2024
7168 Papillary thyroid carcinoma co-existing with intrathyroidal metastasis from lung neuroendocrine tumor
Balasubramanian P, Ladenheim A, Gilani S, Gibson C, Kunz P. 7168 Papillary thyroid carcinoma co-existing with intrathyroidal metastasis from lung neuroendocrine tumor. Journal Of The Endocrine Society 2024, 8: bvae163.2027. PMCID: PMC11453623, DOI: 10.1210/jendso/bvae163.2027.Peer-Reviewed Original ResearchLung neuroendocrine tumorsPapillary thyroid carcinomaNeuroendocrine tumorsThyroid carcinomaPapillary thyroid cancerIntrathyroidal metastasisThyroid cancerThyroid metastasisPET-CTThyroid nodulesMetastatic lung NETsLow-risk thyroid cancerLeft thyroid noduleCentral neck dissectionFDG PET-CTMedullary thyroid carcinomaTreatment response evaluationIncidental thyroid nodulesInitiation of treatmentYear old femaleDiagnosed primary malignancyRate of FDGCalcitonin stainingFinal pathologyNeck dissectionImpact of Synthetic PET Evaluation prior to PET-Guided Functional Modeling in Optimizing Patient Selection for Biology-Guided Radiotherapy
Hicks D, Chen H, Kim J, Tressel L, Wallington D, Becht K, Johung K, Young M, Feghali K, de Jong D, Chen Z, Carlson D, Park H. Impact of Synthetic PET Evaluation prior to PET-Guided Functional Modeling in Optimizing Patient Selection for Biology-Guided Radiotherapy. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: s162-s163. DOI: 10.1016/j.ijrobp.2024.07.2188.Peer-Reviewed Original ResearchPlanning target volumeInternal target volumeBiology-guided radiotherapyStereotactic body radiotherapyGross tumor volumeTarget volumeCT simulationOptimal patient selectionPET evaluationStereotactic body radiotherapy planLung target volumesPatient selectionPTV edgesLung casesBgRTPET-CTTumor sizeTumor volumeRadiotherapyCase 2PET dataLungActivity concentrationsPatientsConsistent with resultsA Comparison of Machine Learning Models to Predict Lymph Node Metastasis with Primary Tumor Transcriptome in Non-Small Cell Lung Cancer
Lee V, Park H, Aneja S, Patel A. A Comparison of Machine Learning Models to Predict Lymph Node Metastasis with Primary Tumor Transcriptome in Non-Small Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e638. DOI: 10.1016/j.ijrobp.2024.07.1402.Peer-Reviewed Original ResearchNon-small cell lung cancerLymph nodal metastasisCell lung cancerMedian AUCNodal metastasisPrimary tumorEndobronchial ultrasoundNon-small cell lung cancer stagingLung cancerDiagnostic uncertaintyPrediction of nodal metastasisPET-avid lesionsTreatment strategy formulationPrimary lung adenocarcinomaEBUS-guided biopsiesLymph node metastasisPrimary tumor tissuesReceiver operating characteristic curveTumor transcriptomic dataPET-CTNode metastasisNeedle aspirationCT scanNon-smallClinical decision-makingLymph node metastasis prediction with non-small cell lung cancer histopathology imaging.
Lee V, King A, Sritharan D, Moore N, Chadha S, Maresca R, Hager T, Aneja S. Lymph node metastasis prediction with non-small cell lung cancer histopathology imaging. Journal Of Clinical Oncology 2024, 42: 8063-8063. DOI: 10.1200/jco.2024.42.16_suppl.8063.Peer-Reviewed Original ResearchNon-small cell lung cancerLymph nodal metastasisNational Lung Screening TrialLymph node metastasisNodal metastasisNode metastasisEndobronchial ultrasound-guided transbronchial needle aspirationUltrasound-guided transbronchial needle aspirationTreatment strategy formulationTransbronchial needle aspirationCell lung cancerDistant metastasis statusLymph node metastasis predictionPrimary tumor dataHematoxylin and eosin (H&EInvasive diagnostic techniquesInfluence clinical decisionsN0 diseaseN3 diseaseEosin (H&EPrimary resectionDistant metastasisPET-CTNeedle aspirationCT scan
2023
1541-P: Sympathetic Nervous System Activity in Response to Food Ingestion Is Impacted by Obesity
CHUNG T, DEAJON-JACKSON J, BINI J, SONG H, SANCHEZ RANGEL E, YECKEL C, HWANG J, STACHENFELD N, BELFORT-DEAGUIAR R. 1541-P: Sympathetic Nervous System Activity in Response to Food Ingestion Is Impacted by Obesity. Diabetes 2023, 72 DOI: 10.2337/db23-1541-p.Peer-Reviewed Original ResearchSympathetic nervous system activityMuscle sympathetic nerve activityMixed meal testNormal weightNervous system activityDistribution volume ratioPET-CTHeart rateSympathetic nerve activitySystem activityIngestion of foodMSNA increasesEndogenous NEMeal testNE releaseNerve activityOB subjectsObesity altersKidney diseaseDeltoid muscleLean individualsOB individualsNE transporterObeseFood ingestion
2020
Predictive Value of PET-CT in Patients with T-Cell Lymphoma Undergoing Autologous and Allogeneic Stem Cell Transplant
Isufi I, Chandhok N, Boddu P, Pucar D, Seropian S, Gowda L, Perreault S, Wilson L, Roberts K, Foss F. Predictive Value of PET-CT in Patients with T-Cell Lymphoma Undergoing Autologous and Allogeneic Stem Cell Transplant. Transplantation And Cellular Therapy 2020, 26: s244. DOI: 10.1016/j.bbmt.2019.12.492.Peer-Reviewed Original ResearchRelapse-free survivalPET-CT scanTime of SCTTime of alloSCTPET-CTT-NHLBM biopsyAllo-SCTCT scanPositive PET/CT scanPredictive valueLong-term relapse-free survivalPositive PET-CT scanAllogeneic stem cell transplantPeripheral blood flow cytometryPET/CT scansIntermediate-high riskBlood flow cytometryAggressive clinical courseStem cell transplantT-cell lymphomaMajority of ptsPositive PET-CTAuto-SCTMedian follow
2018
119. Prospective Validation of a 3-Gene Signature for Tuberculosis Diagnosis, Predicting Progression and Evaluating Treatment Response
Warsinske H, Rao A, Moreira F, Dos Santos P, Liu A, Scott M, Malherbe S, Ronacher K, Walzl G, Winter J, Sweeney T, Croda J, Andrews J, Khatri P. 119. Prospective Validation of a 3-Gene Signature for Tuberculosis Diagnosis, Predicting Progression and Evaluating Treatment Response. Open Forum Infectious Diseases 2018, 5: s5-s5. PMCID: PMC6253029, DOI: 10.1093/ofid/ofy209.010.Peer-Reviewed Original ResearchNegative predictive valueTB scoreWorld Health OrganizationActive tuberculosisATB patientsCohort studyTriage testTreatment responseHigh negative predictive valueProspective cohort studyCase-control trialEnd of treatmentIndependent prospective cohortsAdolescent cohort studySputum positivityActive diseaseProspective cohortTreatment initiationSputum testDisease onsetProspective validationPET-CTPredicting ProgressionTuberculosis diagnosisPredictive value
2017
Indications for invasive mediastinal staging in patients with early non-small cell lung cancer staged with PET-CT
Gao SJ, Kim AW, Puchalski JT, Bramley K, Detterbeck FC, Boffa DJ, Decker RH. Indications for invasive mediastinal staging in patients with early non-small cell lung cancer staged with PET-CT. Lung Cancer 2017, 109: 36-41. PMID: 28577947, DOI: 10.1016/j.lungcan.2017.04.018.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinoma, Non-Small-Cell LungClinical Decision-MakingDiagnostic ImagingFemaleHumansLung NeoplasmsMaleMediastinumMiddle AgedNeoplasm MetastasisNeoplasm StagingPatient SelectionPositron Emission Tomography Computed TomographyPractice Guidelines as TopicRetrospective StudiesConceptsOccult N2 diseaseOccult N2 metastasesGround-glass componentInvasive mediastinal stagingCurative-intent therapyT2 tumorsN2 metastasisPET-CTInvasive stagingN2 diseaseT1 tumorsNegative predictive valueMediastinal stagingEarly non-small cell lung cancerExact testPredictive valueSolid tumorsNon-small cell lung cancerClinical stage I NSCLCN2 lymph nodesNode-negative NSCLCOccult nodal involvementPure-solid tumorsStage I NSCLCT1-2N0 diseasePatterns of Utilization of Imaging Studies and Serum Tumor Markers Among Patients With De Novo Metastatic Breast Cancer.
Di Meglio A, Lin NU, Freedman RA, Barry WT, Winer EP, Vaz-Luis I. Patterns of Utilization of Imaging Studies and Serum Tumor Markers Among Patients With De Novo Metastatic Breast Cancer. Journal Of The National Comprehensive Cancer Network 2017, 15: 316-324. PMID: 28275032, DOI: 10.6004/jnccn.2017.0031.Peer-Reviewed Original ResearchConceptsMetastatic breast cancerDe novo metastatic breast cancerNovo metastatic breast cancerTM testingPET/PET-CTTumor markersBreast cancerPET-CTDisease sitesDana-Farber Cancer InstituteSerum tumor markersTiming of imagingPET-CT scanFrequency of imagingCourse of treatmentPatterns of utilizationAsymptomatic patientsNeurologic symptomsRetrospective cohortClinicopathologic factorsTreatment initiationRadiographic studiesCancer InstitutePatientsTumor subtypes
2015
A prospective trial of dynamic contrast-enhanced MRI perfusion and fluorine-18 FDG PET-CT in differentiating brain tumor progression from radiation injury after cranial irradiation
Hatzoglou V, Yang TJ, Omuro A, Gavrilovic I, Ulaner G, Rubel J, Schneider T, Woo KM, Zhang Z, Peck KK, Beal K, Young RJ. A prospective trial of dynamic contrast-enhanced MRI perfusion and fluorine-18 FDG PET-CT in differentiating brain tumor progression from radiation injury after cranial irradiation. Neuro-Oncology 2015, 18: 873-880. PMID: 26688076, PMCID: PMC4864262, DOI: 10.1093/neuonc/nov301.Peer-Reviewed Original ResearchConceptsRadiation injuryPET-CTRadiation therapyProspective trialDCE-MRITumor progressionMaximum standardized uptake valueFluorine-18 fluorodeoxyglucose PET-CTFDG PET-CTDiagnosis of progressionNormal brain ratioFluorodeoxyglucose PET-CTStandardized uptake valueDynamic contrast-enhanced MRIWilcoxon rank sum testContrast-enhanced MRIBrain tumor progressionEffective imaging techniqueVolume transfer coefficientRank sum testCranial irradiationBrain ratioBrain malignanciesLesion outcomeBrain lesionsProspective evaluation of 18F‐fluorodeoxyglucose positron emission tomography in patients receiving hepatic arterial and systemic chemotherapy for unresectable colorectal liver metastases
Correa-Gallego C, Gavane S, Grewal R, Cercek A, Klimstra D, Gewirtz A, Kingham T, Fong Y, DeMatteo R, Allen P, Jarnagin W, Kemeny N, D'Angelica M. Prospective evaluation of 18F‐fluorodeoxyglucose positron emission tomography in patients receiving hepatic arterial and systemic chemotherapy for unresectable colorectal liver metastases. Hepato Pancreato Biliary 2015, 17: 644-650. PMID: 26010778, PMCID: PMC4474513, DOI: 10.1111/hpb.12421.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Combined Chemotherapy ProtocolsColorectal NeoplasmsDisease ProgressionDisease-Free SurvivalFemaleFluorodeoxyglucose F18HumansKaplan-Meier EstimateLiver NeoplasmsMaleMiddle AgedMultimodal ImagingNew York CityPositron-Emission TomographyPredictive Value of TestsProportional Hazards ModelsProspective StudiesRadiopharmaceuticalsRisk FactorsTime FactorsTomography, X-Ray ComputedTreatment OutcomeConceptsUnresectable colorectal liver metastasesProgression-free survivalHepatic arterial infusionColorectal liver metastasesStandardized uptake valueSystemic chemotherapyPositron emission tomographyOverall survivalMetabolic parametersOncological outcomesLiver metastasesPET-CTComputed tomographyCombined hepatic arterial infusionMedian progression-free survivalYear progression-free survivalEmission tomographyRecurrence-free survivalMedian follow-upMonths of therapyPhase II trialCox regression analysisMedian OSHepatic recurrenceArterial infusionImaging human brown adipose tissue under room temperature conditions with 11C-MRB, a selective norepinephrine transporter PET ligand
Hwang JJ, Yeckel CW, Gallezot JD, Aguiar RB, Ersahin D, Gao H, Kapinos M, Nabulsi N, Huang Y, Cheng D, Carson RE, Sherwin R, Ding YS. Imaging human brown adipose tissue under room temperature conditions with 11C-MRB, a selective norepinephrine transporter PET ligand. Metabolism 2015, 64: 747-755. PMID: 25798999, PMCID: PMC4408242, DOI: 10.1016/j.metabol.2015.03.001.Peer-Reviewed Original ResearchConceptsBrown adipose tissueDistribution volume ratioSympathetic nervous systemAdipose tissueRole of BATCold stimulationFDG PET-CT imagingNorepinephrine transporterSupraclavicular brown adipose tissueHuman brown adipose tissueTotal body fatLean body massCold-stimulated conditionsBody temperaturePET-CT imagingBioelectrical impedance analysisCore body temperatureFDG uptakePET-CTOccipital cortexBody fatNervous systemBody compositionPET ligandBasal state
2014
Comparison of MRI Perfusion and PET-CT in Differentiating Brain Tumor Progression From Radiation Injury After Cranial Irradiation
Yang T, Young R, Hatzoglou V, Ulaner G, Schneider T, Omuro A, Chan T, Yamada Y, Beal K. Comparison of MRI Perfusion and PET-CT in Differentiating Brain Tumor Progression From Radiation Injury After Cranial Irradiation. International Journal Of Radiation Oncology • Biology • Physics 2014, 90: s164. DOI: 10.1016/j.ijrobp.2014.05.660.Peer-Reviewed Original ResearchMyocardial Defect Detection Using PET-CT: Phantom Studies
Mananga E, Fakhri G, Schaefferkoetter J, Bonab A, Ouyang J. Myocardial Defect Detection Using PET-CT: Phantom Studies. PLOS ONE 2014, 9: e88200. PMID: 24505429, PMCID: PMC3914931, DOI: 10.1371/journal.pone.0088200.Peer-Reviewed Original ResearchConceptsMyocardial defect detectionFiltered back projectionChannelized Hotelling observerPhantom studyActivity distributionSubset expectation maximizationDefect detectionCardiac PET studiesMyocardial defectsHotelling observerNoise levelBack-projectionPET-CTPhantomExpectation maximizationOP-OSEMReconstruction schemePET studiesOSEMDefectsNoiseEffect of Post-Reconstruction Gaussian Filtering on Image Quality and Myocardial Blood Flow Measurement with N-13 Ammonia PET.
Kim H, Cho S, Kim J, Kwon S, Lee B, Bom H. Effect of Post-Reconstruction Gaussian Filtering on Image Quality and Myocardial Blood Flow Measurement with N-13 Ammonia PET. Asia Oceania Journal Of Nuclear Medicine And Biology 2014, 2: 104-10. PMID: 27408866, PMCID: PMC4937694.Peer-Reviewed Original ResearchSignal-to-noise ratioResting myocardial blood flowCoronary flow reserveFiltered back projectionPost-reconstruction Gaussian filteringAmmonia positron emission tomographyGaussian filterN-13 ammonia positron emission tomographyMyocardial blood flowPositron emission tomographyFiltering methodImage qualitySize of filterDynamic N-13 ammonia positron emission tomographyVisual analysis of image qualityCoronary artery diseaseChi-square and Kruskal-Wallis testsAnalysis of image qualityMyocardial blood flow measurementsFilter sizeKruskal-Wallis testVisual analysisPET-CTContrast recoveryNo significant difference
2013
Bias Atlases for Segmentation-Based PET Attenuation Correction Using PET-CT and MR
Ouyang J, Chun Y, Petibon Y, Bonab A, Alpert N, Fakhri G. Bias Atlases for Segmentation-Based PET Attenuation Correction Using PET-CT and MR. IEEE Transactions On Nuclear Science 2013, 60: 3373-3382. PMID: 24966415, PMCID: PMC4067048, DOI: 10.1109/tns.2013.2278624.Peer-Reviewed Original ResearchAttenuation correctionBias imagesLung density variationsPET attenuation correctionPET-MR scannersAttenuation mapFat identificationOriginal CTPET reconstructionOverall standard deviationPET-MRMR imagingVariation of biasDensity variationsCT-based studyPET accuracyPET-CTStandard deviation of biasCorrectionFat segmentationTissue classesPatientsSoft tissueAttenuationLungState of the Art in Cardiac Hybrid Technology: PET/MR
Nappi C, El Fakhri G. State of the Art in Cardiac Hybrid Technology: PET/MR. Current Cardiovascular Imaging Reports 2013, 6: 338-345. PMID: 24073295, PMCID: PMC3780420, DOI: 10.1007/s12410-013-9213-5.Peer-Reviewed Original ResearchMagnetic resonance imagingPositron emission tomographyAbsence of ionizing radiationPositron emission tomography systemLimitations of PET/MRISensitivity of positron emission tomographyRespiratory motionPhotomultiplier tubeClinical cardiac applicationsSoft tissue contrastPET-CTDetection chainPositron emission tomography dataCardiac morphologyCardiac PET/MRIClinical promisePET/MRIEmission tomographySimultaneous PET/MRIImaging modalitiesPET imagingResonance imagingClinical settingDynamic PET imagesTissue contrastEducational Exhibit Abstract No. 393 Future improvements in the role of PET-CT in the assessment of hepatocellular carcinoma, prior to and following the selective internal radiation therapy (SIRT) of Yttrium-90 (Y-90)
Chheang S, Tarlington L, Osborne J, Deh K, Madoff D. Educational Exhibit Abstract No. 393 Future improvements in the role of PET-CT in the assessment of hepatocellular carcinoma, prior to and following the selective internal radiation therapy (SIRT) of Yttrium-90 (Y-90). Journal Of Vascular And Interventional Radiology 2013, 24: s167. DOI: 10.1016/j.jvir.2013.01.422.Peer-Reviewed Original ResearchSelective internal radiation therapyHepatocellular carcinomaNovel PET tracersPET-CTFDG-PETMaximum standardized uptake valuePET tracersNonresectable hepatocellular carcinomaFDG PET-CTStandardized uptake valueInternal radiation therapyPost-treatment evaluationPET-CT imagingY90 radioembolizationConcurrent inflammationResidual tumorMultiple neoplasmsPotential adjunctTreatment outcomesTreatment responseRadiation therapyGI tractNew agentsUptake valueYttrium-90
2012
Multicentric Castleman Disease with Complete Duodenal Obstruction in an HIV Patient
Sethi T, Alireza A, Kloecker G, Slone S. Multicentric Castleman Disease with Complete Duodenal Obstruction in an HIV Patient. Blood 2012, 120: 4834. DOI: 10.1182/blood.v120.21.4834.4834.Peer-Reviewed Original ResearchMulticentric Castleman's diseaseBody cavity lymphomasComplete duodenal obstructionEbstein-Barr virusCastleman's diseaseDuodenal obstructionHigh plasma titersHHV-8Peripancreatic involvementExcisional lymphHIV patientsPlasma titersPET-CTMultiple myeloma oncogene 1Human herpes virus-8 (HHV-8) DNASetting of HIVUse of HAARTBilateral pleural effusionPancreatic head massMesenteric lymph nodesPlasma cell variantPleural fluid cytologyHistory of HIVEpithelial membrane antigenFine-needle aspiration
2007
Endometrioma Presenting as a Cavitary Lung Mass With Intense 18F-FDG Uptake on PET-CT
Derman A, Sperling D, Merav A, Jain V, Levin M, Jana S, Haramati L. Endometrioma Presenting as a Cavitary Lung Mass With Intense 18F-FDG Uptake on PET-CT. Journal Of Thoracic Imaging 2007, 22: 172-175. PMID: 17527123, DOI: 10.1097/01.rti.0000213564.40667.c6.Peer-Reviewed Case Reports and Technical Notes
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