2025
Cancer Mortality
Hjartåker A, Weiderpass E, Bray F. Cancer Mortality. 2025, 171-182. DOI: 10.1016/b978-0-323-99967-0.00162-9.Peer-Reviewed Original ResearchCancer mortality burdenMortality burdenCancer mortality trendsGlobal cancer controlCancer deathCancer mortality dataHigher-income settingsProportion of deathsMortality trendsMortality dataCause of cancer deathCancer controlColorectal cancerMiddle-income economiesMeasure of progressLiver cancerCancer formsMortality rateColorectalBurdenData sourcesWorld regionsCancerDeathFrequent cause
2023
Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and anti-tumor immunity through eNOS/Src
Sjöberg E, Melssen M, Richards M, Ding Y, Chanoca C, Chen D, Nwadozi E, Pal S, Love D, Ninchoji T, Shibuya M, Simons M, Dimberg A, Claesson-Welsh L. Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and anti-tumor immunity through eNOS/Src. Journal Of Clinical Investigation 2023, 133: e161366. PMID: 37651195, PMCID: PMC10575733, DOI: 10.1172/jci161366.Peer-Reviewed Original ResearchConceptsEndothelial nitric oxide synthaseRenal cell carcinomaAnti-tumor immunityVascular leakageT cellsEndothelial barrierClear cell renal cell carcinomaCell renal cell carcinomaRegulatory T cellsHelper T cellsNitric oxide synthaseImmune cell activationAntitumor immunityImmunosuppressive cytokinesPoor prognosisCell carcinomaPLCγ pathwayOxide synthaseVascular permeabilityB cellsActivation of PLCγCell activationTumor vesselsDecreased expressionCancer forms
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