2021
Congenital iRHOM2 deficiency causes ADAM17 dysfunction and environmentally directed immunodysregulatory disease
Kubo S, Fritz J, Raquer-McKay H, Kataria R, Vujkovic-Cvijin I, Al-Shaibi A, Yao Y, Zheng L, Zou J, Waldman A, Jing X, Farley T, Park A, Oler A, Charles A, Makhlouf M, AbouMoussa E, Hasnah R, Saraiva L, Ganesan S, Al-Subaiey A, Matthews H, Flano E, Lee H, Freeman A, Sefer A, Sayar E, Çakır E, Karakoc-Aydiner E, Baris S, Belkaid Y, Ozen A, Lo B, Lenardo M. Congenital iRHOM2 deficiency causes ADAM17 dysfunction and environmentally directed immunodysregulatory disease. Nature Immunology 2021, 23: 75-85. PMID: 34937930, PMCID: PMC11060421, DOI: 10.1038/s41590-021-01093-y.Peer-Reviewed Original ResearchMeSH KeywordsA549 CellsADAM17 ProteinAnimalsCarrier ProteinsChildChild, PreschoolCitrobacter rodentiumColitisCytokinesEnterobacteriaceae InfectionsFemaleHEK293 CellsHumansInfant, NewbornMacrophagesMaleMiceMice, Inbred C57BLMutationPrimary Immunodeficiency DiseasesPseudomonas aeruginosaPseudomonas InfectionsSignal TransductionConceptsIRhom2 deficiencyLoss-of-function mutationsLocal microbial environmentLoss of iRhom2Diverse clinical phenotypesRecurrent respiratory infectionsWild-type miceRelease of cytokinesTumor necrosis factorHemorrhagic colitisCitrobacter rodentiumADAM17 metalloproteinaseFecal microbiotaSuperfamily membersRecurrent infectionsRecurrent pneumoniaTumor necrosisLung involvementColonic involvementHuman immunodeficiencyInflammatory colitisMicrobial environmentOral speciesPseudomonas aeruginosaColitis patientsMinocycline attenuates oxycodone-induced positive subjective responses in non-dependent, recreational opioid users
Mogali S, Askalsky P, Madera G, Jones JD, Comer SD. Minocycline attenuates oxycodone-induced positive subjective responses in non-dependent, recreational opioid users. Pharmacology Biochemistry And Behavior 2021, 209: 173241. PMID: 34298029, PMCID: PMC8429209, DOI: 10.1016/j.pbb.2021.173241.Peer-Reviewed Original ResearchConceptsAnalgesic effectRecreational opioid usersReceptor-selective agonistOpioid usersPreclinical studiesAbuse liabilityNew York State Psychiatric InstituteRelease of cytokinesPositive subjective effectsTetracycline antibiotic minocyclineYears of ageDouble-blind outpatient studyPositive subjective responsesGlial activationAcute administrationCertain medicationsHuman research volunteersOutpatient studyGlial cellsNon-treatment seekingSame dosesRewarding effectsOxycodoneDrug AdministrationMinocycline
2020
Headache in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Narrative Review
Tolebeyan A, Zhang N, Cooper V, Kuruvilla D. Headache in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Narrative Review. Headache The Journal Of Head And Face Pain 2020, 60: 2131-2138. PMID: 33017479, PMCID: PMC7675458, DOI: 10.1111/head.13980.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Clinical manifestationsAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSevere acute respiratory syndrome coronavirus 2Syndrome coronavirus 2 infectionAcute respiratory syndrome coronavirus 2SARS-CoV-2 infectionCOVID-19Respiratory syndrome coronavirus 2Manifestations of coronavirusCoronavirus 2 infectionCommon clinical manifestationsSyndrome coronavirus 2Nociceptive sensory neuronsRelease of cytokinesCommon neurologic complaintsCourse of infectionCOVID-19 epidemiologyPulmonary manifestationsInflammatory mechanismsNeurologic findingsNeurologic manifestationsViral neuroinvasionHypercoagulable state
2016
Advanced Glycation End Products and its Soluble Receptors in the Pathogenesis of Thoracic Aortic Aneurysm
Prasad K, Sarkar A, Zafar MA, Shoker A, Moselhi HE, Tranquilli M, Ziganshin BA, Elefteriades JA. Advanced Glycation End Products and its Soluble Receptors in the Pathogenesis of Thoracic Aortic Aneurysm. Aorta 2016, 04: 1-10. PMID: 27766267, PMCID: PMC5068493, DOI: 10.12945/j.aorta.2015.15.018.Peer-Reviewed Original ResearchAdvanced glycation end productsEndogenous secretory RAGEThoracic aortic aneurysmGlycation end productsMatrix metalloproteinasesSerum sRAGEAortic aneurysmSoluble receptorFormation of TAALevels of AGEsPathogenesis of TAALevels of sRAGEAGE-RAGE axisLevels of cytokinesProduction of cytokinesRelease of cytokinesAGEs/Control subjectsRisk factorsStudy populationSRAGEBlood samplesMMP-2CytokinesELISA kit
2015
Mechanisms of chorioamnionitis‐associated preterm birth: interleukin‐1β inhibits progesterone receptor expression in decidual cells
Guzeloglu-Kayisli O, Kayisli UA, Semerci N, Basar M, Buchwalder LF, Buhimschi CS, Buhimschi IA, Arcuri F, Larsen K, Huang JS, Schatz F, Lockwood CJ. Mechanisms of chorioamnionitis‐associated preterm birth: interleukin‐1β inhibits progesterone receptor expression in decidual cells. The Journal Of Pathology 2015, 237: 423-434. PMID: 26175191, DOI: 10.1002/path.4589.Peer-Reviewed Original ResearchConceptsProgesterone receptor expressionPreterm birthDecidual cellsPR expressionIL-1βDC culturesReceptor expressionPR levelsIL-1β suppressionLower PR levelsFunctional progesterone withdrawalCOX-2 expressionRelease of cytokinesIL-1β treatmentDecidual prostaglandin productionP38 MAPK signaling cascadesCervical ripeningProgesterone withdrawalCOX inhibitorsImmunohistochemical stainingChorioamnionitisFetal membrane ruptureNF-kBProstaglandin productionPGF2α production
2005
Cytokines and cardiovascular disease
Mehra VC, Ramgolam VS, Bender JR. Cytokines and cardiovascular disease. Journal Of Leukocyte Biology 2005, 78: 805-818. PMID: 16006537, DOI: 10.1189/jlb.0405182.Peer-Reviewed Original ResearchConceptsCardiovascular diseaseMyocardial functionNitric oxideMyocardial depressant effectsProgression of atherosclerosisRole of cytokinesRelease of cytokinesArachidonic acid metabolitesInflammatory mechanismsHeart failureInflammatory cascadeDepressant effectCytokine influenceImmune cascadeAcid metabolitesCytokinesBiochemical effectsDiseaseCommon formAtherosclerosisChemokinesReviewPathogenesisProgressionComprehensive review
2002
Acute pancreatitis
Nagar AB, Gorelick FS. Acute pancreatitis. Current Opinion In Gastroenterology 2002, 18: 552-557. PMID: 17033332, DOI: 10.1097/00001574-200209000-00005.Peer-Reviewed Original ResearchSystemic inflammatory responseAcute pancreatitisInflammatory responseDistant organ failureMultiple inciting factorsEndoscopic retrograde cholangiopancreatography (ERCP) resultsSpecific inflammatory mediatorsAcute pancreatic injuryHuman acute pancreatitisExperimental acute pancreatitisIntra-acinar activationRelease of cytokinesClinical acute pancreatitisMultiorgan failurePancreatic injuryOrgan failureProinflammatory mediatorsInflammatory mediatorsCascade of eventsClinical syndromePancreatitisAnimal modelsInciting factorsMajor determinantMediators
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