2025
Psychosocial Burden and Suicidality in Epilepsy: A Public Health Concern.
Kiriakopoulos E, Chu F, Salpekar J, Baslet G, Ghearing G, Altalib H, Sajatovic M. Psychosocial Burden and Suicidality in Epilepsy: A Public Health Concern. Epilepsy Currents 2025, 15357597251318577. PMID: 40028187, PMCID: PMC11869224, DOI: 10.1177/15357597251318577.Peer-Reviewed Original ResearchPsychosocial burdenSelf-harmPublic health concernEvidence-based suicide prevention strategiesHealth concernSuicide prevention strategiesSocial stressorsHigh riskGlobal public health concernMultidisciplinary cliniciansSuicide preventionPrevention strategiesGeneral populationAdjunctive supportSuicide riskIncreased riskIdentification of patientsEarly identificationSuicideBurdenRiskFunctional seizuresPeoplePatient subpopulationsPsychosocialEnvironMental Health: A Framework for an Emerging Field at the Intersection of the Environment and Mental Health Crises
Ratjen L, Goddard E, Gilcher E, Nguyen B, Kelley M, Feldman H, Akalaonu K, Nyhan K, Backhaus A, Lascurain M, Wyrtzen N, Smith S, Prabhu M, Lowe S, Chen K, Zimmerman J, Anastas P. EnvironMental Health: A Framework for an Emerging Field at the Intersection of the Environment and Mental Health Crises. GeoHealth 2025, 9: e2024gh001254. PMID: 39958831, PMCID: PMC11826329, DOI: 10.1029/2024gh001254.Peer-Reviewed Original ResearchCognitive healthReview of reviewsMental health conditionsMental health crisisAttention-deficit/hyperactivity disorderBehavioral healthMental healthHealth conditionsHealthPublic healthEconomic burdenWell-beingNeuropsychological healthHealth crisisSocial factorsContextual needsAttention-deficit/hyperactivityEnvironmental factorsGreen spacesHealthcareDementiaFunding strategiesConceptual frameworkFundingBurdenA framework for managing infectious diseases in rural areas in low- and middle-income countries in the face of climate change—East Africa as a case study
Worsley-Tonks K, Angwenyi S, Carlson C, Cissé G, Deem S, Ferguson A, Fèvre E, Kimaro E, Kimiti D, Martins D, Merbold L, Mottet A, Murray S, Muturi M, Potter T, Prasad S, Wild H, Hassell J. A framework for managing infectious diseases in rural areas in low- and middle-income countries in the face of climate change—East Africa as a case study. PLOS Global Public Health 2025, 5: e0003892. PMID: 39883787, PMCID: PMC11781624, DOI: 10.1371/journal.pgph.0003892.Peer-Reviewed Original ResearchMiddle-income countriesHealth systemDisease riskClimate changeRural areasExposure to climate-related hazardsInfectious disease riskClimate change adaptation strategiesBurden of infectious diseasesChange adaptation strategiesClimate change impactsContext of climate changeClimate-related hazardsDisease burdenHealthRural communitiesChange impactsHuman healthSystems climateAdaptation strategiesClimateInfectious diseasesBurdenDisease scenariosRiskAssociation between psychological flexibility and self-perceived burden in patients with cervical cancer: A computer-simulated network analysis
Chen F, Xiong Y, Li S, Deng Y, Zhang Q, Xiao Z, Knobf M, Ye Z. Association between psychological flexibility and self-perceived burden in patients with cervical cancer: A computer-simulated network analysis. European Journal Of Oncology Nursing 2025, 74: 102822. PMID: 39893708, DOI: 10.1016/j.ejon.2025.102822.Peer-Reviewed Original ResearchBehavioral Medicine Can Tackle Cardiovascular Disease Risk and Burden: A Call for New Priorities
Burg M, Stewart J, Gaffey A, Särnholm J, Vela A, Kovacs R. Behavioral Medicine Can Tackle Cardiovascular Disease Risk and Burden: A Call for New Priorities. Policy Insights From The Behavioral And Brain Sciences 2025 DOI: 10.1177/23727322241306071.Peer-Reviewed Original ResearchCardiovascular disease riskCardiovascular diseaseHealth-related quality of lifeCosts of cardiovascular diseaseBehavioral medicineHealth-related qualityQuality of lifeCardiovascular behavioral medicinePsychosocial healthPsychosocial factorsCV careProfessional groupsDisease riskModify behaviorAnnual costRiskMedicineCareHealthcareHealthTreatment of cardiovascular diseasesTacklesBurdenPreventionTrainingCancer Mortality
Hjartåker A, Weiderpass E, Bray F. Cancer Mortality. 2025, 171-182. DOI: 10.1016/b978-0-323-99967-0.00162-9.Peer-Reviewed Original ResearchCancer mortality burdenMortality burdenCancer mortality trendsGlobal cancer controlCancer deathCancer mortality dataHigher-income settingsProportion of deathsMortality trendsMortality dataCause of cancer deathCancer controlColorectal cancerMiddle-income economiesMeasure of progressLiver cancerCancer formsMortality rateColorectalBurdenData sourcesWorld regionsCancerDeathFrequent cause
2024
Defining Documentation Burden (DocBurden) and Excessive DocBurden for All Health Professionals: A Scoping Review
Levy D, Withall J, Mishuris R, Tiase V, Diamond C, Douthit B, Grabowska M, Lee R, Moy A, Sengstack P, Adler-Milstein J, Detmer D, Johnson K, Cimino J, Corley S, Murphy J, Rosenbloom S, Cato K, Rossetti S. Defining Documentation Burden (DocBurden) and Excessive DocBurden for All Health Professionals: A Scoping Review. Applied Clinical Informatics 2024, 15: 898-913. PMID: 39137903, PMCID: PMC11524753, DOI: 10.1055/a-2385-1654.Peer-Reviewed Original ResearchHealth professionalsDocumentation burdenScoping reviewHealthcare teams' experiencesMeta-Analyses ExtensionReducing documentation burdenGrey literature sourcesPreferred Reporting ItemsClinician wellnessCare deliveryPatient safetyPatient careReporting ItemsSystematic reviewNational initiativesMeta-analysesHeavy workDocumentation systemPeer reviewCareTeam experienceHealthProfessionalsBurdenLiterature sourcesAn Opportunity for Developing Cancer Prevention Leadership in Mexico
ML V, N R, JA T, M P, D C, JE B, MA J, M A, A M, S A, S O, O A, LA H, E H, S C. An Opportunity for Developing Cancer Prevention Leadership in Mexico. Journal Of Cancer Education 2024, 1-7. PMID: 39446268, DOI: 10.1007/s13187-024-02525-7.Peer-Reviewed Original ResearchCancer preventionCancer prevention effortsCancer prevention curriculumEducation programsPrevention education programAdult learning techniquesProfessional education programsOncology professionalsPrevention effortsPrevention curriculumControl trainingTraining instructorsProfessionalsPublic burdenPreventionCareer opportunitiesCancerFavorable ratingsTrainingVideo conferencing toolsProgramCurriculumSmall groupOncologyBurdenBurden of non-communicable diseases due to population ageing in China: challenges to healthcare delivery and long term care services
Lv Y, Fan L, Zhou J, Ding E, Shen J, Tang S, He Y, Shi X. Burden of non-communicable diseases due to population ageing in China: challenges to healthcare delivery and long term care services. The BMJ 2024, 387: e076529. PMID: 39424307, PMCID: PMC11484826, DOI: 10.1136/bmj-2023-076529.Peer-Reviewed Original ResearchWHO global research priorities for antimicrobial resistance in human health
Bertagnolio S, Dobreva Z, Centner C, Olaru I, Donà D, Burzo S, Huttner B, Chaillon A, Gebreselassie N, Wi T, Hasso-Agopsowicz M, Allegranzi B, Sati H, Ivanovska V, Kothari K, Balkhy H, Cassini A, Hamers R, Van Weezenbeek K, Collaborators W, Aanensen D, Alanio A, Alastruey-Izquierdo A, Alemayehu T, Al-Hasan M, Allegaert K, Al-Maani A, Al-Salman J, Alshukairi A, Amir A, Applegate T, Araj G, Villalobos M, Årdal C, Ashiru-Oredope D, Ashley E, Babin F, Bachmann L, Bachmann T, Baker K, Balasegaram M, Bamford C, Baquero F, Barcelona L, Bassat Q, Bassetti M, Basu S, Beardsley J, Vásquez G, Berkley J, Bhatnagar A, Bielicki J, Bines J, Bongomin F, Bonomo R, Bradley J, Bradshaw C, Brett A, Brink A, Brown C, Brown J, Buising K, Carson C, Carvalho A, Castagnola E, Cavaleri M, Cecchini M, Chabala C, Chaisson R, Chakrabarti A, Chandler C, Chandy S, Charani E, Chen L, Chiara F, Chowdhary A, Chua A, Chuki P, Chun D, Churchyard G, Cirillo D, Clack L, Coffin S, Cohn J, Cole M, Conly J, Cooper B, Corso A, Cosgrove S, Cox H, Daley C, Darboe S, Darton T, Davies G, de Egea V, Dedeić-Ljubović A, Deeves M, Denkinger C, Dillon J, Dramowski A, Eley B, Esposito S, Essack S, Farida H, Farooqi J, Feasey N, Ferreyra C, Fifer H, Finlayson H, Frick M, Gales A, Galli L, Gandra S, Gerber J, Giske C, Gordon B, Govender N, Guessennd N, Guindo I, Gurbanova E, Gwee A, Hagen F, Harbarth S, Haze J, Heim J, Hendriksen R, Heyderman R, Holt K, Hönigl M, Hook E, Hope W, Hopkins H, Hughes G, Ismail G, Issack M, Jacobs J, Jasovský D, Jehan F, Pearson A, Jones M, Joshi M, Kapil A, Kariuki S, Karkey A, Kearns G, Keddy K, Khanna N, Kitamura A, Kolho K, Kontoyiannis D, Kotwani A, Kozlov R, Kranzer K, Kularatne R, Lahra M, Langford B, Laniado-Laborin R, Larsson J, Lass-Flörl C, Le Doare K, Lee H, Lessa F, Levin A, Limmathurotsakul D, Lincopan N, Vecchio A, Lodha R, Loeb M, Longtin Y, Lye D, Mahmud A, Manaia C, Manderson L, Mareković I, Marimuthu K, Martin I, Mashe T, Mei Z, Meis J, De Melo F, Mendelson M, Miranda A, Moore D, Morel C, Moremi N, Moro M, Moussy F, Mshana S, Mueller A, Ndow F, Nicol M, Nunn A, Obaro S, Obiero C, Okeke I, Okomo U, Okwor T, Oladele R, Omulo S, Ondoa P, de Canese J, Ostrosky-Zeichner L, Padoveze M, Pai M, Park B, Parkhill J, Parry C, Peeling R, Peixe L, Perovic O, Pettigrew M, Principi N, Pulcini C, Puspandari N, Rawson T, Reddy D, Reddy K, Redner P, Tudela J, Rodríguez-Baño J, Van Katwyk S, Roilides E, Rollier C, Rollock L, Ronat J, Ruppe E, Sadarangani M, Salisbury D, Salou M, Samison L, Sanguinetti M, Sartelli M, Schellack N, Schouten J, Schwaber M, Seni J, Senok A, Shafer W, Shakoor S, Sheppard D, Shin J, Sia S, Sievert D, Singh I, Singla R, Skov R, Soge O, Sprute R, Srinivasan A, Srinivasan S, Sundsfjord A, Tacconelli E, Tahseen S, Tangcharoensathien V, Tängdén T, Thursky K, Thwaites G, de Souza Peral R, Tong D, Tootla H, Tsioutis C, Turner K, Turner P, Omar S, van de Sande W, van den Hof S, van Doorn R, Veeraraghavan B, Verweij P, Wahyuningsih R, Wang H, Warris A, Weinstock H, Wesangula E, Whiley D, White P, Williams P, Xiao Y, Moscoso M, Yang H, Yoshida S, Yu Y, Żabicka D, Zignol M, Rudan I. WHO global research priorities for antimicrobial resistance in human health. The Lancet Microbe 2024, 5: 100902. PMID: 39146948, PMCID: PMC11543637, DOI: 10.1016/s2666-5247(24)00134-4.Peer-Reviewed Original ResearchAntimicrobial resistanceTreatment of antimicrobial-resistant infectionsConsequences of antimicrobial resistanceAntimicrobial resistance epidemiologyAntimicrobial-resistant infectionsDrug-resistant pathogensAntimicrobial resistance dynamicsResearch prioritiesComprehensive scoping reviewGeneration of evidenceGlobal research prioritiesScoping reviewWHOKnowledge gapsExpert inputResearch agendaHealthBurdenPathogensFungal pathogensPolicy translationTuberculosisDiagnosisInfectionPatient Perspectives on Social and Identity Factors Affecting Multiple Myeloma Care: Barriers and Opportunities
Neparidze N, Godara A, Lin D, Le H, Fixler K, Shea L, Everson S, Brittle C, Brunisholz K. Patient Perspectives on Social and Identity Factors Affecting Multiple Myeloma Care: Barriers and Opportunities. Healthcare 2024, 12: 1587. PMID: 39201146, PMCID: PMC11354118, DOI: 10.3390/healthcare12161587.Peer-Reviewed Original ResearchDisease journeyHealth care providersImprove patient supportCare providersPatient prioritiesPatient advocatesPatient perspectiveMedical appointmentsMultiple myelomaPatient supportMultiple barriersInformed treatment decisionsPrioritized needsMultidisciplinary teamTreatment adherenceDisease burdenFocus group researchComprehensive supportImprove outcomesSocial workersTreatment decisionsInsurance optionsMixing methodBurdenSupportA Crisis in Scope: Recruitment and Retention Challenges Reported by VA Gastroenterology Section Chiefs.
von Rosenvinge E, Vela S, Paine E, Chang M, Hanson B, Taddei T, Smalley W, Dunbar K, Khan N, Kahng L, Anwar J, Zing R, Gawron A, Dominitz J, Baffy G. A Crisis in Scope: Recruitment and Retention Challenges Reported by VA Gastroenterology Section Chiefs. Federal Practitioner 2024, 41: 256-260. PMID: 39410921, PMCID: PMC11473028, DOI: 10.12788/fp.0504.Peer-Reviewed Original ResearchBarriers to recruitmentHuman resource challengesVeterans AffairsUS Department of Veterans AffairsDepartment of Veterans AffairsAdministrative burdenBarriers to retentionHealth of veteransVA Medical CenterSection chiefsLow salariesResource challengesRetention challengesMedical specialtiesSupport staffReducing administrative burdensMedical CenterStaffing supportUS DepartmentBurdenDigestive healthCurrent vacanciesSecond-mostRecruitmentSalaryAssociations of Plasma Tau with Amyloid and Tau PET: Results from the Community-Based Framingham Heart Study
Ramos-Cejudo J, Scott M, Tanner J, Pase M, McGrath E, Ghosh S, Osorio R, Thibault E, Fakhri G, Johnson K, Beiser A, Seshadri S. Associations of Plasma Tau with Amyloid and Tau PET: Results from the Community-Based Framingham Heart Study. Journal Of Alzheimer's Disease 2024, 100: 487-494. PMID: 38875034, DOI: 10.3233/jad-231320.Peer-Reviewed Original ResearchConceptsCommunity-based Framingham Heart StudyFramingham Heart StudyHeart StudyCross-sectional associationsPlasma total tauMiddle-aged participantsRisk of ADCognitively healthy individualsCommunity-basedCompound B (PiB)-PETMiddle-agedPositive associationPlasma tauParticipantsTau-PETAssociationTotal tau levelsAD brain pathologyTotal-tauHealthy individualsAPOEe4Tau levelsBurdenRhinal cortexPrecuneus regionsCancer research is not correlated with driver gene mutation burdens
Mendiratta G, Liarakos D, Tong M, Ito S, Ke E, Goshua G, Stites E. Cancer research is not correlated with driver gene mutation burdens. Med 2024, 5: 832-838.e4. PMID: 38908369, DOI: 10.1016/j.medj.2024.05.013.Peer-Reviewed Original ResearchCancer patient populationCancer researchCancer research effortsResearch allocation decisionsNational InstitutePatient populationResearch fundingBurdenBurden of mutationsFunding decisionsCancerGenetic driversGene mutation burdenFunding amountFundingGenetic drivers of cancerAllocation decisionsCancer-associated genesEpidemiologyDrivers of cancerMutational burdenBaselineEffortsFactorsBalance of prioritiesPrevalence and prognostic importance of exercise limitation and physical inactivity in COPD
Vaes A, Burtin C, Casaburi R, Celli B, Evans R, Lareau S, Nici L, Rochester C, Troosters T. Prevalence and prognostic importance of exercise limitation and physical inactivity in COPD. Breathe 2024, 20: 230179. PMID: 38873237, PMCID: PMC11167648, DOI: 10.1183/20734735.0179-2023.Peer-Reviewed Original ResearchPhysical inactivityExercise limitationWalk testExercise performanceEndurance shuttle walk testExercise capacityMeasures of exercise performanceShuttle walk testAssess exercise capacityAssociated with mortalityExerciseDisease burdenInactivityPredictive of adverse outcomesAdverse outcomesCOPDAdditional resourcesNegative outcomesOutcomesTreadmillRespiratory impairmentEnduranceCliniciansPrevalenceBurdenGlobal and Regional Cardiovascular Mortality Attributable to Nonoptimal Temperatures Over Time
Hundessa S, Huang W, Zhao Q, Wu Y, Wen B, Alahmad B, Armstrong B, Gasparrini A, Sera F, Tong S, Madureira J, Kyselý J, Schwartz J, Vicedo-Cabrera A, Hales S, Johnson A, Li S, Guo Y, Jaakkola J, Ryti N, Urban A, Tobias A, Royé D, Lavigne E, Ragettli M, Åström C, Raz R, Pascal M, Kan H, Goodman P, Zeka A, Hashizume M, Diaz M, Seposo X, Nunes B, Kim H, Lee W, Íñiguez C, Guo Y, Pan S, Zanobetti A, Dang T, Van Dung, Schneider A, Entezari A, Analitis A, Forsberg B, Ameling C, Houthuijs D, Indermitte E, Mayvaneh F, Acquaotta F, de'Donato F, Carrasco-Escobar G, Orru H, Katsouyanni K, de Sousa Zanotti Stagliorio Coelho M, Ortega N, Scovronick N, Michelozzi P, Correa P, Saldiva P, Abrutzky R, Osorio S, Colistro V, Huber V, Honda Y, Kim Y, Bell M, Xu R, Yang Z, Roradeh H, Arellano E, Rao S, Chua P, da Silva S, da Silva S, De la Cruz Valencia C. Global and Regional Cardiovascular Mortality Attributable to Nonoptimal Temperatures Over Time. Journal Of The American College Of Cardiology 2024, 83: 2276-2287. PMID: 38839202, DOI: 10.1016/j.jacc.2024.03.425.Peer-Reviewed Original ResearchConceptsCardiovascular deathCardiovascular mortalityExcess mortality ratesCardiovascular mortality riskMultivariate meta-regression modelTemperature-mortality associationsMeta-regression modelsTemperature-related deathsMortality burdenMortality riskEffect estimatesHeat-related deathsSub-Saharan AfricaMortality attributesTemporal trendsCold-related deathsMortality rateGlobal assessmentSub-SaharanInvestigated spatiotemporal trendsDeath ratioMortalityBurdenComprehensive global assessmentDeathGlobal, regional, and national burden of heatwave-related mortality from 1990 to 2019: A three-stage modelling study
Zhao Q, Li S, Ye T, Wu Y, Gasparrini A, Tong S, Urban A, Vicedo-Cabrera A, Tobias A, Armstrong B, Royé D, Lavigne E, de’Donato F, Sera F, Kan H, Schwartz J, Pascal M, Ryti N, Goodman P, Saldiva P, Bell M, Guo Y, Network O. Global, regional, and national burden of heatwave-related mortality from 1990 to 2019: A three-stage modelling study. PLOS Medicine 2024, 21: e1004364. PMID: 38743771, PMCID: PMC11093289, DOI: 10.1371/journal.pmed.1004364.Peer-Reviewed Original ResearchConceptsMortality burdenExcess deathsGlobal mortality burdenTemporal changesAssociated with heatwavesMultivariate meta-regressionAdaptation planningGeographic disparitiesNational burdenLow-incomeClimate changeHeatwavesMeta-regressionPremature deathSector adaptationDaily deathsClimateLack of dataResidentsBurdenDisparitiesDeath ratioAssociationStigma associated with cutaneous leishmaniasis in rural Sri Lanka: development of a conceptual framework
Nuwangi H, Dikomitis L, Weerakoon K, Liyanage C, Agampodi T, Agampodi S. Stigma associated with cutaneous leishmaniasis in rural Sri Lanka: development of a conceptual framework. International Health 2024, 16: 553-561. PMID: 38487983, PMCID: PMC11375585, DOI: 10.1093/inthealth/ihae021.Peer-Reviewed Original ResearchManifestations of stigmaEvidence-based frameworkMultimethod qualitative studyQuality of lifeStigma driversRural Sri LankaAddress stigmaStigma experiencesReduce stigmaSelf-stigmaTargeted interventionsQualitative studyStigmaSystematic reviewTreatment burdenAnuradhapura districtInternational evidenceFacilitationConceptual frameworkSri LankaStigma formationAwarenessPeopleInterventionBurdenColonoscopy vs the Fecal Immunochemical Test: Which is Best?
Robertson D, Rex D, Ciani O, Drummond M. Colonoscopy vs the Fecal Immunochemical Test: Which is Best? Gastroenterology 2024, 166: 758-771. PMID: 38342196, DOI: 10.1053/j.gastro.2023.12.027.Peer-Reviewed Original ResearchFecal immunochemical testImmunochemical testEffectiveness of colorectal cancer screeningColorectal cancer screeningColorectal cancer outcomesComparative effectiveness trialHealth economic perspectiveCost-effective screening modalityCancer screeningReduce disease burdenCurrent United States guidelinesCancer outcomesEffectiveness trialScreening modalitiesScreening toolDisease burdenColonoscopyUnited States guidelinesStool testState guidelinesScreeningHealthModalitiesBurdenReviewGlobal, regional, and national burden of mortality associated with cold spells during 2000–19: a three-stage modelling study
Gao Y, Huang W, Zhao Q, Ryti N, Armstrong B, Gasparrini A, Tong S, Pascal M, Urban A, Zeka A, Lavigne E, Madureira J, Goodman P, Huber V, Forsberg B, Kyselý J, Sera F, Guo Y, Li S, Network M, Gao Y, Huang W, Zhao Q, Ryti N, Armstrong B, Gasparrini A, Tong S, Pascal M, Urban A, Zeka A, Lavigne E, Madureira J, Goodman P, Huber V, Forsberg B, Kyselý J, Sera F, Bell M, Hales S, Honda Y, Jaakkola J, Tobias A, Vicedo-Cabrera A, Abrutzky R, de Sousa Zanotti Stagliorio Coelho M, Saldiva P, Correa P, Ortega N, Kan H, Osorio S, Roye D, Orru H, Indermitte E, Schneider A, Katsouyanni K, Analitis A, Carlsen H, Mayvaneh F, Roradeh H, Raz R, Michelozzi P, de'Donato F, Hashizume M, Kim Y, Alahmad B, Cauchy J, Diaz M, Arellano E, De la Cruz Valencia C, Overcenco A, Houthuijs D, Ameling C, Rao S, Carrasco G, Seposo X, Chua P, da Silva S, Nunes B, Holobaca I, Cvijanovic I, Mistry M, Scovronick N, Acquaotta F, Kim H, Lee W, Íñiguez C, Åström C, Ragettli M, Guo Y, Pan S, Colistro V, Zanobetti A, Schwartz J, Dang T, Van Dung, Guo Y, Li S. Global, regional, and national burden of mortality associated with cold spells during 2000–19: a three-stage modelling study. The Lancet Planetary Health 2024, 8: e108-e116. PMID: 38331527, DOI: 10.1016/s2542-5196(23)00277-2.Peer-Reviewed Original ResearchConceptsAssociated with cold spellsGlobal mortality burdenExcess death rateMortality burdenExcess deathsMeta-regression modelsMortality associationsDeath rateAnnual excess deathsMultivariate meta-regression modelExposure to cold spellsDeath ratioQuasi-Poisson regressionAssociated with mortalityNational burdenPublic health threatBurdenAssociationHealth threatMortalityCold spellsDeath
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