2023
Efficacy and safety of subcutaneous spesolimab for the prevention of generalised pustular psoriasis flares (Effisayil 2): an international, multicentre, randomised, placebo-controlled trial
Morita A, Strober B, Burden A, Choon S, Anadkat M, Marrakchi S, Tsai T, Gordon K, Thaçi D, Zheng M, Hu N, Haeufel T, Thoma C, Lebwohl M. Efficacy and safety of subcutaneous spesolimab for the prevention of generalised pustular psoriasis flares (Effisayil 2): an international, multicentre, randomised, placebo-controlled trial. The Lancet 2023, 402: 1541-1551. PMID: 37738999, DOI: 10.1016/s0140-6736(23)01378-8.Peer-Reviewed Original ResearchConceptsPhysician Global Assessment scoreGPP flaresGlobal assessment scoreFlare preventionDose-response relationshipPrimary endpointAssessment scoresPhase 2b trialPustular psoriasis flarePlacebo-controlled trialReceptor monoclonal antibodyEligible study participantsQuality of lifeDose-response curveSubcutaneous placeboPlacebo groupWeek 48Pustular psoriasisPrimary outcomePsoriasis flareTreatment armsPatient groupHypersensitivity reactionsPatient morbiditySpesolimab
2022
Deucravacitinib versus placebo and apremilast in moderate to severe plaque psoriasis: Efficacy and safety results from the 52-week, randomized, double-blinded, phase 3 Program fOr Evaluation of TYK2 inhibitor psoriasis second trial
Strober B, Thaçi D, Sofen H, Kircik L, Gordon K, Foley P, Rich P, Paul C, Bagel J, Colston E, Throup J, Kundu S, Sekaran C, Linaberry M, Banerjee S, Papp K. Deucravacitinib versus placebo and apremilast in moderate to severe plaque psoriasis: Efficacy and safety results from the 52-week, randomized, double-blinded, phase 3 Program fOr Evaluation of TYK2 inhibitor psoriasis second trial. Journal Of The American Academy Of Dermatology 2022, 88: 40-51. PMID: 36115523, DOI: 10.1016/j.jaad.2022.08.061.Peer-Reviewed Original ResearchConceptsGlobal assessment scoreSevere plaque psoriasisStatic Physician's Global Assessment scorePhysician Global Assessment scorePlaque psoriasisAdverse eventsPsoriasis AreaWeek 16Assessment scoresFrequent adverse eventsPhase 3 trialSerious adverse eventsSeverity IndexPhase 3 programSecond trialApremilast patientsWeek 52Laboratory parametersPsoriasis pathogenesisSafety resultsPlaceboDeucravacitinibStudy durationPsoriasisPatientsSuper‐response to guselkumab treatment in patients with moderate‐to‐severe psoriasis: age, body weight, baseline Psoriasis Area and Severity Index, and baseline Investigator's Global Assessment scores predict complete skin clearance
Reich K, Gordon K, Strober B, Langley R, Miller M, Yang Y, Shen Y, You Y, Zhu Y, Foley P, Blauvelt A. Super‐response to guselkumab treatment in patients with moderate‐to‐severe psoriasis: age, body weight, baseline Psoriasis Area and Severity Index, and baseline Investigator's Global Assessment scores predict complete skin clearance. Journal Of The European Academy Of Dermatology And Venereology 2022, 36: 2393-2400. PMID: 35920762, DOI: 10.1111/jdv.18474.Peer-Reviewed Original ResearchConceptsGlobal assessment scoreInvestigator's Global Assessment scoreSevere psoriasisGuselkumab treatmentChronic immune-mediated inflammatory skin diseaseBody weightImmune-mediated inflammatory skin diseaseAssessment scoresStepwise logistic regression analysisBaseline Psoriasis AreaComplete skin clearanceEarly clinical responseLess obese patientsVOYAGE 2 studiesBaseline body weightSubset of patientsInflammatory skin diseaseLogistic regression analysisHuman monoclonal antibodyPASI 100PASI 75Skin clearanceBaseline characteristicsBaseline demographicsClinical responseDeucravacitinib versus placebo and apremilast in moderate to severe plaque psoriasis: Efficacy and safety results from the 52-week, randomized, double-blinded, placebo-controlled phase 3 POETYK PSO-1 trial
Armstrong A, Gooderham M, Warren R, Papp K, Strober B, Thaçi D, Morita A, Szepietowski J, Imafuku S, Colston E, Throup J, Kundu S, Schoenfeld S, Linaberry M, Banerjee S, Blauvelt A. Deucravacitinib versus placebo and apremilast in moderate to severe plaque psoriasis: Efficacy and safety results from the 52-week, randomized, double-blinded, placebo-controlled phase 3 POETYK PSO-1 trial. Journal Of The American Academy Of Dermatology 2022, 88: 29-39. PMID: 35820547, DOI: 10.1016/j.jaad.2022.07.002.Peer-Reviewed Original ResearchConceptsSevere plaque psoriasisGlobal assessment scorePlaque psoriasisWeek 16Static Physician's Global Assessment scoreResponse ratePhysician Global Assessment scoreCoprimary end pointsAdverse event ratesOne-year durationPASI 75Psoriasis AreaWeek 52Psoriasis treatmentPlaceboSafety resultsDeucravacitinibApremilastEnd pointEvent ratesAssessment scoresPsoriasisSeverity IndexKinase 2 inhibitorTyrosine kinase 2 inhibitorEffect of Intensive Blood Pressure Control on Incident Stroke Risk in Patients With Mild Cognitive Impairment
de Havenon A, Sharma R, Falcone GJ, Prabhakaran S, Sheth KN. Effect of Intensive Blood Pressure Control on Incident Stroke Risk in Patients With Mild Cognitive Impairment. Stroke 2022, 53: e242-e245. PMID: 35502662, PMCID: PMC9246875, DOI: 10.1161/strokeaha.122.038818.Peer-Reviewed Original ResearchConceptsIntensive BP controlIntensive blood pressure controlMild cognitive impairmentMontreal Cognitive Assessment scoreBlood pressure controlBP controlIncident strokePrimary outcomeCognitive Assessment scoreCognitive impairmentCox modelPressure controlAssessment scoresAnalysis of SPRINTIncident stroke riskStandard BP controlIncident stroke eventsRace/ethnicityBaseline BPRandomization armHazard ratioStroke riskPatient ageStroke eventsAtrial fibrillationImproving Emergency Preparedness in Pediatric Primary Care Offices: A Simulation-Based Interventional Study
Yuknis ML, Abulebda K, Whitfill T, Pearson KJ, Montgomery EE, Auerbach MA, Simulation I. Improving Emergency Preparedness in Pediatric Primary Care Offices: A Simulation-Based Interventional Study. Academic Pediatrics 2022, 22: 1167-1174. PMID: 35367402, DOI: 10.1016/j.acap.2022.03.018.Peer-Reviewed Original ResearchConceptsPediatric primary care officeQuality of carePrimary care officesPrimary care practicesCare officesBaseline assessmentCare practicesPediatric primary care practicesSingle-center studyMonth intervention periodPediatrics policy statementEmergency preparednessSimulated settingRespiratory distressAAP guidelinesCenter studyProspective studyInterventional studyIntervention periodPediatric emergenciesEmergency carePreparedness scoreAmerican AcademyAssessment scoresCare
2021
Reflections on New Evidence on Crisis Standards of Care in the COVID-19 Pandemic.
Tolchin B, Latham SR, Bruce L, Ferrante LE, Kraschel K, Jubanyik K, Hull SC, Herbst JL, Kapo J, Moritz ED, Hughes J, Siegel MD, Mercurio MR. Reflections on New Evidence on Crisis Standards of Care in the COVID-19 Pandemic. The Journal Of Clinical Ethics 2021, 32: 358-360. PMID: 34928864, DOI: 10.1086/jce2021324358.Commentaries, Editorials and LettersConceptsSOFA scoreBlack patientsCrisis standardsSequential Organ Failure Assessment scoreOrgan Failure Assessment scoreAccurate prognostic scoresNext public health emergencyCOVID-19 patientsLife-saving medical resourcesMedical resourcesCOVID-19 pandemicSame scoring systemPublic health emergencyPrognostic scoreBody of evidenceRare casePatientsScoring systemTriage purposesAssessment scoresHealth emergencyCareHealthcare systemCOVID-19ScoresMachine Learning Prediction of Death in Critically Ill Patients With Coronavirus Disease 2019
Churpek MM, Gupta S, Spicer AB, Hayek SS, Srivastava A, Chan L, Melamed ML, Brenner SK, Radbel J, Madhani-Lovely F, Bhatraju PK, Bansal A, Green A, Goyal N, Shaefi S, Parikh CR, Semler MW, Leaf DE, Walther C, Anumudu S, Arunthamakun J, Kopecky K, Milligan G, McCullough P, Nguyen T, Shaefi S, Krajewski M, Shankar S, Pannu A, Valencia J, Waikar S, Kibbelaar Z, Athavale A, Hart P, Ajiboye O, Itteera M, Green A, Rachoin J, Schorr C, Shea L, Edmonston D, Mosher C, Shehata A, Cohen Z, Allusson V, Bambrick-Santoyo G, Bhatti N, Metha B, Williams A, Brenner S, Walters P, Go R, Rose K, Hernán M, Zhou A, Kim E, Lisk R, Chan L, Mathews K, Coca S, Altman D, Saha A, Soh H, Wen H, Bose S, Leven E, Wang J, Mosoyan G, Nadkarni G, Friedman A, Guirguis J, Kapoor R, Meshberger C, Parikh C, Garibaldi B, Corona-Villalobos C, Wen Y, Menez S, Malik R, Cervantes C, Gautam S, Chang C, Nguyen H, Ahoubim A, Thomas L, Guru P, Bergl P, Zhou Y, Rodriguez J, Shah J, Gupta M, Kumar P, Lazarous D, Kassaye S, Melamed M, Johns T, Mocerino R, Prudhvi K, Zhu D, Levy R, Azzi Y, Fisher M, Yunes M, Sedaliu K, Golestaneh L, Brogan M, Thakkar J, Kumar N, Ross M, Chang M, Raichoudhury R, Schenck E, Cho S, Plataki M, Alvarez-Mulett S, Gomez-Escobar L, Pan D, Lee S, Krishnan J, Whalen W, Charytan D, Macina A, Ross D, Srivastava A, Leidner A, Martinez C, Kruser J, Wunderink R, Hodakowski A, Velez J, Price-Haywood E, Matute-Trochez L, Hasty A, Mohamed M, Avasare R, Zonies D, Leaf D, Gupta S, Baron R, Sise M, Newman E, Abu Omar S, Pokharel K, Sharma S, Singh H, Gaviria S, Shaukat T, Kamal O, Wang W, Yang H, Boateng J, Lee M, Strohbehn I, Li J, Muhsin S, Mandel E, Mueller A, Cairl N, Madhani-Lovely F, Rowan C, Madhai-Lovely F, Peev V, Reiser J, Byun J, Vissing A, Kapania E, Post Z, Patel N, Hermes J, Sutherland A, Patrawalla A, Finkel D, Danek B, Arikapudi S, Paer J, Radbel J, Puri S, Sunderram J, Scharf M, Ahmed A, Berim I, Vatson J, Anand S, Levitt J, Garcia P, Boyle S, Song R, Zhang J, Sharshir M, Rusnak V, Bansal A, Podoll A, Chonchol M, Sharma S, Burnham E, Rashidi A, Hejal R, Judd E, Latta L, Tolwani A, Albertson T, Adams J, Chang S, Beutler R, Schulze C, Macedo E, Rhee H, Liu K, Jotwani V, Koyner J, Shah C, Jaikaransingh V, Toth-Manikowski S, Joo M, Lash J, Neyra J, Chaaban N, Iardino A, Au E, Sharma J, Sosa M, Taldone S, Contreras G, De La Zerda D, Gershengorn H, Hayek S, Blakely P, Berlin H, Azam T, Shadid H, Pan M, Hayer P, Meloche C, Feroze R, Padalia K, Leya J, Donnelly J, Admon A, Flythe J, Tugman M, Brown B, Leonberg-Yoo A, Spiardi R, Miano T, Roche M, Vasquez C, Bansal A, Ernecoff N, Kovesdy C, Molnar M, Hedayati S, Nadamuni M, Khan S, Willett D, Short S, Renaghan A, Bhatraju P, Malik A, Semler M, Vijayan A, Joy C, Li T, Goldberg S, Kao P, Schumaker G, Goyal N, Faugno A, Schumaker G, Hsu C, Tariq A, Meyer L, Christov M, Wilson F, Arora T, Ugwuowo U. Machine Learning Prediction of Death in Critically Ill Patients With Coronavirus Disease 2019. Critical Care Explorations 2021, 3: e0515. PMID: 34476402, PMCID: PMC8378790, DOI: 10.1097/cce.0000000000000515.Peer-Reviewed Original ResearchSequential Organ Failure Assessment scoreOrgan Failure Assessment scoreNational Early Warning ScoreCoronavirus disease 2019Early Warning ScoreDisease 2019CURB-65Warning ScoreIll patientsAssessment scoresModified Sequential Organ Failure Assessment scoreCharacteristic curveExternal validationCritically Ill PatientsClinical trial enrichmentPrognostic enrichmentICU admissionInhospital mortalityAdult patientsHighest areaICU patientsPrimary outcomeArterial pHTrial enrichmentU.S. ICUsPerformance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States
Jezmir J, Bharadwaj M, Chaitoff A, Diephuis B, Crowley C, Kishore S, Goralnick E, Merriam L, Milliken A, Rhee C, Sadovnikoff N, Shah S, Gupta S, Leaf D, Feldman W, Kim E, Walther C, Anumudu S, Arunthamakun J, Kopecky K, Milligan G, McCullough P, Nguyen T, Shaefi S, Krajewski M, Shankar S, Pannu A, Valencia J, Waikar S, Kibbelaar Z, Athavale A, Hart P, Upadhyay S, Vohra I, Oyintayo A, Green A, Rachoin J, Schorr C, Shea L, Edmonston D, Mosher C, Shehata A, Cohen Z, Allusson V, Bambrick-Santoyo G, Bhatti N, Mehta B, Williams A, Brenner S, Walters P, Go R, Rose K, Hernán M, Zhou A, Kim E, Lisk R, Chan L, Mathews K, Coca S, Altman D, Saha A, Soh H, Wen H, Bose S, Leven E, Wang J, Mosoyan G, Nadkarni G, Pattharanitima P, Friedman A, Guirguis J, Kapoor R, Meshberger C, Kelly K, Parikh C, Garibaldi B, Corona-Villalobos C, Wen Y, Menez S, Malik R, Cervantes E, Gautam S, Mallappallil M, Ouyang J, John S, Yap E, Melaku Y, Mohamed I, Bajracharya S, Puri I, Thaxton M, Bhattacharya J, Wagner J, Boudourakis L, Nguyen H, Ahoubim A, Thomas L, Sirganagari D, Guru P, Kashani K, Zhou Y, Bergl P, Rodriguez J, Shah J, Gupta M, Kumar P, Lazarous D, Kassaye S, Melamed M, Johns T, Mocerino R, Prudhvi K, Zhu D, Levy R, Azzi Y, Fisher M, Yunes M, Sedaliu K, Golestaneh L, Brogan M, Kumar N, Chang M, Raichoudhury R, Athreya A, Farag M, Schenck E, Cho S, Plataki M, Alvarez-Mulett S, Gomez-Escobar L, Pan D, Lee S, Krishnan J, Whalen W, Charytan D, Macina A, Chaudhry S, Wu B, Modersitzki F, Srivastava A, Leidner A, Martinez C, Kruser J, Wunderink R, Hodakowski A, Velez J, Price-Haywood E, Matute-Trochez L, Hasty A, Mohamed M, Avasare R, Zonies D, Leaf D, Gupta S, Sise M, Newman E, Abu Omar S, Pokharel K, Sharma S, Singh H, Correa S, Shaukat T, Kamal O, Wang W, Yang H, Boateng J, Lee M, Strohbehn I, Li J, Mueller A, Redfern R, Cairl N, Naimy G, Abu-Saif A, Hall D, Bickley L, Rowan C, Madhani-Lovely F, Cruz V, Hess K, Jacobs A, Peev V, Reiser J, Byun J, Vissing A, Kapania E, Post Z, Patel N, Hermes J, Sutherland A, Patrawalla A, Finkel D, Danek B, Arikapudi S, Paer J, Cangialosi P, Liotta M, Radbel J, Puri S, Sunderram J, Scharf M, Ahmed A, Berim I, Vatson J, Anand S, Levitt J, Boyle S, Song R, Zhang J, Woo S, Deng X, Katz-Greenberg G, Senter K, Sharshir M, Rusnak V, Ali M, Bansal A, Podoll A, Chonchol M, Sharma S, Burnham E, Rashidi A, Hejal R, Judd E, Latta L, Tolwani A, Albertson T, Adams J, Chang S, Beutler R, Macedo E, Rhee H, Liu K, Jotwani V, Koyner J, Shah C, Jaikaransingh V, Toth-Manikowski S, Joo M, Lash J, Neyra J, Chaaban N, Elias M, Ahmad Y, Iardino A, Au E, Sharma J, Sosa M, Taldone S, Contreras G, De La Zerda D, Gershengorn H, Shukla B, Fornoni A, Ferreira T, Hayek S, Blakely P, Berlin H, Azam T, Shadid H, Pan M, Hayer P, Meloche C, Feroze R, Kaakati R, Perry D, Bitar A, Anderson E, Padalia K, Donnelly J, Admon A, Flythe J, Tugman M, Chang E, Brown B, Leonberg-Yoo A, Spiardi R, Miano T, Roche M, Vasquez C, Bansal A, Ernecoff N, Kapoor S, Verma S, Kovesdy C, Molnar M, Azhar A, Hedayati S, Nadamuni M, Shastri S, Willett D, Short S, Renaghan A, Enfield K, Bhatraju P, Malik A, Semler M, Vijayan A, Joy C, Li T, Goldberg S, Kao P, Schumaker G, Goyal N, Faugno A, Schumaker G, Hsu C, Tariq A, Meyer L, Kshirsagar R, Weiner D, Jose A, Christov M, Griffiths J, Gupta S, Kapoor A, Wilson P, Arora T, Ugwuowo U. Performance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States. Cell Reports Medicine 2021, 2: 100376. PMID: 34337554, PMCID: PMC8316067, DOI: 10.1016/j.xcrm.2021.100376.Peer-Reviewed Original ResearchConceptsSOFA scoreCare guidelinesSequential Organ Failure Assessment scoreIll COVID-19 patientsOrgan Failure Assessment scoreScarce critical care resourcesCOVID-19 patientsCrisis standardsCritical care resourcesIll patientsMulticenter cohortWhite patientsMechanical ventilationModest discriminationCare resourcesComorbiditiesPotential exacerbationAssessment scoresPatientsPopulation benefitsCOVID-19COVID-19 pandemicScoresCohortGuidelinesElectronic health record risk score provides earlier prognostication of clinical outcomes in patients admitted to the cardiac intensive care unit
Kunitomo Y, Thomas A, Chouairi F, Canavan ME, Kochar A, Khera R, Katz JN, Murphy C, Jentzer J, Ahmad T, Desai NR, Brennan J, Miller PE. Electronic health record risk score provides earlier prognostication of clinical outcomes in patients admitted to the cardiac intensive care unit. American Heart Journal 2021, 238: 85-88. PMID: 33891906, DOI: 10.1016/j.ahj.2021.04.004.Peer-Reviewed Original ResearchConceptsCardiac intensive care unitIntensive care unitRothman IndexCare unitRisk scoreModern cardiac intensive care unitSequential Organ Failure Assessment scoreOrgan Failure Assessment scoreElectronic health recordsCICU mortalityCICU patientsSOFA scoreCICU admissionClinical outcomesEarly prognosticationObservational studyPrognostic abilityAssessment scoresOutcome predictionHealth recordsGood calibrationSuperior discriminationPatientsAdmissionScores
2020
SOFA score and short-term mortality in acute decompensated heart failure
Elias A, Agbarieh R, Saliba W, Khoury J, Bahouth F, Nashashibi J, Azzam Z. SOFA score and short-term mortality in acute decompensated heart failure. Scientific Reports 2020, 10: 20802. PMID: 33257739, PMCID: PMC7705654, DOI: 10.1038/s41598-020-77967-2.Peer-Reviewed Original ResearchConceptsAcute decompensated heart failureSequential Organ Function Assessment (SOFA) scoreShort-term mortalityDecompensated heart failureSOFA scoreHigh-risk patientsHospital mortalityRisk patientsHeart failureLife-threatening conditionCurve (AUC) of receiverFirst hospitalizationPrimary diagnosisRisk scorePatientsMortalityAssessment scoresStrict monitoringExcellent scoresCharacteristic curveHospitalizationScoresGood predictive accuracyProper managementSepsisAssociation between patient-physician gender concordance and patient experience scores. Is there gender bias?
Chekijian S, Kinsman J, Taylor RA, Ravi S, Parwani V, Ulrich A, Venkatesh A, Agrawal P. Association between patient-physician gender concordance and patient experience scores. Is there gender bias? The American Journal Of Emergency Medicine 2020, 45: 476-482. PMID: 33069544, DOI: 10.1016/j.ajem.2020.09.090.Peer-Reviewed Original ResearchConceptsPatient satisfaction surveyFemale patientsProvider scoresOverall assessment scoreEmergency departmentPatient satisfactionPhysician genderPatient-physician gender concordanceFemale physiciansAssessment scoresGender concordancePatient satisfaction survey dataSatisfaction surveyEffect of patientFemale emergency physiciansPatient experience scoresLogistic regression modelsCross-sectional analysisElectronic health recordsPatients' oddsAdult patientsPatient genderEmergency physiciansLower oddsEmergency care
2019
Angiotensin II in Decompensated Cirrhosis Complicated by Septic Shock
Coleman P, Nissen A, Kim D, Ainsworth C, McCurdy M, Mazzeffi M, Chow J. Angiotensin II in Decompensated Cirrhosis Complicated by Septic Shock. Seminars In Cardiothoracic And Vascular Anesthesia 2019, 24: 266-272. PMID: 31540560, DOI: 10.1177/1089253219877876.Peer-Reviewed Original ResearchConceptsAngiotensin IISeptic shockAng-2End-stage liver disease (MELD) scoreSequential Organ Failure Assessment scoreOrgan Failure Assessment scoreLiver Disease scoreSynthetic angiotensin IIConventional vasopressorsVasodilatory shockAldosterone systemDecompensated cirrhosisArterial pressureBeneficial medicationsLiver failureExclusion criteriaDisease scoreShock trialsAssessment scoresPatientsScoresVasopressorsCirrhosisBacteremiaMedicationsUS real-world effectiveness of secukinumab for the treatment of psoriasis: 6-month analysis from the Corrona Psoriasis Registry
Strober B, Germino R, Guana A, Greenberg J, Litman H, Guo N, Lebwohl M. US real-world effectiveness of secukinumab for the treatment of psoriasis: 6-month analysis from the Corrona Psoriasis Registry. Journal Of Dermatological Treatment 2019, 31: 333-341. PMID: 31035822, DOI: 10.1080/09546634.2019.1603361.Peer-Reviewed Original ResearchConceptsPatient-reported outcomesCorrona Psoriasis RegistryGlobal assessment scoreBody surface areaReal-world effectivenessPsoriasis RegistryReal-world studySecukinumab treatmentDisease severityInvestigator's Global Assessment scoreMajority of patientsTreatment of psoriasisQuality of lifeEligible patientsSecukinumabPatientsSignificant improvementFollowAssessment scoresRegistryVisitsWork productivityPsoriasisDaily activitiesTreatment
2018
Objective Evaluation of a Didactic Curriculum for the Radiation Oncology Medical Student Clerkship
Golden D, Kauffmann G, McKillip R, Farnan J, Park Y, Schwartz A, Group R, Hirsch A, Warren L, Spektor A, Rudra S, Jimenez R, Colbert L, Gunther J, Das P, Wu A, Du K, Kruser T, Nabavizadeh N, Thomas C, Hara W, McDonald A, Chang E, Braunstein S, Chmura S, Amsbaugh M, Yechieli R, Takita C, Dean M, Asher D, Taunk N, Vargo J, Beriwal S, Ye J, Ballas L, Ballo M, Brower J, Bradley K, Rao Y, Stahl J, Higgins S. Objective Evaluation of a Didactic Curriculum for the Radiation Oncology Medical Student Clerkship. International Journal Of Radiation Oncology • Biology • Physics 2018, 101: 1039-1045. PMID: 29908787, PMCID: PMC6538302, DOI: 10.1016/j.ijrobp.2018.04.052.Peer-Reviewed Original ResearchConceptsRadiation Oncology Education Collaborative Study GroupRadiation oncology clerkshipsRadiation Oncology Education Collaborative Study Group curriculumAcademic medical centerKnowledge assessmentMedical CenterPost-curriculumMultiple academic medical centersAssessment scoresMedical student clerkshipDidactic curriculumLate time pointsCollaborative Study GroupMean assessment scoreStudy groupCurriculum efficacyMedical studentsEducational approachCurriculum exposureCurriculumStudentsStudent clerkshipTime pointsPost-scoresPre-scores
2017
The positive predictive value of PI-RADS 4 lesions stratified by lesion number in biopsy naïve men.
Syed J, Javier-desloges J, Nguyen K, Sheridan A, Levi A, Weinreb J, Sprenkle P. The positive predictive value of PI-RADS 4 lesions stratified by lesion number in biopsy naïve men. Journal Of Clinical Oncology 2017, 35: 29-29. DOI: 10.1200/jco.2017.35.6_suppl.29.Peer-Reviewed Original ResearchPI-RADS 4 lesionsPositive predictive valueBiopsy-naïve menNaïve menPredictive valuePI-RADS 3PI-RADS version 2PI-RADS 4Cancer detection rateChi-square testPSA densityEntire cohortMean ageFusion biopsyProstate cancerSingle lesionLesion locationGroup 2Group 1Group 3LesionsAssessment scoresLesion numberCategorical variablesFurther assessmentComparison of Tc-99m maraciclatide and Tc-99m sestamibi molecular breast imaging in patients with suspected breast cancer
O’Connor M, Morrow MMB, Hunt KN, Boughey JC, Wahner-Roedler DL, Conners AL, Rhodes DJ, Hruska CB. Comparison of Tc-99m maraciclatide and Tc-99m sestamibi molecular breast imaging in patients with suspected breast cancer. EJNMMI Research 2017, 7: 5. PMID: 28091980, PMCID: PMC5237435, DOI: 10.1186/s13550-017-0255-6.Peer-Reviewed Original ResearchBreast cancerBenign lesionsMolecular subtypesBreast lesionsTumor molecular subtypeOverall diagnostic performancePathologic sizeAnalyzable patientsTumor extentMalignant tumorsLesion extentBlinded fashionLesion sizeSestamibiMolecular breastPatientsLesionsAlternative radiotracersLesion uptakeAssessment scoresROC analysisCancerInterest analysisDiagnostic performanceExamination one
2016
Comparative effectiveness of biologic agents for the treatment of psoriasis in a real-world setting: Results from a large, prospective, observational study (Psoriasis Longitudinal Assessment and Registry [PSOLAR])
Strober B, Bissonnette R, Fiorentino D, Kimball A, Naldi L, Shear N, Goyal K, Fakharzadeh S, Calabro S, Langholff W, You Y, Galindo C, Lee S, Lebwohl M. Comparative effectiveness of biologic agents for the treatment of psoriasis in a real-world setting: Results from a large, prospective, observational study (Psoriasis Longitudinal Assessment and Registry [PSOLAR]). Journal Of The American Academy Of Dermatology 2016, 74: 851-861.e4. PMID: 26853180, DOI: 10.1016/j.jaad.2015.12.017.Peer-Reviewed Original ResearchMeSH KeywordsAdalimumabAdultBiological ProductsConfidence IntervalsDose-Response Relationship, DrugDrug Administration ScheduleEtanerceptFemaleFollow-Up StudiesGlobal HealthHumansInfliximabLongitudinal StudiesMaleMiddle AgedOdds RatioPatient SatisfactionProspective StudiesPsoriasisQuality of LifeRegistriesSeverity of Illness IndexTime FactorsTreatment OutcomeUstekinumabConceptsPhysician Global Assessment scoreGlobal assessment scoreBody surface areaReal-world settingAssessment scoresPsoriasis Longitudinal AssessmentProportion of patientsTreatment of psoriasisEffectiveness of biologicsTreatment selection biasTumor necrosis factorBiologic agentsEfficacy dataTherapeutic responseTumor necrosisNecrosis factorObservational studyTreatment decisionsAnalysis of covarianceEtanerceptComparative effectivenessAdalimumabInfliximabLongitudinal assessmentLogistic regression
2014
In Situ Pediatric Trauma Simulation
Auerbach M, Roney L, Aysseh A, Gawel M, Koziel J, Barre K, Caty MG, Santucci K. In Situ Pediatric Trauma Simulation. Pediatric Emergency Care 2014, 30: 884-891. PMID: 25407035, DOI: 10.1097/pec.0000000000000297.Peer-Reviewed Original Research
2012
Physical examination and radiographic interpretation of carpal anatomy in orthopedic residents and emergency medicine physicians.
Russo GS, Olson RL, Varthi A, Patel N, Leger R, Rodner CM. Physical examination and radiographic interpretation of carpal anatomy in orthopedic residents and emergency medicine physicians. The American Journal Of Orthopedics 2012, 41: 262-7. PMID: 22837989.Peer-Reviewed Original ResearchConceptsEmergency medicine physiciansMedicine physiciansOrthopaedic residentsEmergency medicine residentsRadiographic interpretationCarpal bonesMedicine residentsEmergency medicine groupCarpal anatomyOrthopaedic surgery residentsPhysical examinationMedicine groupAssessment scoresBony landmarksPhysiciansSurgery residentsEducational interventionResident cohortResident involvementEmergency medicineCohortPalpationYear medical studentsAnatomyRadiographic anatomy
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