2023
When to use which molecular prognostic scoring system in the management of patients with MDS?
Kewan T, Bewersdorf J, Gurnari C, Xie Z, Stahl M, Zeidan A. When to use which molecular prognostic scoring system in the management of patients with MDS? Best Practice & Research Clinical Haematology 2023, 36: 101517. PMID: 38092484, DOI: 10.1016/j.beha.2023.101517.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInternational Prognostic Scoring SystemPrognostic scoring systemAcute myeloid leukemiaScoring systemRisk stratificationRecurrent molecular alterationsHigh-risk patientsAppropriate risk stratificationManagement of patientsRecurrent genetic mutationsIntensive therapyMyeloid leukemiaTreatment strategiesPrognostic toolDisease pathogenesisMolecular alterationsHematopoietic cancersClinical decisionHeterogeneous groupGenetic mutationsNext-generation sequencingPrognostic systemPatientsVariable propensitySubsequent revisionOnconephrology: Core Curriculum 2023
Yarandi N, Shirali A. Onconephrology: Core Curriculum 2023. American Journal Of Kidney Diseases 2023, 82: 743-761. PMID: 37855786, DOI: 10.1053/j.ajkd.2023.04.014.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsKidney diseaseChimeric antigen receptor T cellsAntigen receptor T cellsAJKD's Core CurriculumAcute kidney injuryKidney transplant recipientsChronic kidney diseaseReceptor T cellsKidney injuryTransplant recipientsElectrolyte disordersCell transplantClinical syndromeMonoclonal gammopathyGlomerular diseaseT cellsCancer riskClinical decisionCancer treatmentDiseaseOnconephrologySyndromeCancerSpecific considerationsHypertensionFrequency, Type, and Degree of Potential Harm of Adverse Safety Events among Pediatric Emergency Medical Services Encounters
Cicero M, Baird J, Brown L, Auerbach M, Adelgais K. Frequency, Type, and Degree of Potential Harm of Adverse Safety Events among Pediatric Emergency Medical Services Encounters. Prehospital Emergency Care 2023, 28: 883-889. PMID: 37698357, DOI: 10.1080/10903127.2023.2257775.Peer-Reviewed Original ResearchAdverse safety eventsDiagnosis/EMS encountersFluid administrationPediatric encountersSafety eventsCare categoriesClinical decisionEmergency medical services (EMS) patientsMedical service patientsCross-sectional studyPotential harmMedical service encountersChart reviewHospital recordsService patientsPrehospital recordsEMS patientsMedication administrationUnintended injuryFrequent associationPatientsClinical interventionsHarm severityEMS agenciesElectronic Health Record Embedded Strategies for Improving Care of Patients With Heart Failure
Fuery M, Kadhim B, Samsky M, Freeman J, Clark K, Desai N, Wilson F, Ahmed T, Ahmad T. Electronic Health Record Embedded Strategies for Improving Care of Patients With Heart Failure. Current Heart Failure Reports 2023, 20: 280-286. PMID: 37552356, DOI: 10.1007/s11897-023-00614-0.Peer-Reviewed Original ResearchConceptsHeart failure patientsFailure patientsElectronic health recordsEHR alertClinical trialsRandomized clinical trialsCare of patientsQuality of careHeart failureClinician satisfactionRandomized fashionRecent FindingsTherePatientsUnmet needPatient careClinical decisionEvidence-based decisionsFuture interventionsCareHealth recordsTrialsCliniciansInterventionFindingsTherePatient Safety in MRI with the Use of a Joint-Spanning External Fixator for Knee Dislocation
Marcel A, Green J, Alaia E, Alaia M, Katz L, Medvecky M. Patient Safety in MRI with the Use of a Joint-Spanning External Fixator for Knee Dislocation. JBJS Reviews 2023, 11: e23.00070. PMID: 37535762, DOI: 10.2106/jbjs.rvw.23.00070.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingKnee-spanning external fixatorExternal fixatorMR boreConstruct configurationsKnee dislocationMR ConditionalMRI scanningPatient benefitUS FoodDrug AdministrationClinical decisionResonance imagingMedical teamPatient safetySmall sample sizeFixatorPhysiciansSafety guidelinesManufacturer's labelSample sizeBorePrevious studiesPatientsDevicesSynthesizing and Applying Molecular Targeted Imaging Results in Patients With Prostate Cancer (RADAR VII)
Crawford E, Harris R, Slovin S, Concepcion R, Albala D, Gomella L, Orio P, Sellinger S, Petrylak D, Koo P. Synthesizing and Applying Molecular Targeted Imaging Results in Patients With Prostate Cancer (RADAR VII). JU Open Plus 2023, 1 DOI: 10.1097/ju9.00000000000000011.Peer-Reviewed Original ResearchProstate cancerNonmetastatic castrate-resistant prostate cancerClinical decisionCastrate-resistant prostate cancerConventional imagingLimited clinical dataTreatment of patientsFuture clinical trialsTreatment decision makingProstate cancer researchLimited available evidenceNuclear medicine specialistsLocalized diseaseMetastatic diseaseMedical oncologistsProspective studyBiochemical recurrenceClinical trialsRadiographic assessmentClinical dataMore robust recommendationsMedicine specialistsClinical experienceConsensus guidanceRadiation oncologistsChapter 23 Vaginal remnants, strictures, and fistula after masculinizing surgery
Sterling J, Schardein J, Nikolavsky D. Chapter 23 Vaginal remnants, strictures, and fistula after masculinizing surgery. 2023, 381-398. DOI: 10.1016/b978-0-323-98377-8.00023-3.Peer-Reviewed Original ResearchGender affirmation surgeryGenital reconstructive surgeryIndividual patient goalsVaginal remnantCommon complicationComplication rateConservative managementPreoperative workupSurgical revisionUrethrocutaneous fistulaTreatment optionsUrethral strictureEndoscopic repairPatient goalsTransmasculine patientsSurgical techniqueReconstructive surgerySurgical reconstructionSurgeryClinical decisionComplicationsPatientsVaginal cavityGenital surgeryFistula
2022
Outcome Prediction in Cerebral Venous Thrombosis: The IN-REvASC Score
Klein P, Shu L, Nguyen TN, Siegler JE, Omran SS, Simpkins AN, Heldner M, de Havenon A, Aparicio HJ, Abdalkader M, Psychogios M, Vedovati MC, Paciaroni M, von Martial R, Liebeskind DS, de Sousa D, Coutinho JM, Yaghi S, Group F. Outcome Prediction in Cerebral Venous Thrombosis: The IN-REvASC Score. Journal Of Stroke 2022, 24: 404-416. PMID: 36221944, PMCID: PMC9561213, DOI: 10.5853/jos.2022.01606.Peer-Reviewed Original ResearchCerebral venous thrombosisPoor neurological outcomePoor outcomeNeurological outcomeVenous thrombosisPrognostic scoreRisk factorsInternational multicenter retrospective studyMulticenter retrospective studyMultivariable logistic regressionFuture clinical trialsActive cancerHigher NIHSSConsecutive patientsMedian ageMultivariable analysisRetrospective studyMRS 3Black raceRadiographic characteristicsClinical trialsPrognostic accuracyHigh riskPatientsClinical decisionA Qualitative Description of Clinician Free-Text Rationales Entered within Accountable Justification Interventions
Brown T, Zelch B, Lee J, Doctor J, Linder J, Sullivan M, Goldstein N, Rowe T, Meeker D, Knight T, Friedberg M, Persell S. A Qualitative Description of Clinician Free-Text Rationales Entered within Accountable Justification Interventions. Applied Clinical Informatics 2022, 13: 820-827. PMID: 36070799, PMCID: PMC9451951, DOI: 10.1055/s-0042-1756366.Peer-Reviewed Original ResearchConceptsClinical content areasClinical appropriatenessClinical decision support alertsPrimary care physiciansDecision support alertsAppropriate clinical decisionsUnique cliniciansOpioid prescribingCare physiciansClinical detailsAccountable justificationCDS alertsPilot interventionClinical decisionClinical casesCliniciansParticular diagnosisOlder adultsInterventionPhysiciansDelphi techniquePolypharmacyPrescribingPatientsSymptomsUrine testing to differentiate glomerular from tubulointerstitial diseases on kidney biopsy
Tran AC, Melchinger H, Weinstein J, Shaw M, Kent C, Perazella MA, Wilson FP, Parikh CR, Moledina DG. Urine testing to differentiate glomerular from tubulointerstitial diseases on kidney biopsy. Practical Laboratory Medicine 2022, 30: e00271. PMID: 35465621, PMCID: PMC9018443, DOI: 10.1016/j.plabm.2022.e00271.Peer-Reviewed Original ResearchTubulointerstitial diseaseKidney biopsyGlomerular diseaseUrine albuminHistological diagnosisUrine uromodulinUrine testsHigher urine albuminUrine sediment microscopyCohort of participantsDipstick hematuriaTubular injuryAppropriate patientsUrine testingMultivariable modelHigher oddsBiopsyClinical decisionSediment microscopyDiseasePatientsHealth biomarkersUrine samplesDiagnosisCohortGenome-wide identification and analysis of prognostic features in human cancers
Smith JC, Sheltzer JM. Genome-wide identification and analysis of prognostic features in human cancers. Cell Reports 2022, 38: 110569. PMID: 35354049, PMCID: PMC9042322, DOI: 10.1016/j.celrep.2022.110569.Peer-Reviewed Original ResearchConceptsAdverse biomarkersSignificant prognostic biomarkerShorter survival timePromising therapeutic targetPatient survival dataPreclinical cancer researchPrognostic featuresAggressive malignancyClinical trialsPatient outcomesPatient riskPrognostic biomarkerSurvival timeTherapeutic targetSuccessful drug targetsClinical decisionCancerSurvival dataTherapeutic developmentHuman cancersBiomarkersBiomarker analysisDriver genesCancer researchCancer driver genesSubtyping intestinal metaplasia in patients with chronic atrophic gastritis: an interobserver variability study
Lerch JM, Pai RK, Brown I, Gill AJ, Jain D, Kővári B, Kushima R, Sheahan K, Slavik T, Srivastava A, Lauwers GY, Langner C. Subtyping intestinal metaplasia in patients with chronic atrophic gastritis: an interobserver variability study. Pathology 2022, 54: 262-268. PMID: 35221041, DOI: 10.1016/j.pathol.2021.12.288.Peer-Reviewed Original ResearchConceptsGastric intestinal metaplasiaChronic atrophic gastritisAmerican Gastroenterological AssociationAtrophic gastritisIntestinal metaplasiaConsensus diagnosisInterobserver variabilityCurrent practice guidelinesExpert pathologistsSubstantial overall agreementHigh interobserver agreementHistological diagnosisGastrointestinal endoscopyGastroenterological AssociationPractice guidelinesGastric cancerBiopsy piecesMucosal surfacesClinical decisionLevel of agreementInterobserver agreementInterobserver variability studyEuropean SocietyPredominant patternKappa statistics
2021
B-cell lymphoma 6 expression is not associated with live birth in a normal responder in vitro fertilization population
Klimczak AM, Herlihy NS, Scott CS, Hanson BM, Kim JG, Titus S, Seli E, Scott RT. B-cell lymphoma 6 expression is not associated with live birth in a normal responder in vitro fertilization population. Fertility And Sterility 2021, 117: 351-358. PMID: 34809978, DOI: 10.1016/j.fertnstert.2021.09.036.Peer-Reviewed Original ResearchConceptsB-cell lymphoma 6 (Bcl6) expressionLive birth groupLive birthsFertilization populationNormal respondersBirth groupProportion of patientsLive birth ratePopulation of patientsEuploid embryo transferCase-control studyEndometrial tissue samplesPreimplantation genetic testingGroup of womenIVF stimulationMean HSCOREIVF outcomesInfertility centerIVF successMAIN OUTCOMEGroup 2Group 1Embryo transferPatientsClinical decisionSeizure Prophylaxis After Spontaneous Intracerebral Hemorrhage
Jones F, Sanches P, Smith J, Zafar S, Blacker D, Hsu J, Schwamm L, Newhouse J, Westover M, Moura L. Seizure Prophylaxis After Spontaneous Intracerebral Hemorrhage. JAMA Neurology 2021, 78: 1128-1136. PMID: 34309642, PMCID: PMC8314179, DOI: 10.1001/jamaneurol.2021.2249.Peer-Reviewed Original ResearchConceptsEarly seizure prophylaxisSpontaneous intracerebral hemorrhageAdverse drug reactionsRisk-guided strategyLate seizuresLong-term therapyHigh riskSeizure prophylaxisPrimary prophylaxisIntracerebral hemorrhageLower riskLong-term adverse drug reactionsLow-risk patientsShort-term prophylaxisDecision analytical modelSecondary therapyProphylaxis strategiesDrug reactionsProphylaxisMAIN OUTCOMESeizuresPatientsClinical decisionTherapyAverage riskA Review of the Evidence and Recommendations on Communication Skills and the Patient–Provider Relationship: A Rome Foundation Working Team Report
Drossman DA, Chang L, Deutsch JK, Ford AC, Halpert A, Kroenke K, Nurko S, Ruddy J, Snyder J, Sperber A. A Review of the Evidence and Recommendations on Communication Skills and the Patient–Provider Relationship: A Rome Foundation Working Team Report. Gastroenterology 2021, 161: 1670-1688.e7. PMID: 34331912, DOI: 10.1053/j.gastro.2021.07.037.Peer-Reviewed Original ResearchMeSH KeywordsAttitude of Health PersonnelBrain-Gut AxisCommunication BarriersComprehensionConsensusDelphi TechniqueGastroenterologistsGastroenterologyGastrointestinal DiseasesHealth CommunicationHealth Knowledge, Attitudes, PracticeHealth LiteracyHumansPatient SatisfactionPatient-Centered CarePhysician-Patient RelationsTelemedicineConceptsPatient-provider relationshipPatient satisfactionRome Foundation Working Team ReportCommunication skills trainingGut-brain interactionEvidence-based reviewRole of telehealthEffective patient-provider relationshipsPatient-provider interactionsCare dissatisfactionMultidisciplinary working teamClinical outcomesChronic illnessPatient's perspectivePatient needsHealth outcomesPatientsCare processesProvider experienceClinical decisionIllness contextAbstractTextCommunication skillsRome FoundationSkills trainingPatient-centric decision framework for treatment alterations in patients with Chemotherapy-induced Peripheral Neuropathy (CIPN)
Hertz DL, Childs DS, Park SB, Faithfull S, Ke Y, Ali NT, McGlown SM, Chan A, Grech LB, Loprinzi CL, Ruddy KJ, Lustberg M. Patient-centric decision framework for treatment alterations in patients with Chemotherapy-induced Peripheral Neuropathy (CIPN). Cancer Treatment Reviews 2021, 99: 102241. PMID: 34174668, DOI: 10.1016/j.ctrv.2021.102241.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyNeurotoxic chemotherapy treatmentTreatment alterationsCIPN severityPeripheral neuropathyPatient factorsChemotherapy treatmentRelative dose intensityClinical Oncology guidelinesNeurotoxic chemotherapyDose intensityProspective trialOncology guidelinesRetrospective analysisAdult cancersIndividual patientsInconsistent recommendationsPatientsTreatment efficacyClinical decisionSeverityNeuropathyAmerican SocietyTreatmentCliniciansBiobank Scale Pharmacogenomics Informs the Genetic Underpinnings of Simvastatin Use
Wendt FR, Koller D, Pathak GA, Jacoby D, Miller EJ, Polimanti R. Biobank Scale Pharmacogenomics Informs the Genetic Underpinnings of Simvastatin Use. Clinical Pharmacology & Therapeutics 2021, 110: 777-785. PMID: 33837531, PMCID: PMC8376807, DOI: 10.1002/cpt.2260.Peer-Reviewed Original ResearchConceptsLDL-C concentrationsSimvastatin useLow-density lipoprotein cholesterol concentrationsLipoprotein cholesterol concentrationsDrug-metabolizing enzymesElectronic medical recordsStatin therapyStatin treatmentActivity scoreMedical recordsPilot cohortCholesterol concentrationsEuropean ancestry participantsMetabolizer phenotypeClinical decisionNAT2 allelesPolygenic riskNAT2Good responseUK BiobankBiological mechanismsPharmacogenesAssociationPotential benefitsPhenotypeInterventions supporting medical practitioners in the provision of lactation care: A systematic review and narrative analysis
Boss M, Saxby N, Pritchard D, Pérez‐Escamilla R, Clifford R. Interventions supporting medical practitioners in the provision of lactation care: A systematic review and narrative analysis. Maternal And Child Nutrition 2021, 17: e13160. PMID: 33590635, PMCID: PMC8189190, DOI: 10.1111/mcn.13160.Peer-Reviewed Original ResearchConceptsRisk of biasSystematic reviewMedical practitionersCochrane Library databasesInfant feeding decisionsFull-text articlesQuality of reportingPractitioner careIntervention reportingInclusion criteriaEvidence-based decision supportLactation careLibrary databasesClinical practiceGood quality researchClinical decisionHealth interventionsMost childrenFeeding decisionsCareSuch visitsPeer-reviewed empirical studiesInterventionRiskImplementation strategies
2020
Neonatal Cardiac Emergencies: A Multidisciplinary Simulation Curriculum for Neonatology and Pediatric Cardiology Fellows
Simmons MA, Otero-Luna A, Redmond B, Fahey J, Beach C, Bruno C, Johnston L. Neonatal Cardiac Emergencies: A Multidisciplinary Simulation Curriculum for Neonatology and Pediatric Cardiology Fellows. MedEdPORTAL 2020, 16: 11045. PMID: 33365389, PMCID: PMC7751327, DOI: 10.15766/mep_2374-8265.11045.Peer-Reviewed Original ResearchConceptsCardiac diseaseMean overall satisfaction scoreNeonatal cardiac emergencyManagement of neonatesCongenital heart diseaseRemote consultationsPediatric cardiology fellowsOverall satisfaction scoreCardiac concernsCardiogenic shockMultidisciplinary managementUnstable arrhythmiasBedside evaluationPediatric cardiologistsCardiac careHeart diseaseCardiac emergenciesPediatric cardiologyClinical decisionSatisfaction scoresCyanosisNeonatesSimulation curriculumCardiology fellowsDiseaseThe Use of Experts to Evaluate a Child Abuse Guideline in Community Emergency Departments
Shum M, Asnes A, Leventhal JM, Bechtel K, Gaither JR, Tiyyagura G. The Use of Experts to Evaluate a Child Abuse Guideline in Community Emergency Departments. Academic Pediatrics 2020, 21: 521-528. PMID: 33160081, DOI: 10.1016/j.acap.2020.11.001.Peer-Reviewed Original ResearchConceptsGuideline implementationExpert recommendationsIndeterminate casesCommunity emergency departmentsEvaluation of infantsGold standard testPostguideline implementationProvider adherenceCommunity EDRetrospective reviewED providersEmergency departmentCPS reportingClinical decisionTeam consultationInfantsInjurySignificant increaseAdherenceHigh percentageInterventionConsultationProvidersAbuseGuidelines
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