diseases: Proceedings from the Society of Interventional Radiology Foundation Multidisciplinary Research Consensus Panel. Journal Of Vascular And Interventional Radiology 2022, 33: 1247-1257. PMID: 35809805, DOI: 10.1016/j.jvir.2022.06.025.Peer-Reviewed Original ResearchConceptsGallbladder diseaseInterventional radiologyPercutaneous imageConsensus panelAnastomotic biliary stricturesProspective research studyIntraductal cholangiocarcinomaNonsurgical patientsCalculous cholecystitisMultimodality managementPercutaneous drainBiliary stricturesPatients' qualityStent placementClinical relevanceResearch prioritiesDiseaseMultidisciplinary groupTotal durationPatientsManagement protocolCurrent dataUnanswered questionsCholecystitisCholedochoscopyNorth American Biliary Stricture Management Strategies in Children After Liver Transplantation: A Multicenter Analysis From the Society of Pediatric Liver Transplantation (SPLIT) Registry
Valentino PL, Wang T, Shabanova V, Ng VL, Bucuvalas JC, Feldman AG, Gonzalez‐Peralta R, Gupta NA, Miloh TA, Mohammad S, Pace E, Sundaram SS, Yazigi NA, Soltys K, Transplantation S. North American Biliary Stricture Management Strategies in Children After Liver Transplantation: A Multicenter Analysis From the Society of Pediatric Liver Transplantation (SPLIT) Registry. Liver Transplantation 2022, 28: 819-833. PMID: 34837468, PMCID: PMC10167704, DOI: 10.1002/lt.26379.Peer-Reviewed Original ResearchConceptsEndoscopic retrograde cholangiopancreatographyPercutaneous transhepatic cholangiographyPediatric Liver Transplantation (SPLIT) registryHepatic artery thrombosisLiver transplantationAnastomotic strictureBiliary stricturesStricture resolutionArtery thrombosisGraft survivalTransplantation RegistryPediatric liver transplantation recipientsLiver transplantation recipientsPediatric liver transplantationRisk of recurrenceAnalysis of outcomesAllograft salvageBiliary outcomesExtrahepatic stricturesGraft lossTransplantation recipientsMulticenter analysisTranshepatic cholangiographyRetrograde cholangiopancreatographyOperative reportsSignificance of KRAS mutation testing in biliary brushing cytology specimens: A 10‐year retrospective review
Sun T, Zuo T, Hui P, Cai G. Significance of KRAS mutation testing in biliary brushing cytology specimens: A 10‐year retrospective review. Cancer Cytopathology 2022, 130: 558-565. PMID: 35417072, DOI: 10.1002/cncy.22579.Peer-Reviewed Original ResearchConceptsExtrahepatic biliary stenosisKRAS mutation testingKRAS mutational analysisKRAS mutationsBiliary stenosisBiliary ductsInstitutional review board approvalResults of cytologyPancreatic duct adenocarcinomaBiliary brushing cytologyReview board approvalCytological diagnostic categoriesRetrospective reviewBiliary stricturesDuct adenocarcinomaAbsolute riskCytology examinationDuct brushingsBiliary brushingsBrushing cytologyMalignant conditionsCytological diagnosisBoard approvalClinical practiceCytology specimens
2021
Digital Cholangioscopic Interpretation: When North Meets the South
Kahaleh M, Raijman I, Gaidhane M, Tyberg A, Sethi A, Slivka A, Adler DG, Sejpal D, Shahid H, Sarkar A, Martins F, Boumitri C, Burton S, Bertani H, Tarnasky P, Gress F, Gan I, Ardengh JC, Kedia P, Arnelo U, Jamidar P, Shah RJ, Robles-Medranda C. Digital Cholangioscopic Interpretation: When North Meets the South. Digestive Diseases And Sciences 2021, 67: 1345-1351. PMID: 33783691, DOI: 10.1007/s10620-021-06961-z.Peer-Reviewed Original ResearchConceptsIndeterminate biliary stricturesOverall diagnostic accuracyPapillary projectionsPolypoid patternInflammatory patternVillous patternBiliary stricturesDiagnostic accuracyInterrater agreementSingle-operator cholangioscopyMucosal changesBiliary treeFinal diagnosisMucosal featuresMalignant lesionsBenign lesionsInterventional endoscopistsTortuous vesselsIntraclass correlation analysisLesionsStrictureSuperior visualizationPoor interrater agreementUlcerationClassification criteria
2018
Sa1331 UNILATERAL VERSUS BILATERAL METAL STENTS FOR INOPERABLE MALIGNANT HILAR BILIARY STRICTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS
Hammad T, Khan M, Abdel-Aziz Y, Imam M, Ketwaroo G, Pappas S. Sa1331 UNILATERAL VERSUS BILATERAL METAL STENTS FOR INOPERABLE MALIGNANT HILAR BILIARY STRICTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Gastrointestinal Endoscopy 2018, 87: ab216-ab217. DOI: 10.1016/j.gie.2018.04.1482.Peer-Reviewed Original Research
2015
Single-operator cholangioscopy and targeted biopsies in the diagnosis of indeterminate biliary strictures: a systematic review
Navaneethan U, Hasan MK, Lourdusamy V, Njei B, Varadarajulu S, Hawes RH. Single-operator cholangioscopy and targeted biopsies in the diagnosis of indeterminate biliary strictures: a systematic review. Gastrointestinal Endoscopy 2015, 82: 608-614.e2. PMID: 26071061, PMCID: PMC4826032, DOI: 10.1016/j.gie.2015.04.030.Peer-Reviewed Original ResearchConceptsMalignant biliary stricturesBiliary stricturesDiagnostic odds ratioIndeterminate biliary stricturesSpyBite biopsiesIntraductal biopsiesPeroral cholangioscopyPooled sensitivitySpyGlass cholangioscopySystematic reviewCholangioscopy-guided biopsyPrevious negative imagingRole of cholangioscopyDiagnosis of CCASingle-operator cholangioscopyTargeted biopsiesEmbase databasesBrush cytologyOdds ratioNegative imagingMAIN OUTCOMEBiopsyCholangioscopyStrictureStandard brushingProbe‐Based Confocal Laser Endomicroscopy for Indeterminate Biliary Strictures: Refinement of the Image Interpretation Classification
Kahaleh M, Giovannini M, Jamidar P, Gan SI, Cesaro P, Caillol F, Filoche B, Karia K, Smith I, Gaidhane M, Slivka A. Probe‐Based Confocal Laser Endomicroscopy for Indeterminate Biliary Strictures: Refinement of the Image Interpretation Classification. Gastroenterology Research And Practice 2015, 2015: 675210. PMID: 25866506, PMCID: PMC4377502, DOI: 10.1155/2015/675210.Peer-Reviewed Original Research
2014
Comparative effectiveness of biliary brush cytology and intraductal biopsy for detection of malignant biliary strictures: a systematic review and meta-analysis
Navaneethan U, Njei B, Lourdusamy V, Konjeti R, Vargo JJ, Parsi MA. Comparative effectiveness of biliary brush cytology and intraductal biopsy for detection of malignant biliary strictures: a systematic review and meta-analysis. Gastrointestinal Endoscopy 2014, 81: 168-176. PMID: 25440678, PMCID: PMC4824293, DOI: 10.1016/j.gie.2014.09.017.Peer-Reviewed Original ResearchConceptsMalignant biliary stricturesBiliary stricturesIntraductal biopsiesPooled diagnostic odds ratioDiagnostic odds ratioBrush cytologyOdds ratioComparative effectivenessMalignant-appearing biliary stricturesLow-quality studiesBiliary brush cytologyIndeterminate biliary stricturesReferral centerEmbase databasesEgger's testBiopsyStrictureSystematic reviewPublication biasAnalysis of tissuePooled sensitivityBegg-MazumdarCytologyDiagnostic correlationBrushingComparative Effectiveness of Biliary Brushings and Biopsies in the Diagnosis of Malignant Biliary Strictures: A Systematic Review and Meta-Analysis
Navaneethan U, Njei B, Lourdusamy V, Sanaka M. Comparative Effectiveness of Biliary Brushings and Biopsies in the Diagnosis of Malignant Biliary Strictures: A Systematic Review and Meta-Analysis. The American Journal Of Gastroenterology 2014, 109: s665. DOI: 10.14309/00000434-201410002-02283.Peer-Reviewed Original ResearchEndoscopic ultrasound in the diagnosis of cholangiocarcinoma as the etiology of biliary strictures: a systematic review and meta-analysis
Navaneethan U, Njei B, Venkatesh PG, Lourdusamy V, Sanaka MR. Endoscopic ultrasound in the diagnosis of cholangiocarcinoma as the etiology of biliary strictures: a systematic review and meta-analysis. Gastroenterology Report 2014, 3: 209-215. PMID: 25169922, PMCID: PMC4527262, DOI: 10.1093/gastro/gou057.Peer-Reviewed Original ResearchDiagnosis of cholangiocarcinomaBiliary stricturesEUS-FNAFine-needle aspirationEndoscopic ultrasoundPooled sensitivityEvaluation of cholangiocarcinomaNegative brush cytologyExtrahepatic biliary stricturesMain outcome measurementsCross-sectional imagingNegative likelihood ratioLikelihood ratioNegative cytologyExtrahepatic cholangiocarcinomaMass lesionEmbase databasesBrush cytologyNeedle aspirationCholangiocarcinomaOutcome measurementsPatientsStrictureSystematic reviewEtiologyIntraductal Radiofrequency Ablation for Management of Malignant Biliary Obstruction
Rustagi T, Jamidar PA. Intraductal Radiofrequency Ablation for Management of Malignant Biliary Obstruction. Digestive Diseases And Sciences 2014, 59: 2635-2641. PMID: 24906696, DOI: 10.1007/s10620-014-3237-9.Peer-Reviewed Original ResearchConceptsIntraductal radiofrequency ablationSelf-expandable metal stentsMalignant biliary obstructionRadiofrequency ablationBiliary obstructionEndoscopic ablative techniquesMalignant biliary stricturesTreatment of occlusionPalliative managementBiliary stricturesBile ductLocal tumorPercutaneous approachMalignant stricturesAblative techniquesTumor ingrowthMetal stentsStrictureCurrent standardObstructionOcclusionAblationPalliationPatencyDirect affectOC.20.2 IMPACT OF OPTICAL BIOPSY ON MANAGEMENT OF PATIENTS WITH BILIARY STRICTURES: INTERIM RESULTS OF A MULTICENTER STUDY
Cesaro P, Slivka A, Gan S, Giovannini M, Caillol F, Kahaleh M, Jamidar P, Costamagna G. OC.20.2 IMPACT OF OPTICAL BIOPSY ON MANAGEMENT OF PATIENTS WITH BILIARY STRICTURES: INTERIM RESULTS OF A MULTICENTER STUDY. Digestive And Liver Disease 2014, 46: s43. DOI: 10.1016/s1590-8658(14)60120-1.Peer-Reviewed Original Research
2013
761 Distinguishing Benign From Malignant Dominant Biliary Strictures in Patients With Primary Sclerosing Cholangitis Utilizing Probe-Based Confocal LASER Endomicroscopy (pCLE): a Multi-Center, Expert Consensus Review
Shah R, Chennat J, Cesaro P, Slivka A, Sejpal D, Jamidar P, Sethi A, Gan S, Walter M, Gaidhane M, Kahaleh M. 761 Distinguishing Benign From Malignant Dominant Biliary Strictures in Patients With Primary Sclerosing Cholangitis Utilizing Probe-Based Confocal LASER Endomicroscopy (pCLE): a Multi-Center, Expert Consensus Review. Gastrointestinal Endoscopy 2013, 77: ab164. DOI: 10.1016/j.gie.2013.04.110.Peer-Reviewed Original Research
2012
Endoscopic treatment of anastomotic biliary strictures after living donor liver transplantation: outcomes after maximal stent therapy
Hsieh TH, Mekeel KL, Crowell MD, Nguyen CC, Das A, Aqel BA, Carey EJ, Byrne TJ, Vargas HE, Douglas DD, Mulligan DC, Harrison ME. Endoscopic treatment of anastomotic biliary strictures after living donor liver transplantation: outcomes after maximal stent therapy. Gastrointestinal Endoscopy 2012, 77: 47-54. PMID: 23062758, DOI: 10.1016/j.gie.2012.08.034.Peer-Reviewed Original ResearchMeSH KeywordsAlanine TransaminaseAlkaline PhosphataseAspartate AminotransferasesBiliary Tract DiseasesBilirubinCholangiopancreatography, Endoscopic RetrogradeCholestasisEndoscopy, Digestive SystemFemaleFollow-Up StudiesHumansLiver TransplantationLiving DonorsMalePostoperative ComplicationsRecurrenceRetrospective StudiesStentsTreatment OutcomeConceptsLiving-donor liver transplantationAnastomotic biliary stricturesEndoscopic retrograde cholangiographyPercutaneous transhepatic cholangiographyBiliary stricturesEndoscopic therapyLiver transplantationEndoscopic treatmentRetrograde cholangiographySurgical revisionRetrospective studyTertiary care academic medical centerAggressive endoscopic approachStent placement strategyUnsuccessful endoscopic therapyDonor liver transplantationOptimal endoscopic treatmentAcademic medical centerDuct anastomosisInitial therapyBile leakageEndoscopic dilationBalloon dilationCommon complicationComplication rate
2011
Confocal Endomicroscopic Examination of Malignant Biliary Strictures and Histologic Correlation With Lymphatics
Loeser CS, Robert ME, Mennone A, Nathanson MH, Jamidar P. Confocal Endomicroscopic Examination of Malignant Biliary Strictures and Histologic Correlation With Lymphatics. Journal Of Clinical Gastroenterology 2011, 45: 246-252. PMID: 21063210, PMCID: PMC3572850, DOI: 10.1097/mcg.0b013e3181fbdc38.Peer-Reviewed Original ResearchConceptsRat bile ductBiliary stricturesMalignant biliary stricturesIndeterminate biliary stricturesBile ductConfocal laser endomicroscopyProbe-based confocal laser endomicroscopyReticular patternUnderwent endoscopic retrograde cholangiopancreatographyLaser endomicroscopyCommon bile ductEndoscopic retrograde cholangiopancreatographyPossible malignancyRetrograde cholangiopancreatographyBiliary treeBenign stricturesNormal patientsHistologic basisSpecial stainsStrictureConfocal endomicroscopyHistologic correlationImaging studiesHistologic structureStandard brushingEndoscopic Treatment of Anastomotic Biliary Strictures After Living Donor Liver Transplantation: Outcomes After Maximal Stent Therapy
Hsieh T, Harrison M, Crowell M, Mekeel K, Aqel B, Carey E, Byrne T, Vargas H, Douglas D, Rakela J, Reddy K, Moss A, Mulligan D. Endoscopic Treatment of Anastomotic Biliary Strictures After Living Donor Liver Transplantation: Outcomes After Maximal Stent Therapy. Clinical Gastroenterology And Hepatology 2011, 9: 184. DOI: 10.1016/j.cgh.2010.11.016.Peer-Reviewed Original Research
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