2022
Randomized Trial of Chocolate Touch Compared With Lutonix Drug-Coated Balloon in Femoropopliteal Lesions (Chocolate Touch Study)
Shishehbor MH, Zeller T, Werner M, Brodmann M, Parise H, Holden A, Lichtenberg M, Parikh SA, Kashyap VS, Pietras C, Tirziu D, Ardakani S, Beschorner U, Krishnan P, Niazi KA, Wali AU, Lansky AJ. Randomized Trial of Chocolate Touch Compared With Lutonix Drug-Coated Balloon in Femoropopliteal Lesions (Chocolate Touch Study). Circulation 2022, 145: 1645-1654. PMID: 35377157, DOI: 10.1161/circulationaha.122.059646.Peer-Reviewed Original ResearchConceptsLutonix drug-coated balloonDrug-coated balloonsEnd pointPrimary efficacy end pointPrimary safety end pointIndependent clinical events committeeIschemic rest painPrimary efficacy rateEfficacy end pointPrimary end pointSafety end pointClinical events committeeMajor adverse eventsRate of restenosisDrug-Coated BalloonNoninferiority end pointSafety event rateAverage lesion lengthMajor amputationPopliteal diseaseRest painBailout stentingEfficacy ratePrimary patencyAdverse events
2008
Exeqüibilidade, eficácia e segurança do sistema de stent CardioMindTM no tratamento de lesões em vasos de fino calibre: um estudo seriado com angiografia e ultra-som intracoronário
Chamié D, Costa J, Abizaid A, Gottschald M, Feres F, Mattos L, Staico R, Costa R, Siqueira D, Abizaid A, Tanajura L, Chaves Á, Centemero M, Sousa A, Sousa J. Exeqüibilidade, eficácia e segurança do sistema de stent CardioMindTM no tratamento de lesões em vasos de fino calibre: um estudo seriado com angiografia e ultra-som intracoronário. Journal Of Transcatheter Interventions 2008, 16: 193-199. DOI: 10.1590/s2179-83972008000200013.Peer-Reviewed Original ResearchCoronary artery diseaseTreatment of small vessel coronary artery diseaseVessel coronary artery diseaseSmall vessel coronary artery diseaseEnd-points of efficacyNeointimal obstructionIntravascular ultrasoundStent systemIn-stent late lossCases of cardiac deathCohort of patientsImmediately post-procedureLong-term resultsLate lumen lossReference vessel diameterPercutaneous coronary interventionRate of restenosisNative coronary arteriesPost-procedureProcedural successClinical impactCardiac deathMean ageBinary restenosisLate lossStents auto-expansíveis versus balão-expansíveis para tratamento de lesões em vasos de fino calibre: estudo com ultra-som intracoronário tridimensional
Chamié D, Costa J, Abizaid A, Feres F, Devito F, Mattos L, Staico R, Abizaid A, Tanajura L, Fitzgerald P, Whitbourn R, Sousa A, Sousa J. Stents auto-expansíveis versus balão-expansíveis para tratamento de lesões em vasos de fino calibre: estudo com ultra-som intracoronário tridimensional. Journal Of Transcatheter Interventions 2008, 16: 341-352. DOI: 10.1590/s2179-83972008000300017.Peer-Reviewed Original ResearchMonths of follow-upSmall vesselsAssociated with poor short-Less vessel injuryIntravascular ultrasoundNeointimal hyperplasiaLong-term outcomesVolumetric intravascular ultrasoundPercutaneous coronary interventionRate of restenosisBalloon-expandable stentsSelf-expanding stentsMechanical propertiesHistorical cohortPoor short-Mean ageFollow-upTreatment of SVCoronary interventionIn-stentVessel injuryInclusion criteriaStentLuminal areaLuminal volume
2006
Inhibition of Restenosis Development after Mechanical Injury: A New Field of Application for Malononitrilamides?
Schrepfer S, Deuse T, Sultan K, Haddad M, Böger R, Münzel T, Schäfer H, Pelletier M, Robbins R, Reichenspurner H. Inhibition of Restenosis Development after Mechanical Injury: A New Field of Application for Malononitrilamides? Cardiology 2006, 108: 128-137. PMID: 17028423, DOI: 10.1159/000096037.Peer-Reviewed Original ResearchMeSH KeywordsAlkynesAnimalsAorta, AbdominalCarrier ProteinsCell MovementCell ProliferationEndothelium, VascularGraft Occlusion, VascularHyperplasiaImmunosuppressive AgentsIsoxazolesMaleMuscle, Smooth, VascularMyocytes, Smooth MuscleNitrilesRatsRats, Inbred LewRNA, MessengerSirolimusSmad7 ProteinTacrolimusTransforming Growth Factor beta1Tunica IntimaVasodilationVasodilator AgentsConceptsSmooth muscle cellsMalononitrilamide FK778Restenosis developmentVascular fibrosisSmooth muscle cell proliferation/migrationAcetylcholine dose responseVascular smooth muscle cellsAntimigratory effectsOrgan chamber studiesIn vivoProfibrotic gene expressionIntimal hyperplasiaPercutaneous transluminal coronary angioplastyRate of restenosisIn vitro studiesFK778 treatmentTransluminal coronary angioplastyLuminal obliterationFK778Endothelial dysfunctionAbdominal aortaMuscle cellsHistological evaluationNeointima formationSynthesis blockade
2005
In–Vitro model for evaluation of the effects of supercooling and re-warming on vascular cells
Yiu W, Aruny J, Cheng S, Sumpio B. In–Vitro model for evaluation of the effects of supercooling and re-warming on vascular cells. International Journal Of Angiology 2005, 14: 237-241. DOI: 10.1007/s00547-005-2055-5.Peer-Reviewed Original ResearchInitial technical success rateEndothelial cellsRe-warming phasePeripheral vascular diseaseTransluminal balloon angioplastyRate of restenosisTechnical success rateTUNEL-positive cellsSmooth muscle cellsBalloon angioplastyVascular diseaseEndothelial cell survivalMuscle cellsVascular cellsVitro modelVessel wallSuccess rateUnderlying mechanismRestenosisCell survivalCellsCellular responsesCritical roleAngioplastyCilostazol Inhibits Leukocyte Integrin Mac-1, Leading to a Potential Reduction in Restenosis After Coronary Stent Implantation
Sumpio BE, Aruny J. Cilostazol Inhibits Leukocyte Integrin Mac-1, Leading to a Potential Reduction in Restenosis After Coronary Stent Implantation. Perspectives In Vascular Surgery And Endovascular Therapy 2005, 17: 265-267. PMID: 16273169, DOI: 10.1177/153100350501700317.Peer-Reviewed Original ResearchCoronary stent implantationCoronary stentingStent implantationRate of restenosisLeukocyte integrin Mac-1Mechanism of restenosisP-selection expressionIntegrin Mac-1Cilostazol groupConsecutive patientsStent placementPhosphodiesterase IIIRestenosisMac-1Granule releasePatientsCilostazolStentingP-selectionLower ratesUpregulationPlateletsImplantationInhibitsTiclopidineIn–Vitro model for evaluation of the effects of supercooling and re-warming on vascular cells
Yiu W, Aruny J, Cheng S, Sumpio B. In–Vitro model for evaluation of the effects of supercooling and re-warming on vascular cells. International Journal Of Angiology 2005, 237-241. DOI: 10.1055/s-0031-1276516.Peer-Reviewed Original ResearchInitial technical success rateEndothelial cellsRe-warming phasePeripheral vascular diseaseTransluminal balloon angioplastyRate of restenosisTechnical success rateTUNEL-positive cellsSmooth muscle cellsBalloon angioplastyVascular diseaseEndothelial cell survivalMuscle cellsVascular cellsVitro modelVessel wallSuccess rateUnderlying mechanismRestenosisCell survivalCellsCellular responsesCritical roleAngioplasty
2002
Clinical and angiographic outcomes after use of 90Strontium/90Yttrium beta radiation for the treatment of in-stent restenosis: results from the Stents and Radiation Therapy 40 (START 40) registry
Suntharalingam M, Laskey W, Lansky AJ, Waksman R, White L, Teirstien P, Massullo V, Rutherford B, Elman A, Kuntz RE, Popma JJ, Bonan R, Investigators T. Clinical and angiographic outcomes after use of 90Strontium/90Yttrium beta radiation for the treatment of in-stent restenosis: results from the Stents and Radiation Therapy 40 (START 40) registry. International Journal Of Radiation Oncology • Biology • Physics 2002, 52: 1075-1082. PMID: 11958904, DOI: 10.1016/s0360-3016(01)02712-2.Peer-Reviewed Original ResearchConceptsMinimum luminal diameterPlacebo groupStent restenosisAngiographic analysisInjury lengthBinary restenosisRevascularization ratesPlacebo armSTART trialSource trainTarget vessel revascularization rateMajor adverse cardiac eventsTarget lesion revascularization rateAdverse cardiac eventsLesion revascularization rateRepeat balloon angioplastyVessel revascularization rateTarget vessel revascularizationNative coronary arteriesManagement of patientsRate of restenosisQuantitative angiographic analysisResults of patientsLate aneurysm formationPercent diameter stenosis
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