2024
MAP kinase phosphatase-1 inhibition of p38α within lung myofibroblasts is essential for spontaneous fibrosis resolution
Fortier S, Walker N, Penke L, Baas J, Shen Q, Speth J, Huang S, Zemans R, Bennett A, Peters-Golden M. MAP kinase phosphatase-1 inhibition of p38α within lung myofibroblasts is essential for spontaneous fibrosis resolution. Journal Of Clinical Investigation 2024, 134: e172826. PMID: 38512415, PMCID: PMC11093610, DOI: 10.1172/jci172826.Peer-Reviewed Original ResearchConceptsMAPK phosphatase 1Fibrosis resolutionPulmonary fibrosisSpontaneous resolutionLung fibrosisBleomycin-induced lung fibrosisLung fibroblastsProgressive pulmonary fibrosisFibroblast-specific deletionExperimental lung fibrosisCells to apoptosisLung injuryRegulation of MAPK activityApoptosis-resistant myofibroblastsTransgenic miceResident fibroblastsTissue injuryFibrosisLung myofibroblastsLoss-of-function studiesGain- and loss-of-function studiesLungVX-702MyofibroblastsMAPK activation
2023
Spontaneous vesicoureteral reflux resolution curves based on ureteral diameter ratio
Arlen A, Leong T, Kirsch A, Cooper C. Spontaneous vesicoureteral reflux resolution curves based on ureteral diameter ratio. Journal Of Pediatric Urology 2023, 19: 468.e1-468.e6. PMID: 37188603, DOI: 10.1016/j.jpurol.2023.04.028.Peer-Reviewed Original ResearchConceptsUreteral diameter ratioUrinary tract infectionPrimary vesicoureteral refluxVesicoureteral refluxSpontaneous resolutionRisk groupsBreakthrough febrile urinary tract infectionDistal ureteral diameter ratioFebrile urinary tract infectionLargest ureteral diameterObjective prognostic informationGrade of refluxHigh-risk patientsLow-risk patientsHigh-risk groupLow-risk groupLow-risk childrenVUR resolutionPrimary refluxProphylactic antibioticsVUR gradeConservative managementPersistent refluxRisk patientsTract infections
2022
Spontaneous resolution of silent sinus syndrome in a pediatric patient
Ihnat J, Williams L, Baum E, Waldman E. Spontaneous resolution of silent sinus syndrome in a pediatric patient. Otolaryngology Case Reports 2022, 25: 100485. DOI: 10.1016/j.xocr.2022.100485.Peer-Reviewed Original Research
2021
The role of choroidal optical coherence tomography for follow-up of carotid cavernous fistula with anterior drainage
Arat Y, İnam O, Yavas G, Arat A. The role of choroidal optical coherence tomography for follow-up of carotid cavernous fistula with anterior drainage. Eye 2021, 36: 2020-2027. PMID: 34408315, PMCID: PMC9500102, DOI: 10.1038/s41433-021-01744-2.Peer-Reviewed Original ResearchConceptsChoroidal vascularity indexCarotid-cavernous fistulaCentral foveal thicknessSubfoveal choroidal thicknessChoroidal thickness measurementsOptical coherence tomographyTortuosity indexFollow-upCavernous fistulaCoherence tomographySpectral-domain optical coherence tomographyClinically unaffected eyesOcclusion of fistulaAnterior drainageChoroidal thicknessFoveal thicknessUnaffected eyesLongitudinal observational studyEndovascular treatmentEvaluate occlusionSpontaneous resolutionVascular indexCarotid angiogramFistulaObservational studyResolution of sclerotic lesions of dysosteosclerosis due to biallelic SLC29A3 variant in a Turkish girl
Alkaya D, Akpınar E, Bilguvar K, Tüysüz B. Resolution of sclerotic lesions of dysosteosclerosis due to biallelic SLC29A3 variant in a Turkish girl. American Journal Of Medical Genetics Part A 2021, 185: 2271-2277. PMID: 33837634, DOI: 10.1002/ajmg.a.62198.Peer-Reviewed Original ResearchConceptsCortical thickeningShort statureThree-year-old girlLarge anterior fontanelleLong bone metaphysisDiffuse sclerosisFracture historyElbow contractureAnterior fontanelleSclerotic lesionsBone fragilitySpontaneous resolutionBone metaphysisMild sclerosisSkeletal radiographsSclerosisMelanocytic neviBone dysplasiaSkull baseHeterogeneous disorderSLC29A3 mutationsVertebral endplatesBiallelic mutationsTurkish girlPelvic bones
2020
Spontaneous Resolution of Primary Hypercortisolism of Cushing Disease After Pituitary Hemorrhage
Siwakoti K, Omay SB, Inzucchi SE. Spontaneous Resolution of Primary Hypercortisolism of Cushing Disease After Pituitary Hemorrhage. AACE Clinical Case Reports 2020, 6: e23-e29. PMID: 32984518, PMCID: PMC7279773, DOI: 10.4158/accr-2019-0292.Peer-Reviewed Original ResearchPituitary apoplexySpontaneous resolutionBiochemical remissionPrimary hypercortisolismSellar massLow-dose dexamethasone suppression testDose dexamethasone suppression testMagnetic resonance imaging (MRI) scansUrine free cortisolSymptoms of hypercortisolismDexamethasone suppression testResonance imaging scansSymptomatic hemorrhageSurgical resectionCushing's diseaseInitial presentationPituitary hemorrhageFree cortisolFunctional adenomasImaging scansElevated plasmaSerum cortisolSuppression testClinical signsPathologic information
2017
Validation of the ureteral diameter ratio for predicting early spontaneous resolution of primary vesicoureteral reflux
Arlen AM, Kirsch AJ, Leong T, Cooper CS. Validation of the ureteral diameter ratio for predicting early spontaneous resolution of primary vesicoureteral reflux. Journal Of Pediatric Urology 2017, 13: 383.e1-383.e6. PMID: 28256423, DOI: 10.1016/j.jpurol.2017.01.012.Peer-Reviewed Original ResearchConceptsPrimary vesicoureteral refluxUreteral diameter ratioVesicoureteral refluxReflux gradeSpontaneous resolutionVUR gradeMultivariable modelUreteral diameterDistal ureteral diameter ratioGrade of VURLargest ureteral diameterPersistent vesicoureteral refluxVesicoureteral reflux gradeGrade of refluxImportant prognostic factorSpontaneous resolution rateValuable prognostic informationL3 vertebral bodyUnit increaseExternal validation studyHighest likelihood ratioVUR timingPersistent diseasePrimary outcomePrognostic factors
2016
Early Spontaneous Resolution of an Iatrogenic Acute Type A Aortic Dissection
Zafar MA, Pang PYK, Henry GA, Ziganshin BA, Tranquilli M, Elefteriades JA. Early Spontaneous Resolution of an Iatrogenic Acute Type A Aortic Dissection. Aorta 2016, 04: 235-239. PMID: 28516101, PMCID: PMC5425262, DOI: 10.12945/j.aorta.2016.16.067.Peer-Reviewed Original ResearchAortic dissectionAcute Type A Aortic DissectionFollow-up computed tomography scanType A Aortic DissectionAnti-impulse therapyDeBakey type IA Aortic DissectionAcute aortic dissectionComputed tomography scanDevastating complicationCardiac catheterizationArch vesselsComplete resolutionElderly femalesTomography scanSpontaneous resolutionDissectionType IAngioplastyCatheterizationComplicationsPatientsAortaTherapyMonthsInter-rater reliability of distal ureteral diameter ratio compared to grade of VUR
Swanton A, Arlen A, Alexander S, Kieran K, Storm D, Cooper C. Inter-rater reliability of distal ureteral diameter ratio compared to grade of VUR. Journal Of Pediatric Urology 2016, 13: 207.e1-207.e5. PMID: 28089295, DOI: 10.1016/j.jpurol.2016.10.021.Peer-Reviewed Original ResearchConceptsUreteral diameter ratioDistal ureteral diameter ratioVesicoureteral refluxVUR gradeInter-rater reliabilityReflux gradePediatric urologistsGrade of VURGrading of VURLargest ureteral diameterHigh grade refluxImportant prognostic factorPrimary vesicoureteral refluxConfidence intervalsSignificant inter-rater variabilityGood inter-rater reliabilityPrognostic factorsClinical courseClinical outcomesPredictive factorsRenal unitsUreteral diameterInter-rater agreementSpontaneous resolutionBlinded fashionVesicoureteral Reflux
Arlen A, Cooper C. Vesicoureteral Reflux. 2016, 95-113. DOI: 10.1007/978-3-319-29219-9_6.Peer-Reviewed Original ResearchUrinary tract infectionVesicoureteral refluxSurgical correctionRecurrent febrile urinary tract infectionsFebrile urinary tract infectionLaparoscopic/robotic approachContinuous antibiotic prophylaxisMorbidity of treatmentRenal cortical scarringUpper urinary tractAntibiotic prophylaxisCortical scarringRenal injuryTract infectionsUrinary tractSpontaneous resolutionFurther infectionRobotic approachChildren's riskRetrograde flowInfectionRefluxParental preferencesRiskProphylaxisComputer model predicting breakthrough febrile urinary tract infection in children with primary vesicoureteral reflux
Arlen AM, Alexander SE, Wald M, Cooper CS. Computer model predicting breakthrough febrile urinary tract infection in children with primary vesicoureteral reflux. Journal Of Pediatric Urology 2016, 12: 288.e1-288.e5. PMID: 27072485, DOI: 10.1016/j.jpurol.2016.03.005.Peer-Reviewed Original ResearchConceptsBreakthrough febrile urinary tract infectionFebrile urinary tract infectionPrimary vesicoureteral refluxBladder-bowel dysfunctionOnset of VURUrinary tract infectionVesicoureteral refluxLow bladder volumesBladder volumeUTI historyTract infectionsPrognostic calculatorSpontaneous resolutionRecurrent febrile urinary tract infectionsCorrect vesicoureteral refluxRecurrent febrile infectionsRenal parenchymal scarringIndividual child's riskCharacteristic curve areaParenchymal scarringVCUG findingsRenal scarringPatient demographicsVUR gradeFebrile infections
2015
Diagnostik und Therapie der Sarkoidose
Frye B, Schupp J, Köhler T, Müller-Quernheim J. Diagnostik und Therapie der Sarkoidose. Der Internist 2015, 56: 1346-1352. PMID: 26563335, DOI: 10.1007/s00108-015-3757-1.ChaptersConceptsIntrathoracic lymph nodesLymph nodesGranulomatous diseaseSteroid-refractory diseaseFurther therapeutic optionsNon-necrotizing granulomasDiagnostik und TherapieLung transplantationSarcoidosis treatmentSteroid therapyCNS involvementStarting doseSymptomatic therapyOrgan impairmentTherapeutic optionsUnd TherapieEndobronchial ultrasoundSpontaneous resolutionBody weightSarcoidosisOrphan diseaseMonoclonal antibodiesDiseaseSymptomatic patternGranulomas
2009
Glucose Normalization and Outcomes in Patients With Acute Myocardial Infarction
Kosiborod M, Inzucchi SE, Krumholz HM, Masoudi FA, Goyal A, Xiao L, Jones PG, Fiske S, Spertus JA. Glucose Normalization and Outcomes in Patients With Acute Myocardial Infarction. JAMA Internal Medicine 2009, 169: 438-446. PMID: 19273773, DOI: 10.1001/archinternmed.2008.593.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionInsulin therapyMyocardial infarctionGlucose levelsGlucose normalizationBetter survivalElevated blood glucose levelsMultivariable logistic regression modelPropensity-matched analysisMean glucose levelBlood glucose levelsPropensity-matching methodsLow glucose levelsLogistic regression modelsHospital mortalityMultivariable adjustmentImproved survivalHyperglycemic patientsSpontaneous resolutionPatientsMortality rateUS hospitalsAdmissionInfarctionTherapyReperfusion normalizes motor activation patterns in large‐vessel disease
Chmayssani M, Lazar RM, Hirsch J, Marshall RS. Reperfusion normalizes motor activation patterns in large‐vessel disease. Annals Of Neurology 2009, 65: 203-208. PMID: 19259970, PMCID: PMC2653600, DOI: 10.1002/ana.21554.Peer-Reviewed Original ResearchConceptsMotor activation patternsVasomotor reactivityActivation patternsInterest analysisIpsilateral motor activationLarge vessel diseaseNormal neurological functionHealthy control subjectsHigh-grade stenosisBlood oxygen level-dependent (BOLD) signalNormal blood flowDynamic functional reorganizationLevel-dependent signalFunctional magnetic resonanceRepeated-measures analysisHemodynamic failureHemodynamic impairmentRevascularization proceduresIpsilateral hemisphereNeurological functionControl subjectsClinical consequencesBlood flowFunctional reorganizationSpontaneous resolution
1998
RESOLUTION OF SPUR CELL ANEMIA WITH LIVER TRANSPLANTATION
Chitale AA, Sterling RK, Post AB, Silver BJ, Mulligan DC, Schulak JA. RESOLUTION OF SPUR CELL ANEMIA WITH LIVER TRANSPLANTATION. Transplantation 1998, 65: 993-995. PMID: 9565106, DOI: 10.1097/00007890-199804150-00021.Peer-Reviewed Original ResearchConceptsSpur cell anemiaCell anemiaOrthotopic liver transplantationLiver transplantationYounger patientsDiseased liverHemolytic anemiaSpur cellsSpontaneous resolutionAlcohol abuseUnusual caseAnemiaIncreased percentageCirrhosisLiverErythrocytesCell surfacePatientsTransplantationNumerous spiculesHemochromatosis
1997
EBV-associated Kikuchi's histiocytic necrotizing lymphadenitis with cutaneous manifestations
Yen A, Fearneyhough P, Raimer S, Hudnall S. EBV-associated Kikuchi's histiocytic necrotizing lymphadenitis with cutaneous manifestations. Journal Of The American Academy Of Dermatology 1997, 36: 342-346. PMID: 9039215, DOI: 10.1016/s0190-9622(97)80413-6.Peer-Reviewed Original ResearchConceptsHistiocytic necrotizing lymphadenitisKikuchi's histiocytic necrotizing lymphadenitisNecrotizing lymphadenitisCutaneous manifestationsSkin lesionsAtypical lymphoid cellsEBER-1 RNACrusted papulesLymph nodesMalignant lymphomaPathologic findingsKaryorrhectic debrisSerologic studiesPatchy necrosisHistiocytic aggregatesSpontaneous resolutionImmunoperoxidase stainingLymphoid cellsLymphadenitisCausative agentLesionsEBVSitu hybridizationManifestationsMyalgia
1996
Isolated lymphadenopathy on chest radiographs of HIV-infected patients
Haramati L, Choi Y, Widrow C, Austin J. Isolated lymphadenopathy on chest radiographs of HIV-infected patients. Clinical Radiology 1996, 51: 345-349. PMID: 8641098, DOI: 10.1016/s0009-9260(96)80113-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS-Related ComplexAIDS-Related Opportunistic InfectionsFemaleHumansLung DiseasesLymphatic DiseasesMaleMiddle AgedMycobacterium avium ComplexMycobacterium avium-intracellulare InfectionMycobacterium InfectionsMycobacterium tuberculosisRetrospective StudiesTomography, X-Ray ComputedTuberculosis, Lymph NodeTuberculosis, PulmonaryConceptsIsolated intrathoracic lymphadenopathyMycobacterium avium-intracellulare complexIntrathoracic lymphadenopathyChest radiographsInner-city HIVMedian patient ageSerial chest radiographsIsolated lymphadenopathyCryptococcal infectionAortopulmonary windowClinical chartsPatient ageAnterior mediastinumThymic hyperplasiaPatient presentsNodal stationsMycobacterial infectionLymphadenopathyMycobacterial diseaseSpontaneous resolutionHIVPatientsMycobacterium tuberculosisRadiographsClinic development
1991
Low human chorionic somatomammotropin fails to predict spontaneous resolution of unruptured ectopic pregnancies
Carson S, Stovall T, Ling F, Buster J. Low human chorionic somatomammotropin fails to predict spontaneous resolution of unruptured ectopic pregnancies. Fertility And Sterility 1991, 55: 629-630. PMID: 2001763, DOI: 10.1016/s0015-0282(16)54198-3.Peer-Reviewed Original Research
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