2021
Phosphatidylserine binding directly regulates TIM-3 function
Smith CM, Li A, Krishnamurthy N, Lemmon MA. Phosphatidylserine binding directly regulates TIM-3 function. Biochemical Journal 2021, 478: 3331-3349. PMID: 34435619, PMCID: PMC8454703, DOI: 10.1042/bcj20210425.Peer-Reviewed Original ResearchConceptsTim-3T cell receptorTherapeutic targetCo-signaling receptorsTim-3 functionTim-3 ligandTim-3 signalingCo-inhibitory receptorsCo-stimulatory receptorsImmune modulation approachesIL-2 secretionPotential therapeutic targetNF-κB signalingImportant therapeutic targetPD-1Jurkat cellsCultured Jurkat cellsT cellsCell receptorTCR stimulationReceptorsImportance of phosphatidylserineDifferent studiesCellsSignaling
2020
Risk Factors and Prevalence of Mental Illness
Zimbrean P, Dahal R. Risk Factors and Prevalence of Mental Illness. 2020, 195-214. DOI: 10.1007/978-3-030-47668-7_13.ChaptersRisk factorsMental illnessPosttraumatic stress disorderMental distressMental health screeningCommon mental illnessHealth screeningMajor depressionIllnessStress disorderPrevalenceSomatic manifestationsAvailable literatureDistressPost-migration phasesDifferent studiesMethodological differencesPosttraumatic growthSyndromeFactorsEvaluation of confounding in epidemiologic studies assessing alcohol consumption on the risk of ischemic heart disease
Wallach JD, Serghiou S, Chu L, Egilman AC, Vasiliou V, Ross JS, Ioannidis JPA. Evaluation of confounding in epidemiologic studies assessing alcohol consumption on the risk of ischemic heart disease. BMC Medical Research Methodology 2020, 20: 64. PMID: 32171256, PMCID: PMC7071725, DOI: 10.1186/s12874-020-0914-6.Peer-Reviewed Original ResearchConceptsIschemic heart disease riskHeart disease riskObservational studyImpact of alcoholPotential confoundersHeart diseaseDisease riskMultivariate modelIschemic heart diseaseResidual confoundingDisease relationshipsEpidemiologic studiesAlcohol consumptionConfoundersMultivariate analysisLack of consensusIndividual studiesStratification variablesDiseaseRiskSame exposureConfoundingDifferent studiesStudy findingsDifferent investigators
2018
The Complexities of Evaluating the Exposome in Psychiatry: A Data-Driven Illustration of Challenges and Some Propositions for Amendments
Guloksuz S, Rutten B, Pries L, Have M, de Graaf R, van Dorsselaer S, Klingenberg B, van Os J, Ioannidis J, Group T. The Complexities of Evaluating the Exposome in Psychiatry: A Data-Driven Illustration of Challenges and Some Propositions for Amendments. Schizophrenia Bulletin 2018, 44: 1175-1179. PMID: 30169883, PMCID: PMC6192470, DOI: 10.1093/schbul/sby118.Peer-Reviewed Original ResearchConceptsMental health outcomesHealth outcomesNetherlands Mental Health SurveyMental Health SurveyPre-specified analysis planFalsification endpointsModifiable factorsSources of heterogeneityHealth SurveyIntervention effectsSelective reportingAnalysis planP-valueOutcomesEffect sizeVibration of effectsAnalytical planSame outcomeDifferent studiesExploratory analysisExposureStudy 2 dataP-value threshold
2016
Large-scale functional network overlap is a general property of brain functional organization: Reconciling inconsistent fMRI findings from general-linear-model-based analyses
Xu J, Potenza MN, Calhoun VD, Zhang R, Yip SW, Wall JT, Pearlson GD, Worhunsky PD, Garrison KA, Moran JM. Large-scale functional network overlap is a general property of brain functional organization: Reconciling inconsistent fMRI findings from general-linear-model-based analyses. Neuroscience & Biobehavioral Reviews 2016, 71: 83-100. PMID: 27592153, PMCID: PMC5140707, DOI: 10.1016/j.neubiorev.2016.08.035.Peer-Reviewed Original ResearchConceptsBrain functional organizationNeuronal activitySpatial independent component analysisMagnetic resonance imaging studyFunctional networksResonance imaging studyFunctional magnetic resonance imaging studyFunctional organizationFunctional heterogeneityBrain propertiesLarge-scale functional networksElectrophysiological studiesWhole brainImaging studiesOpposite modulationFMRI findingsNew findingsBalanced excitationSignificant modulationDifferent studiesFindingsA meta-analysis of MSI frequency and race in colorectal cancer
Ashktorab H, Ahuja S, Kannan L, Llor X, Ellis NA, Xicola RM, Laiyemo AO, Carethers JM, Brim H, Nouraie M. A meta-analysis of MSI frequency and race in colorectal cancer. Oncotarget 2016, 7: 34546-34557. PMID: 27120810, PMCID: PMC5085175, DOI: 10.18632/oncotarget.8945.Peer-Reviewed Original ResearchConceptsColorectal cancerMSI frequencyMicrosatellite instabilityAfrican AmericansAssociation of raceSub-group analysisMeta-regression analysisAvailable race dataClinical factorsTumor locationHigh riskMSI ratesDifferent literature databasesLiterature databasesRacial disparitiesCancerCaucasiansHispanicsDifferent studiesCaucasian samplesRandom effectsUnivariate effectsHigh frequencyRace data
2015
Chapter 49 Antioxidant Status in Vascular Dementia
Zito G, Squitti R, Polimanti R. Chapter 49 Antioxidant Status in Vascular Dementia. 2015, 529-537. DOI: 10.1016/b978-0-12-407824-6.00049-5.Peer-Reviewed Original ResearchVascular dementiaSystemic oxidative stress markersAdministration of antioxidantsOxidative stress markersVaD patientsPathological featuresSupplementation therapyAntioxidant statusStress markersCognitive declineOxidative stressEffectiveness of antioxidantsDementiaVADCommon formClinical experimentsPatientsAntioxidantsDifferent studiesPathogenesisTherapyAdministrationCaregivers
2014
Open-Access Biorepository for Idiopathic Pulmonary Fibrosis. The Way Forward
White ES, Brown KK, Collard HR, Conoscenti CS, Cosgrove GP, Flaherty KR, Leff JA, Martinez FJ, Roman J, Rose D, Violette S, Kaminski N. Open-Access Biorepository for Idiopathic Pulmonary Fibrosis. The Way Forward. Annals Of The American Thoracic Society 2014, 11: 1171-1175. PMID: 25167209, PMCID: PMC4299004, DOI: 10.1513/annalsats.201406-289oi.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisPulmonary fibrosisInvestigator-initiated clinical studyHuman lung diseasesHuman lung tissuePatient-derived samplesLung diseaseLung tissueClinical dataClinical studiesClinical phenotypingOutcome dataLung samplesAnimal modelingStandardized fashionHuman specimensTranslational researchPulmonary researchFibrosisBiorepositoryFuture studiesInvestigational processHuman physiologyCurrent knowledge gapsDifferent studies
2008
Fellow Involvement May Increase Adenoma Detection Rates During Colonoscopy
Rogart JN, Siddiqui UD, Jamidar PA, Aslanian HR. Fellow Involvement May Increase Adenoma Detection Rates During Colonoscopy. The American Journal Of Gastroenterology 2008, 103: ajg2008568. PMID: 18759826, DOI: 10.1111/j.1572-0241.2008.02085.x.Peer-Reviewed Original ResearchConceptsAdenoma detection rateRetrospective studyFellow involvementPercentage of patientsAdvanced adenomasSurveillance colonoscopyMore adenomasDetection rateProcedure timeColonoscopyFellow participationAdenomasGI fellowsSignificant differencesPatientsFurther investigationAttendingsDifferent studiesVisual scanningInvolvementTotal numberFellowsQuality indicatorsTechnical aspects
2002
Inhibition of return in temporal order saccades
Li CS, Lin SC. Inhibition of return in temporal order saccades. Vision Research 2002, 42: 2089-2093. PMID: 12169428, DOI: 10.1016/s0042-6989(02)00123-2.Peer-Reviewed Original Research
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