2024
Intrathecal lactate dehydrogenase A inhibitors FX11 and oxamate alleviate chronic constriction injury-induced nociceptive sensitization through neuroinflammation and angiogenesis
Cheng H, Chen N, Chen W, Wu Z, Sun Y, Teng W, Su F, Sung C, Wen Z. Intrathecal lactate dehydrogenase A inhibitors FX11 and oxamate alleviate chronic constriction injury-induced nociceptive sensitization through neuroinflammation and angiogenesis. The Journal Of Headache And Pain 2024, 25: 207. PMID: 39587478, PMCID: PMC11590346, DOI: 10.1186/s10194-024-01916-x.Peer-Reviewed Original ResearchConceptsLactate dehydrogenase ANeuropathic painNociceptive sensitizationLDHA inhibitorsTreat neuropathic painType of painUpregulation of glycolysisCCI-induced neuroinflammationCentral nervous systemBackgroundNeuropathic painNeuropathic ratsSpinal roleNociceptive behaviorBlood vessel growthImmunohistochemical analysisControl inflammationPainEffective treatmentConclusionIn conclusionHIF-1aCellular mechanismsNervous systemTherapeutic targetVessel growthWestern blottingSelective Use of CT Fractional Flow at a Large Academic Medical Center: Insights from Clinical Implementation after 1 Year of Practice.
Randhawa M, Takigami A, Thondapu V, Ranganath P, Zhang E, Parakh A, Goiffon R, Baliyan V, Foldyna B, Lu M, Tower-Rader A, Meyersohn N, Hedgire S, Ghoshhajra B. Selective Use of CT Fractional Flow at a Large Academic Medical Center: Insights from Clinical Implementation after 1 Year of Practice. Radiology Cardiothoracic Imaging 2024, 6: e230073. PMID: 38573127, PMCID: PMC11056747, DOI: 10.1148/ryct.230073.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersConstriction, PathologicFractional Flow Reserve, MyocardialHumansPercutaneous Coronary InterventionTomography, X-Ray ComputedConceptsRate of invasive coronary angiographyCoronary CTAInvasive coronary angiographyCoronary CT angiographyCT-FFR analysisPercutaneous coronary interventionHeart rate controlCT-FFRRetrospective observational studyFractional flow reserveCT angiographyDual-source coronary CT angiographyCT fractional flow reserveFlow reserveObservational studyCoronary bypass graftingEarly diastolic periodBeats per minuteCoronary angiographyPhysician's discretionChart reviewClinical outcomesBypass graftingCTA acquisitionAcademic medical centerEmergent Large Vessel Occlusion due to Intracranial Stenosis: Identification, Management, Challenges, and Future Directions
Al Kasab S, Nguyen T, Derdeyn C, Yaghi S, Amin-Hanjani S, Kicielinski K, Zaidat O, de Havenon A. Emergent Large Vessel Occlusion due to Intracranial Stenosis: Identification, Management, Challenges, and Future Directions. Stroke 2024, 55: 355-365. PMID: 38252763, DOI: 10.1161/strokeaha.123.043635.Peer-Reviewed Original ResearchConceptsIntracranial atherosclerotic stenosisVessel occlusionRecurrence riskEarly recurrence riskHigh-risk patientsAggressive medical managementRecurrent stroke riskEndovascular therapyHemodynamic failureTreatment strategiesPerfusion imagingAdvanced ageEndovascular interventionIntracranial stenosisMedical managementRisk factorsHigh riskAdvanced imagingAtherosclerotic stenosisStroke riskOcclusionStenosisPatientsRisk
2023
Differences between Lower Extremity Arterial Occlusion vs. Stenosis and Predictors of Successful Endovascular Interventions
Kokkinidis D, Schizas D, Pargaonkar S, Karamanis D, Mylonas K, Hasemaki N, Palaiodimos L, Varrias D, Tzavellas G, Siasos G, Klonaris C, Kharawala A, Chlorogiannis D, Georgopoulos S, Bakoyiannis C. Differences between Lower Extremity Arterial Occlusion vs. Stenosis and Predictors of Successful Endovascular Interventions. Medicina 2023, 59: 2029. PMID: 38004078, PMCID: PMC10673017, DOI: 10.3390/medicina59112029.Peer-Reviewed Original ResearchConceptsChronic total occlusionHistory of malignancyCTO groupRevascularization proceduresSuccessful revascularizationLower extremity chronic total occlusionChronic limb-threatening ischemiaEnd-stage renal diseaseSuccessful endovascular interventionUse of aspirinBaseline clinical variablesLimb-threatening ischemiaPeripheral artery diseaseNegative predictorHigh disease burdenInterventional characteristicsAngiographic characteristicsAspirin useCTO patientsEndovascular revascularizationPositive predictorArtery diseaseStenosis patientsRenal diseaseVascular centersClinical and Hemodynamic Outcomes of Balloon-Expandable Mitral Valve-in-Valve Positioning and Asymmetric Deployment The VIVID Registry
Simonato M, Whisenant B, Unbehaun A, Kempfert J, Ribeiro H, Kornowski R, Erlebach M, Bleiziffer S, Windecker S, Pilgrim T, Tomii D, Guerrero M, Ahmad Y, Forrest J, Montorfano M, Ancona M, Adam M, Wienemann H, Finkelstein A, Villablanca P, Codner P, Hildick-Smith D, Ferrari E, Petronio A, Shamekhi J, Presbitero P, Bruschi G, Rudolph T, Cerillo A, Attias D, Nejjari M, Abizaid A, Felippi de Sá Marchi M, Horlick E, Wijeysundera H, Andreas M, Thukkani A, Agrifoglio M, Iadanza A, Baer L, Nanna M, Dvir D. Clinical and Hemodynamic Outcomes of Balloon-Expandable Mitral Valve-in-Valve Positioning and Asymmetric Deployment The VIVID Registry. JACC Cardiovascular Interventions 2023, 16: 2615-2627. PMID: 37968032, DOI: 10.1016/j.jcin.2023.08.047.Peer-Reviewed Original ResearchConceptsLeft ventricular outflow tractLeft ventricular outflow tract obstructionAssociated with residual stenosisResidual stenosisDepth of implantationValve stenosisValve Academic Research Consortium definitionsAssociated with LVOT obstructionAcademic Research Consortium definitionsMitral valve-in-valveVentricular outflow tractMitral valve stenosisValve-in-valveCore lab evaluationLVOT obstructionOutflow tractHemodynamic outcomesSuboptimal hemodynamicsClinical endpointsSAPIEN 3Atrial implantsBalloon-expandableStenosisObstructionImplantationResults of an International Survey on Spinal Imaging by the ASNR/ASSR/ESNR/ESSR “Nomenclature 3.0” Working Group
D'Anna G, Shah L, Kranz P, Hirsch J, Khan M, Johnson M, Feydy A, Nathan J, Manfre L, Nguyen D, Sze G, Van Goethem J, Vanhoenacker F. Results of an International Survey on Spinal Imaging by the ASNR/ASSR/ESNR/ESSR “Nomenclature 3.0” Working Group. Seminars In Musculoskeletal Radiology 2023, 27: 561-565. PMID: 37816364, DOI: 10.1055/s-0043-1768247.Peer-Reviewed Original ResearchMeSH KeywordsConstriction, PathologicHumansIntervertebral Disc DegenerationLumbar VertebraeMagnetic Resonance ImagingSpinal StenosisSurveys and QuestionnairesUnited StatesConceptsStructured reporting templateForaminal stenosisEuropean SocietySpinal canal stenosisLumbar disc diseaseLumbar disc pathologyClinical information questionnaireAmerican SocietyCanal stenosisSpinal canalDisc diseaseDisc pathologySpinal imagingStenosisInformation questionnaireReporting templateE-mail-based surveyMusculoskeletal radiologyMost respondentsNeuroradiologySpine radiologyRadiologyWorking GroupInternational surveyOnline surveyLongitudinal Comparative Analysis of Complications and Subsequent Interventions Following Stand-Alone Interspinous Spacers, Open Decompression, or Fusion for Lumbar Stenosis
Whang P, Tran O, Rosner H. Longitudinal Comparative Analysis of Complications and Subsequent Interventions Following Stand-Alone Interspinous Spacers, Open Decompression, or Fusion for Lumbar Stenosis. Advances In Therapy 2023, 40: 3512-3524. PMID: 37289411, PMCID: PMC10329952, DOI: 10.1007/s12325-023-02562-6.Peer-Reviewed Original ResearchConceptsLong-term complicationsLumbar spinal stenosisLumbar spine surgeryFirst surgical interventionLife-threatening eventsSurgical interventionISD patientsSurgery cohortOpen decompressionOpen surgerySpine surgerySubsequent interventionsComplication-related costsOpen surgery cohortSubsequent surgical interventionInterspinous spacer devicesFusion cohortLSS patientsConservative therapyBaseline characteristicsPatient agePostoperative outcomesLumbar stenosisSpinal stenosisMedicare databaseAnastomotic Stricture After Minimally Invasive Esophagectomy
Feingold P, Bryan D, Kuckelman J, Kennedy-Shaffer L, Wang V, Deeb A, Wee J, Jaklitsch M, Marshall M. Anastomotic Stricture After Minimally Invasive Esophagectomy. The Annals Of Thoracic Surgery 2023, 116: 712-719. PMID: 37244601, DOI: 10.1016/j.athoracsur.2023.05.013.Peer-Reviewed Original ResearchConceptsMinimally invasive esophagectomyInvasive esophagectomyAnastomotic strictureMinimally invasive esophagectomy approachesUnivariate analysis of patientsSingle-institution retrospective reviewAssociated with strictureAnalysis of patientsProportion of patientsDay of surgeryPercentage of patientsAssociated with anastomotic strictureTumor histologyTumor stageAnastomotic dilatationInitial dilationSurgeon variablesUnivariate analysisMultivariate analysisPrimary outcomeEsophagectomyStricturePatientsRisk factorsImprove outcomesAdvances in Coronary Computed Tomographic Angiographic Imaging of Atherosclerosis for Risk Stratification and Preventive Care
Bienstock S, Lin F, Blankstein R, Leipsic J, Cardoso R, Ahmadi A, Gelijns A, Patel K, Baldassarre L, Hadley M, LaRocca G, Sanz J, Narula J, Chandrashekhar Y, Shaw L, Fuster V. Advances in Coronary Computed Tomographic Angiographic Imaging of Atherosclerosis for Risk Stratification and Preventive Care. JACC Cardiovascular Imaging 2023, 16: 1099-1115. PMID: 37178070, DOI: 10.1016/j.jcmg.2023.02.002.Peer-Reviewed Original ResearchConceptsCoronary Computed Tomography AngiographyCoronary artery diseaseAtherosclerotic plaquesArtery diseaseRisk stratificationPreventive carePlaque volumeHigh-risk plaque featuresNonobstructive coronary artery diseaseCoronary CTAMeasurements of atherosclerosisEffective risk stratificationHigh-risk patientsTotal plaque volumeComputed tomography angiographyPatient-specific factorsCoronary artery dimensionsIntravascular ultrasound measurementsHealth care systemCoronary dominanceCardiovascular preventionPatient subsetsPlaque featuresArtery sizeTomography angiographyHigh-Risk Characteristics for Clinical Failure after Isolated Femoropopliteal Peripheral Vascular Interventions
Kim T, Schneider P, Iannuzzi J, Ochoa Chaar C. High-Risk Characteristics for Clinical Failure after Isolated Femoropopliteal Peripheral Vascular Interventions. Annals Of Vascular Surgery 2023, 96: 253-260. PMID: 37088359, DOI: 10.1016/j.avsg.2023.04.010.Peer-Reviewed Original ResearchMeSH KeywordsAmputation, SurgicalConsensusConstriction, PathologicFemaleHumansMiddle AgedRisk FactorsTreatment OutcomeUnited StatesConceptsPaclitaxel-coated devicesPeripheral vascular interventionsClinical failureHigh riskRisk scoreRest painVascular interventionsMultivariable hierarchical logistic regressionRisk score developmentPrimary end pointHigh-risk patientsVascular Quality InitiativeLower extremity revascularizationTrans-Atlantic InterInsulin-dependent diabetesNovel risk scoreHigh-risk characteristicsLoss of patencyHierarchical logistic regressionMajor amputationLate mortalityMinor amputationExtremity revascularizationOcclusion lengthFemale sexRecurrence risk in symptomatic intracranial stenosis treated medically in the real world
Yaghi S, Shu L, Goldstein E, Chang A, Kala N, Stretz C, Burton T, Perelstein E, Furie K, Jayaraman M, Torabi R, Moldovan K, de Havenon A, Khatri P, Gebregziabher M, Liebeskind D, Prabhakaran S. Recurrence risk in symptomatic intracranial stenosis treated medically in the real world. Journal Of Stroke And Cerebrovascular Diseases 2023, 32: 107086. PMID: 37030126, DOI: 10.1016/j.jstrokecerebrovasdis.2023.107086.Peer-Reviewed Original ResearchMeSH KeywordsAgedCerebral InfarctionConstriction, PathologicDual Anti-Platelet TherapyFemaleHumansIntracranial ArteriosclerosisIschemic StrokeMaleRecurrenceRisk FactorsStrokeConceptsIntracranial atherosclerotic stenosisSymptomatic intracranial atherosclerotic stenosisClinical trialsRecurrence riskRecurrent strokeInclusion criteriaReal-world settingMaximal medical treatmentRecurrent stroke rateDual antiplatelet therapyAcute ischemic strokeReal-world cohortSymptomatic intracranial stenosisPharmacological treatment strategiesCox regression modelMeeting inclusion criteriaLow event ratesAntiplatelet therapyStroke RegistryIschemic eventsIschemic strokeWorld CohortHospitalized patientsEarly recurrenceIntracranial stenosisUtility of Hook Sign in the Diagnosis of Median Arcuate Ligament Syndrome
Chan S, Weininger G, Kozhimala M, Sumpio B, Levine L, Harris S, Zheng S, Ochoa Chaar C, Guzman R, Sumpio B. Utility of Hook Sign in the Diagnosis of Median Arcuate Ligament Syndrome. Annals Of Vascular Surgery 2023, 94: 165-171. PMID: 37023920, DOI: 10.1016/j.avsg.2023.03.018.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal PainCeliac ArteryConstriction, PathologicFemaleHumansMaleMedian Arcuate Ligament SyndromeRetrospective StudiesTreatment OutcomeConceptsMedian arcuate ligament syndromeBody mass indexCeliac artery compressionArcuate ligament syndromeCeliac arteryInstitutional review board-approved retrospective chart reviewDiagnosis of MALSElectronic medical record reviewMedian arcuate ligamentNonspecific abdominal painRetrospective chart reviewMedical record reviewTertiary academic centerSignificant predictorsHook signWilcoxon rank sum testRank sum testMALS patientsAbdominal painTomography angiography imagesArtery compressionChart reviewPatient demographicsArcuate ligamentRadiologic characteristicsReduced-order modeling and analysis of dynamic cerebral autoregulation via diffusion maps
dos Santos K, Katsidoniotaki M, Miller E, Petersen N, Marshall R, Kougioumtzoglou I. Reduced-order modeling and analysis of dynamic cerebral autoregulation via diffusion maps. Physiological Measurement 2023, 44: 044001. PMID: 36963111, PMCID: PMC11271258, DOI: 10.1088/1361-6579/acc780.Peer-Reviewed Original ResearchMeSH KeywordsArterial PressureCarotid StenosisConstriction, PathologicHomeostasisHumansReproducibility of ResultsConceptsDiffusion mapsState-space descriptionReduced-order modelingIntrinsic dynamicsTime derivativeLow-dimensional representationRandom walkMarkov matrixParsimonious modelingSignificant eigenvaluesEigenvalue ratioFurther dimension reductionEigenvalue analysisTransfer function analysisDimension reductionData-driven techniquesMain resultsDynamicsEigenvaluesFlow velocityModelingSuperior performanceMap techniqueGraphWalkProspective, randomized, multicenter clinical study comparing a self-expanding covered stent to percutaneous transluminal angioplasty for treatment of upper extremity hemodialysis arteriovenous fistula stenosis
Dolmatch B, Cabrera T, Pergola P, Balamuthusamy S, Makris A, Cooper R, Moore E, Licht J, Macaulay E, Maleux G, Pfammatter T, Settlage R, Cristea E, Lansky A, Investigators A, Dolmatch B, Goh G, Hawkins S, Macaulay E, Spark I, de Graff R, Deutschmann H, Kickuth R, Maleux G, Pfammatter T, Kirksey L, Mendes R, Aruny J, Ali V, Cabrera T, Pergola P, Sharma D, Moore E, Shah H, Dwyer A, Yee D, Teng W, Cooper R, Balamuthusamy S, Lipkowitz G, Saad T, Licht J, Makris A, Rogers T, Burgess J, Hoggard J. Prospective, randomized, multicenter clinical study comparing a self-expanding covered stent to percutaneous transluminal angioplasty for treatment of upper extremity hemodialysis arteriovenous fistula stenosis. Kidney International 2023, 104: 189-200. PMID: 36990214, DOI: 10.1016/j.kint.2023.03.015.Peer-Reviewed Original ResearchConceptsTarget lesion primary patencyAccess circuit primary patencyPercutaneous transluminal angioplastyTarget lesion reinterventionPrimary patencyTransluminal angioplastyArteriovenous fistulaAVF stenosisAdditional clinical outcomesCircuit primary patencyCovered stent groupLesion primary patencyMulticenter clinical studyHemodialysis arteriovenous fistula stenosisArteriovenous fistula stenosisHemodialysis patientsPrimary outcomeRandomized studyClinical outcomesAVF dysfunctionStent groupClinical studiesFistula stenosisSix monthsPatientsAssessing the safety of continued perioperative antithrombotic therapy in endoscopic airway surgery for laryngotracheal stenosis
Shah H, Reeder A, Rohrbaugh T, Kohli N. Assessing the safety of continued perioperative antithrombotic therapy in endoscopic airway surgery for laryngotracheal stenosis. American Journal Of Otolaryngology 2023, 44: 103857. PMID: 37030129, PMCID: PMC10033492, DOI: 10.1016/j.amjoto.2023.103857.Peer-Reviewed Original ResearchConceptsEndoscopic airway surgeryAntithrombotic therapyAirway surgeryPerioperative continuationLaryngotracheal stenosisEndoscopic surgeryOpen airway surgeryPerioperative antithrombotic therapyCases of patientsPerioperative cessationPreoperative continuationPostoperative bleedingProlonged intubationAntithrombotic usePrimary outcomeRetrospective studyTracheal stenosisSingle institutionProspective InvestigationInclusion criteriaSurgeryPatientsTherapyComplicationsStenosisPitfalls in Carotid Doppler Interpretation and How to Avoid Them
Gunabushanam G, Kent R, Scoutt L. Pitfalls in Carotid Doppler Interpretation and How to Avoid Them. Journal Of Ultrasound In Medicine 2023, 42: 1907-1921. PMID: 36896465, DOI: 10.1002/jum.16218.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsFunctional and Safety Outcomes of Carotid Artery Stenting and Mechanical Thrombectomy for Large Vessel Occlusion Ischemic Stroke With Tandem Lesions
Farooqui M, Zaidat O, Hassan A, Quispe-Orozco D, Petersen N, Divani A, Ribo M, Abraham M, Fifi J, Guerrero W, Malik A, Siegler J, Nguyen T, Sheth S, Yoo A, Linares G, Janjua N, Galecio-Castillo M, Tekle W, Ringheanu V, Oliver M, Dawod G, Kobsa J, Prasad A, Ikram A, Lin E, Below K, Zevallos C, Gadea M, Qureshi A, Dajles A, Matsoukas S, Rana A, Abdalkader M, Salazar-Marioni S, Soomro J, Gordon W, Vivanco-Suarez J, Turabova C, Mokin M, Yavagal D, Jumaa M, Ortega-Gutierrez S. Functional and Safety Outcomes of Carotid Artery Stenting and Mechanical Thrombectomy for Large Vessel Occlusion Ischemic Stroke With Tandem Lesions. JAMA Network Open 2023, 6: e230736. PMID: 36857054, PMCID: PMC9978940, DOI: 10.1001/jamanetworkopen.2023.0736.Peer-Reviewed Original ResearchConceptsSymptomatic intracranial hemorrhageCarotid artery stenting groupCarotid artery stentingLarge vessel occlusionNonstented groupDigital subtraction angiographyModified Rankin ScaleMechanical thrombectomyFunctional outcomesCross-sectional studyCervical lesionsSafety outcomesTandem lesionsMRS scoreSubtraction angiographyOdds of favorable functional outcomeIncreased risk of sICHArtery stentingAnterior circulation tandem lesionsDegree of cervical stenosisRisk of symptomatic intracranial hemorrhageOutcomes of carotid artery stentingCervical internal carotid arteryOdds of symptomatic intracranial hemorrhageInternal carotid artery stenosisKRAS mutational analysis: a new supplementary diagnostic tool for extrahepatic biliary stenosis
Sun T. KRAS mutational analysis: a new supplementary diagnostic tool for extrahepatic biliary stenosis. Future Oncology 2023, 19: 5-6. PMID: 36651534, DOI: 10.2217/fon-2022-0937.Peer-Reviewed Original ResearchSafety of Carotid Endarterectomy for Symptomatic Stenosis by Age: Meta-Analysis With Individual Patient Data
Leung Y, Bera K, Rodriguez D, Dardik A, Mas J, Simonte G, Rerkasem K, Howard D. Safety of Carotid Endarterectomy for Symptomatic Stenosis by Age: Meta-Analysis With Individual Patient Data. Stroke 2023, 54: 457-467. PMID: 36647921, PMCID: PMC9855737, DOI: 10.1161/strokeaha.122.040819.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCarotid StenosisConstriction, PathologicEndarterectomy, CarotidHumansMyocardial InfarctionProspective StudiesRisk FactorsStrokeTreatment OutcomeConceptsIndividual patient dataSymptomatic elderly patientsSymptomatic carotid stenosisCarotid endarterectomyPerioperative strokeElderly patientsStroke riskMedical therapyCarotid stenosisMyocardial infarctionPatient dataStroke risk increasesRecurrent stroke riskSymptomatic stenosisInterventional armPerioperative deathsPerioperative riskAdverse eventsProspective cohortSymptomatic patientsRandomized trialsOutcome ratesObservational studyOctogenariansEndarterectomy
2022
Artificial intelligence–assisted cholangioscopy for automatic detection of malignant biliary strictures
Njei B, McCarty T, Navaneethan U. Artificial intelligence–assisted cholangioscopy for automatic detection of malignant biliary strictures. Gastrointestinal Endoscopy 2022, 96: 1092-1093. PMID: 36404092, DOI: 10.1016/j.gie.2022.07.005.Peer-Reviewed Original ResearchMeSH KeywordsArtificial IntelligenceBiliary Tract Surgical ProceduresCholestasisConstriction, PathologicGallbladderHumans
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