2023
Early cellular and molecular signatures correlate with severity of West Nile virus infection
Lee H, Zhao Y, Fleming I, Mehta S, Wang X, Vander Wyk B, Ronca S, Kang H, Chou C, Fatou B, Smolen K, Levy O, Clish C, Xavier R, Steen H, Hafler D, Love J, Shalek A, Guan L, Murray K, Kleinstein S, Montgomery R. Early cellular and molecular signatures correlate with severity of West Nile virus infection. IScience 2023, 26: 108387. PMID: 38047068, PMCID: PMC10692672, DOI: 10.1016/j.isci.2023.108387.Peer-Reviewed Original ResearchWest Nile virusEffective anti-viral responseInnate immune cell typesWest Nile virus infectionPro-inflammatory markersAcute time pointsImmune cell typesAnti-viral responseMolecular signaturesHost cellular activitiesAcute infectionAsymptomatic donorsPeripheral bloodSevere infectionsVirus infectionImmune responseSevere casesCell activityIll individualsSerum proteomicsInfectionInfection severityHigh expressionTime pointsNile virusPrefrontal cortex astroglia modulate anhedonia-like behavior
Codeluppi S, Xu M, Bansal Y, Lepack A, Duric V, Chow M, Muir J, Bagot R, Licznerski P, Wilber S, Sanacora G, Sibille E, Duman R, Pittenger C, Banasr M. Prefrontal cortex astroglia modulate anhedonia-like behavior. Molecular Psychiatry 2023, 28: 4632-4641. PMID: 37696873, PMCID: PMC10914619, DOI: 10.1038/s41380-023-02246-1.Peer-Reviewed Original ResearchGlial fibrillary acidic proteinAnhedonia-like behaviorPrefrontal cortexCell depletionDiphtheria toxin administrationDepressive-like behaviorChronic stress modelTreatment of depressionDiphtheria toxin receptorFibrillary acidic proteinDevelopment of anhedoniaCortical astrogliaToxin administrationDesigner receptorsCell activityAcidic proteinViral expressionToxin receptorDesigner drugsExperimental depletionAstrogliaDeficitsReceptorsDepressionCritical role
2022
SILAC Phosphoproteomics Reveals Unique Signaling Circuits in CAR‑T Cells and the Inhibition of B Cell-Activating Phosphorylation in Target Cells
Griffith AA, Callahan KP, King NG, Xiao Q, Su X, Salomon AR. SILAC Phosphoproteomics Reveals Unique Signaling Circuits in CAR‑T Cells and the Inhibition of B Cell-Activating Phosphorylation in Target Cells. Journal Of Proteome Research 2022, 21: 395-409. PMID: 35014847, PMCID: PMC8830406, DOI: 10.1021/acs.jproteome.1c00735.Peer-Reviewed Original ResearchConceptsCD19 CAR T cellsChimeric antigen receptorRaji B cellsT cellsB cellsCAR T cell activityT cell activityB-cell malignanciesT cell receptor signalingCAR T cell signalingCell receptor signalingCD19-CARCell malignanciesT cell signalingCell activityReceptor signalingAntigen receptorLiquid chromatography-tandem mass spectrometryTarget cellsSignificant decreaseChromatography-tandem mass spectrometryTCR signalingReceptorsResponse of cellsCells
2020
Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting
Kontos C, El Bounkari O, Krammer C, Sinitski D, Hille K, Zan C, Yan G, Wang S, Gao Y, Brandhofer M, Megens RTA, Hoffmann A, Pauli J, Asare Y, Gerra S, Bourilhon P, Leng L, Eckstein HH, Kempf WE, Pelisek J, Gokce O, Maegdefessel L, Bucala R, Dichgans M, Weber C, Kapurniotu A, Bernhagen J. Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting. Nature Communications 2020, 11: 5981. PMID: 33239628, PMCID: PMC7689490, DOI: 10.1038/s41467-020-19764-z.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnimalsAntigens, CDAtherosclerosisBinding SitesCarotid Artery, CommonChemokine CXCL12Crystallography, X-RayDisease Models, AnimalDrug DesignDrug Evaluation, PreclinicalEndarterectomy, CarotidFemaleHumansIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMaleMiceMice, Knockout, ApoEMiddle AgedPeptide FragmentsReceptors, CXCR4SialyltransferasesSignal TransductionConceptsMacrophage migration inhibitory factorCXC motif chemokine receptor 4Chemokine receptorsChemokine/receptor axisCXCR4/CXCL12 interactionHuman carotid endarterectomy specimensMigration inhibitory factorChemokine receptor 4MIF/CD74Carotid endarterectomy specimensAtherogenic inflammationCXCL12 interactionReceptor axisReceptor 4MIF inhibitorsReceptor-based strategiesAtherosclerotic plaquesAtherosclerosisAtypical chemokineLeukocyte adhesionCell activityProtective pathwaysInflammationChemokinesPlaques
2019
Impact of Interleukin-27p28 on T and B Cell Responses during Toxoplasmosis
Park J, DeLong JH, Knox JJ, Konradt C, Wojno EDT, Hunter CA. Impact of Interleukin-27p28 on T and B Cell Responses during Toxoplasmosis. Infection And Immunity 2019, 87: 10.1128/iai.00455-19. PMID: 31548322, PMCID: PMC6867838, DOI: 10.1128/iai.00455-19.Peer-Reviewed Original ResearchConceptsIL-27p28IL-27Parasite-specific antibody titersEffector T cell populationsT cell-mediated pathologyCell-mediated pathologyT cell activityReduced parasite burdenT cell populationsB cell responsesCentral nervous systemInterleukin-27Antibody titersMajor inhibitory effectHeterodimeric cytokineParasite replicationImmune serumNervous systemParasite burdenCell responsesCell activityInhibitory effectIntracellular parasitesCell populationsToxoplasmosisNestin+NG2+ Cells Form a Reserve Stem Cell Population in the Mouse Prostate
Hanoun M, Arnal-Estapé A, Maryanovich M, Zahalka AH, Bergren SK, Chua CW, Leftin A, Brodin PN, Shen MM, Guha C, Frenette PS. Nestin+NG2+ Cells Form a Reserve Stem Cell Population in the Mouse Prostate. Stem Cell Reports 2019, 12: 1201-1211. PMID: 31130357, PMCID: PMC6565923, DOI: 10.1016/j.stemcr.2019.04.019.Peer-Reviewed Original ResearchConceptsReserve stem cell populationLineage-tracing analysisStem cell populationStem cell activityProstate stem cellsEpithelial cellsBipotential capacityProstate epithelial cellsTissue maintenanceLuminal epithelial cellsMesenchymal cellsStem cellsCell populationsOrgan damageProstate organoidsNG2 expressionRegenerative capacityRare subsetMouse prostateProstate epitheliumTransgenic miceTissue graftCell activityClonal levelCellsMolecular layer interneurons shape the spike activity of cerebellar Purkinje cells
Brown A, Arancillo M, Lin T, Catt D, Zhou J, Lackey E, Stay T, Zuo Z, White J, Sillitoe R. Molecular layer interneurons shape the spike activity of cerebellar Purkinje cells. Scientific Reports 2019, 9: 1742. PMID: 30742002, PMCID: PMC6370775, DOI: 10.1038/s41598-018-38264-1.Peer-Reviewed Original ResearchConceptsMolecular layer interneuronsPurkinje cellsGABAergic neurotransmissionSpike firingVesicular GABA transporterClasses of interneuronsPurkinje cell functionCerebellar Purkinje cellsComplex spike firingPurkinje cell activityPurkinje cell simple spike firingInhibitory molecular layer interneuronsConditional genetic approachPurkinje cell simple spikesSynaptic inputsStellate cellsSpike activitySimple spike firingFiring propertiesGABA transporterCell activityInterneuronsSelective depletionCell functionComplex spikes
2018
Sno-derived RNAs are prevalent molecular markers of cancer immunity
Chow RD, Chen S. Sno-derived RNAs are prevalent molecular markers of cancer immunity. Oncogene 2018, 37: 6442-6462. PMID: 30072739, PMCID: PMC6294694, DOI: 10.1038/s41388-018-0420-z.Peer-Reviewed Original ResearchConceptsCancer immunityCytolytic T cell activityCancer typesHuman cancer immunityTumor immune signatureT cell infiltrationT cell activityTumor immune microenvironmentHuman cancersClinical outcomesImmunosuppressive markersPatient survivalCell infiltrationDistinct cancer typesTumor vasculatureCell activityPatient samplesExpression signaturesImmunityCancerMarkersMolecular markersLike propertiesSdRNAsLarge panel
2017
Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors
Lewis AS, Pittenger ST, Mineur YS, Stout D, Smith PH, Picciotto MR. Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors. Neuropsychopharmacology 2017, 43: 1267-1275. PMID: 29114104, PMCID: PMC5916354, DOI: 10.1038/npp.2017.276.Peer-Reviewed Original ResearchConceptsΑ7 nAChRsDentate gyrusNicotinic acetylcholine receptorsGTS-21Resident-intruder interactionsAlpha 7 nicotinic acetylcholine receptorAcetylcholine receptorsΑ7 nicotinic acetylcholine receptorExcitatory-inhibitory balancePromising therapeutic interventionGranule cell activityAggressive behaviorResident-intruder testHippocampal α7Wild-type controlsUnderlying neurobiological substratesGABAergic interneuronsMale micePotential neural circuitsRegulation of aggressionGranule cellsTherapeutic interventionsPartial agonistBrain regionsCell activityCanonical and cross-reactive binding of NK cell inhibitory receptors to HLA-C allotypes is dictated by peptides bound to HLA-C
Sim M, Malaker S, Khan A, Stowell J, Shabanowitz J, Peterson M, Rajagopalan S, Hunt D, Altmann D, Long E, Boyton R. Canonical and cross-reactive binding of NK cell inhibitory receptors to HLA-C allotypes is dictated by peptides bound to HLA-C. The Journal Of Immunology 2017, 198: 222.25-222.25. DOI: 10.4049/jimmunol.198.supp.222.25.Peer-Reviewed Original ResearchKiller cell Ig-like receptorsHLA-C allotypesCross-reactive bindingHuman NK cell activityNK cell inhibitory receptorsNK cell activityNK cell functionInhibitory killer cell Ig-like receptorsNK cell activationDisorders of pregnancyCell inhibitory receptorsIg-like receptorsInhibitory receptorsHLA genotypeKIR2DL1-C2Viral infectionHLACell activationCell activityKIR2DL1Cell functionEndogenous peptidesPotential mechanismsDisease associationsSpecific binding
2016
Cellular Activity of New Small Molecule Protein Arginine Deiminase 3 (PAD3) Inhibitors
Jamali H, Khan HA, Tjin CC, Ellman JA. Cellular Activity of New Small Molecule Protein Arginine Deiminase 3 (PAD3) Inhibitors. ACS Medicinal Chemistry Letters 2016, 7: 847-851. PMID: 27660689, PMCID: PMC5018872, DOI: 10.1021/acsmedchemlett.6b00215.Peer-Reviewed Original ResearchProtein arginine deiminasesThapsigargin-induced cell deathPost-translational deiminationHEK293T cellsArginine side chainHuman disease statesInhibitor 2Cellular activitiesCell deathPAD isozymesArginine deiminasesCell growthPAD activityPAD3Representative inhibitorsDisease statesNeurodegenerative responseSide chainsInhibitorsDeiminationApoptosisIsozymesActivityFirst timeCell activity
2015
Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses
Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, Tsui YC, Cui G, Micevic G, Perales JC, Kleinstein SH, Abel ED, Insogna KL, Feske S, Locasale JW, Bosenberg MW, Rathmell JC, Kaech SM. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. Cell 2015, 162: 1217-1228. PMID: 26321681, PMCID: PMC4567953, DOI: 10.1016/j.cell.2015.08.012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCD4-Positive T-LymphocytesEndoplasmic ReticulumGlycolysisHexokinaseImmunotherapyLymphocytes, Tumor-InfiltratingMelanomaMiceMonitoring, ImmunologicNFATC Transcription FactorsPhosphoenolpyruvateReceptors, Antigen, T-CellSarcoplasmic Reticulum Calcium-Transporting ATPasesSignal TransductionTransforming Growth Factor betaTumor MicroenvironmentConceptsAnti-tumor T cell responsesT cell responsesT cellsEffector functionsCell responsesTumor-reactive T cellsTumor-infiltrating T cellsPhosphoenolpyruvate carboxykinase 1Tumoricidal effector functionsTumor-specific CD4CD8 T cellsT cell activityMelanoma-bearing miceAerobic glycolysisActivated T cellsMetabolic checkpointTumor growthCell activityTumor microenvironmentNFAT SignalingMetabolic reprogrammingCarboxykinase 1Anabolic metabolismCellsATPase activity
2014
An Unconventional Glutamatergic Circuit in the Retina Formed by vGluT3 Amacrine Cells
Lee S, Chen L, Chen M, Ye M, Seal RP, Zhou ZJ. An Unconventional Glutamatergic Circuit in the Retina Formed by vGluT3 Amacrine Cells. Neuron 2014, 84: 708-715. PMID: 25456497, PMCID: PMC4254642, DOI: 10.1016/j.neuron.2014.10.021.Peer-Reviewed Original ResearchConceptsDirection-selective ganglion cellsAmacrine cellsGlutamatergic circuitsGanglion cellsCalcium-dependent glutamate releaseVGluT3 amacrine cellsExcitatory glutamatergic inputGanglion cell activityOFF light responsesReceptive field structureOFF channelsGlutamate releaseGlutamatergic inputsInner retinaExcitatory inputsInhibitory neuronsBipolar cellsMouse retinaCell activityOFF responsesRetinaExcitatory interactionsVertebrate retinaCellsVisual signalsChapter Four Epithelial Stem Cells in Adult Skin
Tadeu AM, Horsley V. Chapter Four Epithelial Stem Cells in Adult Skin. Current Topics In Developmental Biology 2014, 107: 109-131. PMID: 24439804, PMCID: PMC5595246, DOI: 10.1016/b978-0-12-416022-4.00004-4.Peer-Reviewed Original ResearchConceptsAdult skin epitheliumTissue-specific stem cellsDifferent stem cell populationsStem cellsStem cell nicheNormal skin homeostasisStem cell populationStem cell activityCell nicheEpithelial stem cellsSkin homeostasisAbnormal regulationCell populationsAdult skinSkin epitheliumExtrinsic componentsEnvironmental aggressionsCellsNicheAdult lifeHomeostasisFirst lineRegulationRecent effortsCell activity
2012
PTHrP regulates the modeling of cortical bone surfaces at fibrous insertion sites during growth
Wang M, VanHouten JN, Nasiri AR, Johnson RL, Broadus AE. PTHrP regulates the modeling of cortical bone surfaces at fibrous insertion sites during growth. Journal Of Bone And Mineral Research 2012, 28: 598-607. PMID: 23109045, PMCID: PMC3574208, DOI: 10.1002/jbmr.1801.Peer-Reviewed Original ResearchConceptsCortical bone surfaceCortical surfaceParathyroid hormone-related proteinLong bonesHormone-related proteinMedial collateral ligamentBone cell activityBone surfaceLong bone growthTendon insertionForme frusteCollateral ligamentFibrous enthesesInitial genetic evidenceCell activityInsertion sitePTHrPConditional deletionLinear growthEnthesesLigamentPeriosteal componentBiomechanical controlBoneFrusteLeptin regulates glutamate and glucose transporters in hypothalamic astrocytes
Fuente-Martín E, García-Cáceres C, Granado M, de Ceballos ML, Sánchez-Garrido MÁ, Sarman B, Liu ZW, Dietrich MO, Tena-Sempere M, Argente-Arizón P, Díaz F, Argente J, Horvath TL, Chowen JA. Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes. Journal Of Clinical Investigation 2012, 122: 3900-3913. PMID: 23064363, PMCID: PMC3484452, DOI: 10.1172/jci64102.Peer-Reviewed Original ResearchConceptsGlial structural proteinsPathology of obesityHypothalamic proopiomelanocortin (POMC) neuronsGlial cell activityOffspring of mothersHigh-fat dietActivity of neuronsExpression of glucoseProopiomelanocortin neuronsHypothalamic astrocytesGlial cellsBody weightSynaptic efficacyGlutamate transportersNeuronal functionCell activityLeptinGlucose uptakeMetabolic statusElectrical activityMetabolic signalsNeuronsAppetiteGlucose transporterKey regulator
2011
Biological functions of Mycobacterium tuberculosis-specific CD4+T cells were impaired by tuberculosis pleural fluid
Li Q, Li L, Liu Y, Fu X, Wang H, Lao S, yang B, Wu C. Biological functions of Mycobacterium tuberculosis-specific CD4+T cells were impaired by tuberculosis pleural fluid. Immunology Letters 2011, 138: 113-121. PMID: 21549757, DOI: 10.1016/j.imlet.2011.03.008.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAmino Acid SequenceAntibodies, NeutralizingAntigens, BacterialBacterial ProteinsBody FluidsCD4-Positive T-LymphocytesCells, CulturedFemaleHumansInterferon-gammaInterleukin-10Interleukin-2LungLymphocyte ActivationMaleMiddle AgedMolecular Sequence DataMonocytesMycobacterium tuberculosisTransforming Growth Factor betaTuberculosis, PleuralTumor Necrosis Factor-alphaConceptsPleural fluid mononuclear cellsPleural fluidAntigen-specific cellular immune responsesFluid mononuclear cellsIFN-γ productionMycobacterium tuberculosis infectionCellular immune responsesProduction of IFNT cell functionDose-dependent mannerTuberculosis patientsIL-10Tuberculosis infectionTuberculosis pleurisyCytokine productionMononuclear cellsIL-2Activation moleculeImmune responseCell activation processCFSE labelingCell activationFunctional predominanceCell activityStrong inhibitory effect
2007
Functional Coupling between the Prefrontal Cortex and Dopamine Neurons in the Ventral Tegmental Area
Gao M, Liu C, Yang S, Jin G, Bunney B, Shi W. Functional Coupling between the Prefrontal Cortex and Dopamine Neurons in the Ventral Tegmental Area. Journal Of Neuroscience 2007, 27: 5414-5421. PMID: 17507563, PMCID: PMC6672349, DOI: 10.1523/jneurosci.5347-06.2007.Peer-Reviewed Original ResearchConceptsVentral tegmental areaVTA DA neuronsDA neuronsPrefrontal cortexPFC neuronsDopamine neuronsTegmental areaAction potential-dependent DA releaseSlow oscillationsChloral hydrate-anesthetized ratsIntra-PFC infusionsFunctional couplingPFC terminalsVTA DAGlutamate releaseDA releaseExcitatory influenceRelay neuronsInhibitory influenceCell activityBrain functionNeuronsImportant new insightsCortexMultiple pathways
2004
Characterizing the Protective Component of the αβ T Cell Response to Transplantable Squamous Cell Carcinoma
Girardi M, Oppenheim D, Glusac EJ, Filler R, Balmain A, Tigelaar RE, Hayday AC. Characterizing the Protective Component of the αβ T Cell Response to Transplantable Squamous Cell Carcinoma. Journal Of Investigative Dermatology 2004, 122: 699-706. PMID: 15086556, DOI: 10.1111/j.0022-202x.2004.22342.x.Peer-Reviewed Original ResearchConceptsT cell responsesImmune responseCell responsesProtective anti-tumor effectTransplantable squamous cell carcinomaT cell-deficient miceAlphabeta T cell responsesCell-deficient miceT cell activityCellular immune responsesSquamous cell carcinomaΑβ T cell responsesSquamous cell carcinoma linesAlphabeta T cellsAnti-tumor effectsNK receptorsCell carcinomaT cellsFocal necrosesRAE-1Protective potentialTumor growthProtective responseStromal bedCell activity
2001
Stress-Induced Changes in Skin Barrier Function in Healthy Women
Altemus M, Rao B, Dhabhar F, Ding W, Granstein R. Stress-Induced Changes in Skin Barrier Function in Healthy Women. Journal Of Investigative Dermatology 2001, 117: 309-317. PMID: 11511309, DOI: 10.1046/j.1523-1747.2001.01373.x.Peer-Reviewed Original ResearchConceptsNatural killer cell activityKiller cell activityBarrier function recoverySkin barrier functionSkin barrier function recoveryFunction recoveryCell activityInterview stressSleep deprivationTumor necrosisBarrier functionInterleukin-1betaNatural killer cell numbersStress-induced changesPlasma interleukin-1betaHelper T cellsPeripheral blood leukocytesCytolytic T lymphocytesTransepidermal water lossClear exacerbationCytokine responsesHealthy womenInterleukin-10Exercise protocolPlasma levels
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