2023
Incidence of Severe Adverse Drug Reactions to Ultrasound Enhancement Agents in a Contemporary Echocardiography Practice
Ali M, Johnson M, Irwin T, Henry S, Sugeng L, Kansal S, Allison T, Bremer M, Jones V, Martineau M, Wong C, Marecki G, Stebbins J, Michelena H, McCully R, Svatikova A, Padang R, Scott C, Kanuga M, Arsanjani R, Pellikka P, Kane G, Thaden J. Incidence of Severe Adverse Drug Reactions to Ultrasound Enhancement Agents in a Contemporary Echocardiography Practice. Journal Of The American Society Of Echocardiography 2023, 37: 276-284.e3. PMID: 37879379, DOI: 10.1016/j.echo.2023.10.010.Peer-Reviewed Original ResearchConceptsUltrasound enhancing agentsAdverse drug reactionsSevere adverse drug reactionsDrug reactionsEchocardiography databaseHealth systemFrequency of severe adverse drug reactionsIsolated back painUS health systemST-segment elevationIncidence of severe adverse drug reactionsLoss of pulseCardiopulmonary involvementLoss of consciousnessMRNA vaccinesLumasonMatched controlsRare riskEnhancing agentsADR rateProspective reportsCOVID-19 vaccineAdministrationPainHeadacheAdapting psychedelic medicine for headache and chronic pain disorders
Schindler E, Hendricks P. Adapting psychedelic medicine for headache and chronic pain disorders. Expert Review Of Neurotherapeutics 2023, 23: 867-882. PMID: 37652000, DOI: 10.1080/14737175.2023.2246655.Peer-Reviewed Original ResearchConceptsChronic pain disordersPain disordersHeadache disordersChronic pain patientsRecent case reportsDifferent treatment paradigmsPsychedelic medicineSubstance use disordersMechanism of actionPain patientsChronic painCase reportClinical trialsTreatment paradigmTreatment outcomesTherapeutic effectLarge dosesUse disordersAdjunctive psychotherapyTherapeutic outcomesHeadacheBeneficial effectsSubjective effectsBranches of medicineDisordersHospital admission risks and excess costs for neurological symptoms attributable to long-term exposure to fine particulate matter in New York State, USA
Min J, Lee W, Bell M, Kim Y, Heo S, Kim G, Kim J, Yun J, Kim S, Schwartz J, Ha E. Hospital admission risks and excess costs for neurological symptoms attributable to long-term exposure to fine particulate matter in New York State, USA. Environmental Research 2023, 229: 115954. PMID: 37086882, DOI: 10.1016/j.envres.2023.115954.Peer-Reviewed Original ResearchConceptsNeurological symptomsLong-term PMLong-term exposureExcess costsHospital admissionNew York Statewide PlanningNew World Health Organization guidelinesHospital admission costsHospital admission riskResearch Cooperative SystemRisk of headacheWorld Health Organization guidelinesHealth Organization guidelinesAdmission riskWHO Air Quality GuidelinesAdmission costsNew York State populationStatewide PlanningNew York StateOrganization guidelinesConvulsionsSubstantial healthRelevant studiesAir quality guidelinesLag 0Understanding headache classification coding within the veterans health administration using ICD-9-CM and ICD-10-CM in fiscal years 2014–2017
Fodeh S, Fenton B, Wang R, Skanderson M, Altalib H, Kuruvilla D, Schindler E, Haskell S, Brandt C, Sico J. Understanding headache classification coding within the veterans health administration using ICD-9-CM and ICD-10-CM in fiscal years 2014–2017. PLOS ONE 2023, 18: e0279163. PMID: 36598881, PMCID: PMC9812322, DOI: 10.1371/journal.pone.0279163.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationHeadache diagnosisICD-10-CMICD-10-CM diagnosisICD-10-CM codingSpecialty care clinicsSpecific headache diagnosesICD-9-CM codingDifferent headache typesICD-9-CMRace/ethnicityHeadache comorbidityHeadache NOSPatient ageCare clinicsChronic conditionsHeadache typesProvider typeSociodemographic factorsHealth AdministrationDiagnosisTwo yearsHeadachePatientsMigraine
2022
Exploratory investigation of a patient‐informed low‐dose psilocybin pulse regimen in the suppression of cluster headache: Results from a randomized, double‐blind, placebo‐controlled trial
Schindler E, Sewell R, Gottschalk C, Luddy C, Flynn L, Zhu Y, Lindsey H, Pittman B, Cozzi N, D'Souza D. Exploratory investigation of a patient‐informed low‐dose psilocybin pulse regimen in the suppression of cluster headache: Results from a randomized, double‐blind, placebo‐controlled trial. Headache The Journal Of Head And Face Pain 2022, 62: 1383-1394. PMID: 36416492, DOI: 10.1111/head.14420.Peer-Reviewed Original ResearchConceptsAttacks/weekPulse regimenCluster headachePsychotropic effectsAttack frequencyPlacebo-controlled studyPlacebo-controlled trialSerious adverse eventsEffects of psilocybinEffect sizeChronic participantsEfficacy outcomesAdverse eventsModerate effect sizeHeadache burdenHeadache disordersTherapeutic effectHeadache diaryPsilocybin administrationDrug sessionsExperimental drugsRegimenPsilocybin-containing mushroomsDefinitive studiesFinal analysisCharacteristics and Gender Differences of Headache in the Veterans Health Administration
Sico JJ, Seng E, Wang K, Skanderson M, Schindler E, Ney JP, Lorenze N, Kimber A, Lindsey H, Grinberg AS, Kuruvilla D, Higgins D, Graham G, Sandbrink F, Scholten J, Shapiro RE, Lipton RB, Fenton B. Characteristics and Gender Differences of Headache in the Veterans Health Administration. Neurology 2022, 99: e1993-e2005. PMID: 36100437, PMCID: PMC9651459, DOI: 10.1212/wnl.0000000000200905.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationHeadache diagnosisHealthcare utilizationIncidence rateHeadache careHeadache typesHealth AdministrationSociodemographic characteristicsMilitary-related exposuresAge-adjusted incidenceEmergency department utilizationElectronic health record dataRetrospective cohort designType of headacheHigh incidence rateTraumatic brain injuryUnited States veteransHealth record dataPost-traumatic stress disorderGender differencesMilitary sexual traumaHeadache disordersBrain injuryHeadache specialistsCohort designFrequency, Demographics, Comorbidities, and Health Care Utilization by Veterans With Migraine
Seng EK, Fenton BT, Wang K, Lipton RB, Ney J, Damush T, Grinberg AS, Skanderson M, Sico JJ. Frequency, Demographics, Comorbidities, and Health Care Utilization by Veterans With Migraine. Neurology 2022, 99: e1979-e1992. PMID: 36100439, PMCID: PMC9651466, DOI: 10.1212/wnl.0000000000200888.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationHealth care utilizationStudy periodCare utilizationHealth AdministrationOne-year period prevalenceOverweight/obesityMental health disordersChi-square testStudent's t-testMilitary sexual traumaAnnual encountersHeadache comorbidityPain comorbiditiesCohort entryCommon comorbiditiesPain disordersTotal cohortAnnual incidenceHealthcare utilizationHigher proportionPeriod prevalenceEmergency departmentMigraine carePrimary careMeasuring interictal burden among people affected by migraine: a descriptive survey study
Hubig L, Smith T, Williams E, Powell L, Johnston K, Harris L, L’Italien G, Coric V, Lloyd A, Lo S. Measuring interictal burden among people affected by migraine: a descriptive survey study. The Journal Of Headache And Pain 2022, 23: 97. PMID: 35941572, PMCID: PMC9358846, DOI: 10.1186/s10194-022-01467-z.Peer-Reviewed Original ResearchConceptsMonthly migraine daysMonthly headache daysInterictal burdenMAb treatmentHIT-6Calcitonin gene-related peptide monoclonal antibodiesMean HIT-6 scoreOverall disease burdenHealth-related qualityIndependent positive associationHeadache Impact TestHIT-6 scoresImpact of migrainePeptide monoclonal antibodyMigraine-free daysPositive associationCross-sectional online surveyMigraine daysPatient characteristicsPatient demographicsMigraine frequencyHeadache daysMigraine attacksMigraine episodesBurden ScaleTelehealth perceptions and utilization for the delivery of headache care before and during the COVID‐19 pandemic: A mixed‐methods study
Grinberg AS, Fenton BT, Wang K, Lindsey H, Goldman RE, Baird S, Riley S, Burrone L, Seng EK, Damush TM, Sico JJ. Telehealth perceptions and utilization for the delivery of headache care before and during the COVID‐19 pandemic: A mixed‐methods study. Headache The Journal Of Head And Face Pain 2022, 62: 613-623. PMID: 35545754, PMCID: PMC9348149, DOI: 10.1111/head.14310.Peer-Reviewed Original ResearchConceptsVeterans Health Administration facilitiesTelehealth deliveryHeadache centerHeadache careAdministration facilitiesCoronavirus disease 2019 (COVID-19) pandemicUtilization of telehealthDisease 2019 pandemicRace/ethnicityPatient ageTelephone visitsPerson appointmentsTelehealth visitsOutpatient visitsPatient groupPatient preferencesHeadache disordersPerson visitsHeadache treatmentMultiple delivery methodsPatientsPatient engagementProviders' perceptionsHeadache servicesPatient accessRelationship Between Headache Characteristics and a Remote History of TBI in Veterans
Coffman C, Reyes D, Hess MC, Giakas AM, Thiam M, Sico JJ, Seng E, Renthal W, Rhoades C, Cai G, Androulakis XM. Relationship Between Headache Characteristics and a Remote History of TBI in Veterans. Neurology 2022, 99: e187-e198. PMID: 35470141, PMCID: PMC9280992, DOI: 10.1212/wnl.0000000000200518.Peer-Reviewed Original ResearchConceptsMigraine-like featuresAlteration of consciousnessAdjusted odds ratioHeadache severityHeadache outcomesSevere headacheMild TBIPosttraumatic amnesiaTBI evaluationRetrospective chart reviewTraumatic brain injury severityComprehensive TBI evaluationBrain injury severityMental health diagnosesUnique risk factorsDose-response relationshipGreater headache severityRace/ethnicityNonblast injuriesChart reviewInjury characteristicsTBI severity groupsRemote historyRisk factorsSevere TBIPostdural Puncture Headache—Risks and Current Treatment
Li H, Wang Y, Oprea AD, Li J. Postdural Puncture Headache—Risks and Current Treatment. Current Pain And Headache Reports 2022, 26: 441-452. PMID: 35353358, DOI: 10.1007/s11916-022-01041-x.Peer-Reviewed Original ResearchConceptsPostdural puncture headacheCurrent treatmentDevelopment of PDPHMild postdural puncture headacheSevere postdural puncture headacheSelf-limited headacheEpidural blood patchFirst-line treatmentLong-term complicationsTherapy of choiceDull achingHeadache riskPDPH patientsPharmacological managementConservative treatmentBlood patchConservative managementFrequent complicationNerve blockNeuraxial blockNeuraxial techniquesPuncture headacheBed restChronic headacheFemale sexEssential components of care in a multidisciplinary headache center: Perspectives from headache neurology specialists
Goldman RE, Damush TM, Kuruvilla DE, Lindsey H, Baird S, Riley S, BS L, Grinberg AS, Seng EK, Fenton BT, Sico JJ. Essential components of care in a multidisciplinary headache center: Perspectives from headache neurology specialists. Headache The Journal Of Head And Face Pain 2022, 62: 306-318. PMID: 35293614, DOI: 10.1111/head.14277.Peer-Reviewed Original ResearchConceptsMultidisciplinary headache centerHeadache centerHeadache careNeurology specialistsChronic headacheIntegrative health modalitiesBotulinum toxin injectionImmersion/crystallization techniqueType of careSemi-structured telephone interviewsBehavioral health practitionersCognitive behavioral therapyToxin injectionMultidisciplinary careNerve blockPain managementUnsuccessful treatmentHeadache specialistsNew medicationsPhysical therapySuccessful careMultiple doctorsPatientsOccupational therapySleep medicineThe Primary Care Management of Headache: Synopsis of the 2020 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline
Sico JJ, Macedo F, Lewis J, Spevak C, Vogsland R, Ford A, Skop K, Sall J. The Primary Care Management of Headache: Synopsis of the 2020 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline. Military Medicine 2022, 187: e1091-e1102. PMID: 35022782, DOI: 10.1093/milmed/usab490.Peer-Reviewed Original ResearchConceptsClinical practice guidelinesPractice guidelinesDefense Clinical Practice GuidelineJoint clinical practice guidelineTrustworthy clinical practice guidelinesPractice Work GroupMedication overuse headachePrimary care managementPreferences of patientsGuideline development panelMedicine's tenetsPharmacologic managementRecommendations AssessmentOveruse headacheGuideline panelCare managementHeadacheDevelopment panelVeterans AffairsClinical stakeholdersPatientsGuidelinesIndividual needsDepartmentPrevention
2021
Phase 3 Trials of Tapinarof Cream for Plaque Psoriasis
Lebwohl M, Stein Gold L, Strober B, Papp K, Armstrong A, Bagel J, Kircik L, Ehst B, Hong H, Soung J, Fromowitz J, Guenthner S, Piscitelli S, Rubenstein D, Brown P, Tallman A, Bissonnette R. Phase 3 Trials of Tapinarof Cream for Plaque Psoriasis. New England Journal Of Medicine 2021, 385: 2219-2229. PMID: 34879448, DOI: 10.1056/nejmoa2103629.Peer-Reviewed Original ResearchConceptsPrimary end pointPatient-reported outcomesTapinarof creamGlobal assessment scoreBody surface areaPlaque psoriasisWeek 12End pointPGA responseAdverse eventsPGA scoreMean changeSkin barrier protein filaggrinSecondary efficacy end pointsUpper respiratory tract infectionPhysician Global Assessment scoreNumeric rating scale scoreTotal body surface areaTotal scoreEfficacy end pointIdentical phase 3Local adverse eventsSymptom diary scoresProportion of patientsSecondary end pointsScenarios to improve CT head utilization in the emergency department delineated by critical results reporting
Tu LH, Venkatesh AK, Malhotra A, Taylor RA, Sheth KN, Forman HP, Yaesoubi R. Scenarios to improve CT head utilization in the emergency department delineated by critical results reporting. Emergency Radiology 2021, 29: 81-88. PMID: 34617133, DOI: 10.1007/s10140-021-01947-w.Peer-Reviewed Original ResearchConceptsAdult ED encountersCommon chief complaintChief complaintEmergency departmentED encountersPatient selectionHead examsLoss of consciousnessAcademic medical centerChest painBlood sugarRetrospective studyHead injuryMental statusNew headacheMedical CenterPsychiatric evaluationConclusionOur studyBetter outcomesAdvanced imagingAlcohol intoxicationTotal encountersComplaintsHeadacheSignificant differencesResection of Symptomatic Pineal Cysts Provides Durable Clinical Improvement: A Breakdown of Presenting Symptoms and Lessons Learned
Yeung JT, Young IM, Profyris C, Katsos K, Sughrue ME, Teo C. Resection of Symptomatic Pineal Cysts Provides Durable Clinical Improvement: A Breakdown of Presenting Symptoms and Lessons Learned. World Neurosurgery 2021, 150: e668-e674. PMID: 33771749, DOI: 10.1016/j.wneu.2021.03.087.Peer-Reviewed Original ResearchConceptsSymptomatic pineal cystsPineal cystsSurgical resectionClinical improvementDurable clinical improvementExhaustive conservative managementNon-headache symptomsDurable symptomatic reliefYears of agePresenting symptomConservative managementSymptomatic patientsSurgical candidacySymptomatic reliefVisual disturbancesClinical outcomesPatient populationRadiographic changesCerebral aqueductRetrospective analysisResectionPatientsVariable symptomsCystsHeadacheStructural brain network characteristics in patients with episodic and chronic migraine
Michels L, Koirala N, Groppa S, Luechinger R, Gantenbein A, Sandor P, Kollias S, Riederer F, Muthuraman M. Structural brain network characteristics in patients with episodic and chronic migraine. The Journal Of Headache And Pain 2021, 22: 8. PMID: 33657996, PMCID: PMC7927231, DOI: 10.1186/s10194-021-01216-8.Peer-Reviewed Original ResearchMOG-associated encephalitis following SARS-COV-2 infection
Peters J, Alhasan S, Vogels CBF, Grubaugh ND, Farhadian S, Longbrake EE. MOG-associated encephalitis following SARS-COV-2 infection. Multiple Sclerosis And Related Disorders 2021, 50: 102857. PMID: 33647592, PMCID: PMC7900751, DOI: 10.1016/j.msard.2021.102857.Peer-Reviewed Case Reports and Technical Notes
2020
The Surgical Resection of Brainstem Glioma: Outcomes and Prognostic Factors
Faulkner H, Arnaout O, Hoshide R, Young IM, Yeung JT, Sughrue ME, Teo C. The Surgical Resection of Brainstem Glioma: Outcomes and Prognostic Factors. World Neurosurgery 2020, 146: e639-e650. PMID: 33152495, DOI: 10.1016/j.wneu.2020.10.147.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAstrocytomaAtaxiaBrain Stem NeoplasmsCerebrospinal Fluid LeakChildChild, PreschoolDiplopiaEpendymomaFemaleGlioblastomaGliomaHeadacheHumansHydrocephalusInfantInfant, NewbornKaplan-Meier EstimateKarnofsky Performance StatusMachine LearningMagnetic Resonance ImagingMaleMiddle AgedMultivariate AnalysisNauseaNeoplasm GradingNeoplasm, ResidualNeurosurgical ProceduresPostoperative ComplicationsPrognosisRetrospective StudiesSurvival RateTumor BurdenVomitingYoung AdultConceptsBrainstem gliomasSurgical resectionPrognostic factorsSurgical treatmentTransient neurologic deficitsRadical surgical resectionHigh-grade tumorsPostoperative radiographic evaluationMagnetic resonance imagingChart reviewNeurologic deficitsOverall survivalSurgical candidatesConfers survival advantageMedian ageSurgical indicationsPatient selectionSurvival outcomesRadiographic evaluationSelect subgroupRadiographic featuresPrimary treatmentPermanent deficitsSurvival advantageTreatment selectionHeadache in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Narrative Review
Tolebeyan A, Zhang N, Cooper V, Kuruvilla D. Headache in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Narrative Review. Headache The Journal Of Head And Face Pain 2020, 60: 2131-2138. PMID: 33017479, PMCID: PMC7675458, DOI: 10.1111/head.13980.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Clinical manifestationsAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSevere acute respiratory syndrome coronavirus 2Syndrome coronavirus 2 infectionAcute respiratory syndrome coronavirus 2SARS-CoV-2 infectionCOVID-19Respiratory syndrome coronavirus 2Manifestations of coronavirusCoronavirus 2 infectionCommon clinical manifestationsSyndrome coronavirus 2Nociceptive sensory neuronsRelease of cytokinesCommon neurologic complaintsCourse of infectionCOVID-19 epidemiologyPulmonary manifestationsInflammatory mechanismsNeurologic findingsNeurologic manifestationsViral neuroinvasionHypercoagulable state
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