2023
Common Data Elements for Disorders of Consciousness: Recommendations from the Electrophysiology Working Group
Carroll E, Der-Nigoghossian C, Alkhachroum A, Appavu B, Gilmore E, Kromm J, Rohaut B, Rosanova M, Sitt J, Claassen J. Common Data Elements for Disorders of Consciousness: Recommendations from the Electrophysiology Working Group. Neurocritical Care 2023, 39: 578-585. PMID: 37606737, DOI: 10.1007/s12028-023-01795-1.Peer-Reviewed Original Research
2021
Contributions of NaV1.8 and NaV1.9 to excitability in human induced pluripotent stem-cell derived somatosensory neurons
Alsaloum M, Labau JIR, Liu S, Estacion M, Zhao P, Dib-Hajj F, Waxman SG. Contributions of NaV1.8 and NaV1.9 to excitability in human induced pluripotent stem-cell derived somatosensory neurons. Scientific Reports 2021, 11: 24283. PMID: 34930944, PMCID: PMC8688473, DOI: 10.1038/s41598-021-03608-x.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAutopsyCell DifferentiationElectrophysiologyHumansImmunohistochemistryInduced Pluripotent Stem CellsMembrane PotentialsMutationNAV1.8 Voltage-Gated Sodium ChannelNAV1.9 Voltage-Gated Sodium ChannelNeuronsNeurosciencesPainPatch-Clamp TechniquesProtein IsoformsSensory Receptor CellsSomatosensory CortexConceptsNeuronal excitabilitySomatosensory neuronsPluripotent stem cell-derived sensory neuronsDynamic clamp electrophysiologyTreatment of painPromising novel modalityVoltage-gated sodium channelsSodium channel isoformsNeuronal membrane potentialGenetic knockout modelsNav1.9 currentsPharmacologic blockSensory neuronsNav1.8Cellular correlatesRepetitive firingClamp electrophysiologyExcitabilityNeuronal backgroundNovel modalityChannel isoformsSodium channelsNeuronsNav1.9Knockout modelsThe Electrophysiology Laboratory: Anesthetic Considerations and Staffing Models
Siegrist KK, Fernandez Robles C, Kertai MD, Oprea AD. The Electrophysiology Laboratory: Anesthetic Considerations and Staffing Models. Journal Of Cardiothoracic And Vascular Anesthesia 2021, 35: 2775-2783. PMID: 33773891, DOI: 10.1053/j.jvca.2021.02.050.Peer-Reviewed Original Research
2020
Cannabidiol interactions with voltage-gated sodium channels
Sait LG, Sula A, Ghovanloo MR, Hollingworth D, Ruben PC, Wallace B. Cannabidiol interactions with voltage-gated sodium channels. ELife 2020, 9: e58593. PMID: 33089780, PMCID: PMC7641581, DOI: 10.7554/elife.58593.Peer-Reviewed Original ResearchMeSH KeywordsBinding SitesCannabidiolCrystallography, X-RayElectrophysiologyProtein ConformationSequence AlignmentVoltage-Gated Sodium ChannelsConceptsVoltage-gated sodium channelsNavMs voltage-gated sodium channelHigh-resolution X-ray crystallographyIon translocation pathwaySodium channelsCentral hydrophobic cavitySodium channel mutationsTranslocation pathwayMolecular mechanismsNovel siteNovel insightsTRPV2 channelsTarget siteChannel mutationsX-ray crystallographyNon-psychoactive compoundFunctional effectsHydrophobic cavityCannabis plantChannel inhibitionSitesPlantsMutationsNeurological diseasesType of epilepsy
2019
Mammalian TRP ion channels are insensitive to membrane stretch
Nikolaev YA, Cox CD, Ridone P, Rohde PR, Cordero-Morales JF, Vásquez V, Laver DR, Martinac B. Mammalian TRP ion channels are insensitive to membrane stretch. Journal Of Cell Science 2019, 132: jcs238360. PMID: 31722978, PMCID: PMC6918743, DOI: 10.1242/jcs.238360.Peer-Reviewed Original ResearchConceptsTRP channelsTouch-insensitive mutantsMembrane stretchIon channelsTRP ion channel familyIon channel familyTransient receptor potential (TRP) ion channelsTRP ion channelsMammalian subfamiliesMammalian membersPotential ion channelsArtificial bilayer systemInsensitive mutantsCytoplasmic tethersDownstream componentsMechanosensory processesSignaling cascadesChannel familyCellular componentsBlood pressure regulationCell membraneCerebrospinal fluid flowMechanical forcesStretch activationPressure regulationUnpacking Transient Event Dynamics in Electrophysiological Power Spectra
Quinn A, van Ede F, Brookes M, Heideman S, Nowak M, Seedat Z, Vidaurre D, Zich C, Nobre A, Woolrich M. Unpacking Transient Event Dynamics in Electrophysiological Power Spectra. Brain Topography 2019, 32: 1020-1034. PMID: 31754933, PMCID: PMC6882750, DOI: 10.1007/s10548-019-00745-5.Peer-Reviewed Original ResearchMeSH KeywordsElectrophysiological PhenomenaElectrophysiologyHumansMarkov ChainsModels, NeurologicalNeuronsConceptsHidden Markov ModelBurst detectionSpectral eventsDetect different typesSpectral burstsPower spectraPower spectrumBurst metricsMarkov modelBurst typeFrequency-domain power spectrumElectrophysiological recordings of neuronal activityBurstRecordings of neuronal activityMethod to empirical dataEvent dynamicsFrequency bandOuter hair cell electromotility is low-pass filtered relative to the molecular conformational changes that produce nonlinear capacitance
Santos-Sacchi J, Iwasa KH, Tan W. Outer hair cell electromotility is low-pass filtered relative to the molecular conformational changes that produce nonlinear capacitance. The Journal Of General Physiology 2019, 151: 1369-1385. PMID: 31676485, PMCID: PMC6888751, DOI: 10.1085/jgp.201812280.Peer-Reviewed Original ResearchA flexible geometry for panoramic visual and optogenetic stimulation during behavior and physiology
Creamer MS, Mano O, Tanaka R, Clark DA. A flexible geometry for panoramic visual and optogenetic stimulation during behavior and physiology. Journal Of Neuroscience Methods 2019, 323: 48-55. PMID: 31103713, PMCID: PMC6708602, DOI: 10.1016/j.jneumeth.2019.05.005.Peer-Reviewed Original Research
2018
Feedback processing in adolescents with prenatal cocaine exposure: an electrophysiological investigation
Morie KP, Wu J, Landi N, Potenza MN, Mayes LC, Crowley MJ. Feedback processing in adolescents with prenatal cocaine exposure: an electrophysiological investigation. Developmental Neuropsychology 2018, 43: 183-197. PMID: 29461102, PMCID: PMC6047522, DOI: 10.1080/87565641.2018.1439945.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCocaineElectrophysiologyEvoked PotentialsFeedback, PsychologicalFemaleHumansMalePregnancyPrenatal Exposure Delayed EffectsConceptsFeedback-related negativityEvent-related potentialsFeedback processingWin feedbackDorsal anterior cingulate cortexImpaired cognitive controlP300 time windowP300 ERP componentsSmaller P300 amplitudesCocaine exposureAnterior cingulate cortexPrenatal cocaine exposureCognitive controlPCE adolescentsERP componentsNeural correlatesP300 amplitudeWin/Cingulate cortexAdolescentsSource analysisElectrophysiological investigationsTaskProcessingNegativityElectrophysiological response during auditory gap detection: Biomarker for sensory and communication alterations in autism spectrum disorder?
Foss-Feig JH, Stavropoulos KKM, McPartland JC, Wallace MT, Stone WL, Key AP. Electrophysiological response during auditory gap detection: Biomarker for sensory and communication alterations in autism spectrum disorder? Developmental Neuropsychology 2018, 43: 109-122. PMID: 29436853, PMCID: PMC5972824, DOI: 10.1080/87565641.2017.1365869.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderAuditory gap detectionSpectrum disorderP2 event-related potential (ERP) componentsEvent-related potential componentGap detectionLanguage-related impairmentsAuditory processing deficitsElectrophysiological responsesProcessing deficitsAuditory stimuliNeural responsesAuditory inputASD biomarkersSilent gapsPotential componentsCommunication alterationsTemporal aspectsDeficitsAmplitude reductionDisordersStimuliSensory symptomsTreatment responseImpairment
2016
GABA interneurons mediate the rapid antidepressant-like effects of scopolamine
Wohleb ES, Wu M, Gerhard DM, Taylor SR, Picciotto MR, Alreja M, Duman RS. GABA interneurons mediate the rapid antidepressant-like effects of scopolamine. Journal Of Clinical Investigation 2016, 126: 2482-2494. PMID: 27270172, PMCID: PMC4922686, DOI: 10.1172/jci85033.Peer-Reviewed Original ResearchConceptsAntidepressant-like effectsMajor depressive disorderMedial prefrontal cortexRapid antidepressant-like effectsRapid antidepressant effectsM1-AChRAntidepressant effectsGABA interneuronsSST interneuronsM1-type muscarinic acetylcholine receptorsNonselective muscarinic acetylcholine receptor antagonistMuscarinic acetylcholine receptor antagonistAcetylcholine receptor antagonistMuscarinic acetylcholine receptorsViral-mediated knockdownPromising pharmacological targetActivity-dependent synapticAntidepressant therapyGABAergic neuronsSomatostatin interneuronsGlutamatergic neuronsSocioeconomic burdenGABAergic interneuronsGlutamatergic interneuronsReceptor antagonistLoss-of-Function Mutations in FRRS1L Lead to an Epileptic-Dyskinetic Encephalopathy
Madeo M, Stewart M, Sun Y, Sahir N, Wiethoff S, Chandrasekar I, Yarrow A, Rosenfeld JA, Yang Y, Cordeiro D, McCormick EM, Muraresku CC, Jepperson TN, McBeth LJ, Seidahmed MZ, Khashab H, Hamad M, Azzedine H, Clark K, Corrochano S, Wells S, Elting MW, Weiss MM, Burn S, Myers A, Landsverk M, Crotwell PL, Waisfisz Q, Wolf NI, Nolan PM, Padilla-Lopez S, Houlden H, Lifton R, Mane S, Singh BB, Falk MJ, Mercimek-Mahmutoglu S, Bilguvar K, Salih MA, Acevedo-Arozena A, Kruer MC. Loss-of-Function Mutations in FRRS1L Lead to an Epileptic-Dyskinetic Encephalopathy. American Journal Of Human Genetics 2016, 98: 1249-1255. PMID: 27236917, PMCID: PMC4908178, DOI: 10.1016/j.ajhg.2016.04.008.Peer-Reviewed Original ResearchConceptsGlutamatergic neurotransmissionMovement disordersAbnormalities of glutamateEpileptic-dyskinetic encephalopathyHyperkinetic movement disordersChildhood movement disordersBiallelic pathogenic variantsChronic abnormalitiesNeurological diseasesNeurological disordersMammalian brainPathogenic variantsEpilepsyDisordersFunction mutationsNeurotransmissionAbnormalitiesMonogenic neurological diseasesOuter core proteinFRRS1LEncephalopathyEtiologyChoreoathetosisAMPAExcitatory
2014
Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism
Piochon C, Kloth A, Grasselli G, Titley H, Nakayama H, Hashimoto K, Wan V, Simmons D, Eissa T, Nakatani J, Cherskov A, Miyazaki T, Watanabe M, Takumi T, Kano M, Wang S, Hansel C. Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism. Nature Communications 2014, 5: 5586. PMID: 25418414, PMCID: PMC4243533, DOI: 10.1038/ncomms6586.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderMotor learningDelay eyeblink conditioningSocial behavior deficitsSpectrum disorderCerebellum-dependent motor learningEyeblink conditioningSurplus climbing fibresAutismLong-term depressionMotor problemsMajority of childrenMotor behaviorMotor controlBehavior deficitsCerebellar functionCerebellar plasticityMouse modelDeficitsSynaptic plasticitySynaptic pruningLearningParallel fiber-Purkinje cell synapsesFiber-Purkinje cell synapsesCerebellar synaptic plasticityApplication of neurophysiological biomarkers for Huntington's disease: Evaluating a phosphodiesterase 9A inhibitor
Nagy D, Tingley FD, Stoiljkovic M, Hajós M. Application of neurophysiological biomarkers for Huntington's disease: Evaluating a phosphodiesterase 9A inhibitor. Experimental Neurology 2014, 263: 122-131. PMID: 25315303, DOI: 10.1016/j.expneurol.2014.10.001.Peer-Reviewed Original ResearchMeSH Keywords3',5'-Cyclic-AMP PhosphodiesterasesAcoustic StimulationAnimalsAuditory CortexDisease Models, AnimalElectrophysiologyEnzyme InhibitorsEvoked Potentials, AuditoryHippocampusHuntington DiseaseMiceMice, Inbred C57BLMice, TransgenicPyrazolesPyrimidinonesRatsRats, Sprague-DawleyRats, TransgenicSensory GatingConceptsBACHD transgenic ratsPrimary auditory cortexAuditory gatingDisease patientsHuntington's diseaseAuditory cortexBACHD ratsTransgenic ratsPF-04447943Sub-chronic treatmentPotential translational biomarkersHuntington's disease patientsTransgenic animal modelsBasic neuropathologyDaily administrationTranslational biomarkersQ175 miceNeurophysiological abnormalitiesSystemic administrationNeurophysiological biomarkersLast treatmentAnimal modelsTransgenic miceGamma band powerBrain regionsChloride and Salicylate Influence Prestin-dependent Specific Membrane Capacitance SUPPORT FOR THE AREA MOTOR MODEL* * This work was supported, in whole or in part, by National Institutes of Health Grant NIDCD DC00273 (to J. S. S.).
Santos-Sacchi J, Song L. Chloride and Salicylate Influence Prestin-dependent Specific Membrane Capacitance SUPPORT FOR THE AREA MOTOR MODEL* * This work was supported, in whole or in part, by National Institutes of Health Grant NIDCD DC00273 (to J. S. S.). Journal Of Biological Chemistry 2014, 289: 10823-10830. PMID: 24554714, PMCID: PMC4036195, DOI: 10.1074/jbc.m114.549329.Peer-Reviewed Original Research
2013
Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium
Turnbull IC, Karakikes I, Serrao GW, Backeris P, Lee J, Xie C, Senyei G, Gordon RE, Li RA, Akar FG, Hajjar RJ, Hulot J, Costa KD. Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium. The FASEB Journal 2013, 28: 644-654. PMID: 24174427, PMCID: PMC3898643, DOI: 10.1096/fj.13-228007.Peer-Reviewed Original ResearchConceptsHuman myocardiumPreclinical modelsCardiac tissueAlternative preclinical modelsAction potential durationFrank-Starling mechanismCycle length dependenceHuman embryonic stem cell-derived cardiomyocytesDose-response curveEmbryonic stem cell-derived cardiomyocytesStem cell-derived cardiomyocytesHuman heart musclePositive chronotropicInotropic responseCardiac refractorinessCell-derived cardiomyocytesTrabecular musclesPotential durationPharmacodynamic modelMRNA expressionMyocardiumHeart muscleCardiac-specific genesTranslational researchCardiac electrophysiologyGuidelines and Best Practices for Electrophysiological Data Collection, Analysis and Reporting in Autism
Webb SJ, Bernier R, Henderson HA, Johnson MH, Jones EJ, Lerner MD, McPartland JC, Nelson CA, Rojas DC, Townsend J, Westerfield M. Guidelines and Best Practices for Electrophysiological Data Collection, Analysis and Reporting in Autism. Journal Of Autism And Developmental Disorders 2013, 45: 425-443. PMID: 23975145, PMCID: PMC4141903, DOI: 10.1007/s10803-013-1916-6.Peer-Reviewed Original ResearchReal Time Measures of Prestin Charge and Fluorescence during Plasma Membrane Trafficking Reveal Sub-Tetrameric Activity
Bian S, Navaratnam D, Santos-Sacchi J. Real Time Measures of Prestin Charge and Fluorescence during Plasma Membrane Trafficking Reveal Sub-Tetrameric Activity. PLOS ONE 2013, 8: e66078. PMID: 23762468, PMCID: PMC3677934, DOI: 10.1371/journal.pone.0066078.Peer-Reviewed Original ResearchConceptsObligate tetramerPlasma membraneMembrane motor proteinIntegral membrane proteinsTetracycline-inducible cell lineMembrane proteinsMotor proteinsPrestin densityTemperature blockPrestinFluorescence measuresMembrane fluorescenceCell linesNonlinear capacitanceCochlear amplificationProteinTetramerMembraneFluorescencePrevious observationsVoltage clampFluorescence methodCellsAmplificationLactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia
Herzog RI, Jiang L, Herman P, Zhao C, Sanganahalli BG, Mason GF, Hyder F, Rothman DL, Sherwin RS, Behar KL. Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia. Journal Of Clinical Investigation 2013, 123: 1988-1998. PMID: 23543056, PMCID: PMC3638906, DOI: 10.1172/jci65105.Peer-Reviewed Original ResearchConceptsAntecedent recurrent hypoglycemiaRecurrent hypoglycemiaHypoglycemic conditionsIntensive insulin therapyTight glycemic controlType 2 diabetesInsulin therapyGlycemic controlBrain metabolismElevated lactateNeuronal metabolismRodent modelsNeuronal activityGlucose metabolismHypoglycemiaLactate uptakeNeuronal functionType 1Metabolic regulatorOxidative capacityModest incrementLactateMetabolismUnexpected findingBrain
2012
Cooperativity between calmodulin-binding sites in Kv7.2 channels
Alaimo A, Alberdi A, Gomis-Perez C, Fernández-Orth J, Gómez-Posada JC, Areso P, Villarroel A. Cooperativity between calmodulin-binding sites in Kv7.2 channels. Journal Of Cell Science 2012, 126: 244-253. PMID: 23203804, DOI: 10.1242/jcs.114082.Peer-Reviewed Original Research
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