2024
Short-Term Effects of Lower Air Temperature and Cold Spells on Myocardial Infarction Hospitalizations in Sweden
Ni W, Stafoggia M, Zhang S, Ljungman P, Breitner S, Bont J, Jernberg T, Atar D, Agewall S, Schneider A. Short-Term Effects of Lower Air Temperature and Cold Spells on Myocardial Infarction Hospitalizations in Sweden. Journal Of The American College Of Cardiology 2024, 84: 1149-1159. PMID: 39230547, DOI: 10.1016/j.jacc.2024.07.006.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCold TemperatureFemaleHospitalizationHumansMaleMiddle AgedMyocardial InfarctionSwedenTime FactorsConceptsST-segment elevation myocardial infarctionAssociated with increased riskRisk of hospitalizationShort-term effectsConditional logistic regression modelsPopulation-based nationwide studyMyocardial infarctionMyocardial infarction hospitalizationsCase-crossover designCase-crossover studyIncreased riskAssociated with decreased riskIncreased risk of hospitalizationCases admitted to hospitalLogistic regression modelsElevation myocardial infarctionNationwide studyRegression modelsHospitalExposure indicatorsPercentile temperatureNSTEMIORRiskLow air temperatureGlobal and Regional Cardiovascular Mortality Attributable to Nonoptimal Temperatures Over Time
Hundessa S, Huang W, Zhao Q, Wu Y, Wen B, Alahmad B, Armstrong B, Gasparrini A, Sera F, Tong S, Madureira J, Kyselý J, Schwartz J, Vicedo-Cabrera A, Hales S, Johnson A, Li S, Guo Y, Jaakkola J, Ryti N, Urban A, Tobias A, Royé D, Lavigne E, Ragettli M, Åström C, Raz R, Pascal M, Kan H, Goodman P, Zeka A, Hashizume M, Diaz M, Seposo X, Nunes B, Kim H, Lee W, Íñiguez C, Guo Y, Pan S, Zanobetti A, Dang T, Van Dung, Schneider A, Entezari A, Analitis A, Forsberg B, Ameling C, Houthuijs D, Indermitte E, Mayvaneh F, Acquaotta F, de'Donato F, Carrasco-Escobar G, Orru H, Katsouyanni K, de Sousa Zanotti Stagliorio Coelho M, Ortega N, Scovronick N, Michelozzi P, Correa P, Saldiva P, Abrutzky R, Osorio S, Colistro V, Huber V, Honda Y, Kim Y, Bell M, Xu R, Yang Z, Roradeh H, Arellano E, Rao S, Chua P, da Silva S, da Silva S, De la Cruz Valencia C. Global and Regional Cardiovascular Mortality Attributable to Nonoptimal Temperatures Over Time. Journal Of The American College Of Cardiology 2024, 83: 2276-2287. PMID: 38839202, DOI: 10.1016/j.jacc.2024.03.425.Peer-Reviewed Original ResearchConceptsCardiovascular deathCardiovascular mortalityExcess mortality ratesCardiovascular mortality riskMultivariate meta-regression modelTemperature-mortality associationsMeta-regression modelsTemperature-related deathsMortality burdenMortality riskEffect estimatesHeat-related deathsSub-Saharan AfricaMortality attributesTemporal trendsCold-related deathsMortality rateGlobal assessmentSub-SaharanInvestigated spatiotemporal trendsDeath ratioMortalityBurdenComprehensive global assessmentDeathImpact of population aging on future temperature-related mortality at different global warming levels
Chen K, de Schrijver E, Sivaraj S, Sera F, Scovronick N, Jiang L, Roye D, Lavigne E, Kyselý J, Urban A, Schneider A, Huber V, Madureira J, Mistry M, Cvijanovic I, Gasparrini A, Vicedo-Cabrera A. Impact of population aging on future temperature-related mortality at different global warming levels. Nature Communications 2024, 15: 1796. PMID: 38413648, PMCID: PMC10899213, DOI: 10.1038/s41467-024-45901-z.Peer-Reviewed Original ResearchEstimating the effects of vegetation and increased albedo on the urban heat island effect with spatial causal inference
Calhoun Z, Willard F, Ge C, Rodriguez C, Bergin M, Carlson D. Estimating the effects of vegetation and increased albedo on the urban heat island effect with spatial causal inference. Scientific Reports 2024, 14: 540. PMID: 38177220, PMCID: PMC10766998, DOI: 10.1038/s41598-023-50981-w.Peer-Reviewed Original Research
2023
Temporal variation in the association between temperature and cause-specific mortality in 15 German cities
Rai M, Breitner S, Huber V, Zhang S, Peters A, Schneider A. Temporal variation in the association between temperature and cause-specific mortality in 15 German cities. Environmental Research 2023, 229: 115668. PMID: 36958378, DOI: 10.1016/j.envres.2023.115668.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiovascular DiseasesCause of DeathCitiesCold TemperatureFemaleHot TemperatureHumansMaleMortalityTemperatureConceptsCVD mortalityNon-accidentalRelative riskMortality riskAge- and sex-stratified analysesMultivariate meta-analytic modelsCause-specific mortalitySex-stratified analysesAge groupsTemperature-mortality associationsRD mortalityYounger age groupsOlder age groupsMeta-analytic modelCold-relatedStudy periodRD deathsMortalityAssociationRiskTemperature percentileHeat-related risksCVDGerman citiesTime series analysis
2022
Associations Between Extreme Temperatures and Cardiovascular Cause-Specific Mortality: Results From 27 Countries
Alahmad B, Khraishah H, Royé D, Vicedo-Cabrera A, Guo Y, Papatheodorou S, Achilleos S, Acquaotta F, Armstrong B, Bell M, Pan S, de Sousa Zanotti Stagliorio Coelho M, Colistro V, Dang T, Van Dung D, De' Donato F, Entezari A, Guo Y, Hashizume M, Honda Y, Indermitte E, Íñiguez C, Jaakkola J, Kim H, Lavigne E, Lee W, Li S, Madureira J, Mayvaneh F, Orru H, Overcenco A, Ragettli M, Ryti N, Saldiva P, Scovronick N, Seposo X, Sera F, Silva S, Stafoggia M, Tobias A, Garshick E, Bernstein A, Zanobetti A, Schwartz J, Gasparrini A, Koutrakis P. Associations Between Extreme Temperatures and Cardiovascular Cause-Specific Mortality: Results From 27 Countries. Circulation 2022, 147: 35-46. PMID: 36503273, PMCID: PMC9794133, DOI: 10.1161/circulationaha.122.061832.Peer-Reviewed Original ResearchConceptsMinimum mortality temperatureExcess deathsIschemic heart diseaseCardiovascular causesCardiovascular deathCause-specific mortalityCardiovascular health needsCase-crossover modelsMortality temperatureAssociated with higher riskHeart diseaseRisk of mortalityCold daysHealth needsMortality associationsTemperature percentileData collection protocolsExtreme temperaturesDeath proportionCardiovascular conditionsHeart failureCardiovascular diseaseCold temperaturesReanalysis modelsHigh riskShort-term effects of cold spells on plasma viscosity: Results from the KORA cohort study in Augsburg, Germany
Ni W, Schneider A, Wolf K, Zhang S, Chen K, Koenig W, Peters A, Breitner S. Short-term effects of cold spells on plasma viscosity: Results from the KORA cohort study in Augsburg, Germany. Environmental Pollution 2022, 302: 119071. PMID: 35231540, DOI: 10.1016/j.envpol.2022.119071.Peer-Reviewed Original ResearchConceptsPlasma viscosityCardiac eventsDistributed lag nonlinear modelsKORA cohort studyAdverse cardiac eventsCross-sectional studyLag 0Cohort studyCardiovascular diseaseShort-term effectsSignificant associationConsecutive daysBlood parametersAdverse effectsCold exposureExposure dataLag nonlinear modelsMultiple mechanismsDaysSup
2021
Differential inflammatory responses of the native left and right ventricle associated with donor heart preservation
Lei I, Huang W, Ward PA, Pober JS, Tellides G, Ailawadi G, Pagani FD, Landstrom AP, Wang Z, Mortensen RM, Cascalho M, Platt J, Chen Y, Lam HYK, Tang PC. Differential inflammatory responses of the native left and right ventricle associated with donor heart preservation. Physiological Reports 2021, 9: e15004. PMID: 34435466, PMCID: PMC8387788, DOI: 10.14814/phy2.15004.Peer-Reviewed Original ResearchConceptsRight ventricleCold ischemiaIL-10Inflammatory responseIL-6 protein levelsCold ischemic preservationEx vivo ischemiaLeft ventricle dysfunctionCold ischemic timeDonor heart preservationInflammatory cytokine expressionCell deathDifferential inflammatory responseTumor necrosis factorComparable inflammatory responsesHuman donor heartsCaspase-3 expressionIschemic preservationVentricle dysfunctionInflammasome expressionIschemic timeRNA sequencingContractile dysfunctionDonor heartsWarm perfusionPotential use of new cooling technologies during Tokyo 2020 Olympics and associated ethical dilemmas
Muniz-Pardos B, Angeloudis K, Guppy FM, Tanisawa K, Hosokawa Y, Ash G, Schobersberger W, Grundstein A, Bargoria V, Lwande GO, Ombaka JH, Ergen E, Yamasawa F, Racinais S, Casa DJ, Pitsiladis YP. Potential use of new cooling technologies during Tokyo 2020 Olympics and associated ethical dilemmas. British Journal Of Sports Medicine 2021, 55: 1315-1316. PMID: 33990295, DOI: 10.1136/bjsports-2021-104014.Peer-Reviewed Original ResearchFoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance
Stöhr O, Tao R, Miao J, Copps K, White M. FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance. Cell Reports 2021, 34: 108893. PMID: 33761350, PMCID: PMC8529953, DOI: 10.1016/j.celrep.2021.108893.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAdipocytes, BrownAdipose Tissue, BrownAnimalsBlood GlucoseBody WeightCold TemperatureDiet, High-FatFibroblast Growth FactorsForkhead Box Protein O1Gene Expression RegulationGlucoseHomeostasisInsulinInsulin Receptor Substrate ProteinsInsulin ResistanceLipid MetabolismLiverMice, KnockoutOrgan SpecificityOxidation-ReductionThermogenesisConceptsHepatic insulin resistanceInsulin resistanceGlucose utilizationHigher plasma Fgf21 levelsSevere hepatic insulin resistanceFGF21 knockout micePlasma FGF21 levelsPeripheral glucose utilizationInsulin-resistant miceThermogenic gene expressionFGF21 resistancePharmacologic formsFGF21 levelsCold intoleranceFGF21 functionMetabolic healthBAT functionGlucose homeostasisKnockout miceFGF21Adenoviral infectionMiceWeight lossSkeletal muscleAcute cold tolerancemicroRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity
Horie T, Nakao T, Miyasaka Y, Nishino T, Matsumura S, Nakazeki F, Ide Y, Kimura M, Tsuji S, Rodriguez RR, Watanabe T, Yamasaki T, Xu S, Otani C, Miyagawa S, Matsushita K, Sowa N, Omori A, Tanaka J, Nishimura C, Nishiga M, Kuwabara Y, Baba O, Watanabe S, Nishi H, Nakashima Y, Picciotto MR, Inoue H, Watanabe D, Nakamura K, Sasaki T, Kimura T, Ono K. microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity. Nature Communications 2021, 12: 843. PMID: 33594062, PMCID: PMC7886914, DOI: 10.1038/s41467-021-21107-5.Peer-Reviewed Original ResearchConceptsSympathetic nerve activityAdaptive thermogenesisNerve activityCre miceMiR-33Brown adipose tissue thermogenesisDBH-positive neuronsMiR-33 levelsGABAergic inhibitory neurotransmissionSympathetic nerve toneCentral neural circuitsAdipose tissue thermogenesisGamma-aminobutyric acidDBH-positive cellsMiR-33 deficiencyWhole-body metabolismCold-induced thermogenesisInhibitory neurotransmissionBAT thermogenesisTissue thermogenesisReceptor subunit genesNeural circuitsAdaptive defense mechanismsThermogenesisMice
2020
Burden of cause-specific mortality attributable to heat and cold: A multicity time-series study in Jiangsu Province, China
Ma Y, Zhou L, Chen K. Burden of cause-specific mortality attributable to heat and cold: A multicity time-series study in Jiangsu Province, China. Environment International 2020, 144: 105994. PMID: 32745780, DOI: 10.1016/j.envint.2020.105994.Peer-Reviewed Original ResearchConceptsMortality burdenCardiovascular diseaseMyocardial infarctionRespiratory diseaseTime-series studyChronic obstructive pulmonary diseaseSpecific causesSubstantial mortality burdenHypertensive heart diseaseObstructive pulmonary diseaseRisk of mortalityCause-specific mortalityPrevious epidemiological studiesCases of deathExternal causesPulmonary diseaseTemperature-related mortality burdenDiabetes mortalityMulticity time-series studyCardiorespiratory diseaseHeart diseaseLag non-linear modelMortality riskEpidemiological studiesShort-term exposureUsing electrodermal activity to validate multilevel pain stimulation in healthy volunteers evoked by thermal grills
Posada-Quintero H, Kong Y, Nguyen K, Tran C, Beardslee L, Chen L, Guo T, Cong X, Feng B, Chon K. Using electrodermal activity to validate multilevel pain stimulation in healthy volunteers evoked by thermal grills. AJP Regulatory Integrative And Comparative Physiology 2020, 319: r366-r375. PMID: 32726157, PMCID: PMC7509251, DOI: 10.1152/ajpregu.00102.2020.Peer-Reviewed Original ResearchConceptsVisual analog scaleThermal grillTg stimulationSelf-report pain scalesStimulation levelsLevel of painPain assessment researchAnalog scalePain scalePain studiesHealthy volunteersInduce painPainful stimulationPainCooperative patientGold standardWarm stimuliStimulationPotential harmStimuliSubjectsPhysiological measuresPatientsLevelsCNGA3 acts as a cold sensor in hypothalamic neurons
Feketa VV, Nikolaev YA, Merriman DK, Bagriantsev SN, Gracheva EO. CNGA3 acts as a cold sensor in hypothalamic neurons. ELife 2020, 9: e55370. PMID: 32270761, PMCID: PMC7182431, DOI: 10.7554/elife.55370.Peer-Reviewed Original ResearchHypothermic Ex Situ Perfusion of Human Limbs With Acellular Solution for 24 Hours.
Haug V, Kollar B, Tasigiorgos S, Endo Y, Kauke M, Safi AF, Veeramani A, Abdulrazzak O, Bausk B, Walt D, Pomahac B. Hypothermic Ex Situ Perfusion of Human Limbs With Acellular Solution for 24 Hours. Transplantation 2020, 104: e260-e270. PMID: 32168040, DOI: 10.1097/tp.0000000000003221.Peer-Reviewed Original Research
2019
Effect of Injection Site Cooling and Warming on Insulin Glargine Pharmacokinetics and Pharmacodynamics
Bitton G, Rom V, Hadelsberg U, Raz I, Cengiz E, Weinzimer S, Tamborlane WV. Effect of Injection Site Cooling and Warming on Insulin Glargine Pharmacokinetics and Pharmacodynamics. Journal Of Diabetes Science And Technology 2019, 13: 1123-1128. PMID: 31067999, PMCID: PMC6835184, DOI: 10.1177/1932296819842151.Peer-Reviewed Original ResearchConceptsInjection siteGlucose levelsSerum glucoseSubcutaneous depotMultiple daily insulin injectionsOvernight glucose levelsDaily insulin injectionsBlood glucose controlType 1 diabetesSensor glucose levelsInsulin infusion rateDL increaseInsulin glargineSerum insulinGlucose controlMDI therapyInsulin injectionsInsulin concentrationsPharmacodynamic studiesInfusion rateSkin warmingSeparate daysControl dayRate of absorptionRandom order
2018
Somatosensory Neurons Enter a State of Altered Excitability during Hibernation
Hoffstaetter LJ, Mastrotto M, Merriman DK, Dib-Hajj SD, Waxman SG, Bagriantsev SN, Gracheva EO. Somatosensory Neurons Enter a State of Altered Excitability during Hibernation. Current Biology 2018, 28: 2998-3004.e3. PMID: 30174191, PMCID: PMC6173314, DOI: 10.1016/j.cub.2018.07.020.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsArousalBody TemperatureCold TemperatureHibernationSciuridaeSensory Receptor CellsConceptsSomatosensory neuronsAction potentialsPeripheral somatosensory neuronsVoltage-gated sodium channelsTherapeutic hypothermiaAltered excitabilityFunctional deficitsCase of neuronsSensory functionFiring patternsNeuronsCold exposureInput resistanceSodium channelsRapid restorationBody temperatureHypometabolismHypothermiaDevelopment of strategiesSensory informationProlonged periodAdaptive responseArousalCNSExcitabilityReduced Hypoxia-Related Genes in Porcine Limbs in Ex Vivo Hypothermic Perfusion Versus Cold Storage
Krezdorn N, Sakthivel D, Turk M, Aycart M, Tasigiorgos S, Bueno E, Sinha I, Pomahac B. Reduced Hypoxia-Related Genes in Porcine Limbs in Ex Vivo Hypothermic Perfusion Versus Cold Storage. Journal Of Surgical Research 2018, 232: 137-145. PMID: 30463709, DOI: 10.1016/j.jss.2018.05.067.Peer-Reviewed Original ResearchConceptsStatic cold storagePerfusion groupIschemia-reperfusion injuryPCR gene arrayPorcine limbsMuscle fiber disruptionIschemic injuryPerfadex solutionPerfused limbMachine perfusionHypothermic perfusionHistological changesPreservation modalityMuscle biopsyLimb replantationPerfusionICE groupLess activationPorcine forelimbDownregulation of genesMolecular changesLimbFiber disruptionExpression levelsReplantationKinetics of human brown adipose tissue activation and deactivation
Leitner BP, Weiner LS, Desir M, Kahn PA, Selen DJ, Tsang C, Kolodny GM, Cypess AM. Kinetics of human brown adipose tissue activation and deactivation. International Journal Of Obesity 2018, 43: 633-637. PMID: 29795459, PMCID: PMC6252171, DOI: 10.1038/s41366-018-0104-3.Peer-Reviewed Original ResearchConceptsBrown adipose tissueBAT volumeMetabolic diseasesBrown adipose tissue activationActive brown adipose tissueCold exposureHuman BAT thermogenesisBAT glucose uptakePrevention of obesityPET/CT imagingBAT activationBAT thermogenesisClinical trialsAdipose tissueHealthy adultsCold stimulationTissue activationCT imagingGlucose uptakeDuration of stimuliPotential targetCessation of coolingObesityDiseaseActivation
2017
Acute Stress Time-dependently Modulates Multiple Memory Systems
Goldfarb EV, Mendelevich Y, Phelps EA. Acute Stress Time-dependently Modulates Multiple Memory Systems. Journal Of Cognitive Neuroscience 2017, 29: 1877-1894. PMID: 28699809, DOI: 10.1162/jocn_a_01167.Peer-Reviewed Original Research
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