2025
Epidemiological Profile and Mortality of Infective Endocarditis Over the Past Decade: A Systematic Review and Meta-Analysis of 133 Studies
Tzoumas A, Sagris M, Xenos D, Ntoumaziou A, Kyriakoulis I, Kakargias F, Liaqat W, Nagraj S, Patel R, Korosoglou G, Tousoulis D, Tsioufis K, Kokkinidis D, Palaiodimos L. Epidemiological Profile and Mortality of Infective Endocarditis Over the Past Decade: A Systematic Review and Meta-Analysis of 133 Studies. The American Journal Of Cardiology 2025, 244: 67-88. PMID: 40015544, DOI: 10.1016/j.amjcard.2025.02.023.Peer-Reviewed Original ResearchInfective endocarditisCausative microorganismsMortality of infective endocarditisEpidemiological profileTricuspid valve IEViridans group streptococciMortality rateRandom-effects model meta-analysisMeta-analysisProfile of IEShort-term mortality rateIncidence of health-careSystematic reviewIncreasingly prevalent conditionGroup streptococciAffected valvePubMed/MEDLINE databaseMitral valveStaphylococcus speciesAortic valveCardiac valvesIncreased incidenceStreptococci speciesEnterococci speciesS. aureusPathology of Self-Expanding Transcatheter Aortic Bioprostheses and Hypoattenuated Leaflet Thickening
Sato Y, Torii S, Kawai K, Yahagi K, Kutyna M, Kawakami R, Konishi T, Vozenilek A, Jinnouchi H, Sakamoto A, Mori H, Cornelissen A, Mori M, Tanaka T, Sekimoto T, Kutys R, Ghosh S, Forrest J, Reardon M, Romero M, Kolodgie F, Virmani R, Finn A. Pathology of Self-Expanding Transcatheter Aortic Bioprostheses and Hypoattenuated Leaflet Thickening. Circulation Cardiovascular Interventions 2025, 18: e014523. PMID: 39965045, PMCID: PMC11827688, DOI: 10.1161/circinterventions.124.014523.Peer-Reviewed Original ResearchConceptsHypoattenuated leaflet thickeningLeaflet thickeningHistological findingsClinical trialsEvaluate histological findingsAortic valve proceduresSelf-expanding transcatheter aortic valvesAortic bioprosthetic valvesAortic valve leafletsInfective endocarditisValve proceduresTranscatheter aortic valveValve thrombosisAortic bioprosthesesSurgical explantationInflammation scoreAortic valveAcute thrombusImplant durationOrganized thrombusBioprosthetic valvesDay groupLeaflet thrombosisThrombusValve leafletsMultivalvular vs single-valve infective endocarditis: a systematic review and meta-analysis
Kyriakoulis I, Tzoumas A, Kyriakoulis K, Kardoutsos I, Ntoumaziou A, Nagraj S, Kokkinidis D, Palaiodimos L. Multivalvular vs single-valve infective endocarditis: a systematic review and meta-analysis. Future Cardiology 2025, 21: 113-121. PMID: 39882735, PMCID: PMC11812418, DOI: 10.1080/14796678.2025.2457898.Peer-Reviewed Original ResearchConceptsSystemic embolic eventsInfective endocarditisEmbolic eventsHeart failureAssociated with increased risk of short-term mortalityRisk of short-term mortalityAssociated with increased riskLikelihood of poor prognosisRisk of complicationsOne-year mortalityStudy of patientsShort-term mortalityHeart valvesClinical suspicionSurgical managementPoor prognosisEndocarditisVirulent microorganismsPatientsInclusion criteriaIdentified studiesMortalityPrognosisSystematic searchHeart
2024
Surgical treatment and outcomes in aortic valve endocarditis and perivalvular abscesses
Degife E, Morrison A, Mahmood S, Ragnarsson S, Amabile A, Assi R, Vallabjoyshula P, Geirsson A. Surgical treatment and outcomes in aortic valve endocarditis and perivalvular abscesses. Scientific Reports 2024, 14: 29373. PMID: 39592664, PMCID: PMC11599902, DOI: 10.1038/s41598-024-79256-8.Peer-Reviewed Original ResearchConceptsAortic root abscessAortic valve endocarditisProsthetic valve endocarditisRoot abscessValve endocarditisPerivalvular abscessSurgical treatmentIncreased morbidityAortic valve infective endocarditisPredictors of operative mortalityActive aortic valve endocarditisFive-year survivalPresence of abscessAortocavitary fistulaeEndocarditis surgeryOperative mortalityRoot replacementInfective endocarditisCardiac surgeryPerioperative characteristicsPreoperative imagingHeart blockRepair groupEndocarditisComplex repairExperience with expanded use of oritavancin in a tertiary hospital: indications, tolerability and outcomes
Bandaranayake T, Radcliffe C, Cvercko M, Golden M, Hao R. Experience with expanded use of oritavancin in a tertiary hospital: indications, tolerability and outcomes. JAC-Antimicrobial Resistance 2024, 6: dlae174. PMID: 39493938, PMCID: PMC11524893, DOI: 10.1093/jacamr/dlae174.Peer-Reviewed Original ResearchDose of oritavancinInfective endocarditisTreatment of acute bacterial skinBacterial infectionsLipoglycopeptide antibacterial agentTertiary care medical centreAcute bacterial skinGram-positive bacterial infectionsInvasive bacterial infectionsTreatment failure rateNinety-five adult patientsSoft tissue infectionsProsthetic joint infectionGram-positive organismsBacterial skinDrug discontinuationTissue infectionsRetrospective studyAdult patientsClinical outcomesAdverse eventsOritavancinOff-labelJoint infectionTreat infectionsEndovascular thrombectomy versus medical management for patients with large vessel stroke and infective endocarditis
Chen H, Colasurdo M, Khunte M, Malhotra A, Gandhi D. Endovascular thrombectomy versus medical management for patients with large vessel stroke and infective endocarditis. Journal Of NeuroInterventional Surgery 2024, jnis-2024-022374. PMID: 39317440, DOI: 10.1136/jnis-2024-022374.Peer-Reviewed Original ResearchEfficacy of endovascular thrombectomyLarge vessel occlusionInfective endocarditisPropensity score matchingIntracerebral hemorrhageSubarachnoid hemorrhageMedical managementMultivariable adjustmentOdds of intracerebral hemorrhageEndovascular thrombectomyHome dischargeRate of intracerebral hemorrhageFavorable hospital outcomesRate of in-hospital deathAssociated with significantly higher oddsLarge vessel occlusion strokeIn-hospital mortalityRoutine home dischargeIn-hospital deathRate of subarachnoid hemorrhageRate of home dischargeSignificantly higher oddsRate of routine dischargePrimary outcomeSecondary outcomesDevelopment of a Patient and Clinician Informed Website on Injection Drug Use Related Infective Endocarditis
Chan C, Minahan-Rowley R, Biegacki E, Sue K, Weimer M. Development of a Patient and Clinician Informed Website on Injection Drug Use Related Infective Endocarditis. Substance Use & Addiction Journal 2024, 46: 280-290. PMID: 39087514, DOI: 10.1177/29767342241267077.Peer-Reviewed Original ResearchInjection drug use-related infective endocarditisSemi-structured interviewsInjection drug usePatient participationPatient websitesInjection practicesInfective endocarditisPatient education resourcesHelpfulness of informationHistory of injection drug useDrug useMixed-methods studyHealthcare cliniciansBaseline surveyOpioid use disorderPrevention strategiesInformation websitesEducational materialsCounseling patientsHospitalized adultsPromote educationWebsite sectionsCliniciansSurvey feedbackUse disorderCrossroads of Care: Navigating Injection Drug Use-Associated Endocarditis
Stolear A, Dulgher M, Kaminsky L, Ramponi F, Lancaster G. Crossroads of Care: Navigating Injection Drug Use-Associated Endocarditis. Cureus 2024, 16: e62490. PMID: 39015851, PMCID: PMC11251736, DOI: 10.7759/cureus.62490.Peer-Reviewed Original ResearchMethicillin-susceptible Staphylococcus aureusInjection drug useAddiction medicine specialistsInfective endocarditisComplications of injection drug useActive injection drug useSubstance use disordersMedicine specialistsTricuspid valve repairPulmonary septic emboliTricuspid valve surgeryTricuspid valve vegetationManagement of IEIndividualized surgical interventionDrug useRecurrent IEAntibiotic coursesValve surgerySeptic emboliValve repairValve vegetationsAntibiotic therapySix-week follow-upSurgical interventionIllicit drug use
2023
A Case Series and Literature Review of Subacute Infective Endocarditis: A Clinical Challenge
Callegari S, Cabrera A, Mejia L, Sanchez C. A Case Series and Literature Review of Subacute Infective Endocarditis: A Clinical Challenge. Cureus 2023, 15: e35997. PMID: 37041916, PMCID: PMC10083701, DOI: 10.7759/cureus.35997.Peer-Reviewed Original ResearchClinical presentationCase seriesSubacute endocarditisSubacute infective endocarditisSurgical valve repairRate of complicationsManagement of patientsFastidious microorganismsInfrequent agentInfective endocarditisValve repairAtypical microorganismsUnfavorable outcomeEndocarditisClinical challengeLife-threateningMedical managementTreatment complexityCausal etiologyFastidious pathogensEtiological agentIdentification of microorganismsDiagnosisPresentationTreatmentAortic root allograft reoperations
Witten J, Umana-Pizano J, Houghtaling P, Insler J, Erten O, Nowicki E, Svensson L, Blackstone E, Unai S, Pettersson G. Aortic root allograft reoperations. Journal Of Thoracic And Cardiovascular Surgery 2023, 168: 440-452.e14. PMID: 37074251, DOI: 10.1016/j.jtcvs.2023.02.009.Peer-Reviewed Original ResearchConceptsStructural valve deteriorationAllograft reoperationInfective endocarditisValve deteriorationAllograft preservationAortic valve infective endocarditisRisk of reoperationReoperation techniquesOperative mortalityAllograft explantsSurgical approachExcellent outcomesAdverse eventsPerioperative eventsReoperationEndocarditisAllograftRisk factorsLower mortalityInvestigate outcomesMortalityOperative adverse eventsMorbidityPatientsOutcomesPatterns of Infectious Disease Associated With Injection Drug Use in Massachusetts
Gonsalves G, Paltiel A, Thornhill T, DeMaria A, Cranston K, Klevens R, Warren J. Patterns of Infectious Disease Associated With Injection Drug Use in Massachusetts. Clinical Infectious Diseases 2023, 76: 2134-2139. PMID: 36757712, PMCID: PMC10273381, DOI: 10.1093/cid/ciad073.Peer-Reviewed Original ResearchConceptsSoft tissue infectionsHuman immunodeficiency virusHepatitis C virusInjection drug useHCV casesInfective endocarditisHIV casesDrug useSubstance use disordersLogistic regression modelsClinical sequalaeSSTI casesPublic health crisisTissue infectionsImmunodeficiency virusDisease AssociatedHIV outbreakAbscess incisionC virusUse disordersInfectious diseasesInfectionMultiple outbreaksMedical proceduresSuch associationsChanging Trends in Demographics, Risk Factors, and Clinical Features of Patients With Infective Endocarditis–Related Stroke, 2005–2015
Ridha M, Flaherty M, Aziz Y, Ades L, Alwell K, Khoury J, Woo D, Ferioli S, Adeoye O, Khatri P, De Los Rios La Rosa F, Mistry E, Demel S, Mackey J, Martini S, Coleman E, Jasne A, Slavin S, Walsh K, Star M, Haverbusch M, Madsen T, Broderick J, Kissela B, Kleindorfer D. Changing Trends in Demographics, Risk Factors, and Clinical Features of Patients With Infective Endocarditis–Related Stroke, 2005–2015. Neurology 2023, 100: e1555-e1564. PMID: 36746635, PMCID: PMC10103121, DOI: 10.1212/wnl.0000000000206865.Peer-Reviewed Original ResearchConceptsRisk factorsOpioid epidemicClinical characteristicsClinical featuresGreater Cincinnati/Northern Kentucky regionStudy periodRetrospective cohort studyRates of hypertensionIntravenous drug useIntravenous drug usersICD-10 codesCochran-Armitage testPerioperative strokeAcute strokeCohort studyDefinite endocarditisDuke criteriaHypertension prevalenceIschemic strokeYounger patientsStroke populationInfective endocarditisAtrial fibrillationEpidemiologic descriptionUnadjusted comparisonsMultidisciplinary Management of Opioid Use–Related Infective Endocarditis: Treatment, QTc Values, and Cardiac Arrests due to Ventricular Fibrillation
Rosenfeld L, Jain S, Amabile A, Geirsson A, Krane M, Weimer M. Multidisciplinary Management of Opioid Use–Related Infective Endocarditis: Treatment, QTc Values, and Cardiac Arrests due to Ventricular Fibrillation. Journal Of Clinical Medicine 2023, 12: 882. PMID: 36769531, PMCID: PMC9917424, DOI: 10.3390/jcm12030882.Peer-Reviewed Original ResearchCardiac arrestVentricular fibrillationOpioid useGroup IMOUD useInfective endocarditisYale-New Haven HospitalGroup II patientsCardiac surgeryMultidisciplinary managementQTc prolongationII patientsCS patientsInjection useOpioid epidemicHistorical groupLong-term effectsDisorder treatmentPatientsQTc measurementsQTcHospitalizationEndocarditisSurgeryArrest
2022
Management of Infective Endocarditis in People Who Inject Drugs: A Scientific Statement From the American Heart Association
Baddour LM, Weimer MB, Wurcel AG, McElhinney DB, Marks LR, Fanucchi LC, Garrigos Z, Pettersson GB, DeSimone DC, Fever E. Management of Infective Endocarditis in People Who Inject Drugs: A Scientific Statement From the American Heart Association. Circulation 2022, 146: e187-e201. PMID: 36043414, DOI: 10.1161/cir.0000000000001090.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAmerican Heart AssociationInfective endocarditisHeart AssociationScientific statementInjection drug useAspects of careInfective endocarditis casesEnglish-language articlesRemoval of duplicatesEndocarditis teamVariety of specialistsEndocarditis casesCardiovascular surgeryIncreasing incidenceSubsequent boutEndocarditisHigh riskInitial boutDrug useInfectious diseasesAddiction medicineLiterature searchPreventive measuresUnique populationDrugsEpidemiology, burden, and attributable risks of infective endocarditis in Iran and its provinces: From 1990 to 2019
Ajam A, Shobeiri P, Keykhaei M, Moghaddam S, Momtazmanesh S, Masinaei M, Esfahani Z, Rezaei N, Naderian M, Aminorroaya A, Rashidi M, Rezaei N, Larijani B, Malakan Rad E, Farzadfar F. Epidemiology, burden, and attributable risks of infective endocarditis in Iran and its provinces: From 1990 to 2019. International Journal Of Cardiology 2022, 363: 202-209. PMID: 35777487, DOI: 10.1016/j.ijcard.2022.06.060.Peer-Reviewed Original ResearchConceptsAge-standardized mortality ratesAge-standardized incidence rateAge-standardized prevalence rateDisability-adjusted life yearsAge-standardized DALY rateMortality rateInfectious disease associated with significant morbidityDALY ratesRisk of infective endocarditisDisease associated with significant morbidityGlobal burdenIncidence rateLife yearsPrevalence ratesEscalating incidenceAge groupsStudy dataInfective endocarditisEpidemiological indicesBurdenSignificant morbidityGBDEndocarditisMortalityProvincial levelEchocardiography fails to detect an extensive aortic root abscess in a patient with infective endocarditis: a case report
Zogg CK, Avesta A, Bonde PN, Mani A. Echocardiography fails to detect an extensive aortic root abscess in a patient with infective endocarditis: a case report. European Heart Journal - Case Reports 2022, 6: ytac032. PMID: 35295731, PMCID: PMC8922699, DOI: 10.1093/ehjcr/ytac032.Peer-Reviewed Original ResearchF-flurodeoxyglucose positron-emission tomographyPeriannular abscessInfective endocarditisClinical suspicionNew-onset left bundle branch blockComposite aortic root replacementFirst-degree atrioventricular blockLeft bundle branch blockAortic Root AbscessEvidence of abscessOptimal imaging approachPrompt operative interventionSubsequent FDG-PETAortic root replacementBicuspid aortic valveBundle branch blockAdditional imaging techniquesPossible abscessRoot abscessesRoot replacementOperative interventionHeart blockTransoesophageal echocardiographyAtrioventricular blockActive infectionSimulated Cost-effectiveness and Long-term Clinical Outcomes of Addiction Care and Antibiotic Therapy Strategies for Patients With Injection Drug Use–Associated Infective Endocarditis
Adams JW, Savinkina A, Hudspeth JC, Gai MJ, Jawa R, Marks LR, Linas BP, Hill A, Flood J, Kimmel S, Barocas JA. Simulated Cost-effectiveness and Long-term Clinical Outcomes of Addiction Care and Antibiotic Therapy Strategies for Patients With Injection Drug Use–Associated Infective Endocarditis. JAMA Network Open 2022, 5: e220541. PMID: 35226078, PMCID: PMC8886538, DOI: 10.1001/jamanetworkopen.2022.0541.Peer-Reviewed Original ResearchConceptsOutpatient parenteral antimicrobial therapyIncremental cost-effectiveness ratioOral antibiotic therapyInjection drug use-associated infective endocarditisUsual care strategyAntibiotic therapyOpioid drug useAntibiotic treatment strategiesAntibiotic strategiesCare servicesTreatment strategiesCare strategiesTreatment discontinuationClinical outcomesInfective endocarditisDrug use-associated infective endocarditisDrug useInpatient intravenous antibiotic therapyLong-term clinical outcomesHigher treatment completion rateIntravenous antibiotic therapyObservational cohort studyPercentage of patientsPostacute care facilityParenteral antimicrobial therapyCardiac surgeons’ perspectives and practices regarding people who use drugs: A scoping review
Muncan B, Kim EK, Amabile A, Weimer MB, Tiako M, Vallabhajosyula P, Kalogeropoulos AP, Geirsson A. Cardiac surgeons’ perspectives and practices regarding people who use drugs: A scoping review. Journal Of Cardiac Surgery 2022, 37: 630-639. PMID: 34989450, DOI: 10.1111/jocs.16201.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiac surgeonsInfective endocarditisAddiction medicine specialistsInfectious disease specialistsMultidisciplinary care teamEvidence-based guidelinesJoanna Briggs Institute guidelinesPoor health outcomesPreferred Reporting ItemsComprehensive literature searchWillingness of surgeonsCardiac complicationsCardiovascular complicationsSurgical treatmentSurgical managementDisease specialistsAim of studyCare teamInstitute guidelinesMedicine specialistsEquitable careIndependent authorsPsychosocial factorsReporting ItemsHealth outcomesCardiac Surgeons’ Practices and Attitudes toward Addiction Care for Patients with Substance use Disorders
Tiako M, Mszar R, Brooks C, Bin Mahmood SU, Mori M, Vallabhajosyula P, Geirsson A, Weimer MB. Cardiac Surgeons’ Practices and Attitudes toward Addiction Care for Patients with Substance use Disorders. Substance Use & Addiction Journal 2022, 43: 206-211. PMID: 34038333, DOI: 10.1080/08897077.2021.1917475.Peer-Reviewed Original ResearchConceptsSubstance use disordersUse disordersCardiac surgeonsSurgeon's practiceAddiction careInjection drug useOpioid use disorderMultivariable logistic regressionCare of patientsQuarter of surgeonsMost hospital settingsMinority of surgeonsMost patientsInfective endocarditisHospital settingAddiction specialistsPatientsMost surgeonsIDUsAddiction servicesLogistic regressionMOUDHealth systemSurgeonsLack of educationInfectious Complications of Injection Drug Use
Marks LR, Nolan NS, Liang SY, Durkin MJ, Weimer MB. Infectious Complications of Injection Drug Use. Medical Clinics Of North America 2022, 106: 187-200. PMID: 34823730, DOI: 10.1016/j.mcna.2021.08.006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInjection drug useInjection drug use-related infective endocarditisHuman immunodeficiency virusHepatitis C virusInfectious complicationsDrug useCommon infectious complicationOpioid use disorderCommon risk factorsCause of deathOpioid overdose epidemicViral hepatitisInfective endocarditisImmunodeficiency virusClinical syndromeHIV outbreakInfectious disease epidemicsC virusRisk factorsIntravenous administrationOverdose epidemicUse disordersModel of treatmentMedical careInfectious diseases
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