2024
Comparative Kidney Uptake of Nanobody-Based PET Tracers Labeled with Various Fluorine-18-Labeled Prosthetic Groups
Olkowski C, Basuli F, Fernandes B, Ghaemi B, Shi J, Zhang H, Farber J, Escorcia F, Choyke P, Jacobson O. Comparative Kidney Uptake of Nanobody-Based PET Tracers Labeled with Various Fluorine-18-Labeled Prosthetic Groups. Molecular Pharmaceutics 2024, 22: 533-543. PMID: 39680709, DOI: 10.1021/acs.molpharmaceut.4c01101.Peer-Reviewed Original ResearchDevelopment of Peptide-Based Probes for Molecular Imaging of the Postsynaptic Density in the Brain
Fernandes E, Palner M, Raval N, Jeppesen T, Danková D, Bærentzen S, Werner C, Eilts J, Maric H, Doose S, Aripaka S, Kaalund S, Aznar S, Kjaer A, Schlosser A, Haugaard-Kedström L, Knudsen G, Herth M, Stro̷mgaard K. Development of Peptide-Based Probes for Molecular Imaging of the Postsynaptic Density in the Brain. Journal Of Medicinal Chemistry 2024, 67: 11975-11988. PMID: 38981131, DOI: 10.1021/acs.jmedchem.4c00615.Peer-Reviewed Original ResearchPostsynaptic densityBrain slicesPSD-95Tracer bindingPostsynaptic density protein 95Rat brain slicesMolecular imagingPost-mortem Parkinson's diseaseScaffold proteinQuantitative autoradiographyAbundant proteinsSynaptic transmissionPostsynaptic impairmentHigh-affinity inhibitorsSignaling moleculesImaging studiesFluorescent tagsCell imaging studiesImaging Cardiac and Vascular Inflammation
Tavakoli S, Sadeghi M. Imaging Cardiac and Vascular Inflammation. 2024, 511-530. DOI: 10.1093/med/9780190095659.003.0025.Peer-Reviewed Original ResearchRisk stratification of patientsStratification of patientsPathogenesis of cardiovascular diseaseEvaluating cardiovascular pathologiesPrecision medicine toolsRisk stratificationClinical studiesEarly diagnosisInflammatory processCardiovascular diseaseMedicine toolsCardiovascular pathologyTherapeutic interventionsClinical settingImaging strategiesMolecular imagingImaging Cardiac and Vascular Inflammation
Tavakoli S, Sadeghi M. Imaging Cardiac and Vascular Inflammation. 2024, 131-133. DOI: 10.1093/med/9780197521434.003.0025.Peer-Reviewed Original ResearchRisk stratification of patientsStratification of patientsPathogenesis of cardiovascular diseaseEvaluating cardiovascular pathologiesPrecision medicine toolsRisk stratificationClinical studiesEarly diagnosisInflammatory processCardiovascular diseaseMedicine toolsCardiovascular pathologyTherapeutic interventionsClinical settingImaging strategiesMolecular imaging
2023
A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression
Jauhar S, Arnone D, Baldwin D, Bloomfield M, Browning M, Cleare A, Corlett P, Deakin J, Erritzoe D, Fu C, Fusar-Poli P, Goodwin G, Hayes J, Howard R, Howes O, Juruena M, Lam R, Lawrie S, McAllister-Williams H, Marwaha S, Matuskey D, McCutcheon R, Nutt D, Pariante C, Pillinger T, Radhakrishnan R, Rucker J, Selvaraj S, Stokes P, Upthegrove R, Yalin N, Yatham L, Young A, Zahn R, Cowen P. A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression. Molecular Psychiatry 2023, 28: 3149-3152. PMID: 37322065, PMCID: PMC10618084, DOI: 10.1038/s41380-023-02095-y.Peer-Reviewed Original ResearchNovel Radiotracers for Molecular Imaging of Myocardial Inflammation: an Update Focused on Clinical Translation of Non-18F-FDG Radiotracers
Shi T, Miller E. Novel Radiotracers for Molecular Imaging of Myocardial Inflammation: an Update Focused on Clinical Translation of Non-18F-FDG Radiotracers. Current Cardiovascular Imaging Reports 2023, 16: 1-9. PMID: 36926261, PMCID: PMC9996562, DOI: 10.1007/s12410-023-09574-4.Peer-Reviewed Original ResearchCardiac sarcoidosisMyocardial inflammatory diseaseDisease activityImmunomodulatory therapyInflammatory cardiomyopathyMyocardial inflammationInflammatory diseasesPrognostic performanceReviewThe purposeNovel radiotracersMyocarditisSarcoidosisTherapy guidanceInflammationMolecular featuresRadiotracerClinical translationMolecular imagingMolecular mechanismsHigh specificityCardiomyopathyImproved mechanistic insightsPathogenesisTherapyDisease
2022
Novel Cardiac Computed Tomography Methods for the Assessment of Anthracycline Induced Cardiotoxicity
Feher A, Baldassarre LA, Sinusas AJ. Novel Cardiac Computed Tomography Methods for the Assessment of Anthracycline Induced Cardiotoxicity. Frontiers In Cardiovascular Medicine 2022, 9: 875150. PMID: 35571206, PMCID: PMC9094702, DOI: 10.3389/fcvm.2022.875150.Peer-Reviewed Original ResearchCardiac structureEpicardial coronary arteriesAnthracycline-induced cardiotoxicityAnti-cancer therapyCoronary vasoreactivityCoronary anatomyCoronary arteryInduced cardiotoxicityCardiac functionCardiotoxic effectsPreprocedural planningExtracellular volumeMyocardial deformationPotential roleCardiotoxicityMolecular imagingCurrent manuscriptVasoreactivityComputed tomography methodArteryAnthracyclinesTherapyCardiacPlaquesEvaluationMultimodality Advanced Cardiovascular and Molecular Imaging for Early Detection and Monitoring of Cancer Therapy-Associated Cardiotoxicity and the Role of Artificial Intelligence and Big Data
Kwan JM, Oikonomou EK, Henry ML, Sinusas AJ. Multimodality Advanced Cardiovascular and Molecular Imaging for Early Detection and Monitoring of Cancer Therapy-Associated Cardiotoxicity and the Role of Artificial Intelligence and Big Data. Frontiers In Cardiovascular Medicine 2022, 9: 829553. PMID: 35369354, PMCID: PMC8964995, DOI: 10.3389/fcvm.2022.829553.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMagnetic resonance imagingExtracellular volumeEarly detectionImmune checkpoint inhibitionWall motion abnormalitiesCancer therapyMechanisms of cardiotoxicityTyrosine kinase inhibitorsCurrent imaging modalitiesAssessment of functionCardioprotective medicationsCardiotoxic eventsMolecular radiotracersCardiovascular outcomesMolecular imagingCheckpoint inhibitionNovel cancer therapiesOncologic therapyCancer mortalityMyocardial infarctionMotion abnormalitiesCardiac metabolismCardiotoxicityResonance imagingTherapyDemystifying Medico-legal Challenges of Artificial Intelligence Applications in Molecular Imaging and Therapy
Mezrich JL. Demystifying Medico-legal Challenges of Artificial Intelligence Applications in Molecular Imaging and Therapy. PET Clinics 2022, 17: 41-49. PMID: 34809868, DOI: 10.1016/j.cpet.2021.08.002.Peer-Reviewed Original ResearchConceptsCause of actionMedico-legal challengesLegal causesLegal developmentsProduct liabilityMedical malpracticeArtificial intelligenceArtificial intelligence applicationsVariety of benefitsLawsuitsLegislationLiabilityMalpracticeAppropriate guidelinesHealth careAgenciesIntelligence applicationsActionNotionHurdlesMolecular imaging
2021
Novel SPECT and PET Tracers and Myocardial Imaging
Melvinsdottir I, Avendaño R, Sinusas A. Novel SPECT and PET Tracers and Myocardial Imaging. 2021, 189-228. DOI: 10.1007/978-3-030-83167-7_11.Peer-Reviewed Original ResearchPositron emission tomographyPET imagingMultimodality cardiovascular imagingSingle photon emissionRisk stratificationPathophysiological changesCardiac functionMyocardial remodelingMyocardial diseaseAutonomic regulationMyocardial imagingEmission tomographyHigh-resolution anatomicalMyocardial flowCardiovascular imagingPET tracersNovel SPECTMolecular changesSPECTPhoton emissionHybrid imaging technologyCell deathVivo detectionMolecular imagingImaging
2020
Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging
Gona K, Toczek J, Ye Y, Sanzida N, Golbazi A, Boodagh P, Salarian M, Jung JJ, Rajendran S, Kukreja G, Wu TL, Devel L, Sadeghi MM. Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging. Journal Of Medicinal Chemistry 2020, 63: 15037-15049. PMID: 33206510, PMCID: PMC8010999, DOI: 10.1021/acs.jmedchem.0c01514.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmMMP-12 inhibitorsSelective MMP-12 inhibitorMurine abdominal aortic aneurysmsRadiochemical stabilityFast blood clearanceMolecular imagingAortic aneurysmAAA progressionMMP-12Blood clearanceUpregulated MMPsAortic regionElastase inhibitorLead tracerNovel familyRupture riskMacrophage elastaseInhibitorsSelectivitySpecific bindingSynthesisVivo competitionImagingMolecular imaging to guide precision diagnosis and prevention of cancer therapeutics-related cardiac dysfunction
Oikonomou EK. Molecular imaging to guide precision diagnosis and prevention of cancer therapeutics-related cardiac dysfunction. Expert Review Of Molecular Diagnostics 2020, 20: 355-358. PMID: 31944137, DOI: 10.1080/14737159.2020.1717336.Commentaries, Editorials and Letters32 Cardiac Imaging in Heart Failure
St. John Sutton M, Morrison A, Sinusas A, Ferrari V. 32 Cardiac Imaging in Heart Failure. 2020, 418-448.e5. DOI: 10.1016/b978-0-323-60987-6.00032-6.Peer-Reviewed Original ResearchCardiovascular magnetic resonanceHeart failureCardiac imagingCardiac resynchronization therapyManagement of patientsValvular heart diseaseAssessment of patientsNuclear medicine techniquesDetection of cardiomyopathyAssessment of metabolismAutonomic dysfunctionResynchronization therapyHeart diseaseCMR imagingThree-dimensional echoMedicine techniquesPatientsMolecular imagingImagingMagnetic resonanceStandard techniquesEchocardiographyCardiomyopathyFailureDysfunction
2019
Novel Matrix Metalloproteinase 12 Selective Radiotracers for Vascular Molecular Imaging
Toczek J, Bordenave T, Gona K, Kim HY, Beau F, Georgiadis D, Correia I, Ye Y, Razavian M, Jung J, Lequin O, Dive V, Sadeghi MM, Devel L. Novel Matrix Metalloproteinase 12 Selective Radiotracers for Vascular Molecular Imaging. Journal Of Medicinal Chemistry 2019, 62: 9743-9752. PMID: 31603669, PMCID: PMC7054845, DOI: 10.1021/acs.jmedchem.9b01186.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmVascular molecular imagingMurine abdominal aortic aneurysmsMMP-12 gene expressionMatrix metalloproteinase-12Aortic aneurysmInflammatory diseasesAdjacent aortaH postinjectionMMP-12Blood clearanceMetalloproteinase-12Selective radiotracerFurther evaluationMMP-12 inhibitorsMouse bloodHigh uptakeAortaDiseaseMolecular imagingHuman metalloproteasesRadiotracerMolecular Imaging Targets in Heart Failure and Left Ventricular Remodeling
Boutagy N, Feher A, Sikanderkhel S, Sinusas A. Molecular Imaging Targets in Heart Failure and Left Ventricular Remodeling. 2019, 405-435. DOI: 10.1002/9781118754467.ch13.ChaptersHeart failureManagement of HFMultimodality cardiovascular imagingMolecular imaging targetsMagnetic resonance imagingPositron emission tomographySingle photon emissionExtracellular matrix depositionCardiac injuryVentricle remodelingVentricular remodelingStandard clinical toolResonance imagingEmission tomographyClinical toolCompensatory mechanismsCardiac perfusionCardiovascular imagingNuclear imaging modalitiesImaging modalitiesImaging targetsPhoton emissionMatrix depositionNoninvasive measurementMolecular imaging1ciii AD molecular: Molecular imaging of Alzheimer's disease: PET imaging of neurotransmitter systems
Mecca AP. 1ciii AD molecular: Molecular imaging of Alzheimer's disease: PET imaging of neurotransmitter systems. Progress In Nucleic Acid Research And Molecular Biology 2019, 165: 139-165. PMID: 31481161, DOI: 10.1016/bs.pmbts.2019.04.003.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingDisease pathogenesisSynaptic protein changesAlzheimer's disease (AD) pathogenesisEmission Tomography ImagingPositron emission tomography (PET) imagingNeurotransmitter lossMolecular imagingNeuropsychiatric symptomsImportant etiologyAssessment of cognitionDisease progressionNeurotransmitter systemsAmyloid βTherapeutic efficacyAlzheimer's diseaseResonance imagingSynaptic proteinsTau aggregatesValuable markerStudy of ADVivo molecular imagingTomography imagingPET imagingDiseaseMolecular Imaging of the Heart
Boutagy NE, Feher A, Alkhalil I, Umoh N, Sinusas AJ. Molecular Imaging of the Heart. 2019, 9: 477-533. PMID: 30873600, DOI: 10.1002/cphy.c180007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiovascular diseaseRisk stratificationCardiovascular molecular imagingMultimodality cardiovascular imagingIschemic heart failureMolecular imagingMolecular imaging targetsPositron emission tomographySingle photon emissionNumerous cardiovascular diseasesClinical molecular imagingEjection fractionHeart failureMedical therapySystemic diseaseMyocardial infarctionPathophysiological changesCardiac functionEarly diagnosisDisease processCardiac arrhythmiasEmission tomographyCardiovascular imagingImaging strategiesPhoton emission
2018
Investigation of Nanodroplet Adhesion to Endothelial Cells Under Atheroprone Flow Conditions
Zhang G, Pang K, Ghim M, Weinberg P, Tang M. Investigation of Nanodroplet Adhesion to Endothelial Cells Under Atheroprone Flow Conditions. 2018, 00: 1-4. DOI: 10.1109/ultsym.2018.8579749.Peer-Reviewed Original ResearchNovel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis, 99mTc-labeling, and Evaluation
Ye Y, Toczek J, Gona K, Kim HY, Han J, Razavian M, Golestani R, Zhang J, Wu TL, Ghosh M, Jung JJ, Sadeghi MM. Novel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis, 99mTc-labeling, and Evaluation. Scientific Reports 2018, 8: 11647. PMID: 30076321, PMCID: PMC6076275, DOI: 10.1038/s41598-018-29941-2.Peer-Reviewed Original ResearchConceptsMatrix metalloproteinasesMMP inhibitorsLung tissueTransgenic miceMMP activityHigh radiochemical purityHydroxamate MMP inhibitorsNumber of diseasesTissue remodelingSimilar inhibition potencyPotent inhibitionTherapySpecific bindingInhibitorsMolecular imagingImagingNovel arginineRadiochemical purityTissueHigh radiochemical yieldNew arginineMolecular imaging of prostate cancer
Boustani AM, Pucar D, Saperstein L. Molecular imaging of prostate cancer. British Journal Of Radiology 2018, 91: 20170736. PMID: 29243485, PMCID: PMC5966010, DOI: 10.1259/bjr.20170736.Peer-Reviewed Original ResearchConceptsProstate cancerNational Comprehensive Cancer Network guidelinesMetastatic diseaseMolecular imagingCommon malignancyNetwork guidelinesEffective treatmentMolecular imaging techniquesCancerMetabolic intermediaryTreatmentImaging techniquesRelevant radiotracersImagingTimely detectionAccurate imagingChemotherapySurgeryRecurrenceMalignancyDiseaseReceptors
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