2021
An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation
Rohner E, Witman N, Sohlmer J, De Genst E, Louch W, Sahara M, Chien K. An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation. Molecular Medicine 2021, 27: 102. PMID: 34496741, PMCID: PMC8425124, DOI: 10.1186/s10020-021-00362-8.Peer-Reviewed Original ResearchConceptsNull mutationMolecular pathwaysProtein analysis toolsBulk RNA sequencingRNA sequencing analysisWild-type reporterDetailed molecular pathwaysDistinct transcriptomic signaturesTranscriptional profilingRNA sequencingProteasomal pathwayHuman embryonic stem cell-derived cardiomyocytesEmbryonic stem cell-derived cardiomyocytesProtein expression levelsProteasomal inhibitionChemical inhibitorsDetectable proteinTranscriptomic signaturesSequencing analysisDegradation contributesMRNA constructsStem cell-derived cardiomyocytesPLN proteinExpression levelsDegradation pathway
2013
Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium
Turnbull IC, Karakikes I, Serrao GW, Backeris P, Lee J, Xie C, Senyei G, Gordon RE, Li RA, Akar FG, Hajjar RJ, Hulot J, Costa KD. Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium. The FASEB Journal 2013, 28: 644-654. PMID: 24174427, PMCID: PMC3898643, DOI: 10.1096/fj.13-228007.Peer-Reviewed Original ResearchConceptsHuman myocardiumPreclinical modelsCardiac tissueAlternative preclinical modelsAction potential durationFrank-Starling mechanismCycle length dependenceHuman embryonic stem cell-derived cardiomyocytesDose-response curveEmbryonic stem cell-derived cardiomyocytesStem cell-derived cardiomyocytesHuman heart musclePositive chronotropicInotropic responseCardiac refractorinessCell-derived cardiomyocytesTrabecular musclesPotential durationPharmacodynamic modelMRNA expressionMyocardiumHeart muscleCardiac-specific genesTranslational researchCardiac electrophysiology
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