2025
Prospective REALITI-A Study 2-Year Real-World Benefits of Mepolizumab in Severe Asthma
Caruso C, Canonica G, Patel M, Smith A, Liu M, Alfonso-Cristancho R, Price R, Jakes R, Demetriou L, Valero A, Köhler T, Pilette C, Chupp G, Brusselle G, Howarth P. Prospective REALITI-A Study 2-Year Real-World Benefits of Mepolizumab in Severe Asthma. CHEST Pulmonary 2025, 3: 100107. DOI: 10.1016/j.chpulm.2024.100107.Peer-Reviewed Original ResearchFollow-up periodMepolizumab treatmentAdverse eventsSevere asthmaRate of clinically significant asthma exacerbationsFollow-upMonoclonal antibodies targeting interleukin-5Clinically significant asthma exacerbationsMaintenance oral corticosteroidsAssociated with sustained reductionsProportion of patientsACQ-5 scoresAsthma Control QuestionnaireForced expiratory volumeOral corticosteroidsWell-toleratedACQ-5Clinical benefitMepolizumabProspective studyWeeks 0Asthma exacerbationsInterleukin-5Expiratory volumeSustained reductionEffect of Elexacaftor/Tezacaftor/Ivacaftor on Glucose Tolerance in Adolescents With Cystic Fibrosis
Galderisi A, Weiss L, Besançon A, Stremler N, Reix P, Wizla N, Lustre A, Rames C, Tatopoulos A, Perisson C, Dalphin M, Troussier F, Houdouin V, Bessaci K, Cosson L, Gabsi A, Corvol H, Deneuville E, Storni V, Ramel S, Bui S, Heraud M, Remus N, Huet F, Scalbert M, Mely L, Gachelin E, Giannantonio M, Letierce A, Sahki D, Marguet C, Bonnel A, Sermet-Gaudelus I. Effect of Elexacaftor/Tezacaftor/Ivacaftor on Glucose Tolerance in Adolescents With Cystic Fibrosis. The Journal Of Clinical Endocrinology & Metabolism 2025, dgaf099. PMID: 39977216, DOI: 10.1210/clinem/dgaf099.Peer-Reviewed Original ResearchOral glucose tolerance testBaseline oral glucose tolerance testAbnormal glucose toleranceNormal glucose toleranceAbnormal glucose tolerance groupCystic fibrosisGlucose toleranceNormal glucose tolerance groupEffective CFTR modulatorsCF-related diabetesInsulin secretionImpaired fasting glucoseGlucose tolerance testImpaired glucose toleranceForced expiratory volumeBMIz-scoreCFTR modulatorsBaseline characteristicsRelated diabetesFasting glucoseTolerance testTherapeutic strategiesInsulin treatmentExpiratory volumeGlucose levels
2023
Lung function assessment in preschool children with symptoms of asthma: A preliminary study
Rajapakse S, Agampodi S, Yasaratne D, Chandrakumara J, Amarasiri L. Lung function assessment in preschool children with symptoms of asthma: A preliminary study. Anuradhapura Medical Journal 2023, 17: 11-19. DOI: 10.4038/amj.v17i2.7780.Peer-Reviewed Original ResearchAsthma Control TestSymptoms of asthmaAirway obstructionLung function assessmentAsthma symptomsFunction assessmentAmerican Thoracic Society guidelinesPreschool childrenCross-sectional preliminary studyImprovement of FVCPeripheral airway involvementSignificant bronchodilator reversibilityReversible airway obstructionVital capacity ratioThoracic Society guidelinesSignificant disease burdenEuropean Respiratory SocietyBronchodilator reversibilityParadoxical bronchoconstrictionR5-20Airway involvementSymptom controlConsecutive childrenExpiratory volumeFVC ratioSex modifies the risk of HIV-associated obstructive lung disease in Ugandans postpneumonia
Abelman R, Fitzpatrick J, Zawedde J, Sanyu I, Byanyima P, Kaswabuli S, Musisi E, Hsieh J, Gardner K, Zhang M, Byanova K, Sessolo A, Hunt P, Lalitha R, Davis J, Crothers K, Worodria W, Huang L. Sex modifies the risk of HIV-associated obstructive lung disease in Ugandans postpneumonia. AIDS 2023, 37: 1683-1692. PMID: 37352494, PMCID: PMC10527596, DOI: 10.1097/qad.0000000000003626.Peer-Reviewed Original ResearchConceptsObstructive lung diseaseLung diseaseLung functionAbnormal lung functionMultivariable regression modelsWarrants further studyCommon comorbiditiesExpiratory volumeSpirometric abnormalitiesSmoking statusSpirometric testingTB statusVital capacitySex modifiesStratified analysisHIVWomenDiseaseComorbiditiesMenSexFurther studiesGreater degreeRiskTuberculosisPerformance Comparison of Pulmonary Risk Scoring Systems in Lung Resection
Zorrilla-Vaca A, Grant M, Rehman M, Sarin P, Mendez-Pino L, Urman R, Varelmann D. Performance Comparison of Pulmonary Risk Scoring Systems in Lung Resection. Journal Of Cardiothoracic And Vascular Anesthesia 2023, 37: 1734-1743. PMID: 37330329, DOI: 10.1053/j.jvca.2023.05.035.Peer-Reviewed Original ResearchConceptsPostoperative pulmonary complicationsLung resection surgeryRisk-scoring systemPulmonary complicationsResection surgeryScoring systemLung resectionRisk scoreRisk of PPCsRetrospective cohort study SETTINGLAS VEGASAlternative risk scoresSingle-center cohortCohort study SETTINGAdult patientsExpiratory volumeLung surgeryThoracic surgeryPulmonary riskConcordance indexSurgeryPatientsDiscriminatory powerStudy settingComplicationsRemission outcomes in severe eosinophilic asthma with mepolizumab therapy: Analysis of the REDES study
Pavord I, Gardiner F, Heaney L, Domingo C, Price R, Pullan A, Oppenheimer J, Brusselle G, Nagase H, Chupp G, Pizzichini E, Bañas-Conejero D, Howarth P. Remission outcomes in severe eosinophilic asthma with mepolizumab therapy: Analysis of the REDES study. Frontiers In Immunology 2023, 14: 1150162. PMID: 37122713, PMCID: PMC10131245, DOI: 10.3389/fimmu.2023.1150162.Peer-Reviewed Original ResearchConceptsSevere eosinophilic asthmaClinical remissionEosinophilic asthmaRemission definitionsClinical practiceAsthma Control Test scoresBetter ACT scoresProportion of patientsSubset of patientsACT scoreMepolizumab therapyMepolizumab treatmentOral corticosteroidsPrior exacerbationsOC useSevere asthmaBaseline characteristicsExpiratory volumeLung functionRemission outcomesMedical recordsDisease progressionTreatment outcomesRemissionTreatment goals
2021
Immuno-fibrotic drivers of impaired lung function in post-acute sequelae of SARS-CoV-2
Chun HJ, Coutavas E, Pine AB, Lee AI, Yu VL, Shallow MK, Giovacchini CX, Mathews AM, Stephenson B, Que LG, Lee PJ, Kraft BD. Immuno-fibrotic drivers of impaired lung function in post-acute sequelae of SARS-CoV-2. JCI Insight 2021, 6: e148476. PMID: 34111030, PMCID: PMC8410030, DOI: 10.1172/jci.insight.148476.Peer-Reviewed Original ResearchConceptsCOVID-19 severityIntensive care unitCOVID-19 illnessRespiratory symptomsLipocalin-2Acute COVID-19 illnessSARS-CoV-2 infectionCOVID-19Acute COVID-19Mild COVID-19Prospective cohort studyPulmonary function testsPost-acute sequelaeAmerican Heart AssociationHost response profileSeparate validation cohortAcademic medical centerSARS-CoV-2Plasma biomarker profilesICU groupLung recoveryCohort studyExpiratory volumeLung impairmentPersistent symptomsPredictors of sinonasal disease onset, progression, and severity in pediatric cystic fibrosis patients
Weinstock MS, Shaffer AD, Stapleton AL. Predictors of sinonasal disease onset, progression, and severity in pediatric cystic fibrosis patients. American Journal Of Otolaryngology 2021, 42: 103016. PMID: 33836483, PMCID: PMC8403133, DOI: 10.1016/j.amjoto.2021.103016.Peer-Reviewed Original ResearchConceptsPediatric cystic fibrosis patientsNasal polyposisRecurrent nasal polyposisSinonasal diseaseCystic fibrosis patientsSinus surgeryHigh-risk mutationsHigh riskFibrosis patientsCF chronic rhinosinusitisNasal polyposis recurrenceRisk mutationsExtra-pulmonary manifestationsRetrospective case seriesOutcome Test scoresPancreatic manifestationPolyposis recurrenceRecurrent polyposisChronic rhinosinusitisExpiratory volumeInsulin dependencePediatric patientsCase seriesStandard treatmentSymptom Survey
2020
Costs Associated With Lobectomy for Lung Cancer: An Analysis Merging STS and Medicare Data
Medbery RL, Fernandez FG, Kosinski AS, Tong BC, Furnary AP, Feng L, Onaitis M, Boffa D, Wright CD, Cowper P, Jacobs JP, Putnam JB, Habib RH. Costs Associated With Lobectomy for Lung Cancer: An Analysis Merging STS and Medicare Data. The Annals Of Thoracic Surgery 2020, 111: 1781-1790. PMID: 33188754, DOI: 10.1016/j.athoracsur.2020.08.073.Peer-Reviewed Original ResearchConceptsLung cancerHospital characteristicsMedicare dataClinical stage I lung cancerCare costsRecurrent laryngeal nerve paresisStage I lung cancerEarly-stage lung cancerThoracic Surgeons General Thoracic Surgery DatabaseI lung cancerPreoperative patient factorsChronic kidney diseaseGeneral Thoracic Surgery DatabaseLaryngeal nerve paresisSeverity of complicationsBody mass indexCase-mix factorsCare of patientsNumber of complicationsThoracic Surgery DatabaseNerve paresisPerioperative outcomesPostoperative complicationsRespiratory failureExpiratory volumeAssociations of marijuana with markers of chronic lung disease in people living with HIV
Wenger D, Triplette M, Shahrir S, Akgun K, Wongtrakool C, Brown, Kim J, Hoo G, Rodriguez‐Barradas M, Huang L, Feemster L, Zifodya J, Crothers K. Associations of marijuana with markers of chronic lung disease in people living with HIV. HIV Medicine 2020, 22: 92-101. PMID: 33022830, DOI: 10.1111/hiv.12966.Peer-Reviewed Original ResearchConceptsChronic lung diseaseLung diseaseMarijuana smokingRadiographic emphysemaMarijuana exposureHIV-Associated Lung Emphysema (EXHALE) studyLarger total lung capacityHIV-positive patientsTotal lung capacityHigh lung volumesCross-sectional analysisMarijuana useAssociation of marijuanaExpiratory volumeTobacco smokingVital capacityLung capacityLung healthLung volumeSmokingWeekly marijuana useHIVPLWHLogistic regressionEmphysemaExtracting lung function measurements to enhance phenotyping of chronic obstructive pulmonary disease (COPD) in an electronic health record using automated tools
Akgün KM, Sigel K, Cheung KH, Kidwai-Khan F, Bryant AK, Brandt C, Justice A, Crothers K. Extracting lung function measurements to enhance phenotyping of chronic obstructive pulmonary disease (COPD) in an electronic health record using automated tools. PLOS ONE 2020, 15: e0227730. PMID: 31945115, PMCID: PMC6964890, DOI: 10.1371/journal.pone.0227730.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesData MiningElectronic Health RecordsForced Expiratory VolumeHealth Information SystemsHospitalizationHumansLungNatural Language ProcessingPulmonary Disease, Chronic ObstructiveSeverity of Illness IndexSoftwareUnited StatesUnited States Department of Veterans AffairsVeteransVital CapacityConceptsChronic obstructive pulmonary diseaseVeterans Aging Cohort StudyObstructive pulmonary diseaseFEV1 valuesPulmonary diseasePhenotyping of patientsPulmonary function testsAging Cohort StudyLung function measurementsElectronic health record dataHealth record dataStructured electronic health record dataPositive predictive valueElectronic health recordsAirflow obstructionChart reviewCohort studyExpiratory volumeCOPD phenotypesFunction testsVital capacityFEV1 measurementsDATA SOURCESPredictive valueClinical notes
2018
Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function
Xu J, Bartz T, Chittoor G, Eiriksdottir G, Manichaikul A, Sun F, Terzikhan N, Zhou X, Booth S, Brusselle G, de Boer I, Fornage M, Frazier-Wood A, Graff M, Gudnason V, Harris T, Hofman A, Hou R, Houston D, Jacobs D, Kritchevsky S, Latourelle J, Lemaitre R, Lutsey P, O’Connor G, Oelsner E, Pankow J, Psaty B, Rohde R, Rich S, Rotter J, Smith L, Stricker B, Voruganti V, Wang T, Zillikens M, Barr R, Dupuis J, Gharib S, Lahousse L, London S, North K, Smith A, Steffen L, Hancock D, Cassano P. Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function. British Journal Of Nutrition 2018, 120: 1159-1170. PMID: 30205856, PMCID: PMC6263170, DOI: 10.1017/s0007114518002180.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAgingBlack or African AmericanBlack PeopleCross-Sectional StudiesFemaleForced Expiratory VolumeGenome, HumanHeartHeart DiseasesHumansLungLung DiseasesMaleMiddle AgedMolecular EpidemiologyProspective StudiesRegression AnalysisRespiratory Function TestsSmokingVital CapacityVitamin DWhite PeopleConceptsHeart and Aging ResearchForced vital capacityEuropean ancestryVitamin DNever smokersMeta-analysisAfrican ancestryHigher 25(OH)DPulmonary functionGenomic Epidemiology ConsortiumSerum 25-hydroxyvitamin DAssociation of serum vitamin DSerum vitamin DEpidemiology ConsortiumForced expiratory volumeEffect modificationFormer smokersSmoking statusSerum 25(OH)DVulnerable populationsAging researchSmokersEpidemiological studiesExpiratory volumeVital capacity
2017
Incidence of Occupational Asthma and Exposure to Toluene Diisocyanate in the United States Toluene Diisocyanate Production Industry
Collins JJ, Anteau S, Conner PR, Cassidy LD, Doney B, Wang ML, Kurth L, Carson M, Molenaar D, Redlich CA, Storey E. Incidence of Occupational Asthma and Exposure to Toluene Diisocyanate in the United States Toluene Diisocyanate Production Industry. Journal Of Occupational And Environmental Medicine 2017, 59: s22-s27. PMID: 29200135, PMCID: PMC5763544, DOI: 10.1097/jom.0000000000000890.Peer-Reviewed Original ResearchDietary Patterns and Lung Function: Assessment of the Alternative Health Eating Index‐2010 (AHEI‐2010) and Rate of Change in Forced Expiratory Volume in the First Second (FEV 1 )
Rettig S, Xu J, Karr A, Tang W, Guertin K, Goodman P, Minasian L, Lippman S, Klein E, Cassano P. Dietary Patterns and Lung Function: Assessment of the Alternative Health Eating Index‐2010 (AHEI‐2010) and Rate of Change in Forced Expiratory Volume in the First Second (FEV 1 ). The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.167.8.Peer-Reviewed Original ResearchAHEI-2010 scoreFood frequency questionnaireAHEI-2010US Dietary GuidelinesNever/former smokersDietary guidelinesRate of declineAlternative Healthy Eating Index-2010Dietary patternsMeasure of overall dietary qualitySmoking statusHealthy Eating Index-2010Assess usual dietary intakesDietary intakeOverall dietary qualityForced expiratory volumeFEV 1Lung functionUsual dietary intakeStudies of dietStatistically significant interactionExpiratory volumeDietary qualityFrequency questionnaireLinear mixed-effects models
2015
Guidance on the diagnosis and management of asthma among adults in resource limited settings
Kirenga BJ, Schwartz JI, de Jong C, van der Molen T, Okot-Nwang M. Guidance on the diagnosis and management of asthma among adults in resource limited settings. African Health Sciences 2015, 15: 1189-1199. PMID: 26958020, PMCID: PMC4765426, DOI: 10.4314/ahs.v15i4.18.Peer-Reviewed Original ResearchConceptsResource limited settingsManagement of asthmaLimited settingsInternational asthma guidelinesQuality asthma careRecurrent respiratory symptomsLikelihood of asthmaCurrent wheezeSteroid therapyAsthma guidelinesSalbutamol administrationAsthma careClinical improvementExpiratory volumeRespiratory symptomsAsthma diagnosisAllergic diseasesPatient educationClinical dataFamily historyAsthmaSeverity gradingAssessment of controlHealth providersInternational guidelines
2014
Hospital Readmission After Pulmonary Lobectomy Is Not Affected by Surgical Approach
Assi R, Wong DJ, Boffa DJ, Detterbeck FC, Wang Z, Chupp GL, Kim AW. Hospital Readmission After Pulmonary Lobectomy Is Not Affected by Surgical Approach. The Annals Of Thoracic Surgery 2014, 99: 393-398. PMID: 25497070, DOI: 10.1016/j.athoracsur.2014.10.014.Peer-Reviewed Original ResearchConceptsCharlson Comorbidity IndexDays of dischargePredictors of readmissionIntensive care unitUnplanned returnPulmonary lobectomyComorbidity indexHospital readmissionSurgical approachCare unitHigher Charlson comorbidity indexMedian hospital lengthMultivariate logistic regression methodThoracic surgery serviceHigh-risk patientsPostoperative mortalityPostoperative transferHospital lengthPostoperative complicationsExpiratory volumeSurgery serviceOpen thoracotomyPathologic diagnosisUnplanned transfersMedical recordsFactors Associated With Isolated Right Heart Failure in Women A Pilot Study From Western Kenya
Lagat DK, DeLong AK, Wellenius GA, Carter EJ, Bloomfield GS, Velazquez EJ, Hogan J, Kimaiyo S, Sherman CB. Factors Associated With Isolated Right Heart Failure in Women A Pilot Study From Western Kenya. Global Heart 2014, 9: 249-254. PMID: 25667096, PMCID: PMC4405788, DOI: 10.1016/j.gheart.2014.04.003.Peer-Reviewed Original ResearchConceptsRight heart failureOccupational dust exposureAirflow limitationHeart failureControl subjectsIndoor air pollutionDust exposureIsolated right heart failureHuman immunodeficiency virus (HIV) testingPilot studySmall observational studiesCase-control studyKitchen ventilationSpecific environmental exposuresWestern KenyaSurrogate measureA Pilot StudyAnalysis of subgroupsSmoke exposure timeExpiratory volumeHIV positivityReferral hospitalWalk testOccupational dustThromboembolic disease
2013
Associations with chest illness and mortality in chronic spinal cord injury
Danilack V, Stolzmann K, Gagnon D, Brown R, Tun C, Morse L, Garshick E. Associations with chest illness and mortality in chronic spinal cord injury. Journal Of Spinal Cord Medicine 2013, 37: 662-669. PMID: 24090450, PMCID: PMC4231954, DOI: 10.1179/2045772313y.0000000144.Peer-Reviewed Original ResearchConceptsChronic spinal cord injuryChronic obstructive pulmonary diseaseSpinal cord injuryChest illnessCurrent smokingHazard ratioCord injuryHeart diseasePhysician-diagnosed chronic obstructive pulmonary diseaseCompleteness of SCICompleteness of injuryIndependent risk factorObstructive pulmonary diseaseHeart disease historyMeasures logistic regressionCross-sectional surveyUnderwent spirometryExpiratory volumeIndependent predictorsPulmonary diseaseCox regressionRisk factorsSCI levelDisease historyHealth QuestionnaireModifiable Risk Factors for Pneumonia Requiring Hospitalization of Community‐Dwelling Older Adults: The Health, Aging, and Body Composition Study
Juthani‐Mehta M, De Rekeneire N, Allore H, Chen S, O'Leary JR, Bauer DC, Harris TB, Newman AB, Yende S, Weyant RJ, Kritchevsky S, Quagliarello V, Study F. Modifiable Risk Factors for Pneumonia Requiring Hospitalization of Community‐Dwelling Older Adults: The Health, Aging, and Body Composition Study. Journal Of The American Geriatrics Society 2013, 61: 1111-1118. PMID: 23772872, PMCID: PMC3714374, DOI: 10.1111/jgs.12325.Peer-Reviewed Original ResearchConceptsModifiable risk factorsIncident mobility limitationCommunity-dwelling older adultsBody Composition StudyRisk factorsPlaque scoresMobility limitationsOlder adultsNovel modifiable risk factorsProspective observational cohort studyObservational cohort studyNonmodifiable risk factorsCases of pneumoniaHistory of pneumoniaCommunity-dwelling adultsAverage attributable fractionMonths of baselineCohort studyExpiratory volumePneumonia preventionDental examinationPrimary outcomeOral hygieneMale sexAttributable fraction
2012
Rhinovirus and other respiratory viruses exert different effects on lung allograft function that are not mediated through acute rejection
Sayah DM, Koff JL, Leard LE, Hays SR, Golden JA, Singer JP. Rhinovirus and other respiratory viruses exert different effects on lung allograft function that are not mediated through acute rejection. Clinical Transplantation 2012, 27: e64-e71. PMID: 23278569, PMCID: PMC3558613, DOI: 10.1111/ctr.12054.Peer-Reviewed Original ResearchConceptsLung transplant recipientsAcute rejectionAllograft functionCARV infectionBiopsy-proven acute rejectionIncidence of ARLung allograft functionTransbronchial biopsy resultsReference groupChronic allograft rejectionRespiratory virus infectionsAllograft dysfunctionLung allograftsTransplant recipientsAllograft rejectionExpiratory volumePrimary outcomeRespiratory virusesAdverse outcomesClinical recordsRV infectionBaseline incidenceBiopsy resultsMonths postinfectionVirus infection
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply