2025
Standard to Handheld: A New Wave in Thoracic Ultrasound and Patient Care—A Direct Comparison of Portable Handheld Against Standard in Thoracic Ultrasound
Halim D, Kelly A, Hayes J, Bennett K, Tzouvelekis A, Ampazis D, Sampsonas F. Standard to Handheld: A New Wave in Thoracic Ultrasound and Patient Care—A Direct Comparison of Portable Handheld Against Standard in Thoracic Ultrasound. Medicina 2025, 61: 313. PMID: 40005430, PMCID: PMC11857366, DOI: 10.3390/medicina61020313.Peer-Reviewed Original ResearchConceptsLevels of experienceNon-inferiorityPortable ultrasound deviceOverall image qualityLung pathologyUltrasound deviceInterquartile rangeRespiratory departmentThoracic ultrasoundAnatomical visualizationHandheld ultrasound devicePatient careImprove healthcareOperator's level of experienceNo significant differenceLikert scaleTrainee levelStatistically significant variablesDiagnostic accuracyClinical decisionsOverall perceptionOnline questionnaireClinical utilityMedian rateClinical settingPerioperative Pulmonary Complications in the Older Adults The Forgotten System
Carr Z, Siller S, McDowell B. Perioperative Pulmonary Complications in the Older Adults The Forgotten System. Clinics In Geriatric Medicine 2025, 41: 1-18. PMID: 39551535, DOI: 10.1016/j.cger.2024.03.003.Peer-Reviewed Original ResearchMeSH KeywordsAgedHumansLung DiseasesPerioperative CarePostoperative ComplicationsRisk AssessmentRisk Factors
2024
Postinfectious Pulmonary Complications: Establishing Research Priorities to Advance the Field: An Official American Thoracic Society Workshop Report.
Auld S, Sheshadri A, Alexander-Brett J, Aschner Y, Barczak A, Basil M, Cohen K, Dela Cruz C, McGroder C, Restrepo M, Ridge K, Schnapp L, Traber K, Wunderink R, Zhang D, Ziady A, Attia E, Carter J, Chalmers J, Crothers K, Feldman C, Jones B, Kaminski N, Keane J, Lewinsohn D, Metersky M, Mizgerd J, Morris A, Ramirez J, Samarasinghe A, Staitieh B, Stek C, Sun J, Evans S. Postinfectious Pulmonary Complications: Establishing Research Priorities to Advance the Field: An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2024, 21: 1219-1237. PMID: 39051991, DOI: 10.1513/annalsats.202406-651st.Peer-Reviewed Original ResearchMeSH KeywordsBiomedical ResearchCOVID-19HumansLung DiseasesRespiratory Tract InfectionsSARS-CoV-2Societies, MedicalUnited StatesConceptsPulmonary infectionTreatment of pulmonary infectionsLower respiratory tract infectionsLong-term morbidityRespiratory tract infectionsShort-term outcomesAberrant host responseBurden of morbidityReview potential mechanismsPulmonary complicationsTract infectionsPulmonary pathogensSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Causative pathogenRespiratory syndrome coronavirus 2Therapeutic strategiesSyndrome coronavirus 2Host responseInfectionMorbidityPotential mechanismsCoronavirus 2Phylogeographic Analysis of Mycobacterium kansasii Isolates from Patients with M. kansasii Lung Disease in Industrialized City, Taiwan - Volume 30, Number 8—August 2024 - Emerging Infectious Diseases journal - CDC
Cudahy P, Liu P, Warren J, Sobkowiak B, Yang C, Ioerger T, Wu C, Lu P, Wang J, Chang H, Huang H, Cohen T, Lin H. Phylogeographic Analysis of Mycobacterium kansasii Isolates from Patients with M. kansasii Lung Disease in Industrialized City, Taiwan - Volume 30, Number 8—August 2024 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2024, 30: 1562-1570. PMID: 39043390, PMCID: PMC11286038, DOI: 10.3201/eid3008.240021.Peer-Reviewed Original ResearchConceptsM. kansasii lung diseaseM. kansasii pulmonary diseasePulmonary diseaseM. kansasii isolatesSputum mycobacterial cultureWhole-genome sequencingEvaluate risk factorsPhylogeographic analysisAge of participantsGenetic relatednessEnvironmental acquisitionLung diseaseMycobacterial cultureOdds ratioRisk factorsM. kansasiiPatientsDiseasePlantsEnvironmental transmissionIsolatesPark plantingsCDCRiskConventional and Contrast-enhanced US of the Lung: From Performance to Diagnosis.
Jiménez-Serrano S, Páez-Carpio A, Doménech-Ximenos B, Cornellas L, Sánchez M, Revzin M, Vollmer I. Conventional and Contrast-enhanced US of the Lung: From Performance to Diagnosis. RadioGraphics 2024, 44: e230171. PMID: 38935548, DOI: 10.1148/rg.230171.Peer-Reviewed Original ResearchMeSH KeywordsContrast MediaDiagnosis, DifferentialHumansImage EnhancementImage-Guided BiopsyLungLung DiseasesUltrasonographyConceptsPeripheral lung diseaseContrast-enhanced USDiagnosis of peripheral lung diseasePercutaneous biopsyLung USEnhancement patternLung diseaseImage-guided percutaneous biopsyAccurate differential diagnosisDiagnostic chest imagingLung biopsySubpleural lesionsConventional USDifferential diagnosisPathological findingsPulmonary physiologyChest imagingArterial supplyBiopsyLungDiagnostic testsDiagnosisSoft tissueDiseaseImaging timeBarriers to Pulmonary Rehabilitation.
Rochester C. Barriers to Pulmonary Rehabilitation. Respiratory Care 2024, 69: 713-723. PMID: 38806224, PMCID: PMC11147625, DOI: 10.4187/respcare.11656.Peer-Reviewed Original ResearchConceptsBarriers to PRHealth care professionalsPulmonary rehabilitationPR programChronic respiratory diseasesMultidisciplinary health care professionalsHealth care provider visitsHealth care disparitiesInfluence patients' likelihoodKnowledge of PRAvailability of PRLack of insurance coverageBurden of treatmentCare disparitiesProvider visitsCare professionalsReferral processProvider recommendationRespiratory diseaseTransportation difficultiesRacial disparitiesPatient accessPatient's residenceLack of knowledgeLow knowledge
2023
A 56-Year-Old Man With Progressive Subacute Hypoxemia
Steinberg A, Zeba F, Rassias A, Mota P. A 56-Year-Old Man With Progressive Subacute Hypoxemia. CHEST Journal 2023, 164: e169-e172. PMID: 38070964, DOI: 10.1016/j.chest.2023.06.042.Peer-Reviewed Original ResearchSomatic Mutations: The Next Frontier in Demystifying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis?
Yan X, Kaminski N. Somatic Mutations: The Next Frontier in Demystifying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis? American Journal Of Respiratory And Critical Care Medicine 2023, 208: 1150-1151. PMID: 37856835, PMCID: PMC10868359, DOI: 10.1164/rccm.202310-1774ed.Peer-Reviewed Original ResearchCoexistent Sjogren’s syndrome and Birt-Hogg-Dube´ syndrome: a case report
Lin Y, Guo T, Lei C, Yang B, Yang D, Luo H, Peng H. Coexistent Sjogren’s syndrome and Birt-Hogg-Dube´ syndrome: a case report. BMC Pulmonary Medicine 2023, 23: 460. PMID: 37993820, PMCID: PMC10664354, DOI: 10.1186/s12890-023-02680-5.Peer-Reviewed Original ResearchConceptsSjogren's syndromeBirt-HoggMultiple thin-walled cystic lesionsDiffuse cystic lung diseasesThin-walled cystic lesionsShortness of breathCystic lung diseaseLabial gland biopsyDry eyeLower lungCystic changesCystic lesionsLung diseasePhysical examinationCase reportGland biopsyDube syndromeRare caseComputed tomographyDubé syndromeInsufficient evidenceSyndromeDiagnostic algorithmLungRespiratory soundsIn Situ Simulation and Clinical Outcomes in Infants Born Preterm
Chitkara R, Bennett M, Bohnert J, Yamada N, Fuerch J, Halamek L, Quinn J, Padua K, Gould J, Profit J, Xu X, Lee H. In Situ Simulation and Clinical Outcomes in Infants Born Preterm. The Journal Of Pediatrics 2023, 263: 113715. PMID: 37659586, PMCID: PMC10841094, DOI: 10.1016/j.jpeds.2023.113715.Peer-Reviewed Original ResearchConceptsChronic lung diseaseClinical outcomesNeonatal resuscitationDelivery room continuous positive airway pressureVery low birth weight birthsNeonatal intensive care unit admissionCalifornia Perinatal Quality Care CollaborativeContinuous positive airway pressureVery low birth weightSecondary outcomesNeonatal intensive care unitInfants born pretermLow birth weight birthsSevere intraventricular hemorrhageIntensive care unit admissionPositive airway pressureLow birth weightInfant born pretermEvaluate clinical outcomesIntensive care unitParticipating sitesIntraventricular hemorrhageWeeks gestationBorn pretermCollaborative quality improvement projectPerformance Comparison of Pulmonary Risk Scoring Systems in Lung Resection
Zorrilla-Vaca A, Grant M, Rehman M, Sarin P, Mendez-Pino L, Urman R, Varelmann D. Performance Comparison of Pulmonary Risk Scoring Systems in Lung Resection. Journal Of Cardiothoracic And Vascular Anesthesia 2023, 37: 1734-1743. PMID: 37330329, DOI: 10.1053/j.jvca.2023.05.035.Peer-Reviewed Original ResearchMeSH KeywordsAdultHumansLungLung DiseasesPostoperative ComplicationsRespiration DisordersRetrospective StudiesRisk FactorsConceptsPostoperative pulmonary complicationsLung resection surgeryRisk-scoring systemPulmonary complicationsResection surgeryScoring systemLung resectionRisk scoreRisk of PPCsRetrospective cohort study SETTINGLAS VEGASAlternative risk scoresSingle-center cohortCohort study SETTINGAdult patientsExpiratory volumeLung surgeryThoracic surgeryPulmonary riskConcordance indexSurgeryPatientsDiscriminatory powerStudy settingComplicationsMaintaining Your Certification in Pulmonary Disease and Critical Care Medicine The New ABIM Longitudinal Knowledge Assessment
Tanoue L, Evans L. Maintaining Your Certification in Pulmonary Disease and Critical Care Medicine The New ABIM Longitudinal Knowledge Assessment. CHEST Journal 2023, 163: 1020-1022. PMID: 37164574, DOI: 10.1016/j.chest.2022.12.007.Peer-Reviewed Original ResearchMorbidity and Mortality in Neonates with Symptomatic Congenital Lung Malformation.
Engwall-Gill A, Weller J, Salvi P, Penikis A, Sferra S, Rhee D, Solomon D, Kunisaki S. Morbidity and Mortality in Neonates with Symptomatic Congenital Lung Malformation. Journal Of The American College Of Surgeons 2023, 236: 1139-1146. PMID: 36786474, DOI: 10.1097/xcs.0000000000000653.Peer-Reviewed Original ResearchConceptsCongenital lung malformationsExtracorporeal membrane oxygenationPostoperative length of stayLength of stayNeonatal resectionLung malformationsLung resectionMechanical ventilationCLM patientsExtracorporeal membrane oxygenation rescueMedian postoperative length of stayCongenital pulmonary airway malformationPediatric Health Information System databasePreoperative mechanical ventilationRespiratory complication rateHealth Information System databaseCardiac structural anomaliesPostoperative respiratory complicationsCongenital lobar emphysemaEvaluate risk factorsPrimary outcome measureTreatment of childrenAirway malformationBronchopulmonary sequestrationCardiac structural disease
2022
Real-world abdominal aorta aneurysm screening patterns among patients with new or worsening of symptomatic peripheral artery disease
Lee M, Pichert M, Tran A, Farooq A, Heyligers J, de Vries J, Spertus J, Guzman R, Thomas M, Mena-Hurtado C, Smolderen K. Real-world abdominal aorta aneurysm screening patterns among patients with new or worsening of symptomatic peripheral artery disease. International Journal Of Cardiology 2022, 375: 94-97. PMID: 36577485, PMCID: PMC10371801, DOI: 10.1016/j.ijcard.2022.12.042.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseAbdominal aortic aneurysmScreening ratesArtery diseaseSpecialty centersAdjusted median odds ratioSymptomatic peripheral artery diseaseInternational prospective registryHigh-risk populationMedian odds ratioAbdominal aorta aneurysmAAA positivityMulticenter registryPAD symptomsProspective registryGuideline implementationAortic aneurysmAAA screeningAorta aneurysmOdds ratioPAD managementDisease RegistryPatientsMedian oddsClinical sitesClin‐STAR corner: Recent practice‐changing studies at the interface of pulmonary and critical care medicine and geriatrics
Jain S, Witt L, Ferrante L. Clin‐STAR corner: Recent practice‐changing studies at the interface of pulmonary and critical care medicine and geriatrics. Journal Of The American Geriatrics Society 2022, 71: 705-710. PMID: 36536494, PMCID: PMC10023292, DOI: 10.1111/jgs.18196.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAgedCritical CareCritical IllnessGeriatricsHumansLung DiseasesPulmonary Disease, Chronic ObstructiveConceptsCritical care medicineCritical illnessPulmonary diseaseLung diseaseCare medicineRecent practice-changing clinical trialsChronic obstructive pulmonary diseaseOlder adultsAcute respiratory failurePractice-changing clinical trialsChronic lung diseaseChronic pulmonary diseaseObstructive pulmonary diseaseInterstitial lung diseasePractice-changing studiesGreater side effectsRespiratory failureAdverse outcomesClinical trialsObservational studySide effectsDiseaseIllnessAdultsMedicineOccupational Exposures in Nontuberculous Mycobacterial Pulmonary Disease
Blanc PD, Balmes JR, Redlich C. Occupational Exposures in Nontuberculous Mycobacterial Pulmonary Disease. CHEST Journal 2022, 162: e106-e107. PMID: 35940661, DOI: 10.1016/j.chest.2022.03.049.Commentaries, Editorials and LettersAntibody responses and risk factors associated with impaired immunological outcomes following two doses of BNT162b2 COVID-19 vaccination in patients with chronic pulmonary diseases
Harboe Z, Hamm S, Pérez-Alós L, Sivapalan P, Priemé H, Wilcke T, Kjeldgaard P, Shaker S, Jordan A, Møller D, Heftdal L, Madsen J, Bayarri-Olmos R, Hansen C, Pries-Heje M, Hasselbalch R, Fogh K, Armenteros J, Hilsted L, Sørensen E, Lindegaard B, Browatzki A, Biering-Sørensen T, Frikke-Schmidt R, Ostrowski S, Iversen K, Bundgaard H, Nielsen S, Garred P, Jensen J. Antibody responses and risk factors associated with impaired immunological outcomes following two doses of BNT162b2 COVID-19 vaccination in patients with chronic pulmonary diseases. BMJ Open Respiratory Research 2022, 9: e001268. PMID: 35793836, PMCID: PMC9260234, DOI: 10.1136/bmjresp-2022-001268.Peer-Reviewed Original ResearchConceptsChronic pulmonary diseaseCOVID-19 vaccinationPulmonary diseaseLow respondersRisk factorsHumoral responseBNT162b2 mRNA COVID-19 vaccineBNT162b2 COVID-19 vaccinationMRNA COVID-19 vaccineCharlson Comorbidity IndexProspective cohort studyUse of prednisolonePoor immunological responseFunctional humoral responseCOVID-19 vaccineAU/mLComorbidity indexCohort studyFirst vaccinationSecondary outcomesPrimary outcomeRBD IgGAntibody responseImmunological outcomesAntibody indexOccupational and environmental exposures in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) study
Ryan SM, Mroz MM, Herzog EL, Ryu C, Fingerlin TE, Maier LA, Gulati M. Occupational and environmental exposures in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) study. Respiratory Medicine 2022, 200: 106923. PMID: 35932543, DOI: 10.1016/j.rmed.2022.106923.Peer-Reviewed Original ResearchMeSH Keywordsalpha 1-Antitrypsin DeficiencyEnvironmental ExposureGenomicsHumansLung DiseasesOccupational ExposureSarcoidosisConceptsAlpha-1 antitrypsin deficiencyCardiac sarcoidosisSarcoidosis StudyAntitrypsin deficiencyRadiation exposureNon-cardiac sarcoidosisNon-chronic diseasesMultiple comparisonsEnvironmental exposure dataExtrapulmonary diseasePulmonary involvementGranulomatous disorderSarcoidosis phenotypesRisk factorsSpecific disease phenotypesStage 0Number of exposuresSarcoidosisExposure assessment toolsSusceptible individualsSpecific exposuresDiseaseEnvironmental exposuresExposure dataIndividual exposureBronchial epithelium epithelial-mesenchymal plasticity forms aberrant basaloid-like cells in vitro
Uthaya Kumar DB, Motakis E, Yurieva M, Kohar V, Martinek J, Wu TC, Khoury J, Grassmann J, Lu M, Palucka K, Kaminski N, Koff JL, Williams A. Bronchial epithelium epithelial-mesenchymal plasticity forms aberrant basaloid-like cells in vitro. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2022, 322: l822-l841. PMID: 35438006, PMCID: PMC9142163, DOI: 10.1152/ajplung.00254.2021.Peer-Reviewed Original ResearchMeSH KeywordsEpithelial CellsEpithelial-Mesenchymal TransitionEpitheliumHumansLung DiseasesRespiratory MucosaRNA, Long NoncodingConceptsProtein codingEpithelial-mesenchymal transitionLncRNA genesEMT inductionSingle-cell RNA sequencingSingle-cell RNA-seq dataEpithelial-mesenchymal plasticityRNA-seq dataMechanisms of EMTSingle-cell levelEpithelial cell typesRole of EMTTranscriptional reprogrammingHuman bronchial epithelial cellsRNA genesEMT gene signatureTranscriptional changesTranscriptional differencesRNA sequencingSpecific lncRNAsBronchial epithelial cellsDifferential expressionMyofibroblast conversionCell typesGenes
2021
Wet-dry-wet drug screen leads to the synthesis of TS1, a novel compound reversing lung fibrosis through inhibition of myofibroblast differentiation
Ring NAR, Volpe MC, Stepišnik T, Mamolo MG, Panov P, Kocev D, Vodret S, Fortuna S, Calabretti A, Rehman M, Colliva A, Marchesan P, Camparini L, Marcuzzo T, Bussani R, Scarabellotto S, Confalonieri M, Pham TX, Ligresti G, Caporarello N, Loffredo FS, Zampieri D, Džeroski S, Zacchigna S. Wet-dry-wet drug screen leads to the synthesis of TS1, a novel compound reversing lung fibrosis through inhibition of myofibroblast differentiation. Cell Death & Disease 2021, 13: 2. PMID: 34916483, PMCID: PMC8677786, DOI: 10.1038/s41419-021-04439-4.Peer-Reviewed Original ResearchConceptsAnti-fibrotic effectsDopamine receptor 3Lung fibrosisMyofibroblast activationReceptor 3Idiopathic pulmonary fibrosis patientsMyofibroblast differentiationPulmonary fibrosis patientsProgression of fibrosisTransforming Growth Factor-β PathwayGrowth factor β pathwayHigh-throughput screenDisease progressionMurine modelFibrosisFibrosis patientsFibrotic diseasesDrug screensLung fibroblastsNovel compoundsProgressionΒ pathwayImportant targetDopaminePrimary fibroblasts
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