2023
Mitochondrial DNA-Sensing Pathogen Recognition Receptors in Systemic Sclerosis-Associated Interstitial Lung Disease: a Review
Ghincea A, Woo S, Yu S, Pivarnik T, Fiorini V, Herzog E, Ryu C. Mitochondrial DNA-Sensing Pathogen Recognition Receptors in Systemic Sclerosis-Associated Interstitial Lung Disease: a Review. Current Treatment Options In Rheumatology 2023, 9: 204-220. PMID: 38230363, PMCID: PMC10791121, DOI: 10.1007/s40674-023-00211-1.Peer-Reviewed Original ResearchToll-like receptor 9Interstitial lung diseaseLung diseaseSystemic Sclerosis-Associated Interstitial Lung DiseaseAberrant innate immune activationRecent FindingsRecent advancesCause of morbidityInnate immune activationNovel treatment approachesPathogen recognition receptorsCyclic guanosine monophosphate-adenosine monophosphate synthaseReviewSystemic sclerosisSSc patientsImmune dysregulationImmune activationReceptor 9Inflammatory fibrosisScar formationTreatment approachesRecognition receptorsDiseaseImportant unanswered questionsMechanism of releaseReviewUnanswered questions
2017
Intent to Use Preexposure Prophylaxis (PrEP), HIV Risk Behaviors, and Self-Report Neurocognitive Symptoms by High-Risk Drug Users: A Mediation Analysis
Shrestha R, Karki P, Huedo-Medina TB, Copenhaver M. Intent to Use Preexposure Prophylaxis (PrEP), HIV Risk Behaviors, and Self-Report Neurocognitive Symptoms by High-Risk Drug Users: A Mediation Analysis. Journal Of The Association Of Nurses In AIDS Care 2017, 28: 612-621. PMID: 28478870, PMCID: PMC7451137, DOI: 10.1016/j.jana.2017.04.005.Peer-Reviewed Original ResearchConceptsHIV risk behaviorsNeurocognitive impairmentRisk behaviorsPreexposure prophylaxisSelf-reported neurocognitive symptomsHigh-risk drug usersHigh-risk PWUDPrEP uptakeNeurocognitive symptomsHIV riskDrug usersSimilar outcomesUnderserved populationsSignificant correlatesProphylaxisImportant unanswered questionsPreliminary evidencePrEPDissemination effortsMediation analysisUnanswered questionsVariables of interestHIVSymptomsCliniciansCarnitine acetyltransferase (CRAT) expression in macrophages is dispensable for nutrient stress sensing and inflammation
Goldberg EL, Dixit VD. Carnitine acetyltransferase (CRAT) expression in macrophages is dispensable for nutrient stress sensing and inflammation. Molecular Metabolism 2017, 6: 219-225. PMID: 28180063, PMCID: PMC5279934, DOI: 10.1016/j.molmet.2016.12.008.Peer-Reviewed Original ResearchConceptsNutrient stressFatty acid oxidationAcyl-CoA poolMacrophage energy metabolismAcid oxidationMetabolic stressorsMyeloid lineage cellsStress sensingSwitch mechanismMetabolic homeostasisLineage cellsEnergy metabolismImportant unanswered questionsMuscle cellsHomeostasisCRATHigh-fat diet-induced obesityAcetyltransferase expressionDiet-induced obesityGlucose homeostasisTissue leukocytosisMacrophagesCellsLittermate controlsUnanswered questions
2015
Evolutionary innovations and novelties: Let us get down to business!
Wagner G. Evolutionary innovations and novelties: Let us get down to business! Zoologischer Anzeiger 2015, 256: 75-81. DOI: 10.1016/j.jcz.2015.04.006.Peer-Reviewed Original ResearchCore gene regulatory networkGene regulatory networksRegulatory networksNovel body partsEvolutionary innovationEvolutionary developmental biologyCore regulatory networkBody part identityEvolutionary noveltyEvolutionary biologistsEvolutionary biologyDevelopmental biologyEvolutionary changeBiological processesCell typesImportant unanswered questionsBiologyCritical insightsGenomicsRecent advancesMechanistic aspectsGenesBiologistsUnanswered questionsBody parts
2012
Lactation and Neonatal Nutrition: Defining and Refining the Critical Questions
Neville MC, Anderson SM, McManaman JL, Badger TM, Bunik M, Contractor N, Crume T, Dabelea D, Donovan SM, Forman N, Frank DN, Friedman JE, German JB, Goldman A, Hadsell D, Hambidge M, Hinde K, Horseman ND, Hovey RC, Janoff E, Krebs NF, Lebrilla CB, Lemay DG, MacLean PS, Meier P, Morrow AL, Neu J, Nommsen-Rivers LA, Raiten DJ, Rijnkels M, Seewaldt V, Shur BD, VanHouten J, Williamson P. Lactation and Neonatal Nutrition: Defining and Refining the Critical Questions. Journal Of Mammary Gland Biology And Neoplasia 2012, 17: 167-188. PMID: 22752723, PMCID: PMC3428522, DOI: 10.1007/s10911-012-9261-5.Peer-Reviewed Original ResearchConceptsHuman milk compositionMammary gland developmentGestational diabetesObese mothersPreterm infantsUndernourished mothersMaternal nutritionNeonatal nutritionHuman milkInfant nutritionNeonatal developmentSpecific nutritional challengesSpecific training recommendationsMammary developmentUnanswered questionsHuman lactationMetabolic statusInfantsTherapeutic drugsGland developmentNutritional challengesImportant unanswered questionsMilk componentsBehavioral phenotypesLactation
2008
Stem Cells and the Pathogenesis of Endometriosis
Sasson IE, Taylor HS. Stem Cells and the Pathogenesis of Endometriosis. Annals Of The New York Academy Of Sciences 2008, 1127: 106-115. PMID: 18443337, PMCID: PMC3107843, DOI: 10.1196/annals.1434.014.Peer-Reviewed Original ResearchConceptsPathogenesis of endometriosisGynecological disordersEndometrial stem/progenitor cellsChronic pelvic painCommon gynecological disorderEndometrial stem cellsStem/progenitor cellsStem cellsPelvic painEndometrial tissueUterine cavityLikely multifactorialExtensive morbidityMenstrual cycleEndometriosisRole of geneticsImmune systemNarrative reviewPathogenesisProgenitor cellsPotential roleImportant unanswered questionsSuch cellsDisordersCells
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