2025
Research Priorities in Neuropalliative Care
Lau W, Fehnel C, Macchi Z, Mehta A, Auffret M, Bogetz J, Fleisher J, Graber J, Leeper H, Manglani-Terranova H, Muehlschlegel S, Mroz E, Pedowitz E, Ramanathan U, Sarmet M, Shlobin N, Sokol L, Weeks S, Xu J, Medsger H, Creutzfeldt C, Vranceanu A, Zahuranec D, Hwang D. Research Priorities in Neuropalliative Care. JAMA Neurology 2025, 82: 295-302. PMID: 39899319, DOI: 10.1001/jamaneurol.2024.4932.Peer-Reviewed Original ResearchMeSH KeywordsBiomedical ResearchConsensusHumansNervous System DiseasesNeurologyPalliative CareResearchSocieties, MedicalConceptsNeuropalliative careCare partnersIntegration of palliative careSpecialty palliative care servicesGoal-concordant carePalliative care servicesInterdisciplinary panel of expertsArea of practiceImprove quality of lifeQuality of lifePalliative careCare interventionsCare servicesPanel of expertsDelivery modelsPriority research areasCareInterdisciplinary panelImprove qualityCare SocietyResearch prioritiesResearch funding mechanismsResearch CommitteeSpecialized communicationNeurological diseasesAn international perspective on the future of systemic sclerosis research
Abraham D, Black C, Denton C, Distler J, Domsic R, Feghali-Bostwick C, Gourh P, Hinchcliff M, Kolling F, Kuwana M, Lafyatis R, Landegren U, Mahoney J, Martin J, Matucci-Cerinic M, McMahan Z, Mora A, Mouthon L, Rabinovitch M, Rojas M, Rubin K, Trojanowska M, Varga J, Whitfield M, Gabrielli A, Krieg T. An international perspective on the future of systemic sclerosis research. Nature Reviews Rheumatology 2025, 21: 174-187. PMID: 39953141, DOI: 10.1038/s41584-024-01217-2.Peer-Reviewed Original ResearchConceptsSystemic sclerosisSystemic sclerosis researchHistory of systemic sclerosisInnovative clinical trial designsSystemic autoimmune diseaseEarly pathogenetic eventClinical trial designCollaborative global effortAutoimmune phenomenaImprove patient outcomesDisease activityMicrovascular dysfunctionClinical historyEmergency therapyAutoimmune diseasesDisease-modifying treatmentsTissue fibrosisSingle-cell RNA sequencingClinical heterogeneityEffective disease-modifying treatmentsPersonalized therapyAnimal modelsComplex pathogenesisEffective treatmentNext-generation sequencingObservational research in epidemic settings: a roadmap to reform
Ricotta E, Carrillo F, Angelli-Nichols S, Barugahare J, Benton A, Carlson C, Chang-Rabley E, Dean N, Duda S, Federer L, Fill M, LeRoy E, Linton N, Lipsitch M, Mathur M, Phelan A, Rid A, Rosen J, Sauer L, Sullivan S, Zendt M, Evans N. Observational research in epidemic settings: a roadmap to reform. BMJ Global Health 2025, 10: e017981. PMID: 39929534, PMCID: PMC11815396, DOI: 10.1136/bmjgh-2024-017981.Peer-Reviewed Original ResearchMeSH KeywordsBiomedical ResearchEpidemicsHumansObservational Studies as TopicPublic HealthResearch DesignData Science and Geriatric Anesthesia Research Opportunity and Challenges
Sandhu M, Tickoo M, Bardia A. Data Science and Geriatric Anesthesia Research Opportunity and Challenges. Clinics In Geriatric Medicine 2025, 41: 101-116. PMID: 39551536, DOI: 10.1016/j.cger.2024.03.009.Peer-Reviewed Original Research
2024
Practical Guide for Implementing Cryogenic Electron Microscopy Structure Determination in Dermatology Research
Lomakin I, Devarkar S, Freniere C, Bunick C. Practical Guide for Implementing Cryogenic Electron Microscopy Structure Determination in Dermatology Research. Journal Of Investigative Dermatology 2024, 145: 22-31. PMID: 39601740, PMCID: PMC11748023, DOI: 10.1016/j.jid.2024.10.594.Peer-Reviewed Original ResearchResearch Priorities in Pediatric Asthma Morbidity: Addressing the Impacts of Systemic Racism on Children with Asthma in the United States. An Official American Thoracic Society Workshop Report
Lovinsky-Desir S, Riley I, Bryant-Stephens T, De Keyser H, Forno E, Kozik A, Louisias M, Matsui E, Sheares B, Thakur N, Apter A, Beck A, Bentley-Edwards K, Berkowitz C, Braxton C, Dean J, Jones C, Koinis-Mitchell D, Okelo S, Taylor-Cousar J, Teach S, Wechsler M, Gaffin J, Federico M. Research Priorities in Pediatric Asthma Morbidity: Addressing the Impacts of Systemic Racism on Children with Asthma in the United States. An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2024, 21: 1349-1364. PMID: 39352175, PMCID: PMC11451894, DOI: 10.1513/annalsats.202407-767st.Peer-Reviewed Original ResearchConceptsImpact of systemic racismAsthma morbidityChildhood asthmaSocial determinants of healthAsthma health outcomesPediatric asthma morbidityDeterminants of healthSystemic racismCommunity engagementDrivers of disparitiesEmergency department visitsResearch teamChildhood asthma outcomesImpact of interventionsMultidisciplinary research teamEffects of systemic racismInnovative study designsImpact of racismAsthma disparitiesSocial determinantsHealthcare accessAsthma outcomesHealth outcomesDepartment visitsEvaluate interventionsPostinfectious Pulmonary Complications: Establishing Research Priorities to Advance the Field: An Official American Thoracic Society Workshop Report.
Auld S, Sheshadri A, Alexander-Brett J, Aschner Y, Barczak A, Basil M, Cohen K, Dela Cruz C, McGroder C, Restrepo M, Ridge K, Schnapp L, Traber K, Wunderink R, Zhang D, Ziady A, Attia E, Carter J, Chalmers J, Crothers K, Feldman C, Jones B, Kaminski N, Keane J, Lewinsohn D, Metersky M, Mizgerd J, Morris A, Ramirez J, Samarasinghe A, Staitieh B, Stek C, Sun J, Evans S. Postinfectious Pulmonary Complications: Establishing Research Priorities to Advance the Field: An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2024, 21: 1219-1237. PMID: 39051991, DOI: 10.1513/annalsats.202406-651st.Peer-Reviewed Original ResearchMeSH KeywordsBiomedical ResearchCOVID-19HumansLung DiseasesRespiratory Tract InfectionsSARS-CoV-2Societies, MedicalUnited StatesConceptsPulmonary infectionTreatment of pulmonary infectionsLower respiratory tract infectionsLong-term morbidityRespiratory tract infectionsShort-term outcomesAberrant host responseBurden of morbidityReview potential mechanismsPulmonary complicationsTract infectionsPulmonary pathogensSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Causative pathogenRespiratory syndrome coronavirus 2Therapeutic strategiesSyndrome coronavirus 2Host responseInfectionMorbidityPotential mechanismsCoronavirus 2Public perspectives on increased data sharing in health research in the context of the 2023 National Institutes of Health Data Sharing Policy
de Rivera S, Creber R, Zhao Y, Eslami S, Mangal S, Dugdale L, Turchioe M. Public perspectives on increased data sharing in health research in the context of the 2023 National Institutes of Health Data Sharing Policy. PLOS ONE 2024, 19: e0309161. PMID: 39197051, PMCID: PMC11357082, DOI: 10.1371/journal.pone.0309161.Peer-Reviewed Original ResearchConceptsNational Institutes of HealthHealthcare providersEnglish-speaking US adultsNational Institutes of Health policyNational InstitutePatient perspectivePotential unintended consequencesInstitutes of HealthUS adultsHealth researchPatient autonomyBlack participantsPatients' willingnessSexual healthParticipants' perspectivesParticipants' preferencesAfrican AmericansResearch fundersHealthRacial differencesOnline surveyParticipantsHealthcareEffective JanuaryHealth technology companiesPrivacy-Enhancing Technologies in Biomedical Data Science
Cho H, Froelicher D, Dokmai N, Nandi A, Sadhuka S, Hong M, Berger B. Privacy-Enhancing Technologies in Biomedical Data Science. Annual Review Of Biomedical Data Science 2024, 7: 317-343. PMID: 39178425, PMCID: PMC11346580, DOI: 10.1146/annurev-biodatasci-120423-120107.Peer-Reviewed Original ResearchMeSH KeywordsBiomedical ResearchComputer SecurityConfidentialityData ScienceHumansInformation DisseminationPrivacyConceptsPrivacy-enhancing technologiesAdoption of privacy-enhancing technologiesBiomedical data scienceData scienceAnalyze sensitive dataBiomedical data repositoriesPrivacy protectionSensitive dataPrivacy concernsData silosProtect privacyHuman subject dataBiomedical domainData repositoriesPrivacySubjective dataConventional frameworkPriorities for Clinical Research in Pediatric Extracorporeal Membrane Oxygenation Anticoagulation From the Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference
Muszynski J, Bembea M, Gehred A, Lyman E, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Alexander P, Alexander P, Bembea M, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Almond C, Anders M, Annich G, Brandão L, Chandler W, Delaney M, DiGeronimo R, Emani S, Gadepalli S, Garcia A, Haileselassie B, Himebauch A, Hyslop R, Kneyber M, Kreuziger L, Le J, Loftis L, McMichael A, McMullan D, Monagle P, Nicol K, Paden M, Patregnani J, Priest J, Raffini L, Ryerson L, Sloan S, Teruya J, Yates A, Gehred A, Lyman E, Muszynski J. Priorities for Clinical Research in Pediatric Extracorporeal Membrane Oxygenation Anticoagulation From the Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. Pediatric Critical Care Medicine 2024, 25: e78-e89. PMID: 38959362, PMCID: PMC11216398, DOI: 10.1097/pcc.0000000000003488.Peer-Reviewed Original ResearchMeSH KeywordsAnticoagulantsBiomedical ResearchChildChild, PreschoolCritical IllnessExtracorporeal Membrane OxygenationHumansInfantInfant, NewbornConceptsExtracorporeal membrane oxygenationCritically ill neonatesIll neonatesExtracorporeal membrane oxygenation anticoagulationManagement of extracorporeal membrane oxygenationConsensus conferenceSystematic reviewSystematic review of MEDLINECochrane Library databasesReview of MEDLINECare of neonatesMembrane oxygenationChild Health and Nutrition Research Initiative methodologyHemostasis managementLibrary databasesNeonatesConsensus statementClinical recommendationsAnticoagulationClinical careClinical researchEmbaseCochraneExpert panelPediatricAltmetric Attention Scores and Citations of Published Research With or Without Preprints
Zissette S, Gautam A, Krumholz H, Ross J, Wallach J. Altmetric Attention Scores and Citations of Published Research With or Without Preprints. JAMA Network Open 2024, 7: e2424732. PMID: 39058492, PMCID: PMC11282438, DOI: 10.1001/jamanetworkopen.2024.24732.Peer-Reviewed Original ResearchEvaluating the National Institutes of Health Pipeline for Resuscitation Science Investigators
Coute R, Huebinger R, Perman S, Del Rios M, Kurz M. Evaluating the National Institutes of Health Pipeline for Resuscitation Science Investigators. Journal Of The American Heart Association 2024, 13: e035854. PMID: 38879460, PMCID: PMC11255749, DOI: 10.1161/jaha.124.035854.Peer-Reviewed Original ResearchImpact of COVID-19 pandemic on physician-scientist trainees to faculty one year into the pandemic
Obradovic A, Toubat O, Chen N, Siebert A, Jansen C, Christophers B, Leveille E, Noch E, Kwan J. Impact of COVID-19 pandemic on physician-scientist trainees to faculty one year into the pandemic. BMC Medical Education 2024, 24: 587. PMID: 38807106, PMCID: PMC11134762, DOI: 10.1186/s12909-024-05541-9.Peer-Reviewed Original ResearchConceptsPersonal healthLong-term effects of COVID-19Physician-scientist traineesPhysician-scientistsCross-sectional survey of medical studentsCOVID-19 pandemicSurvey of medical studentsClustering techniqueScientific pursuitsHealth of familiesMultivariate regression analysisEffects of COVID-19ConclusionsThis national surveyLevel of trainingTailored supportPhysician-scientist trainingResearch productivityMental healthFewer physiciansLonger-term impactMedical studentsImpaired productionCOVID-19Long-term effectsReport concernsChallenges in IBD Research 2024: Preclinical Human IBD Mechanisms
Ciorba M, Konnikova L, Hirota S, Lucchetta E, Turner J, Slavin A, Johnson K, Condray C, Hong S, Cressall B, Pizarro T, Hurtado-Lorenzo A, Heller C, Moss A, Swantek J, Garrett W. Challenges in IBD Research 2024: Preclinical Human IBD Mechanisms. Inflammatory Bowel Diseases 2024, 30: s5-s18. PMID: 38778627, PMCID: PMC11491665, DOI: 10.1093/ibd/izae081.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomedical ResearchGastrointestinal MicrobiomeHumansInflammatory Bowel DiseasesPrecision MedicineConceptsInflammatory bowel diseasePreclinical human IBD mechanismsInflammatory bowel disease researchHuman inflammatory bowel diseaseCell statesRisk allelesUnmet medical needExtraintestinal manifestationsPrecision medicineInflammatory bowel disease complicationsPreclinical researchBowel diseasePragmatic clinical researchMultidisciplinary inputBarrier functionDisease researchEnvironmental triggersMedical needClinical researchTranslational scientistsMicrobiomeAllelesEpigeneticsGeneticsRemissionIs it time to reduce the length of postgraduate training for physician-scientists in internal medicine?
Gallagher E, Conlin P, Kazmierczak B, Vyas J, Ajijola O, Kontos C, Baiocchi R, Rhee K, Hu P, Isales C, Williams C, Rockey D. Is it time to reduce the length of postgraduate training for physician-scientists in internal medicine? JCI Insight 2024, 9: e178214. PMID: 38775155, PMCID: PMC11141926, DOI: 10.1172/jci.insight.178214.Peer-Reviewed Original ResearchConceptsMedical school graduatesCareer development awardsInternal medicine residency graduatesResidency graduatesRetention of physician-scientistsInternal medicinePostgraduate trainingPhysician-scientistsSchool graduatesK awardsK awardeesMD-PhD graduatesPatient careComplete trainingTraining durationMedian timeMedical knowledgeDevelopment AwardNIH RePORTERTrainingIK2GraduatesAwardeesMedicineCarePatient Privacy and Data Provenance in Pulmonary and Critical Care Research Using Big Data.
Jain S, Krumholz H. Patient Privacy and Data Provenance in Pulmonary and Critical Care Research Using Big Data. Annals Of The American Thoracic Society 2024, 21: 538-540. PMID: 38259228, DOI: 10.1513/annalsats.202305-497ip.Peer-Reviewed Original ResearchResearch opportunities and ethical considerations for heart and lung xenotransplantation research: A report from the National Heart, Lung, and Blood Institute workshop
Khush K, Bernat J, Pierson R, Silverman H, Parent B, Glazier A, Adams A, Fishman J, Gusmano M, Hawthorne W, Homan M, Hurst D, Latham S, Park C, Maschke K, Mohiuddin M, Montgomery R, Odim J, Pentz R, Reichart B, Savulescu J, Wolpe P, Wong R, Fenton K. Research opportunities and ethical considerations for heart and lung xenotransplantation research: A report from the National Heart, Lung, and Blood Institute workshop. American Journal Of Transplantation 2024, 24: 918-927. PMID: 38514013, PMCID: PMC11144553, DOI: 10.1016/j.ajt.2024.03.015.Peer-Reviewed Original ResearchConceptsMaintenance of immunosuppressionNational HeartEthical questionsBlood Institute workshopDonor organ supplyLung transplantationOrgan injuryImmune activationXenograft survivalXenotransplantation researchClinical trial participationAnimal rightsClinical xenotransplantationRegulatory oversightLungWelfare considerationsDonor organsBlood InstituteProtocol reviewXenotransplantationDeceased humansTrial participantsHeartEthical considerationsBloodPulmonary Fibrosis Stakeholder Summit: A Joint NHLBI, Three Lakes Foundation, and Pulmonary Fibrosis Foundation Workshop Report
Montesi S, Gomez C, Beers M, Brown R, Chattopadhyay I, Flaherty K, Garcia C, Gomperts B, Hariri L, Hogaboam C, Jenkins R, Kaminski N, Kim G, Königshoff M, Kolb M, Kotton D, Kropski J, Lasky J, Magin C, Maher T, McCormick M, Moore B, Nickerson-Nutter C, Oldham J, Podolanczuk A, Raghu G, Rosas I, Rowe S, Schmidt W, Schwartz D, Shore J, Spino C, Craig J, Martinez F. Pulmonary Fibrosis Stakeholder Summit: A Joint NHLBI, Three Lakes Foundation, and Pulmonary Fibrosis Foundation Workshop Report. American Journal Of Respiratory And Critical Care Medicine 2024, 209: 362-373. PMID: 38113442, PMCID: PMC10878386, DOI: 10.1164/rccm.202307-1154ws.Peer-Reviewed Original ResearchMeSH KeywordsBiomedical ResearchHumansIdiopathic Pulmonary FibrosisLakesNational Heart, Lung, and Blood Institute (U.S.)Risk FactorsUnited StatesConceptsSlow lung function declinePulmonary fibrosisLung function declineField of pulmonary fibrosisRisk factorsStudy pulmonary fibrosisProgressive pulmonary fibrosisIdiopathic pulmonary fibrosisPulmonary Fibrosis FoundationIdentification of risk factorsFunctional declineElucidation of disease mechanismsClinical trial designDisease risk factorsFibrosisImprove diagnosisTrial designBiomarker discoveryDisease mechanismsPulmonaryMedicationMorbidityTherapyHow to diversify the dwindling physician–scientist workforce after the US affirmative action ban
Ding J, Christophers B, Rupert D, Tang C, Serafini R, Jansen C, Curtis M, Chesebro A, Waldman A. How to diversify the dwindling physician–scientist workforce after the US affirmative action ban. Nature Medicine 2024, 30: 635-637. PMID: 38291299, DOI: 10.1038/s41591-023-02787-6.Peer-Reviewed Original ResearchAcademic career progression in AANS/CNS Spine Section award recipients
Elsamadicy A, Sherman J, Craft S, Virk M, Elder B, Bonfield C, Snyder L, Ray W, Jones K, Ryu W. Academic career progression in AANS/CNS Spine Section award recipients. Journal Of Neurosurgery Spine 2024, 40: 107-114. DOI: 10.3171/2023.7.spine23259.Peer-Reviewed Original ResearchMeSH KeywordsAwards and PrizesBiomedical ResearchFemaleHumansMaleNeurosurgeonsNeurosurgeryNeurosurgical ProceduresUnited StatesConceptsAcademic medical centerPeer-reviewed journalsMedical CenterPeer-reviewed publicationsMean numberPrincipal investigatorMean h-indexAANS/CNS SectionNational InstituteFederal research fundingPeripheral nervesCNS SectionSpine surgeryOutstanding abstractsPrior recipientsMedical Research ProgramSubspecialty focusHealth fundingRecipientsAppointment statusNeurological SurgeonsPublication rateOne-thirdFaculty appointmentsProgression
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