2025
Reduced removal of waste products from energy metabolism takes center stage in human brain aging
Mangia S, DiNuzzo M, Ponticorvo S, Dienel G, Behar K, Benveniste H, Hyder F, Giove F, Herculano-Houzel S, Petroff O, Eberly L, Filip P, Michaeli S, Rothman D. Reduced removal of waste products from energy metabolism takes center stage in human brain aging. Scientific Reports 2025, 15: 8127. PMID: 40057554, PMCID: PMC11890754, DOI: 10.1038/s41598-025-90342-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAgingBrainCarbon DioxideCerebrovascular CirculationEnergy MetabolismFemaleHumansHydrogen-Ion ConcentrationMaleMiddle AgedOxygen ConsumptionPositron-Emission TomographyYoung AdultNovel F-18-labeled Tracers of Sympathetic Function for Improved Risk Stratification and Clinical Outcomes
Zohora F, Nazari M, Sinusas A. Novel F-18-labeled Tracers of Sympathetic Function for Improved Risk Stratification and Clinical Outcomes. Current Cardiology Reports 2025, 27: 61. PMID: 40009333, DOI: 10.1007/s11886-025-02197-9.Peer-Reviewed Original ResearchConceptsSudden cardiac deathImplantable cardioverter defibrillatorPositron emission tomographyImplantable cardioverter defibrillator placementMyocardial sympathetic denervationRisk stratificationSympathetic denervationIschemic heart diseaseHeart failurePrevention of sudden cardiac deathRisk stratification of patientsHeart diseaseOptimal risk stratificationLow ejection fractionStratification of patientsSympathetic nerve densityImprove risk stratificationHeart failure patientsPositron emission tomography radiotracersPredicting sudden cardiac deathPositron emission tomography tracersPrognostic benefitEjection fractionClinically practical approachNerve density[18F]MK-6240 Radioligand Delivery Indices as Surrogates of Cerebral Perfusion: Bias and Correlation Against [15O]Water.
Fu J, Juttukonda M, Garimella A, Salvatore A, Lois C, Ranasinghe A, Efthimiou N, Sari H, Aye W, Guehl N, El Fakhri G, Johnson K, Dickerson B, Izquierdo-Garcia D, Catana C, Price J. [18F]MK-6240 Radioligand Delivery Indices as Surrogates of Cerebral Perfusion: Bias and Correlation Against [15O]Water. Journal Of Nuclear Medicine 2025, 66: 410-417. PMID: 39947916, PMCID: PMC11876731, DOI: 10.2967/jnumed.124.268701.Peer-Reviewed Original ResearchPET Imaging of Sphingosine-1-Phosphate Receptor 1 with [18F]TZ4877 in Nonhuman Primates
Gu J, Zheng M, Holden D, Fowles K, Qiu L, Felchner Z, Zhang L, Ropchan J, Gropler R, Carson R, Tu Z, Huang Y, Hillmer A. PET Imaging of Sphingosine-1-Phosphate Receptor 1 with [18F]TZ4877 in Nonhuman Primates. Molecular Imaging And Biology 2025, 27: 54-63. PMID: 39779653, DOI: 10.1007/s11307-024-01979-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainFluorine RadioisotopesMacaca mulattaMalePositron-Emission TomographyRadiopharmaceuticalsReceptors, LysosphingolipidSphingosine-1-Phosphate ReceptorsTissue DistributionConceptsSphingosine-1-phosphate receptor 1Absorbed radiation dose estimatesReceptor 1Nonhuman primatesFree fractionPlasma free fractionRadiation dose estimatesMetabolite-corrected input functionF-18 labeled radiotracersArterial blood samplesCritical organsPET/CT systemBolus injectionF-18Anesthetized nonhuman primatesDosimetry studiesHuman studiesDose estimatesVT/fPPET imaging dataS1PR1PET imagingInput functionBlood samplesPonesimodSelective Mu-Opioid Receptor Imaging Using 18F‑Labeled Carfentanils
Lee S, Pearson T, Dhaynaut M, MacDonagh A, Wey H, Wilks M, Roth B, Hooker J, Normandin M. Selective Mu-Opioid Receptor Imaging Using 18F‑Labeled Carfentanils. Journal Of Medicinal Chemistry 2025, 68: 1632-1644. PMID: 39772615, DOI: 10.1021/acs.jmedchem.4c02287.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainFentanylFluorine RadioisotopesHumansMaleMicePositron-Emission TomographyRadiopharmaceuticalsRatsReceptors, Opioid, muTissue DistributionConceptsMu-opioid receptorsPositron emission tomographyIn vivo PET scansCarbon-11Neurobiological studiesCopper-mediated radiofluorinationMu-opioidReceptor imagingPET scansBrain uptakeFavorable pharmacokineticsImaging evaluationHigh molar activityMass doseEmission tomographyHalf-life of fluorine-18Synthetic opioidsFluorine-18Half-lifeIn vitro binding assaysBinding assaysClinical research useMolar activityCarfentanilResearch useIn Vivo Head-to-Head Comparison of [18F]GTP1 with [18F]MK-6240 and [18F]PI-2620 in Alzheimer Disease
Olafson E, Tonietto M, Klein G, Teng E, Stephens A, Russell D, Pickthorn K, Bohorquez S. In Vivo Head-to-Head Comparison of [18F]GTP1 with [18F]MK-6240 and [18F]PI-2620 in Alzheimer Disease. Journal Of Nuclear Medicine 2025, 66: jnumed.124.268623. PMID: 39746756, PMCID: PMC11800736, DOI: 10.2967/jnumed.124.268623.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseBrainCarbolinesFemaleFluorine RadioisotopesHumansIsoquinolinesMaleMiddle AgedPositron-Emission TomographyRadiopharmaceuticalstau ProteinsConceptsAlzheimer's diseaseAccumulation of tau neurofibrillary tanglesTau neurofibrillary tanglesOff-target regionsNeurofibrillary tanglesTau pathologyTau-PET signalTau PET tracersBinding profilesTau-PETMild ADNormal cognitionBraak regionsHead-to-head studiesAD patientsTauMagnitude of uptakeTracer bindingAlzheimerTarget regionCurrent Advances in PARP1‐Targeted Theranostics
Tong J, Chen B, Volpi T, Li Y, Ellison P, Cai Z. Current Advances in PARP1‐Targeted Theranostics. Journal Of Labelled Compounds And Radiopharmaceuticals 2025, 68: e4135. PMID: 39995212, DOI: 10.1002/jlcr.4135.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHumansNeoplasmsPoly (ADP-Ribose) Polymerase-1Poly(ADP-ribose) Polymerase InhibitorsPositron-Emission TomographyTheranostic NanomedicineConceptsPoly (ADP-ribose) polymerase 1Blood-brain barrierCentral nervous systemBlood-tumor barrierPotential clinical useBRCA mutationsHomologous recombination repair pathwayPARP inhibitorsPharmacodynamic evaluationPatient stratificationPersonalized oncologyPharmacological characteristicsClinical useBrain tumorsBrain barrierDiagnostic imagingPET imagingCancerNervous systemTherapeutic interventionsBrain cancerPathophysiological conditionsTreatment assessmentPARPiNeurological disorders
2024
Plasma Aβ42/Aβ40 is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum
Trelle A, Young C, Vossler H, Benitez J, Cody K, Mendiola J, Swarovski M, Le Guen Y, Feinstein I, Butler R, Channappa D, Romero A, Park J, Shahid‐Besanti M, Corso N, Chau K, Smith A, Skylar‐Scott I, Yutsis M, Fredericks C, Tian L, Younes K, Kerchner G, Deutsch G, Davidzon G, Sha S, Henderson V, Longo F, Greicius M, Wyss‐Coray T, Andreasson K, Poston K, Wagner A, Mormino E, Wilson E. Plasma Aβ42/Aβ40 is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum. Alzheimer's & Dementia 2024, 21: e14442. PMID: 39713875, PMCID: PMC11848181, DOI: 10.1002/alz.14442.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseCognitive declinePositron emission tomographyAmyloid-betaTau accumulationAmyloid positivityHippocampal-dependent memoryAlzheimer's disease spectrumAmyloidAmyloid accumulationTau burdenAb accumulationRisk of cognitive declineSensitive to memoryTau positron emission tomographyAlzheimer's Disease Research CenterPredicting cognitive declineAlzheimerTauScalable biomarkersAD continuumCerebral amyloid accumulationCross-sectional associationsCI individualsAccumulationComparative Kidney Uptake of Nanobody-Based PET Tracers Labeled with Various Fluorine-18-Labeled Prosthetic Groups
Olkowski C, Basuli F, Fernandes B, Ghaemi B, Shi J, Zhang H, Farber J, Escorcia F, Choyke P, Jacobson O. Comparative Kidney Uptake of Nanobody-Based PET Tracers Labeled with Various Fluorine-18-Labeled Prosthetic Groups. Molecular Pharmaceutics 2024, 22: 533-543. PMID: 39680709, DOI: 10.1021/acs.molpharmaceut.4c01101.Peer-Reviewed Original ResearchNeuroimaging Biomarkers in Parkinson’s Disease
Holmes S, Tinaz S. Neuroimaging Biomarkers in Parkinson’s Disease. Advances In Neurobiology 2024, 40: 617-663. PMID: 39562459, DOI: 10.1007/978-3-031-69491-2_21.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersBrainHumansMagnetic Resonance ImagingNeuroimagingParkinson DiseasePositron-Emission TomographyConceptsPublic health burdenNeuroimaging biomarkersTreatment developmentRisk of developing PDParkinson's diseaseHealth burdenDiagnosis of PDMultimodal neuroimaging techniquesIdiopathic Parkinson's diseaseNon-motorDifferential diagnosis of PDNeuroimaging techniquesProdromal phaseDifferential diagnosisSymptomatic treatmentDisease progressionClinical applicationBiomarkersPlasma Glial Fibrillary Acid Protein and Phosphorated Tau 181 Association with Presynaptic Density-Dependent Tau Pathology at 18F-SynVesT-1 Brain PET Imaging.
Wu J, Li B, Wang J, Huang Q, Chen X, You Z, He K, Guo Q, Li S, Huang Y, Guo T, Dai W, Xiang W, Chen W, Yang D, Zhao J, Guan Y, Xie F. Plasma Glial Fibrillary Acid Protein and Phosphorated Tau 181 Association with Presynaptic Density-Dependent Tau Pathology at 18F-SynVesT-1 Brain PET Imaging. Radiology 2024, 313: e233019. PMID: 39560478, PMCID: PMC11605102, DOI: 10.1148/radiol.233019.Peer-Reviewed Original ResearchConceptsP-tau-181Alzheimer's diseaseAD-related pathologyAmyloid-bPhosphor-tauTau pathologySynaptic densityTau accumulationSynaptic lossTauTau-PETDecreased synaptic densityGlial fibrillary acidic proteinPlasma glial fibrillary acidic proteinCortical thicknessAcidic proteinFibrillary acidic proteinRuijin HospitalProspective studyRelationship of plasmaBlood assayBlood markersPET/MRIBrain PET imagingPET imagingMemory-related brain potentials for visual objects in early AD show impairment and compensatory mechanisms
Xia J, Kutas M, Salmon D, Stoermann A, Rigatuso S, Farias S, Edland S, Brewer J, Olichney J. Memory-related brain potentials for visual objects in early AD show impairment and compensatory mechanisms. Cerebral Cortex 2024, 34: bhae398. PMID: 39390709, DOI: 10.1093/cercor/bhae398.Peer-Reviewed Original ResearchConceptsEvent-related brain potentialsAmnestic mild cognitive impairmentHippocampal occupancyBrain potentialsMemory abilityNegative ERP effectExecutive function abilitiesVisual memory abilityImpaired episodic memoryVerbal memory abilitiesAlzheimer's diseaseInvestigate neural mechanismsObject recognition taskVisual object recognitionVisual object recognition taskCognitively unimpaired participantsMild cognitive impairmentERP effectsNeuropsychological measuresExecutive functionEpisodic memoryHippocampal functionCompensatory mechanismsVisual memoryNeural mechanismsLong-Term Outcomes of Prostate-Specific Membrane Antigen–PET Imaging of Recurrent Prostate Cancer
Kunst N, Long J, Westvold S, Sprenkle P, Kim I, Saperstein L, Rabil M, Ghaffar U, Karnes R, Ma X, Gross C, Wang S, Leapman M. Long-Term Outcomes of Prostate-Specific Membrane Antigen–PET Imaging of Recurrent Prostate Cancer. JAMA Network Open 2024, 7: e2440591. PMID: 39441595, PMCID: PMC11581571, DOI: 10.1001/jamanetworkopen.2024.40591.Peer-Reviewed Original ResearchMeSH KeywordsAgedHumansMaleMiddle AgedNeoplasm Recurrence, LocalPositron-Emission TomographyProstate-Specific AntigenProstatic NeoplasmsRetrospective StudiesConceptsProstate-specific antigenProstate-specific antigen levelPSMA-PETRecurrent prostate cancerBiochemical recurrenceProstate cancerLong-term outcomesProstate-specific membrane antigen positron emission tomographyEvaluation of biochemical recurrenceDetection of biochemical recurrenceLife yearsConventional imagingDefinitive local therapyPSMA PET imagingProstate cancer deathDetection of metastasesRetrospective cohort studyBase case analysisIncremental life-yearsPositron emission tomographyDecision-analytic modelLocal therapyConventional imaging strategiesDelayed treatmentDisease courseA shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D2/3 receptor densities
Ricard J, Labache L, Segal A, Dhamala E, Cocuzza C, Jones G, Yip S, Chopra S, Holmes A. A shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D2/3 receptor densities. Communications Biology 2024, 7: 1178. PMID: 39300138, PMCID: PMC11413242, DOI: 10.1038/s42003-024-06836-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainCocaine-Related DisordersConnectomeFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission TomographyReceptors, Dopamine D2Receptors, Dopamine D3ConceptsCocaine use disorderPatterns of functional connectivityUse disorderFunctional connectivityReceptor densityLarge-scale functional brain networksMaintenance of substance useDopamine D2/3 receptorsDopamine receptor densityCortico-striatal circuitsProfile of functional connectivitySubstance use disordersFunctional brain networksNeurotransmitter receptor densityD2/3 receptorsDopamine systemTransporter bindingSubcortical systemsBrain networksSubstance useCocaineSpatial topographyDisordersDopamineBiological mechanismsMicroglia-mediated neuroimmune suppression in PTSD is associated with anhedonia
Bonomi R, Hillmer A, Woodcock E, Bhatt S, Rusowicz A, Angarita G, Carson R, Davis M, Esterlis I, Nabulsi N, Huang Y, Krystal J, Pietrzak R, Cosgrove K. Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406005121. PMID: 39172786, PMCID: PMC11363315, DOI: 10.1073/pnas.2406005121.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnhedoniaBrainFemaleHumansLipopolysaccharidesMaleMicrogliaMiddle AgedNeuroimmunomodulationPositron-Emission TomographyReceptors, GABAStress Disorders, Post-TraumaticConceptsPTSD groupPrefrontal-limbic circuitsNeuroimmune responseAssociated with anhedoniaPosttraumatic stress disorderPositron emission tomography brain imagingTranslocator protein availabilityBrain immune functionAnhedonic symptomsStress disorderPeripheral immune dysfunctionPTSDGroup differencesSeverity of symptomsPsychiatric diseasesTranslocator proteinBrain imagingAdministration of lipopolysaccharideSymptomsMicroglial markersLPS-induced increaseCompared to controlsImmune functionSickness symptomsAnhedoniaAssociations of Plasma Tau with Amyloid and Tau PET: Results from the Community-Based Framingham Heart Study
Ramos-Cejudo J, Scott M, Tanner J, Pase M, McGrath E, Ghosh S, Osorio R, Thibault E, Fakhri G, Johnson K, Beiser A, Seshadri S. Associations of Plasma Tau with Amyloid and Tau PET: Results from the Community-Based Framingham Heart Study. Journal Of Alzheimer's Disease 2024, 100: 487-494. PMID: 38875034, DOI: 10.3233/jad-231320.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmyloid beta-PeptidesAniline CompoundsBiomarkersBrainCarbolinesCross-Sectional StudiesFemaleHumansMaleMiddle AgedPositron-Emission Tomographytau ProteinsThiazolesConceptsCommunity-based Framingham Heart StudyFramingham Heart StudyHeart StudyCross-sectional associationsPlasma total tauMiddle-aged participantsRisk of ADCognitively healthy individualsCommunity-basedCompound B (PiB)-PETMiddle-agedPositive associationPlasma tauParticipantsTau-PETAssociationTotal tau levelsAD brain pathologyTotal-tauHealthy individualsAPOEe4Tau levelsBurdenRhinal cortexPrecuneus regionsAssociations of Physical Activity Engagement with Cerebral Amyloid-β and Tau from Midlife
Gonzales M, Kojis D, Spartano N, Thibault E, DeCarli C, Fakhri G, Johnson K, Beiser A, Seshadri S. Associations of Physical Activity Engagement with Cerebral Amyloid-β and Tau from Midlife. Journal Of Alzheimer's Disease 2024, 100: 935-943. PMID: 39031362, DOI: 10.3233/jad-240322.Peer-Reviewed Original ResearchMeSH KeywordsAmyloid beta-PeptidesBrainCohort StudiesCross-Sectional StudiesExerciseFemaleHumansMaleMiddle AgedPositron-Emission Tomographytau ProteinsConceptsPhysical activity indexPhysical activity engagementAssociated with lower dementia riskPhysical activity index scoreAssociation of physical activityActive engagementPhysical activity levelsFramingham Heart StudyCross-sectional associationsCommunity-based cohortCardiovascular risk factorsDementia riskPhysical activityLifestyle interventionHeart StudyLinear regression modelsStratified analysisTau-PET retentionSelf-reportSex disparitiesActivity levelsLate lifeTau positron emission tomographyRisk factorsAge groupsLower Locus Coeruleus Integrity Signals Elevated Entorhinal Tau and Clinical Progression in Asymptomatic Older Individuals
Engels‐Domínguez N, Riphagen J, Van Egroo M, Koops E, Smegal L, Becker J, Prokopiou P, Bueichekú E, Kwong K, Rentz D, Salat D, Sperling R, Johnson K, Jacobs H. Lower Locus Coeruleus Integrity Signals Elevated Entorhinal Tau and Clinical Progression in Asymptomatic Older Individuals. Annals Of Neurology 2024, 96: 650-661. PMID: 39007398, PMCID: PMC11534559, DOI: 10.1002/ana.27022.Peer-Reviewed Original ResearchConceptsLocus coeruleus integrityClinical Dementia RatingBeta-amyloidHippocampal volumePositron emission tomographyClinical progressionAsymptomatic individualsReceiver operating characteristic analysisCortical tau depositionCox proportional hazards modelsLociAccumulation of pathologyBeta-amyloid burdenAsymptomatic older individualsMild cognitive impairmentTau depositionProportional hazards modelTau signalEC tauLocus coeruleusPET-negativeEntorhinal tauCognitive impairmentScreening instrumentCognitive declineNeuroMark PET: Replicable positron emission tomography ICA templates for florbetapir and florbetaben radioligands
Eierud C, Fu Z, Petropoulos H, Bohsali A, Iraji A, Ganz M, Pernet C, Calhoun V. NeuroMark PET: Replicable positron emission tomography ICA templates for florbetapir and florbetaben radioligands. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2024, 00: 1-4. PMID: 40039357, DOI: 10.1109/embc53108.2024.10782228.Peer-Reviewed Original ResearchMeSH KeywordsAgedAniline CompoundsBrainEthylene GlycolsFemaleHumansLigandsMalePositron-Emission TomographyRadiopharmaceuticalsStilbenesRevealing Alzheimer's Disease Dementia Patterns in [18F]Florbetapir PET with Independent Component Analysis
Khasayeva N, Eierud C, Jensen K, Premi E, Borroni B, Calhoun V, Iraji A. Revealing Alzheimer's Disease Dementia Patterns in [18F]Florbetapir PET with Independent Component Analysis. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2024, 00: 1-4. PMID: 40039485, DOI: 10.1109/embc53108.2024.10782873.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseAniline CompoundsBrainEthylene GlycolsFemaleHumansMalePositron-Emission TomographyRadiopharmaceuticalsConceptsPositron emission tomographyFrontal componentIndependent component analysisAlzheimer's Disease Neuroimaging InitiativeInteraction effects of diagnosisPositron emission tomography brain imagingEffect of diagnosisSignificant group effectAlzheimer's diseasePotential of independent component analysisAD dementia groupsSignificant interaction effectEvaluate group differencesGroup differencesDementia groupGeneralized linear modelGroup effectBrain imagingSalienceIC weightsEmission tomographyAD dementiaDementiaDementia patternsNeurobiology
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